Adopting Positive Selection Technology and Improving Seed Quality in Smallholder Potato Farmers in South-Western Uganda. by Kajura, Tibanyendera Deo

“…Demographic, socio-economic, institutional and technological factors that affect the adoption of technologies should be thought of by government and development agencies involved in designing intervention strategies focused on seed quality improvement. …”
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A Closer Look at Periocular Necrotizing Fasciitis: A Systematic Review of Literature by David Oliver-Gutierrez, Elena Ros-Sanchez, Gloria Segura-Duch, Tirso Alonso, Miguel Ángel Arcediano, Alejandra Herranz-Cabarcos, Jessica Matas, Roberto Castro Seco, R. L. P. van der Veen, Anna Boixadera, José García-Arumí, Joan Oliveres

“…Prompt identification and expedited intervention, including debridement and targeted antibiotic therapy, critically influence prognosis. …”
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Lactobacillus plantarum-derived extracellular vesicles from dietary barley leaf supplementation attenuate Citrobacter rodentium infection and intestinal inflammation by Yu Feng, Qian Zhao, Yifan Zhao, Chen Ma, Meiling Tian, Xiaosong Hu, Fang Chen, Daotong Li

“…Our in vivo studies further revealed that live Lactobacillus plantarum (L. plantarum) administration attenuated the pathogenic effects induced by C. rodentium infection, whereas heat-inactivated L. plantarum did not show the same results. …”
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SToP (See, Treat, Prevent) skin sores and scabies trial: study protocol for a cluster randomised, stepped-wedge trial for skin disease control in remote Western Australia by Marianne J Mullane, Timothy C Barnett, Jeffrey W Cannon, Jonathan R Carapetis, Ray Christophers, Juli Coffin, Frieda Mc Loughlin, Vicki O'Donnell, Rebecca Pavlos, Bec Smith, Andrew C Steer, Steven Y C Tong, Roz Walker, Asha C Bowen

“…Secondary outcome measures include scabies diagnosis, other child health indicators, resistance to cotrimoxazole in circulating pathogenic bacteria, determining the economic burden of skin disease and evaluating the cost effectiveness of SToP activities.Ethics and dissemination This study protocol was approved by the health ethics review committees at the Child and Adolescent Health Service (Approval number RGS0000000584), the Western Australian Aboriginal Health Ethics Committee (Reference number: 819) and the University of Western Australia (Reference RA/4/20/4123). …”
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Characterization of intrahepatic B cells in acute-on-chronic liver failure by Yudong Zhao, Wei He, Chenchen Wang, Nana Cui, Changjie Yang, Zhengrui You, Bisheng Shi, Lei Xia, Xiaosong Chen

“…Background and objectivesAcute on chronic liver failure (ACLF) is characterized by the immunologic dissonance during the prolonged pathogenic development. Both abnormal innate immune response and adaptive T-cell response have been reported in patients with ACLF; however, less is known regarding B cells in ACLF pathogenesis. …”
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Multiomic analysis of monocyte-derived alveolar macrophages in idiopathic pulmonary fibrosis by Miaomiao Zhang, Jinghao Zhang, Haisheng Hu, Yuan Zhou, ZhiWei Lin, Hui Jing, Baoqing Sun

“…Abstract Background Monocyte-derived alveolar macrophages (Mo_AMs) are increasingly recognised as potential pathogenic factors for idiopathic pulmonary fibrosis (IPF). …”
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Antiphospholipid antibodies inhibit the migration and invasion of trophoblast cells by suppressing the JNK/C-Jun/MMP1 signaling pathway by Qingchen Wang, Weimin Feng, Yuan Tan, Jiao Qiao, Hongchao Liu, Qi Liu, He Wang, Qian Zhang, Jingjin Tao, Zhongxin Li, Boxin Yang, Zhen Xu, Chong Wang, Shuo Yang, Liyan Cui

“…This represent a potential pathogenic mechanism contributing to adverse pregnancy outcomes in APS patients, highlighting possible therapeutic targets for intervention in APS management.…”
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Whole-genome analysis and antimicrobial resistance phenotype of Vagococcus fluvialis isolated from wild Niviventer by Jian Zhou, Jian Zhou, Ying Liu, Tao Gu, Jingzhu Zhou, Fengming Chen, Yong Hu, Shijun Li, Shijun Li

“…Its zoonotic potential raises concerns for public health, yet research on its antimicrobial resistance and pathogenicity is still limited. This study aimed to isolate and characterize V. fluvialis from wild Niviventer, analyze its genomic features (including antimicrobial resistance and virulence genes), and evaluate its antibiotic susceptibility profile to assess potential public health risks. …”
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Cross-cultural data on romantic love and mate preferences from 117,293 participants across 175 countries by Marta Kowal, Piotr Sorokowski, Biljana Gjoneska, Katarzyna Pisanski, Gerit Pfuhl, Leonardo Aguilar, Steve M. J. Janssen, Benjamin Gelbart, Patrícia Arriaga, Jan Antfolk, Katarina Zvončáková, Linda H. Lidborg, Jorge Contreras-Garduño, Mikhail V. Kozlov, Taciano L. Milfont, Marco A. C. Varella, Valerija Križanić, Mahmoud Boussena, Tina Kavčič, Diana Ribeiro da Silva, Brahim Hamdaoui, Fatima Zahra Sahli, Karlijn Massar, Eliane Deschrijver, Tatsunori Ishii, Hakan Cetinkaya, Oksana Senyk, Farida Guemaz, Koen Ponnet, Yahya Don, Dušana Šakan, Gyesook Yoo, Ravit Nussinson, Joaquín Ungaretti, Ali R. Can, Izzet Duyar, Jiří Čeněk, Joao Carneiro, Norbert Meskó, Luca Kozma, Ellen K. Nyhus, Mona Vintila, Oulmann Zerhouni, Farid Pazhoohi, Maja Zupančič, Sinem Söylemez, Austin H.-E. Wang, Marietta Papadatou-Pastou, Irena Pavela Banai, Pavol Prokop, Mohd Sofian Omar Fauzee, Reza Afhami, Jean C. Natividade, Roberto Baiocco, Mara Morelli, Toivo Aavik, Ezgi Toplu-Demirtaş, Singha Tulyakul, Anna Wlodarczyk, Razieh Chegeni, Anabela C. Santos, Dmitry Grigoryev, Dmitrii Dubrov, Dimitri Chubinidze, Gözde Ikizer, Nana Burduli, Johanna Czamanski-Cohen, Rizwana Amin, Petros Roussos, Evgeniya Hristova, Rūta Sargautytė, Ekaterine Pirtskhalava, Tenuunjargal Avirmed, Arooj Najmussaqib, Abdelilah Charyate, Shagufta Batool, Tatiana Volkodav, Yoshihiko Kunisato, Yuki Yamada, Asako Toyama, Mariia Perun, Seda Dural, Tetyana Mandzyk, Anna Studzinska, Ognen Spasovski, Felipe E. García, Caterina Grano, Merve Boğa, Mehmet Koyuncu, Sangeeta Singh, Ju Hee Park, Derya Atamtürk, Samuel Lins, Martin Pírko, David Lacko, Balazs Aczel, Ferenc Kocsor, Ádám Putz, Tobias Otterbring, Pavol Kačmár, Efisio Manunta, Théo Besson, Nasim Ghahraman Moharrampour, Çağlar Solak, Bojana M. Dinić, Ignacio Estevan, Merve Topcu Bulut, Nicolas Kervyn, Moises Mebarak, Jackson G. Lu, Nejc Plohl, Bojan Musil, Adil Samekin, Kirill G. Miroshnik, Clément Cornec, Isabella Giammusso, Ulf-Dietrich Reips, Maria Rosa Miccoli, Miriam Parise, Sabrina Stöckli, Tiago Marot, Sibele D. Aquino, Amanda Londero-Santos, Antonio Chirumbolo, Aybegum Memisoglu-Sanli, Jaroslava V. Valentova, Cemre Karaarslan, Ivana Hromatko, Kevin Sevag Kertechian, Ogeday Çoker, Matheus F. Ribeiro, Carlota Batres, Ilker Dalgar, Stephanie J. Eder, Katarina Mišetić, Marios Argyrides, Vita Mikuličiūtė, Silvia Mari, Elisabeth Oberzaucher, Kathrin Masuch, Alan D. A. Mattiassi, Salma S. Omar, Elena Piccinelli, Eda Ermagan Caglar, Diogo Lamela, David A. Frederick, Aleksander Kobylarek, Ma Criselda T. Pacquing, Marc Eric S. Reyes, Marcos Zumárraga-Espinosa, Feten Fekih-Romdhane, Talía Gómez Yepes, Edgardo Etchezahar, Katarzyna Galasinska, Jan P. Röer, Ayşegül Şahin, Miguel Landa-Blanco, Izuchukwu L. G. Ndukaihe, Arkadiusz Urbanek, Chee-Seng Tan, Rita Castro, Ksenija Cunichina, Anna Krasnodębska, Daniel Conroy-Beam, Franciszek Ostaszewski, Izabela Chałatkiewicz, Beatriz Abad-Villaverde, Bastien Trémolière, Alexios Arvanitis, Gulmira T. Topanova, William J. Chopik, Grace Akello, Ariela F. Pagani, Silvia Donato, Peter Fedor, Tomasz Frackowiak, Simon Ozer, Marlon Mayorga-Lascano, Farah Khan, Maryanne L. Fisher, Princess Lovella G. Maturan, Tatiana Semenovskikh, Sanjana Dutt, William Tamayo-Agudelo, Gulnara Ismukhanova, Laith Al-Shawaf, Luisa Angelucci, Adam Bode, Sercan Balım, Jovi C. Dacanay, Chiemezie S. Atama, Kai A. D. Morgan Campbell, Tchilissila A. Simões, Barış Özener, Paula Błauciak, Filipe Prazeres

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Zhongfeng Xingnao Liquid Ameliorated the Early Impairment of Intracerebral Hemorrhage by Inhibiting NF-κB/NLRP3 Axis in Rats by Yang H, Luo B, Du Y, Guo J, Zhang S, Wang P, Dai Y, Lu Y, Xu S

“…The inhibition of ZFXN on NF-κB/NLRP3 axis was further confirmed in Lipopolysaccharide (LPS)-induced BV-2 cells.Results: Post-ICH pathology was characterized by progressive hematoma expansion, elevated neurological deficit scores, neuronal damage, and reduced CBF, accompanied by neuroinflammatory. Early ZFXN intervention within 6 hours post-ICH significantly reduced hematoma volume and improved neurological scores (mNSS, Bederson, Zea Longa) at 24 hours, while markedly alleviating perihematomal neuronal damage and enhancing CBF, with optimal efficacy observed following one-hour administration. …”
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A rare case of multiple brain abscesses caused by Nocardia abscessus co-infection with tuberculous meningitis in an immunocompetent patient by Xiuri Wang, Lingyan Liang, Yunxiao Liang, Liuyang Hu

“…Co-infection with both pathogens is unusual. To our knowledge, this is the first reported case of multiple brain abscesses caused by Nocardia abscessus (N. abscessus) in a young immunocompetent patient, complicated by tuberculous meningitis. …”
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Effects of Tanreqing injection against ventilator-associated pneumonia: a meta-analysis and systematic review of clinical studies by Pochen Li, Yang Wu, Danxia Ge, Ruyi Xu, Qianping Zhang, Yujiao Li, Lingyao Zhang, HsuanChieh Peng, Fangyu Yu

“…ObjectiveVentilator-associated pneumonia (VAP) frequently results in difficulties with weaning, high mortality rates, and is often caused by drug-resistant pathogens, emphasizing the critical importance of effective treatment. …”
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High-risk HPV distribution and importance of continuing cervical cancer screening of women aged 65 years and older: a study based on 2 152 766 women in China by Bo Wu, Yu Jiang, Jiahui Wang, Xiaotian Li, He Wang, Fanghui Zhao, Zichen Ye, Yingyu Zhong, Shuyan Jin, Xuelian Zhao, Yueyun Wang

“…Moreover, hr-HPV infections and their pathogenicity exhibit unique patterns in this older group. …”
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Transthyretin amyloid cardiomyopathy in France: A cross-sectional multi-centre study (333 patients) by Thibaud Damy, Erwan Donal, Olivier Lairez, Jean-Christophe Eicher, Mounira Karoubi, Jean-Noël Trochu, Jocelyn Inamo, Gilbert Habib, François Roubille, Albert Hagège, Flore Morio, Eve Cariou, Jérôme Adda, Vincent Algalarrondo, Agathe Coste, Mathilde Bartoli, Jérémie Rudant, Lara Salvi, Bruno Francou, Anne Guiochon-Mantel, David Adams, Jean-Christophe Antoine, Shahram Attarian, Pascal Cintas, Raul Juntas Morales, Emmeline Lagrange, Laurent Magy, Martial Mallaret, Yann Péréon, Philippe Petiot, Cécile Cauquil, Céline Labeyrie, Andoni Echaniz-Laguna, Guilhem Sole, Céline Tard, Silvia Oghina, Philippe Charron, Michel Slama

“…Methods: This was a non-interventional descriptive retrospective multi-centre national study. …”
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Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity by Amy C. Sims, Alexandra Schäfer, Kenichi Okuda, Sarah R. Leist, Jacob F. Kocher, Adam S. Cockrell, Padraig E. Hawkins, Minako Furusho, Kara L. Jensen, Jennifer E. Kyle, Kristin E. Burnum-Johnson, Kelly G. Stratton, Natalie C. Lamar, Carrie D. Niccora, Karl K. Weitz, Richard D. Smith, Thomas O. Metz, Katrina M. Waters, Richard C. Boucher, Stephanie A. Montgomery, Ralph S. Baric, Timothy P. Sheahan

“…Mice lacking key immune cell populations experienced greater virus replication but decreased disease severity implicating the immune system in both protective and pathogenic roles in response to MERS-CoV. These data could be utilized to design new therapeutic strategies targeting specific pathways that contribute to severe disease.…”
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Miraculin Can Contribute to a Reduction in Inflammatory Biomarkers and Cachexia in Malnourished Patients with Cancer and Taste Disorders by Ana Isabel Álvarez-Mercado, Bricia López-Plaza, Julio Plaza-Diaz, Lucía Arcos-Castellanos, Francisco Javier Ruiz-Ojeda, Marco Brandimonte-Hernández, Jaime Feliú-Batlle, Thomas Hummel, Samara Palma-Milla, Ángel Gil

“…Future studies on the molecular signaling pathways and specific mechanisms of action of bioactive compounds within food supplements, such as miraculin, will allow them to be used to target pathogenic mechanisms of cancer cachexia and malnutrition: NCT05486260.…”
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Development and application of an early prediction model for risk of bloodstream infection based on real-world study by Xiefei Hu, Shenshen Zhi, Yang Li, Yuming Cheng, Haiping Fan, Haorong Li, Zihao Meng, Jiaxin Xie, Shu Tang, Wei Li

“…Early identification of BSI is crucial for effective intervention, reducing mortality, and improving patient outcomes. …”
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Study the effect of Lactobacillus plantarum ATCC 14917 for caries prevention and anti-obesity by Wei Yang, Wei Yang, Mingxin Jiang, Bairu Chen, Bairu Chen, Kongzhao Jiang, Nan Ma, Nan Ma, Yimin Li, Yimin Li, Meng Wang, Meng Wang, Meihua Bao, Meihua Bao, Chengyue Wang, Chengyue Wang, Xiaopeng Yang, Xiaopeng Yang

“…The demineralization rate of enamel decreased by 44.10% due to the inhibition of acid production by pathogenic bacteria. Moreover, In intestinal and stomach juice simulations, L. plantarum has a high survival rate. …”
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Sputum colour charts to guide antibiotic self-treatment of acute exacerbation of chronic obstructive pulmonary disease: the Colour-COPD RCT by Eleni Gkini, Rachel L Adams, Daniella Spittle, Paul Ellis, Katherine Allsopp, Sanya Saleem, Matthew McKenna, Nick le Mesurier, Nicola Gale, Sarah Tearne, Peymane Adab, Rachel E Jordan, Nawar Diar Bakerly, Alice M Turner

“…A process evaluation examined trial fidelity and acceptability of the intervention, employing qualitative research methods incorporating patients as co-researchers. …”
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Research progress in intracranial artery dissections over past 25 years: a review and bibliometric analysis by Zixuan Zhou, Zixuan Zhou, Zixuan Zhou, Bingyang Qin, Yang Chen, Yang Chen, Yang Chen, Ren Li, Ren Li, Ren Li, Biao Yang, Biao Yang, Biao Yang, Ziao Li, Ziao Li, Ziao Li, Yongqiang Wu, Yongqiang Wu, Yongqiang Wu, Xiaogang Wang, Xiaogang Wang, Xiaogang Wang, Xiaolong Guo, Xiaolong Guo, Xiaolong Guo, Wenju Zhang, Wenju Zhang, Wenju Zhang, Yuanli Zhao, Geng Guo, Geng Guo, Geng Guo, Geng Guo, Geng Guo

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