Observational study on the current status of thalassaemia in Malaysia: a report from the Malaysian Thalassaemia Registry by Hishamshah Mohd Ibrahim, Zulaiha Muda, Ida Shahnaz Othman, Mohamed Najib Mohamed Unni, Kok Hoi Teh, Asohan Thevarajah, Kogilavani Gunasagaran, Gek Bee Ong, Seoh Leng Yeoh, Aisyah Muhammad Rivai, Che Hadibiah Che Mohd Razali, Nazzlin Dizana Din, Zarina Abdul Latiff, Rahman Jamal, Norsarwany Mohamad, Hany Mohd Ariffin, Hamidah Alias

“…This study aims to report the current status of thalassaemia in Malaysia and provide a comprehensive understanding of the disease through data obtained from the Malaysian Thalassaemia Registry.Design Data were extracted from the Malaysian Thalassaemia Registry, a web-based system accessible to enrolled users through www.mytalasemia.net.my.Setting The Malaysian Thalassaemia Registry data was recorded from reports obtained from 110 participating government and university hospitals in Malaysia.Participants The patients were those attending the 110 participating hospitals for thalassaemia treatment.Intervention Data were collected from the Malaysian Thalassaemia Registry from 2007 until the fourth quarter of 2018.Primary outcome measure 7984 out of 8681 patients with thalassaemia registered in the Malaysian Thalassaemia Registry were reported alive.Results Majority of the patients were reported in the state of Sabah (22.72%); the largest age group affected was 5.0–24.9 years old (64.45%); the largest ethnic group involved was Malay (63.95%); and the major diagnosis was haemoglobin E/β-thalassaemia (34.37%). …”
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Efficacy of Chinese traditional quadruple single pill combination versus valsartan/hydrochlorothiazide for the treatment of hypertension (COSPQ-BP): study protocol for randomised c... by Kai Liu, Yu Yan, Xin Zhang, Yanan Li, Yuanyuan Yao, Lu Liu, Runyu Ye, Si Wang, Xiangyu Yang, Xiaoping Chen, Shanshan Jia, Qingtao Meng, Xianghao Zuo

“…Participants who meet the inclusion criteria will be randomly assigned to a 1:1 ratio to an intervention group (compound reserpine and triamterene tablets) or a control group (valsartan/hydrochlorothiazide). …”
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A novel model-based meta-analysis to indirectly estimate the comparative efficacy of two medications: an example using DPP-4 inhibitors, sitagliptin and linagliptin, in treatment o... by Yan Gong, James Rogers, Christian Friedrich, Sanjay Patel, Alexander Staab, Jorge Luiz Gross, Daniel Polhamus, William Gillespie, Brigitta Ursula Monz, Silke Retlich

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Hip and Trunk Variables in University Students with and without Recurrent Low Back Pain by BJ Lehecka, Jordin Burleson, Paige Diederich, Morgan Salem, Rachel Schoonover, Jason Tejano

“… # Conclusion The findings of this study show statistically significant although clinically non-meaningful differences in hip flexion, extension, and adduction ROM in the rLBP group compared to the control group. This lack of clinically meaningful difference may be relevant to testing procedures and treatment of patients or athletes with rLBP. …”
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Physically Active Adults with Low Back Pain do not Demonstrate Altered Deadlift Mechanics: A Novel Application of Myotonometry to Estimate Inter-Muscular Load Sharing by Jared M. McGowen, Stephanie R. Albin, Carrie W. Hoppes, Jeffrey S. Forsse, John Abt, Shane L. Koppenhaver

“…Separate analyses of covariance were conducted to compare absolute and relative muscle stiffness between the groups for each muscle and condition. # Results Sixty-eight participants (41 female, 21.3 years, 34 LBP) volunteered for the study. …”
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Multinational comparison of new antidepressant use in older adults: a cohort study by Robyn Tamblyn, David Westfall Bates, David L Buckeridge, Will Dixon, Alan J Forster, Nadyne Girard, Jennifer Haas, Bettina Habib, Siyana Kurteva, Jack Li, Therese Sheppard

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Local Anesthesia Versus Saddle Block for Open Hemorrhoidectomy: Cost-Analysis From a Randomized, Double Blind Controlled Trial. by Sikakulya, Franck Katembo, Ssebuufu, Robinson, Okedi, Xaviour Francis, Baluku, Moris, Lule, Herman, Kiyaka, Sonye Magugu, Muhumuza, Joshua, Selamo, Fabrice Molen, Bassara, Godefroy Nyenke, Waziri, Musa Abbas, Kithinji, Stephen Mbae, Mugisho, Munyerenkana Leocadie, Byamungu, Pahari Kagenderezo, Munihire, Jeannot Baanitse, Vahwere, Bienfait Mumbere, Kiswezi, Ahmed, Kyamanywa, Patrick

“…Results Findings of fifty-eight patients were analysed including 29 participants per group. …”
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Binaural auditory beats vs music of choice as audio distraction behaviour guidance technique among children: A randomized controlled trial by Bhuvanesh N. Bhusari, Shivayogi M. Hugar, Niraj Gokhale, Shweta Kajjari, Sanika Karmarkar, Varunika Sahai

“…Methods: In-vivo, double-blind, three-arm, parallel-group randomized study was conducted in the department of pediatric and preventive dentistry where 75 participants were allocated into 3 groups. …”
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The Role of Phosphatidylethanolamine-N-methyltransferase (PEMT) Gene rs12449964 Polymorphism in the Development of Acute Pancreatitis and its Complications by T. A. Samgina, Yu. E. Azarova, Yu. V. Kanishchev, V. A. Lazarenko, P. M. Nazarenko, A. V. Polonikov

“…The study has shown that the frequency of the C allele and the C/C PEMT C/T rs12449964 genotype was higher in the group of patients with acute pancreatitis, while the C/T genotype was predominant in the control group. …”
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SLC7A11 is a potential therapeutic target and prognostic biomarker correlated with immune cell infiltration in cervical cancer by Mutangala Muloye Guy, Tingting Bian, Longyun Sun, Yiping Hao, Xinlin Jiao, Wenjing Zhang, Teng Zhang, Baoxia Cui

“…Methods From the TCGA database, we analyzed SLC7A11 expression profiles and validated its promoting role in cervical cancer by in vitro. Patients were divided into two subgroups according to SLC7A11 expression levels, and differentially expressed genes (DEGs) were identified between these groups. …”
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Comparison of serum ischemia modified albumin levels between preeclamptic and healthy pregnant women by Dinç Zuhal, Çakar Erbil, Kumru Pınar, Erel Özcan, Neşelioğlu Salim, Cimsit Nilüfer, Boz Gizem

“…Results The mean IMA values were found to be significantly higher in the preeclampsia group compared to the control group (p<0,001). Patients were divided into 3 groups; severe preeclampsia(n=29), non-severe preeclampsia(n=37) and healthy pregnant(n=68). …”
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Non-Immersive Virtual Reality Exercise Can Increase Exercise in Older Adults Living in the Community and in Long-Term Care: A Randomized Controlled Trial by Sheehy L, Bharadwaj L, Nissen KA, Estey JL

“…The facility-based sample had 31 participants; the home-based sample had 16. There were no statistically-significant benefits to non-immersive virtual reality in either sample for objective 1), although the facility-based non-immersive virtual reality group showed a clinically-significant improvement in functional walking. …”
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Beneficial and harmful effects of duloxetine versus placebo, ‘active placebo’ or no intervention for adults with major depressive disorder: a systematic review with meta-analysis a... by Christian Gluud, Marija Barbateskovic, Joanna Moncrieff, Faiza Siddiqui, Janus C Jakobsen, Mathias Maagaard, Sophie Juul, Johanne Juul Petersen, Caroline Barkholt Kamp, Mark Abie Horowitz, Kiran Kumar Katakam

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Validation of chronic obstructive pulmonary disease recording in the Clinical Practice Research Datalink (CPRD-GOLD) by John R Hurst, Jennifer K Quint, Hana Müllerova, Liam Smeeth, Harriet Forbes, Susan Eaton, Rachael L DiSantostefano, Kourtney Davis

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A protocol to optimize non-invasive brain stimulation for post-stroke rehabilitation by Ayesha Juhi, Manul Das, Dinesh Bhatia, Suman Dhaka, Rajesh Kumar, Deepak Kumar, Shreya Sharma, Pritam Kumar Chaudhary, Chanchal Goyal, Md Asif Khan, Himel Mondal

“…Patients are divided into four groups for both rTMS (n = 49) and tDCS (n = 49): three groups with different stimulation intensities (1 Hz, 5 Hz, 10 Hz for rTMS; 0.5 mA, 1 mA, 2 mA for tDCS) and a sham control group. …”
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Global, regional and national burden of asthma attributable to NO2 from 1990 to 2021: an analysis from the Global Burden of Disease Study 2021 by Chunyi Zhang, Jian Sun, Jingli Li, E Qin, Lingjing Liu, Guimei Pu

“…Objectives This study aims to systematically assess the global, regional, and national burden of asthma attributable to nitrogen dioxide (NO₂) pollution.Design and setting Analysis of population-level data from 1990 to 2021 obtained from the Global Burden of Disease Study 2021, covering 204 countries and territories.Participants Participants included patients with asthma attributable to NO₂ pollution.Main outcomes and measures Asthma-related disability-adjusted life-years (DALYs) and age-standardised DALY rates (ASDR) attributable to NO₂ pollution across 204 countries and territories. …”
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UK multiple sclerosis risk-sharing scheme: a new natural history dataset and an improved Markov model by Jacqueline Palace, Martin Duddy, Thomas Bregenzer, Mike Boggild, Joel Oger, Helen Tremlett, Charles Dobson, Fheng Zhu

“…Transition probabilities were derived and different Markov models (discrete and continuous) with and without baseline covariates were applied.Setting MS clinics in Canada and the UK.Participants From the BCMS database, 898 ‘untreated’ patients with MS considered eligible for drug treatment based on the UK's Association of British Neurologists criteria.Outcome measure The predicted Expanded Disability Status Scale (EDSS) score was collected and assessed for goodness of fit when compared with actual outcome.Results The BCMS untreated cohort contributed 7335 EDSS scores over a median 6.4 years (6357 EDSS ‘transitions’ recorded at consecutive visits) during the period 1980–1995. …”
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The triglyceride-glucose index trajectories are associated with cardiovascular diseases in people living with HIV: evidence from a prospective cohort study in China, 2005–2022 by Yinsong Luo, Liqin Sun, Yun He, Fang Zhao, Duo Shan, Fan Bu, Lingyun Ge, Xiaorui Li, Yiyao Hu, Xi Xiao, Hongzhou Lu, Jiaye Liu

“…Each 1-standard deviation (SD) increase in the baseline TyG index was associated with a 39% higher risk of CVD (HR 1.39, 95% CI 1.22, 1.59) after adjusting for covariates. Participants were categorized into four distinct TyG trajectory groups: low-stable, low-moderate-stable, high-moderate-stable, and high-increasing. …”
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Immediate Respiratory Warm-Up Effect on Dynamic Inspiratory Muscle Strength in Cardiac Surgery Candidates by Bahareh Mehregan Far, Sedigheh Sadat Naimi, Mohsen Abedi, Seyed Ahmad Raeissadat, Mahmood Beheshti Monfared, Alireza Akbarzadeh Baghban

“…Materials and Methods: This study was conducted as a randomized controlled trial. Forty participants scheduled for heart surgeries were randomly assigned to either the study (RWU between two tests) or control (without RWU) groups. …”
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Asymptomatic testing people for SARS-CoV-2 in healthcare facilities: A systematic review by Olabisi A. Oduwole, Glory Bassey, Grace Esebanmen, Samuel Shoyinka, Johnsolomon Ohenhen, Elise Cogo, Nicholas Henschke, Eleanor Ochodo, Martin M. Meremikwu

“…Very low certainty evidence shows a decrease in occurrence of SARS-CoV-2 infections in the asymptomatic testing group among patients going for index surgery (OR: 0.05, 95 % CI: 0.00–0.82; 501 participants; 1 study) and among long term care facility staff (OR: 0.31, 95 % CI: 0.18–0.52; 3457 participants; 2 studies, I2 = 89%) than the ‘no asymptomatic testing’ group. …”
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