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PRMT5 Inhibitor Synergizes with Chemotherapy to Induce Resembling Mismatch Repair Deficiency and Enhance Anti‐TIGIT Therapy in Microsatellite‐Stable Colorectal Cancer
Published 2025-07-01“…Abstract Microsatellite stable (MSS) colorectal cancer (CRC) is considered an “immune‐cold” tumor, accounting for ≈85% of all CRC cases. The overall response rate to chemotherapy combined with immune checkpoint inhibitors in MSS CRC is typically less than 10%. …”
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HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes
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Mental Health in the Age of Hyperconnectivity: A Crisis Hidden in Plain Sight
Published 2025-07-01“…The constant state of hyper-connectivity creates an information overload that demands continual accessibility from all users, every hour of each day. …”
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Back pain exercise therapy remodels human epigenetic profiles in buccal and human peripheral blood mononuclear cells: an exploratory study in young male participants
Published 2024-10-01“…Monitored exercise therapy is a commonly prescribed treatment to relieve pain and functional limitations. However, the benefits of exercise are often gradual, subtle, and evaluated by subjective self-reported scores. …”
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Effect of adherent perinephric fat on outcomes of nephron-sparing treatment of renal cell cancer
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Ag-TiO2/EVA Composites for Wood Preservation: Antibacterial, Anti-mold, and Anti-Discoloration Performance
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Multimodal smoking cessation treatment combining repetitive transcranial magnetic stimulation, cognitive behavioral therapy, and nicotine replacement in veterans with posttraumatic...
Published 2024-01-01“…The most efficacious strategies being used at the VA for smoking cessation only result in a 23% abstinence rate, and veterans with PTSD only achieve a 4.5% abstinence rate. …”
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A Systematic Literature Review of the Epidemiology, Health-Related Quality of Life Impact, and Economic Burden of Immunoglobulin A Nephropathy
Published 2021-09-01“… # Results Of 123 epidemiologic studies selected for data extraction, 24 reported IgAN diagnosis rates ranging from 6.3% to 29.7% among adult and pediatric patients undergoing renal biopsy, with all reported US rates <15%. …”
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Hormonal Fluctuation and Ankle Instability in Women – Is There a Correlation?
Published 2024-12-01“…The ovulation phase, a state when estrogen levels peak, demonstrated impaired balance with higher postural sway rates, significantly greater ankle joint laxity, and decreased muscle and ligamentous tone and stiffness – an indicator of laxity. …”
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DOES BONE MINERAL DENSITY CHANGE IN EARLY AXIAL SPONDYLOARTHRITIS?
Published 2016-09-01“…The rate of osteoporosis (OP) and the mechanism of its development in patients with ankylosing spondylitis (AS) and other spondyloarthrititides (SpA) have not been sufficiently investigated. …”
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