Key roles of ubiquitination in regulating critical regulators of cancer stem cell functionality by Qianqian Guo, Hai Qin, Zelong Chen, Wenzhou Zhang, Lufeng Zheng, Tingting Qin

“…Recent years have witnessed an upsurge in the momentum surrounding the development of protein-based therapeutics aimed at targeting the Ub system under the sway of cancer stem cells. The article provides a comprehensive overview of the ongoing in-depth discussions regarding the regulation of the Ub system and its impact on the development of cancer stem cells. …”
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In-depth functional analysis of BRD9 in fetal hematopoiesis reveals context-dependent roles by Yifan Zhang, Masaki Nomura, Koutarou Nishimura, Weijia Zang, Yui Koike, Muran Xiao, Hiromi Ito, Miki Fukumoto, Atsushi Tanaka, Yumi Aoyama, Wataru Saika, Chihiro Hasegawa, Hiromi Yamazaki, Akifumi Takaori-Kondo, Daichi Inoue

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In-depth inference of transcriptional regulatory networks reveals NPM1 as a therapeutic ribosomal regulator in MYC-amplified medulloblastoma by Tong Chen, Huiyao Chen, Mingyang Xia, Yunfei Liao, Hao Li, Xinran Dong, Yifeng Lin, Wenhao Zhou

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Single-cell sequencing reveals transcriptional dynamics regulated by ERα in mouse ovaries. by Qicai Hu, Yiqian Gui, Congcong Cao, Jun Xie, Huiru Tang

“…<h4>Aims</h4>The study aims to elucidate the molecular mechanisms of ERα-regulated transcriptional dynamics in ovarian cells using ERα knockout (αERKO) mice created via CRISPR/Cas9.…”
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Research progress on cell cycle regulation-related molecules in the development of oral squamous cell carcinoma by HOU Zeyu, TANG Jinru, LI Longjiang

“…In‐depth research on the regulatory mechanism of cell cycle regulation‐related molecules has revealed that these molecules play various roles in the incidence and progression of OSCC. …”
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In-depth exploration of programmed cell death-related subtypes and development of a prognostic signature model in lung adenocarcinoma by Desheng Zhou, Yachao Cui, Jing Guo, Zhenpeng Wu, Lin Li, Wenguang Yin, Min Deng, Meiyuan Liu

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In‐Depth Cell‐Type‐Specific Proteome Landscape of the Brain from Human Amyloid‐β Overexpression Mouse Model by Taekyung Ryu, Seok‐Young Kim, Thujitha Thuraisamy, Jisu Shin, Yura Jang, Tae‐In Kam, Chan Hyun Na

“…This study reports in‐depth the cell‐type‐specific brain proteome landscape of the human Aβ overexpression mouse model for the first time using an innovative tool that is powerful, straightforward, and applicable to both animal models and human tissues, without the need for prior genetic alterations.…”
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In-depth insight into tumor-infiltrating stromal cells linked to tertiary lymphoid structures and their prospective function in cancer immunotherapy by Maedeh Radandish, Niloofar Mashhadi, Amir Hossein Aghayan, Motahareh Taghizadeh, Sara Salehianfard, Sheida Yahyazadeh, Omid Vakili, Somayeh Igder

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WDR62 affects the progression of ovarian cancer by regulating the cell cycle by Yuqi Yang, Wanting Jing, Lingqi Zhang, Yuhang Zhang, Ying Shang, Ye Kuang

“…WDR62 promotes ovarian cancer progression by regulating the cell cycle and may influence its development through interaction with MAPK8 to mediate the JNK signaling pathway. …”
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Advances in the regulation of macrophage polarization by the tumor microenvironment by Minzhi Peng, Yuan Zhu, Yi Hu, Jianping Wen, Weiguo Huang

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Regulation of Induced Pluripotent Stem Cells(iPS) Differentiation and Disease Model Establishment by Qi Xinyue

“…This paper delves into the mechanism of iPS cell differentiation, differentiation regulation strategies, and their applications in disease model establishment. …”
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Participation of ERM proteins in the regulation of the cell cytoskeleton and the role of the moesin protein in the path ogenesis of adenomyosis by L. V. Adamyan, L. M. Manukyan, V. O. Zayratyants, K. N. Arslanyan, O. N. Loginova

“…The role of ERM proteins in the development and progression of endometriosis is described. An in-depth study of the structure, mass, localization of ERM proteins and their functional relationship with the signaling pathways Rho, RhoA, Rhoc, RhocK1, leading to increased migration and adhesion of ectopic endometrial cells. …”
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Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiation. by Jinyue Liao, Hoi Ching Suen, Alfred Chun Shui Luk, Lele Yang, Annie Wing Tung Lee, Huayu Qi, Tin-Lap Lee

“…Spermatogonial stem cells (SSC), the foundation of spermatogenesis and male fertility, possess lifelong self-renewal activity. …”
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Biological Functions and Clinical Implications of CFLAR: From Cell Death Mechanisms to Therapeutic Targeting in Immune Regulation by Zhang H, Li X, Lin L

“…In addition to its role in cell death, CFLAR is integral to immune regulation, modulating NF-κB-dependent cytokine production (eg, IL-1β, TNF-α) and effector functions of T cells and macrophages. …”
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A genome-wide association study integrated with single-cell and bulk profiles uncovers susceptibility genes for nasopharyngeal carcinoma involved in tumorigenesis via regulation of... by Tong-Min Wang, Wen-Li Zhang, Jin-Ru Xie, Yong-Qiao He, Minzhong Tang, Wen-Qiong Xue, Da-Wei Yang, Chang-Mi Deng, Hua Diao, Zhi-Ming Mai, Ruo-Wen Xiao, Ying Liao, Dan-Hua Li, Yan-Xia Wu, Cheng-Tao Jiang, Jiang-Bo Zhang, Xue-Yin Chen, Yan Du, Cao-Li Tang, Wen-Hui Jia, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Yonglin Cai, Yuming Zheng, Zhe Zhang, Guangfu Jin, Wen Chen, Hai-Qiang Mai, Ying Sun, Zhibin Hu, Jianjun Liu, Xin-Yuan Guan, Fan Bai, Jinxin Bei, Jun Ma, Musheng Zeng, Maria Li Lung, Hans-Olov Adami, Weimin Ye, Tai-Hing Lam, Hongbing Shen, Wei-Hua Jia

“…Five putative causal genes are prioritized. We perform in-depth bioinformatic analysis and functional experiments for EOMES, finding that the nasopharyngeal carcinoma-risk alleles of four functional SNPs upregulate EOMES expression by promoting the activity of regulatory elements in T cells, and EOMES participates in nasopharyngeal carcinoma tumorigenesis via regulation of CD8+ T cell exhaustion in the tumor microenvironment. …”
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Investigation of the Anti-Aging Effects of Composite Nanocarriers Based on Autophagy Regulation and Oxidative Stress Inhibition by Min Liu, Lei Ye, Lingling Jiang, Xi Wang, Cui Sun, Jiuyan Zheng, Wei Liu

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CD47 is a tumor cell-derived exosomal signature and regulates tumor immune microenvironment and immunotherapy responses by Yifei Luan, Yinghui Zhang, Shangjin Li, Caiyun Gao, Xinyi Ying, Shaojie Zhao, Bing Zhang

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RORA Regulates Autophagy in Hair Follicle Stem Cells by Upregulating the Expression Level of the <i>Sqstm1</i> Gene by Xuefei Zhao, Yanchun Xu, Shuqi Li, Suying Bai, Wei Zhang, Yu Zhang

“…Although some of the factors involved in regulating hair follicle development have been characterized, further in-depth research is still needed. …”
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Regulation of RHBDD1 in the invasion of esophageal cancer cells via ELK3/Wnt/β-catenin signaling pathway by Bing Xu, Hui Chen, Xinchen Sun, Hongyan Cheng, Kavimbi Chipusu, Wei Hua, Tingting Chen

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Targeting PERP promotes anti-tumor immunity in HNSCC by regulating tumor immune microenvironment and metabolic homeostasis by Xueying Wang, Yuxi Tian, Xiaohong Wu, Yewen Zhu, Huihong Chen, Zeyao Wang, Zihan Liu, Jiaqi Tan, Zhaoyu Pan, Jiaoyan Cao, Zhenjiang Li, Xin Zhang, Zhongjie Shi, Juncheng Wang, Tong Liu

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