Anti-Inflammatory Mechanism Prediction of Sinomenine Based on Network Pharmacology and Its Biological Activity Verification by Da Song, Afsar Khan, Ming-Hong Dong, Chuan-Wen Lei, Ting-Ting Feng, Ying Zhou, Xin Wei

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Network pharmacology combined with experimental verification for exploring the potential mechanism of phellodendrine against depression by Lili Hu, Na Wu, Jue Wang, Donghui Cai

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Identification of Hub Biomarkers and Immune and Inflammation Pathways Contributing to Kawasaki Disease Progression with RT-qPCR Verification by Hongjun Ba, Lili Zhang, Huimin Peng, Xiufang He, Yuese Lin, Xuandi Li, Shujuan Li, Ling Zhu, Youzhen Qin, Xing Zhang, Yao Wang

“…Hub genes were enriched in immunological and inflammatory pathways. RT-qPCR verification results of FCGR1B (P<0.001), GPR84 (P<0.001), KREMEN1 (P<0.001), LRG1 (P<0.001), and TDRD9 (P<0.001) upregulated expression in Chinese KD patients are consistent with our database analysis. …”
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Network pharmacology and experimental verification to investigate the mechanism of isoliquiritigenin for the treatment of Alzheimer’s disease by Waimao Gao, Guang Yang, Xinjuan Liu, Kaifan Hu, Jie Pan, Xingyu Wang, Yan Zhao, Ying Xu

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Network pharmacology approach and experimental verification of earthworm protein in the treatment of diabetes mellitus-induced erectile dysfunction by Liming Liu, Yuanfeng Zhang, Aiping Zhang, Rui Yan, Xiaowei Ji, Jiashu Yang, Xinping Wang, Yongze Gao, Xiping Xing

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Network Pharmacology, Molecular Docking and Experimental Verification to Explore the Mechanism of Chicoric Acid against Hepatocellular Carcinoma by Wenqian XU, Liangliang ZHANG, Yiping ZHAO, He QIAN, Jianguo XU

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Integrated multi-omics analysis and experimental verification reveal the involvement of the PI3K/Akt signaling pathway in myometrial fibrosis of adenomyosis by Qiaomei Yang, Jingxuan Hong, Jianhui Fu, Xianhua Liu, Xinye Zheng, Junying Jiang, An Zhu, Li Chen, Hao Lin, PengMing Sun

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Microbiomic insights into the unique effects of vaginal microbiota on preterm birth in Chinese pregnant women by Jun Zhang, Zhimin Xu, Mengjun Zhang, Jiaoning Fang, Yijing Zheng, Caihong Jiang, Mian Pan

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The Inhibitory Effect of the Active Ingredients in the Bushen Huoxue Formula on the IL-17A Signaling Pathway and Its Alleviating Effect on Osteoarthritis by Wang X, Zhang Y, Chang X, Wen X, Tian F, Yu H, Li Y

“…Micro-CT analysis showed that BSHXF inhibited osteophyte formation and ameliorated OA pathological conditions.Conclusion: BSHXF has the potential to alleviate OA by suppressing inflammation, inhibiting cartilage apoptosis and hindering extracellular matrix degradation via the IL-17 signaling pathway. Our study elucidated the molecular mechanisms underlying the therapeutic effects of BSHXF on OA, thus highlighting its further research implications as a novel drug candidate.Keywords: osteoarthritis, Bushen Huoxue formula, pharmacological mechanism, network pharmacology, experimental verification…”
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Regulatory Effects of Zhenxin Formula in Treating Doxorubicin-Induced Heart Failure: Network Pharmacology and Animal Experimental Verification by Wu Q, Wang H, Wang YH, Du J, Li B, Gan XN, Liu CY, Liang J, Liu C, Cao M

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Forecast and verification of the active compounds and latent targets of Guyuan decoction in treating frequently relapsing nephrotic syndrome based on network pharmacology by Haiyun Wang, Junjie Shi, Binbin Tang, Yanfeng Liu, Qili Wang

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Integrating network pharmacology, molecular docking and experimental verification to explore the therapeutic effect and potential mechanism of nomilin against triple-negative breas... by Zhixuan Wu, Haoyi Xiang, Xiaowu Wang, Rongrong Zhang, Yangyang Guo, Liangchen Qu, Jingyao Zhou, Yanyi Xiao

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Huangkui capsule combined with finerenone attenuates diabetic nephropathy by regulating the JAK2/STAT3 signaling pathway based on network pharmacology, molecular docking, and experimental verification by Xuanke Liu, Chunjiang Zhang, YanJie Fu, JingJing Dai, Jiaying Lu, Gang Liu, Xiaoping Yang

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Network pharmacology mechanisms and experimental verification of Hedyotis Diffusae Herba-Scutellariae Barbatae Herba drug pair extract in the treatment of nasopharyngeal carcinoma by Tiantian Li, Haijun Chen, Jing Zhang, Jiaxin Liu, Rundong Tang, Liang Zhang, Tian Feng, Yanchun Xiao, Shiwen Liu, Xiangjun Chen

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Treatment of rheumatoid arthritis by Rhododendron molle G. Don: the anti-inflammatory mechanism of its extract was elucidated by network analysis combined with experimental verific... by Wenya Mei, Junbao Yu, Jiayuan Zhu, Ting Deng, Yasi Deng, Qiaozhen Tong, Xiangdan Liu, Huanghe Yu, Ribao Zhou, Xiaorong Liu

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ITGA4 Contributes to 5-Fluorouracil Resistance by Up-Regulating PI3K/AKT Signaling: Evidence from Network Pharmacology, Molecular Docking and Experimental Verification by Yan S, Hu X, Wu Y, Ye W, Zhu Y, He Y, Zhan F, Wu W, Ma Z

“…Kyoto Encyclopaedia of Genes and Genomes (KEGG) enrichment analyses indicated that the PI3K/AKT signaling pathway may be a significant pathway. Combined with molecular docking and database verification, F10, NR3C1, DHFR, CA2, BCHE, ACHE, and ITGA4 were identified as candidate core genes. …”
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Mapping transcriptomic profiles of seminal vesiculitis and experimental verification by Chenkui Miao, Shaobo Zhang, Jiajin Wu, Meiling Bao, Zengjun Wang, Bianjiang Liu

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Enhancing Forecast Verification in National Meteorological and Hydrological Services by Thomas C. Pagano, Elizabeth E. Ebert, Mohammadreza Khanarmuei

“…The framework integrates best practices in governance, data management, verification metrics, and communication. It acknowledges the importance of user‐centered approaches and highlights areas where verification practices can align with user needs. …”
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The processed Sanguisorba officinalis L. triterpenoids prevent colon cancer through the TNF-α/NF-κB signaling pathway, combined with network pharmacology, molecular simulation dynamics and experimental verification by Chunli Gan, Yuanqiu Mu, Shah Syed Faizan Ali, Xuepeng Shi, Shuang Jiang, Zhengyang Wang, Xiaotian Wu, Xiaotong Wang, Zhibin Wang, Shulu Zhang, Zheng Feng, Chunjuan Yang

“…TP play a role in preventing colon cancer by down-regulating TNF-α and thereby inhibiting the NF-κB signaling pathway. This research not only fills the mechanism gap of S.L. in the field of colon cancer prevention, but also provides methodological support and theoretical foundation for its transition from traditional Chinese medicine to clinical practice through the integration of multi-disciplinary technologies and the verification of precise targets.…”
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The Bioinformatics Analysis of Aldosterone-Producing Adenoma and Verification of Differentially Expressed Genes by Yinjie Gao, Xiaosen Ma, Huiping Wang, Yunying Cui, Yushi Zhang, Min Nie, Anli Tong

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