A polymicrobial perspective into the ecological role of Enterococcus faecalis in dental root canal infections by Ana Parga, Jade Mattu, Georgios N. Belibasakis, Kimberly A. Kline, Julian G. Leprince, Daniel Manoil

“…Abstract Enterococcus faecalis, a non-oral nosocomial pathogen, intriguingly ranks among the most frequently retrieved species from polymicrobial infections of dental root canals. This review integrates findings from the latest omics approaches, alongside emerging evidence of E. faecalis interactions within oral polymicrobial communities, to refine our understanding of its role in these infections. …”
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Controlling Oral Polymicrobial Biofilm Using Usnic Acid on the Surface of Titanium in the Artificial Saliva Media by Nazia Tabassum, Fazlurrahman Khan, Geum-Jae Jeong, Do Kyung Oh, Young-Mog Kim

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The Clinical Validity and Utility of PCR Compared to Conventional Culture and Sensitivity Testing for the Management of Complicated Urinary Tract Infections in Adults: A Secondary... by Moustafa Kardjadj, Tara W. Chang, Roel Chavez, DeAndre Derrick, Frank L. Spangler, Itoe P. Priestly, Lauren Y. Park, Thomas K. Huard

“…These findings highlight the limitations of C&S in detecting polymicrobial infections, antimicrobial resistance, and hetero-resistance due to its limited clonal analysis, supporting the integration of PCR for more accurate diagnostics and optimized cUTI management.…”
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Advancing periodontitis microbiome research: integrating design, analysis, and technology by Yibing Han, Pei-Hui Ding

“…Periodontitis, a chronic inflammatory disease affecting 20%-50% of adults worldwide, is driven by polymicrobial synergy and dysbiosis. Despite numerous studies on the oral microbiota in periodontitis, significant heterogeneity exists between findings, posing challenges for treatment strategies. …”
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Green Nanotechnology: Naturally Sourced Nanoparticles as Antibiofilm and Antivirulence Agents Against Infectious Diseases by Habiba lawal, Shamsaldeen Ibrahim Saeed, Mohammed Sani Gaddafi, Nor Fadhilah Kamaruzzaman

“…This study underscores the transformative potential of leveraging naturally sourced nanoparticles as sustainable alternatives to conventional antimicrobials, offering quantitative insights for their future application in combating mono- and polymicrobial infections.…”
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Genotyping problems of microorganisms by R. A. Volkova, E. S. Skolotneva, E. V. Elbert, E. D. Mytsa, D. S. Davydov, A. A. Movsesyants, V. A. Merkulov, V. P. Bondarev, I. V. Borisevich

“…The computing tools for integration the phenotyping and sequencing data have developed. …”
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Evaluating the feasibility, sensitivity, and specificity of next-generation molecular methods for pleural infection diagnosis by Peter T. Bell, Timothy Baird, John Goddard, Olusola S. Olagoke, Andrew Burke, Shradha Subedi, Tiana R. Davey, James Anderson, Derek S. Sarovich, Erin P. Price

“…Accurate diagnosis remains challenging due to low culture positivity rates, frequent polymicrobial involvement, and non-specific diagnostic biomarkers. …”
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Unveiling the Future of Infective Endocarditis Diagnosis: The Transformative Role of Metagenomic Next-Generation Sequencing in Culture-Negative Cases by Shafiu A. Umar Shinge, Binbin Zhang, Baixin Zheng, Yongjia Qiang, Hussein M. Ali, Youmbi T. Vanessa Melchiade, Lu Zhang, Minnan Gao, Guibin Feng, Kuan Zeng, Yanqi Yang

“…For mNGS to be effectively integrated into routine CNE care, standardization, regulatory clarity, and equitable implementation will be essential.…”
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Interplay between C-reactive protein responses and antibiotic prescribing in people with suspected infection by Qingze Gu, Kevin Yuan, Jia Wei, Chang Ho Yoon, Anders Skyrud Danielsen, Augustine Luk, David W. Eyre, A. Sarah Walker

“…Episodes were categorised by blood culture results: Gram-positive, Gram-negative, polymicrobial, contaminants, or culture-negative (having previously shown that 51% culture-negatives have CRP responses indistinguishable from culture-positives). …”
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Management of Fournier’s Gangrene by Indigenous Ayurveda: A Case Report by Mansi Nakum, Devyani Dasar, Naveen Singh, Dhruv Modi, Krishna Shinde

“…This rapidly progressing and potentially fatal condition involves a polymicrobial infection, causing extensive tissue necrosis. …”
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Application of Metagenomic and Targeted Next-Generation Sequencing in Diagnosis of Pulmonary Tuberculosis in Bronchoalveolar Lavage Fluid by Yang Z, Liu Q, Hu Y, Geng S, Ni JX

“…While both mNGS and tNGS demonstrate enhanced capacity for polymicrobial detection, the clinical significance of co-detected microorganisms requires integration with clinical context to differentiate colonization from active infection. …”
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Interspecies Communication and Periodontal Disease by Ajay Mahajan, Baljeet Singh, Divya Kashyap, Amit Kumar, Poonam Mahajan

“…Interactions among human oral bacteria are integral to the development and maturation of the plaque. …”
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Temporal Profiling of Extracellular Polymeric Substances Associated with Biofilm Formation in Bacteria Isolated from Wound Infection by Prabhavati Shinde, Shraddha Jaiswal, Vidya Tale

“…Despite the development of diverse treatments targeting various aspects of wound healing, the formidable obstacle of polymicrobial biofilm consortia persists. The biofilm matrix comprises EPS (Extracellular Polymeric Substances), mainly contains proteins, carbohydrates and eDNA (Extracellular DNA). …”
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Intestinal non-canonical NFκB signaling shapes the local and systemic immune response by Sadeesh K. Ramakrishnan, Huabing Zhang, Xiaoya Ma, Inkyung Jung, Andrew J. Schwartz, Daniel Triner, Samantha N. Devenport, Nupur K. Das, Xiang Xue, Melody Y. Zeng, Yinling Hu, Richard M. Mortensen, Joel K Greenson, Marilia Cascalho, Christiane E. Wobus, Justin A. Colacino, Gabriel Nunez, Liangyou Rui, Yatrik M. Shah

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The role of citric acid in denture cleansing: Effects on biofilm reduction and corrosion resistance of Co-Cr alloys by Maria Helena Rossy BORGES, Luís Fernando Bandeira MIRANDA, Samuel Santana MALHEIROS, Ayrton Geroncio SILVA, João Vicente CALAZANS NETO, Mariana Alves dos SANTOS, Elidiane Cipriano RANGEL, Valentim Adelino Ricardo BARÃO, Bruna Egumi NAGAY

“…Microbial viability, metabolic activity, and morphology of the polymicrobial biofilm were assessed after treatment to evaluate the efficacy of the decontamination solutions. …”
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Medicinal evaluation and molecular docking study of osajin as an anti-inflammatory, antioxidant, and antiapoptotic agent against sepsis-associated acute kidney injury in rats by Mohammad Alhilal, Huseyin Serkan Erol, Serkan Yildirim, Ahmet Cakir, Murat Koc, Suzan Alhilal, Esra Dereli, Omer Alkanoglu, Volkan Ay, Ismail Can, Mesut Bunyami Halici

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Mesalazine: a novel therapeutic agent for periodontitis via regulation of periodontal microbiota and inhibiting Porphyromonas gingivalis by Yuqi Wang, Yuqi Wang, Jun Ma, Haoyu Wang, Haoyu Wang, Jingzheng Yi, Yuxin Bai, Yuxin Bai, Min Hu, Min Hu, Jiaqing Yan, Jiaqing Yan

“…At the nanometer scale, mesalazine induced crumpling and rupture of the P. gingivalis surface, compromising cell membrane integrity. Mesalazine not only suppressed the formation of plaque biofilms by P. gingivalis and polymicrobial communities but also disrupted pre-existing biofilms. …”
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Machine learning-based prognostic model for bloodstream infections in hematological malignancies using Th1/Th2 cytokines by Qin Li, Nan Lin, Zuheng Wang, Yuexi Chen, Yuli Xie, Xuemei Wang, Jirui Tang, Yuling Xu, Min Xu, Na Lu, Yiqian Huang, Jiamin Luo, Zhenfang Liu, Li Jing

“…The predictive model was developed by integrating Th1/Th2 cytokines with clinical features, aiming to enhance the accuracy of 30-day mortality prediction. …”
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Next-generation diagnostics of bloodstream infections enabled by rapid whole-genome sequencing of bacterial cells purified from blood culturesResearch in context by Vincenzo Di Pilato, Chiara Bonaiuto, Fabio Morecchiato, Alberto Antonelli, Tommaso Giani, Gian Maria Rossolini

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Epidemiology and Outcomes of Infected Non-Unions: An Observational Study at an Infectious Disease Referral Centre by Sara Tedeschi, Nicolò Rossi, Eleonora Zamparini, Simone Ambretti, Massimiliano Mosca, Cesare Faldini, Stefano Zaffagnini, Alessandra Maso, Andrea Sambri, Massimiliano De Paolis, Pierluigi Viale

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