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Myofibrillogenesis Regulator-1 in Smooth Muscle Cells Modulates Inflammation Signaling Pathways via Regulating ROCK1 Ubiquitination and Degradation to Impact Aortic Dissection
Published 2025-02-01“…Hang Yin,1– 5,* Xiaoxing Li,6,* Dazhou Lu,1– 5,* Xin Zhao,7,* Zeyu Yang,1– 5 Zerui Wang,1– 5 Feng Xu,1– 5 Yuguo Chen,1– 5 Chuanbao Li1– 5 1Department of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, People’s Republic of China; 2Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Chest Pain Center, Qilu Hospital of Shandong University, Jinan, People’s Republic of China; 3Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Shandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, People’s Republic of China; 4Shandong Key Laboratory: Magnetic Field-Free Medicine & Functional Imaging (MF), Qilu Hospital of Shandong University, Jinan, People’s Republic of China; 5NMPA Key Laboratory for Clinical Research and Evaluation of Innovative Drug, Qilu Hospital of Shandong University, Jinan, People’s Republic of China; 6Department of Geriatrics, Qilu Hospital, Shandong University, Jinan, Shandong, People’s Republic of China; 7Department of Cardiovascular Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chuanbao Li; Yuguo Chen, Department of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, People’s Republic of China, Email bao2460@126.com; chen919085@sdu.edu.cnBackground: Aortic dissection (AD) is a life-threatening cardiovascular emergency and currently lacks effective drug treatment. …”
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Detection of the Extended γ-Ray Emission around TeV Source 1LHAASO J0249+6022 with Fermi-LAT
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Lactate Dehydrogenase-A-Forming LDH5 Promotes Breast Cancer Progression
Published 2025-02-01“…Tianxing Fang,1– 4 Liyu Hu,5 Tianshun Chen,4 Fei Li,6 Liu Yang,4 Bin Liang,7 Wenjun Wang,8 Fancai Zeng4 1Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 2Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, People’s Republic of China; 3Institute of Nuclear Medicine, Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 4Laboratory of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 5Oral & Maxillofacial Reconstruction and Regeneration of Luzhou Key Laboratory, The Affiliated Stomatological Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 6Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 7Department of General Surgery (Breast Surgery), the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 8Institute for Cancer Medicine and School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, People’s Republic of ChinaCorrespondence: Fancai Zeng; Wenjun Wang, Email zfcai@swmu.edu.cn; wenjunwang1213@126.comBackground: Breast cancer (BC) has become the main malignant tumor threatening the health of women worldwide. …”
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Psoriasis: Unraveling Disease Mechanisms and Advancing Pharmacological and Nanotechnological Treatments
Published 2025-02-01“…Miao Miao,1 Jiong Yan,2 Yujin Sun,3 Jia Liu,2 Shun Guo2 1Outpatient Department, Disease Prevention and Control Center of Tongshan District, Xuzhou, People’s Republic of China; 2Dermatology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China; 3Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People’s Republic of ChinaCorrespondence: Jia Liu; Shun Guo, Affiliated Hospital of Nanjing University of Chinese Medicine, 155 Hanzhong Road, Qinhuai District, Nanjing, Jiangsu Province, 210029, People’s Republic of China, Email aliceyoyo1986@163.com; 260873@njucm.edu.cnAbstract: Research into the pathogenesis of inflammatory skin diseases, including dermatitis and psoriasis, has yielded significant advancements in the last decades. …”
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Association of Serum Irisin With Severity and Prognosis in Patients With Coronavirus Disease 2019: A Prospective Cohort Study
Published 2025-02-01“…Xinli Zhang,1,2,* Wennan Wang,1,3,* Ye Li,2 Xiaoning Liu,2 Liangzhu Zhang,2 Zhenyu Cheng,1,4 Mingyan Liu,1,4 Yu Wang,1,4 Lin Fu,1,4 Jin Yang1,4,5 1Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People’s Republic of China; 2The First Department of Tuberculosis, Anhui Chest Hospital, Hefei, Anhui Province, People’s Republic of China; 3The Fifth Department of Tuberculosis, Anhui Chest Hospital, Hefei, Anhui Province, People’s Republic of China; 4Institute of Respiratory Diseases, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People’s Republic of China; 5Information Management Center, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lin Fu; Jin Yang, Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People’s Republic of China, Email fulindev@126.com; yangqj1015@foxmail.comBackground: Irisin is the cleaved form of fibronectin type III domain-containing protein 5 (FNDC5), which can confer antioxidant and anti-inflammatory effects. …”
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Effects of Ciprofol and Propofol General Anesthesia on Postoperative Recovery Quality in Patients Undergoing Ureteroscopy: A Randomized, Controlled, Double-Blind Clinical Trial
Published 2025-02-01“…Shuqi Shi,1,2,* Jimin Wu,1,* Yini Wu,1 Xin Han,1 Hong Dai,1 Xuedong Chen,3 Zhangnan Sun,4 Faxing Wang1,2 1Department of Anesthesiology, Lishui People’s Hospital, Wenzhou Medical University Lishui Hospital, The First Affiliated Hospital of Lishui University, Lishui, People’s Republic of China; 2Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 3Department of Urology, Lishui People’s Hospital, Wenzhou Medical University Lishui Hospital, The First Affiliated Hospital of Lishui University, Lishui, People’s Republic of China; 4Department of Anesthesiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Faxing Wang, Department of Anesthesiology, Lishui People’s Hospital, Wenzhou Medical University Lishui Hospital, The First Affiliated Hospital of Lishui University, No. 15, Dazhong Street, Lishui, Zhejiang Province, 323000, People’s Republic of China, Email wfx2023@wmu.edu.cn Zhangnan Sun, Department of Anesthesiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People’s Republic of China, Email 28703077@hebmu.edu.cnObjective: This study compares postoperative recovery quality between Ciprofol and Propofol, providing a reference for the clinical application of anesthetics.Methods: We randomized 112 patients undergoing ureteroscopic surgery into two groups: the Ciprofol group (Group C), with an induction dose of 0.4 mg/kg and a maintenance dose of 0.8– 1.5 mg/(kg·h), and the Propofol group (Group P), with an induction dose of 2 mg/kg and a maintenance dose of 4– 10 mg/(kg·h). …”
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A Nomogram Based on Circulating Inflammatory Factors for Predicting Prognosis of Newly Diagnosed Multiple Myeloma Patients
Published 2025-02-01“…Mowang Wang,1– 4,* Xiaoyan Yue,5,* Yingying Ding,5,* Zhen Cai,1,4 Haowen Xiao,5 He Huang,1– 4 Jingsong He1,4 1Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People’s Republic of China; 2Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, Zhejiang Province, People’s Republic of China; 3Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang Province, People’s Republic of China; 4Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, Zhejiang Province, People’s Republic of China; 5Department of Hematology and Cell Therapy, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: He Huang; Jingsong He, Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, Zhejiang Province, 310006, People’s Republic of China, Email huanghe@zju.edu.cn; hejingsong@zju.edu.cnPurpose: The growth and survival of multiple myeloma (MM) cells depend heavily on bone marrow microenvironment, where inflammation emerges as a significant feature and is commonly associated with unfavorable prognosis in MM. …”
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Pyrvinium Pamoate Synergizes with Azoles in vitro and in vivo to Exert Antifungal Efficacy Against Candida auris and Other Candida Species
Published 2025-02-01“…Jinqing Zhang,1,* Gaolian Li,2,* Jing Hu,3,* Jingwen Tan,4 Heng Zhang,5 Yizheng Zhou5 1Department of Dermatology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Gynaecology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei Province, People’s Republic of China; 3Department of Clinical Medicine, Xiangyang Polytechnic, Xiangyang, Hubei Province, People’s Republic of China; 4Department of Medical Mycology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China; 5Department of Clinical Laboratory, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yizheng Zhou, Email zhou_yizheng@163.comIntroduction: Treating infections caused by azole-resistant Candida spp. poses a significant challenge. …”
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Individual Differences in Placebo Analgesia: Functional Connectivity and Neural Mechanisms [Letter]
Published 2025-02-01“…Haixing Cao,* Yujie Zhang,* Lingfeng Bai, Xiang Ma The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiang Ma, The First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, Dalian City, Liaoning Province, People’s Republic of China, Email xma9467@vip.sina.com…”
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The Role of Mature Brain-Derived Neurotrophic Factor and Its Precursor in Predicting Early-Onset Insomnia in Stroke Patients Experiencing Early Neurological Deterioration
Published 2025-02-01“…Guomei Shi,1,2 Peng Yu,2,3 Ziru Wang,2,4 Mingyang Xu,2,3 Minwang Guo,2,3 Xiaorong Wang,2,3 Rujuan Zhou2,3 1Department of Neurology, Taixing Clinical College of Bengbu Medical College, Taixing, Jiangsu, People’s Republic of China; 2Stroke Center, Taixing People’s Hospital, Taixing, Jiangsu, People’s Republic of China; 3Department of Neurology, Taixing People’s Hospital, Taixing, Jiangsu, People’s Republic of China; 4Department of Rehabilitation, Taixing People’s Hospital, Taixing, Jiangsu, People’s Republic of ChinaCorrespondence: Rujuan Zhou, Taixing People’s Hospital, No. 1 Changzheng Road, Taixing, Jiangsu Province, 225400, People’s Republic of China, Tel +86-13951158499, Email zhourujuan123@163.comBackground: The investigation and management of early-onset insomnia (EOI) in patients undergoing early neurological deterioration (END) appear to be insufficiently prioritized in clinical practice. …”
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Investigating the Use of Generative Adversarial Networks-Based Deep Learning for Reducing Motion Artifacts in Cardiac Magnetic Resonance
Published 2025-02-01“…Ze-Peng Ma,1,2,* Yue-Ming Zhu,3,* Xiao-Dan Zhang,4 Yong-Xia Zhao,1 Wei Zheng,3 Shuang-Rui Yuan,1 Gao-Yang Li,1 Tian-Le Zhang1 1Department of Radiology, Affiliated Hospital of Hebei University/ Clinical Medical College, Hebei University, Baoding, 071000, People’s Republic of China; 2Hebei Key Laboratory of Precise Imaging of inflammation Tumors, Baoding, Hebei Province, 071000, People’s Republic of China; 3College of Electronic and Information Engineering, Hebei University, Baoding, Hebei Province, 071002, People’s Republic of China; 4Department of Ultrasound, Affiliated Hospital of Hebei University, Baoding, Hebei Province, 071000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiao-Dan Zhang, Department of Ultrasound, Affiliated Hospital of Hebei University, No. 212 of Yuhua East Road, Lianchi District, Baoding, 071000, People’s Republic of China, Tel +86 17325535302, Email xiaodanzhangzxd@126.comObjective: To evaluate the effectiveness of deep learning technology based on generative adversarial networks (GANs) in reducing motion artifacts in cardiac magnetic resonance (CMR) cine sequences.Methods: The training and testing datasets consisted of 2000 and 200 pairs of clear and blurry images, respectively, acquired through simulated motion artifacts in CMR cine sequences. …”
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Role of Computed Tomography in Predicting Programmed Death Ligand-1 Positivity in Gastric Adenocarcinoma
Published 2025-02-01“…Zhi-Hong Yu,1,* Wei-Qin Ma,2,* Ji-Wei Ren,3 Xu-Ting Zhang,3 Lin Chu3 1Department of Ultrasound, Shanxi Provincial People’s Hospital, The Fifth Hospital of Shanxi Medical University, The Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, 030012, People’s Republic of China; 2Department of CT/MRI, Lvliang People’s Hospital, Shanxi Province, Lvliang, Shanxi, 033000, People’s Republic of China; 3Department of Radiology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, 030013, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xu-Ting Zhang; Ji-Wei Ren, Department of Radiology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, No. 3 Zhigongxin Street, Taiyuan, Shanxi, 030013, People’s Republic of China, Tel +86 18335172028, Email xuting_zhang@126.com; renjw2023@sxmu.edu.cnObjective: To examine the association between computed tomography (CT) imaging characteristics and programmed death ligand-1 (PD-L1) expression in patients with gastric adenocarcinoma (GAC), and to develop a nomogram model for prediction.Methods: The patients were randomly allocated into a training set and a validation set at a ratio of 7:3. …”
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Clinical Features and Prognosis of Double-Positive Anti-MDA5 and Anti-CCP Antibodies in Dermatomyositis: A Retrospective Study
Published 2025-02-01“…Xiayu Xu,1 Longyang Zhu,2 Sizhao Li,3 Guochun Wang,3 Yongpeng Ge3 1Department of Rheumatology and Immunology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, People’s Republic of China; 2Peking University, China-Japan Friendship School of Clinical Medicine, Beijing, People’s Republic of China; 3Department of Rheumatology, The Key Laboratory of Myositis, China-Japan Friendship Hospital, Beijing, People’s Republic of ChinaCorrespondence: Yongpeng Ge, Department of Rheumatology, The Key Laboratory of Myositis, China-Japan Friendship Hospital, Beijing, 100029, People’s Republic of China, Email gyp2016@163.comObjective: To investigate the clinical features and prognosis of anti-melanoma differentiation-related gene 5 (MDA5) antibody and anti-cyclic citrullinated peptide (CCP) antibody double-positive dermatomyositis (DM) (MDA5+/CCP+ DM).Methods: A retrospective analysis of 264 consecutive cases of MDA5+ DM hospitalized from March 2018 to March 2022, and patients with anti-CCP antibodies were screened out. …”
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Analysis of Influencing Factors and Construction of a Column Chart Model for Postoperative Pulmonary Infection in Patients With Severe Traumatic Brain Injury
Published 2025-02-01“…Gaoyi Wu,1 Xiwen Zhong,2 Jing Chen1 1Department of Emergency, Wenzhou Central Hospital, Wenzhou City, Zhejiang Province, 325000, People’s Republic of China; 2Department of Gynaecology and Obstetrics, Wenzhou Central Hospital, Wenzhou City, Zhejiang Province, 325000, People’s Republic of ChinaCorrespondence: Jing Chen, Department of Emergency, Wenzhou Central Hospital, No. 252, Baili East Road, Lucheng District, Wenzhou City, Zhejiang Province, 325000, People’s Republic of China, Email Chenioung7643@126.comObjective: To analyze the influencing factors of postoperative pulmonary infection in patients with severe traumatic brain injury, and establish and validate a column chart prediction model.Methods: A retrospective study was conducted on 314 patients with severe traumatic brain injury in our hospital from January 2022 to March 2024. …”
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Remote Continuous Microinjury-Triggered Cytokines Facilitate Severe Diabetic Foot Ulcer Healing via the Ras/Raf/MEK/ERK Pathway
Published 2025-02-01“…Xiajie Huang,1,2,* Jie Liu,1,* Xiaomei Wu,1 Yangzhou Mo,1 Xiping Luo,1 Yongge Yang,1 Chaoquan Yang,1 Xinyun Liang,1 Rongyuan Liang,1 Yeping Chen,1 Zezhen Fan,1 William Lu,3 Yan Chen,1 Qikai Hua1 1Department of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, People’s Republic of China; 2Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed by the Province and Ministry, Guangxi Medical University, Nanning, People’s Republic of China; 3Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan Chen; Qikai Hua, Department of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, People’s Republic of China, Email cy003@connect.hku.hk; hqk100@yeah.netPurpose: Microinjury can trigger in situ tissue repair. …”
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Advances and challenges in platelet counting: evolving from traditional microscopy to modern flow cytometry
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Efficacy of Group O Washed Red Blood Cell Transfusion on Vital Signs and Hematologic Stability in Trauma Patients With Different Blood Types
Published 2025-02-01“…Xian-Juan Gou,1 Lin-Fei Li,1 Xiao-Li He,1 Xi Chen,2 An-Yong Yu,1 Wei-Yan Tian1 1Department of Emergency, Affiliated Hospital of Zunyi Medical University, Zunyi City, Guizhou Province, 563000, People’s Republic of China; 2School of Nursing, Zunyi Medical University, Zunyi City, Guizhou Province, 563000, People’s Republic of ChinaCorrespondence: Wei-Yan Tian, Department of Emergency, Affiliated Hospital of Zunyi Medical University, Zunyi City, Guizhou Province, 563000, People’s Republic of China, Tel +86 19184321912, Email 907359734@qq.comObjective: To comprehensively assess the impact of emergency transfusion of group O washed red blood cells on the vital signs and hematological parameters of patients with severe trauma and to analyze the differential responses among different blood types, thereby providing valuable evidence for optimizing transfusion strategies.Methods: A retrospective analysis was conducted on the clinical data of patients with severe trauma who underwent emergency transfusion in the hospital’s emergency department from April 2023 to March 2024. …”
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Permeability-Enhancing and Protective Effect on Small Intestine of Punicic Acid in Different Forms and Their Nanoemulsions With Low Toxicity
Published 2025-02-01“…Dongyan Duan,1,* Hua Xie,2,* Jiayi Jiang,1 Ping Yang,1 Zhiyuan Guo,2 Xiaoqiang Guo,1 Xingyu Chen,1 Qian Yao1 1Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu, 610106, People’s Republic of China; 2Sichuan Provincial Institute for Drug Control and Research, Chengdu, 610000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qian Yao, School of Pharmacy, Chengdu University, Shiling Town, Longquan District, Chengdu, Sichuan Province, 610106, People’s Republic of China, Email yaoqian@cdu.edu.cnPurpose: Most absorption enhancers boost the oral absorption of drugs via increasing intestinal permeability. …”
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Advances in Focal Segmental Glomerulosclerosis Treatment From the Perspective of the Newest Mechanisms of Podocyte Injury
Published 2025-02-01“…Yan Zhu,1,2 Gaosi Xu1,2 1Department of Nephrology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang City, Jiangxi Province, People’s Republic of China; 2Jiangxi Key Laboratory of Molecular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang City, Jiangxi Province, People’s Republic of ChinaCorrespondence: Gaosi Xu, Email gaosixu@163.comAbstract: Podocyte injury was widely recognized as a fundamental mechanism driving the progression of focal segmental glomerulosclerosis (FSGS). …”
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