Exosomal transfer of pro-pyroptotic miR-216a-5p exacerbates anthracycline cardiotoxicity through breast cancer-heart pathological crosstalk by Yan Ma, Yongjun Wang, Renzheng Chen, Yabin Wang, Yan Fang, Cheng Qin, Tianhu Wang, Xiaoying Shen, Tingwen Zhou, Lei Tian, Ting Sun, Li Fan, Xiaoning Wang, Dong Han, Feng Cao

“…Our findings revealed novel cross-organ pathogenic communication between breast cancer and the heart through the exosomal miR-216a-5p-mediated ITCH/TXNIP/NLRP3 pathway, which drives cardiomyocyte pyroptosis. …”
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Prediction and analysis of toxic and side effects of tigecycline based on deep learning by Yin Xiong, Guoxin Liu, Xin Tang, Boyang Xia, Yalian Yu, Guangjun Fan

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Changes in the Subdoligranulum genus in patients with autoimmune disease: a systematic review and meta-analysis by Lu Shen, Ying Zhao, Shuting Liu, Shangfeng Li, Qian Li, Tao-Hsin Tung, Bo Shen

“…BackgroundAutoimmune diseases have different pathogenic mechanisms but share underlying patterns of gut microbiome perturbation and intestinal barrier dysfunction. …”
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Low Plasma Levels of Contactin-Associated Protein-Like 2 in Children with Autism Spectrum Disorder: Links to Neural Development by Alayadhi LY, Halepoto DM, Alhowikan AM, Elamin NE, Halepota AT

“…Early diagnosis and intervention are decisive for managing symptoms and improving outcomes. …”
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Population structure, resistome, and virulome of Staphylococcus chromogenes strains from milk of subclinical bovine mastitis in South Africa by N. G. Khasapane, S. J. Nkhebenyane, O. Thekisoe, T. Ramatla, K. E. Lekota

“…They underscore the importance of continued genomic surveillance of livestock pathogens to inform targeted intervention strategies and improve animal health in diverse production settings, and further clarify the implications for future antibiotic therapy and prevention of infections associated with this species.…”
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Prevalence and characteristics of transthyretin amyloid cardiomyopathy in hypertrophic cardiomyopathy by Pablo Garcia‐Pavia, Thibaud Damy, Nicolas Piriou, Roberto Barriales‐Villa, Francesco Cappelli, Catherine Bahus, Carmen Munteanu, Denis Keohane, Pablo Mallaina, Perry Elliott, the TTRACK investigators

“…Methods and results TTRACK was a multicentre, non‐interventional, cross‐sectional epidemiologic study funded by Pfizer and conducted in 20 hospitals and medical centres in 11 countries (NCT03842163). …”
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Development and validation of a nomogram for differentiating immune checkpoint inhibitor-related pneumonitis from pneumonia in patients undergoing immunochemotherapy: a multicenter... by Linli Duan, Guanglu Liu, Zijie Huang, Rong Chen, Di Mo, Yuxiao Xia, Jiazhu Hu, Mengzhang He

“…Subsequently respiratory pathogens, management, and outcomes were compared between CIP and No CIP cases.ResultsAmong the 237 patients, 104 were diagnosed with CIP, and 133 were no CIP but pneumonia(No CIP). …”
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Rapid Development of Modified Vaccinia Virus Ankara (MVA)-Based Vaccine Candidates Against Marburg Virus Suitable for Clinical Use in Humans by Alina Tscherne, Georgia Kalodimou, Alexandra Kupke, Cornelius Rohde, Astrid Freudenstein, Sylvia Jany, Satendra Kumar, Gerd Sutter, Verena Krähling, Stephan Becker, Asisa Volz

“…Modified Vaccinia virus Ankara (MVA), a well-established viral vector used to generate vaccines against emerging pathogens, can deliver multiple antigens and has a remarkable clinical safety and immunogenicity record, further supporting its evaluation as a vaccine against MARV. …”
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Probiotic Bacillus pumilus LV149 enhances gut repair, modulates microbiota, and alters transcriptome in DSS-induced colitis mice by Xinyu Sun, Long Yun, Keming Xie, Renhui Liu, Xinyue Ren, Bokun Zeng, Xudong Cao, Zhi Li, Guihao Zhou, Bang Liu, Luo Peng, Lihong Yuan

“…LV149 further modulated the gut microbiota, increasing beneficial bacteria and reducing pathogenic populations. Transcriptomic analysis indicated that LV149-L may exert gut repair effects via the IL-17 signaling pathway, whereas LV149-H appears to act through the JAK-STAT signaling pathway.ConclusionThis study demonstrated that LV149, particularly at a higher dose, effectively mitigated DSS-induced colonic injury by modulating gut microbiota, enhancing gut barrier integrity, and reducing inflammation. …”
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Dissecting the tumor microenvironment in primary breast angiosarcoma: insights from single-cell RNA sequencing by Peikai Ding, Shengbin Pei, Yi Zhai, Zheng Qu, Yazhe Yang, Xiaolong Feng, Qiang Liu, Xiangyu Wang, Wenxiang Zhang, Zhongzhao Wang, Xiangyi Kong, Jing Wang, Yi Fang

“…Due to the limited understanding of its tumor microenvironment (TME) and the absence of effective treatments, further research is essential to elucidate its pathogenic mechanisms and improve therapeutic strategies. …”
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Resistome and Phylogenomics of <i>Escherichia coli</i> Strains Obtained from Diverse Sources in Jimma, Ethiopia by Mulatu Gashaw, Esayas Kebede Gudina, Guenter Froeschl, Ralph Matar, Solomon Ali, Liegl Gabriele, Amelie Hohensee, Thomas Seeholzer, Arne Kroidl, Andreas Wieser

“…<b>Introduction</b>: In recent years, antimicrobial resistance (AMR) rates have increased significantly in bacterial pathogens, particularly extended beta-lactam resistance. …”
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Recent advances of epilepsy associated with neurofibromatosis type 1 by Ying Ren, Ying Ren, Wandong Hu, Wandong Hu, Song Su, Song Su, Qi Zhang, Qi Zhang, Wenchao Zhang, Wenchao Zhang, Hongwei Zhang, Hongwei Zhang, Guangyu Wang, Guangyu Wang

“…Background and aimNeurofibromatosis type 1 (NF1) is an autosomal dominant tumor predisposition syndrome caused by pathogenic variants in the NF1 gene. It exhibits highly variable and unpredictable clinical manifestations involving multiple organ systems, with café-au-lait macules and multiple neurofibromas being hallmark features. …”
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Esophageal cancer and precancerous lesions: focus on resident bacteria and fungi by Liping Yuan, Yi Zhang, Chengli Wen, Sha Liu, Qin Zhang, Wen Yin, Qian Jia, Maolin Chen, Gang Luo, Mingming Deng, Muhan Lv, Wanmeng Xiao

“…Aspergillus demonstrated potential diagnostic value for ESIN, and its ratio to pathogenic functional clusters within network analysis significantly enhanced ESCC detection accuracy. …”
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COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms by Marek Ostaszewski, Anna Niarakis, Alexander Mazein, Inna Kuperstein, Robert Phair, Aurelio Orta‐Resendiz, Vidisha Singh, Sara Sadat Aghamiri, Marcio Luis Acencio, Enrico Glaab, Andreas Ruepp, Gisela Fobo, Corinna Montrone, Barbara Brauner, Goar Frishman, Luis Cristóbal Monraz Gómez, Julia Somers, Matti Hoch, Shailendra Kumar Gupta, Julia Scheel, Hanna Borlinghaus, Tobias Czauderna, Falk Schreiber, Arnau Montagud, Miguel Ponce de Leon, Akira Funahashi, Yusuke Hiki, Noriko Hiroi, Takahiro G Yamada, Andreas Dräger, Alina Renz, Muhammad Naveez, Zsolt Bocskei, Francesco Messina, Daniela Börnigen, Liam Fergusson, Marta Conti, Marius Rameil, Vanessa Nakonecnij, Jakob Vanhoefer, Leonard Schmiester, Muying Wang, Emily E Ackerman, Jason E Shoemaker, Jeremy Zucker, Kristie Oxford, Jeremy Teuton, Ebru Kocakaya, Gökçe Yağmur Summak, Kristina Hanspers, Martina Kutmon, Susan Coort, Lars Eijssen, Friederike Ehrhart, Devasahayam Arokia Balaya Rex, Denise Slenter, Marvin Martens, Nhung Pham, Robin Haw, Bijay Jassal, Lisa Matthews, Marija Orlic‐Milacic, Andrea Senff-Ribeiro, Karen Rothfels, Veronica Shamovsky, Ralf Stephan, Cristoffer Sevilla, Thawfeek Varusai, Jean‐Marie Ravel, Rupsha Fraser, Vera Ortseifen, Silvia Marchesi, Piotr Gawron, Ewa Smula, Laurent Heirendt, Venkata Satagopam, Guanming Wu, Anders Riutta, Martin Golebiewski, Stuart Owen, Carole Goble, Xiaoming Hu, Rupert W Overall, Dieter Maier, Angela Bauch, Benjamin M Gyori, John A Bachman, Carlos Vega, Valentin Grouès, Miguel Vazquez, Pablo Porras, Luana Licata, Marta Iannuccelli, Francesca Sacco, Anastasia Nesterova, Anton Yuryev, Anita de Waard, Denes Turei, Augustin Luna, Ozgun Babur, Sylvain Soliman, Alberto Valdeolivas, Marina Esteban‐Medina, Maria Peña‐Chilet, Kinza Rian, Tomáš Helikar, Bhanwar Lal Puniya, Dezso Modos, Agatha Treveil, Marton Olbei, Bertrand De Meulder, Stephane Ballereau, Aurélien Dugourd, Aurélien Naldi, Vincent Noël, Laurence Calzone, Chris Sander, Emek Demir, Tamas Korcsmaros, Tom C Freeman, Franck Augé, Jacques S Beckmann, Jan Hasenauer, Olaf Wolkenhauer, Egon L Willighagen, Alexander R Pico, Chris T Evelo, Marc E Gillespie, Lincoln D Stein, Henning Hermjakob, Peter D'Eustachio, Julio Saez‐Rodriguez, Joaquin Dopazo, Alfonso Valencia, Hiroaki Kitano, Emmanuel Barillot, Charles Auffray, Rudi Balling, Reinhard Schneider, the COVID‐19 Disease Map Community

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The Arabic Satisfaction with Life Scale (SWLS) and its three-item version: Factor structure and measurement invariance among university students by Amira Mohammed Ali, Saeed A. Al-Dossary, Musheer A. Aljaberi, Maha Atout, Rasmieh Alamer, Mohamed M.H. Suliman, Feten Fekih-Romdhane

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Transcutaneous auricular vagus nerve stimulation regulates gut microbiota mediated peripheral inflammation and metabolic disorders to suppress depressive-like behaviors in CUMS rat... by Xinjiang Zhang, Xun He, Yanan Zhao, Qi Zou, Yulong Liang, Jinling Zhang, Bowen Feng, Peijing Rong, Yu Wang

“…During the last 3 weeks of CUMS treatment, the rats received continuous taVNS intervention for 3 weeks. Depressive-like behavior in SD rats was evaluated through behavioral assessments. …”
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Inhibition of adenosine/A2A receptor signaling suppresses dermal fibrosis by enhancing fatty acid oxidation by Xiaoye Zhang, Jinjian Sun, Jia Guo, Xiaoru Hu, Junyu Zhou, Xiaoyun Xie, Xiang Chen, Hui Luo, Hong Liu, Yuzi Tian

“…Mechanistically, by stimulating dermal fibroblasts with key pathogenic cytokines associated with SSc, we observed significant changes in adenosine receptor A2A expression in response to IL-1β. …”
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Microbiome-driven gene dysregulation in oesophageal cancer: a multi-omics analysis by Chaitali Nath

“…The observed gene expression shifts and microbial signatures align with risk stratification predictions from the Nath Score, further supporting the role of microbiome alterations in early oesophageal cancer detection.8 Conclusion: This study establishes a direct link between microbiome dysbiosis, immune modulation and epithelial transformation in oesophageal cancer.1–3 The presence of pathogenic microbial signatures correlates with tumour-associated gene expression changes, reinforcing the potential of microbiome-based biomarkers for early diagnosis.6,7 The strong concordance between these findings and the Nath Score risk stratification model further underscores the clinical relevance of integrating microbiome analysis into early cancer detection strategies8. …”
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Assessment of Culture-Negative Neonatal Early-Onset Sepsis: Risk Factors and Utility of Currently Used Serum Biomarkers by Diana Iulia Vasilescu, Adriana Mihaela Dan, Laura Andreea Stefan, Sorin Liviu Vasilescu, Vlad Dima, Monica Mihaela Cîrstoiu

“…Introduction: Neonatal sepsis is a severe and life-threatening condition caused by pathogens in the systemic circulation within the first 28 days of life. …”
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Monomorphic sustained right ventricular outflow tract tachycardia in pregnancy with favorable outcomes: a case report by Gidion Edwin, Joshua Ezekiel, Baraka Alphonce, Kelvin Masava, John Meda

“…Abstract Background Monomorphic sustained right ventricular outflow tract tachycardia is a rare and serious condition in pregnancy affecting previously structurally normal heart; however, the exact pathogenic domains remain unclear. This case underscores the importance of timely diagnosis and intervention, which led to favorable outcomes despite the limited evidence on contemporary management. …”
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