Deciphering the secret codes in N7‐methylguanosine modification: Context‐dependent function of methyltransferase‐like 1 in human diseases by Huan Fang, Jing He, Dan Du, Xue Wang, Xinyu Xu, Linping Lu, Yefan Zhou, Yangyang Wen, Fucheng He, Yingxia Li, Hongtao Wen, Mingxia Zhou

“…This review describes the various biological functions of METTL1, summarises recent advances in understanding its pathogenic and disease‐suppressive functions and discusses the underlying molecular mechanisms. …”
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Cervus and cucumis peptides ameliorates bone erosion in experimental arthritis by inhibiting osteoclastogenesis by Ze-Min Lin, Yu-Ting Liu, Yan-Sheng Xu, Xiao-Qian Yang, Feng-Hua Zhu, Wei Tang, Shi-Jun He, Jian-Ping Zuo

“…The impacts of CCP (2 mg/kg) on joint erythema and swelling, production of pathogenic antibodies and the proportion of inflammatory cells were assessed in collagen-induced arthritis (CIA) in DBA/1J mice. …”
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Envisioning urban environments resilient to vector-borne diseases: a protocol to study dengue in Vietnam by Praveen Kumar, Thanh H. Nguyen, Phong V.V. Le, Jinhui Yan, Lei Zhao, Brian F. Allan, Andrew W. Taylor-Robinson

“…Its application may best inform urban planning in low-middle income countries in tropical zones where arboviral pathogens are prevalent.…”
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Precision prediction of intervertebral disc degeneration in ankylosing spondylitis using a nomogram model reveals the pivotal role of Th2-type immune dysregulation by Xiao-nan Wang, Xiao-nan Wang, Xiao-tian Ma, Jie Li, Run-tian Zhou, Yuan-zhang Jin, Xiao-feng Zhao, Dou-dou Jing, Bin Zhao, Bin Zhao

“…Beyond offering a tool for early detection and personalized management, these findings open avenues for investigating overlapping pathogenic mechanisms and potential immunotherapeutic targets in AS-IVDD.…”
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Parvalbumin interneurons in the hippocampal formation of individuals with Alzheimer’s disease: a neuropathological study of abnormal phosphorylated tau in neurons by Paula Merino-Serrais, Paula Merino-Serrais, Paula Merino-Serrais, Sergio Plaza-Alonso, Sergio Plaza-Alonso, Sergio Plaza-Alonso, Silvia Tapia-Gonzalez, Gonzalo León-Espinosa, Gonzalo León-Espinosa, Javier DeFelipe, Javier DeFelipe, Javier DeFelipe

“…Given that PV+ neuron impairment is a key pathogenic mechanism in AD and is associated with cognitive decline, understanding the changes in PV+ neurons during AD progression could provide critical insights into the alterations of neuronal circuits underlying the disease.…”
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Evaluation of Multidrug Resistance of <i>Salmonella</i> Isolated from Pork Meat Obtained from Traditional Slaughter Systems in Romania by Alexandra Tăbăran, Sorin Danel Dan, Liora Mihaela Colobaţiu, Marian Mihaiu, Sergiu Condor, Rodica Mărgăoan, Oana Lucia Crişan-Reget

“…Antibiotic resistance among pathogenic bacteria in humans and animals poses a critical public health challenge, leading to diminished effectiveness of existing antimicrobial treatments. …”
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The overlapping global distribution of dengue, chikungunya, Zika and yellow fever by Ahyoung Lim, Freya M. Shearer, Kara Sewalk, David M. Pigott, Joseph Clarke, Azhar Ghouse, Ciara Judge, Hyolim Kang, Jane P. Messina, Moritz U. G. Kraemer, Katy A. M. Gaythorpe, William M. de Souza, Elaine O. Nsoesie, Michael Celone, Nuno Faria, Sadie J. Ryan, Ingrid B. Rabe, Diana P. Rojas, Simon I. Hay, John S. Brownstein, Nick Golding, Oliver J. Brady

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Beyond the homozygous paradigm: symptomatic partial biotinidase deficiency in a heterozygous child—first case report from Nepal by Jagdish Kunwar, Bijay Kunwar, Anup Ghimire, Aramva Bikram Adhikari, Binay Aryal, Sachchu Thapa, Bina Prajapati Manandhar

“…A whole exome sequencing identified a heterozygous pathogenic variant in the BTD gene (c.38_44delinsTCC, p.Cys13Phefs*36), and retrospective enzyme assay confirmed partial biotinidase deficiency (3.20 nmol/min/mL; ~25% of mean normal activity). …”
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Co-morbid mechanisms of intervertebral disc degeneration and osteoporosis: biomechanical coupling and molecular pathways synergistically driving degenerative lesions by Zhifa Ling, Xiaoli Zeng, Qiaoyan Luo, Xue Li, Lijun Cui

“…Although more research has been done on the two diseases’ distinct causes, epidemiology indicates that their co-morbidity incidence has dramatically grown, pointing to a synergistic pathogenic network. Big data-driven dual-disease research offers a fresh approach to exposing the pathophysiology of co-morbidities, as the conventional single-disease research model makes it challenging to examine the interaction mechanisms. …”
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Dietary Tea Polyphenols Improve Growth Performance and Intestinal Microbiota Under Chronic Crowding Stress in Hybrid Crucian Carp by Zhe Yang, Gege Sun, Jinsheng Tao, Weirong Tang, Wenpei Li, Zehong Wei, Qifang Yu

“…Furthermore, intestinal microbiota analysis revealed that chronic crowding stress significantly increased the abundance of Proteobacteria and decreased the proportion of <i>Firmicutes</i> compared to the low-density control. Dietary TPs intervention, particularly at higher doses, partially restored the <i>Firmicutes</i> abundance and reduced the enrichment of potential pathogenic bacteria associated with stress. …”
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Prevalence of paediatric diarrhoea in Arba minch government health institutions, Southern Ethiopia and associated factors by Matusal Mengistu, Melat Woldemariam, Aseer Manilal, Addis Aklilu, Tsegaye Yohannes, Akbar Idhayadhulla, Hissah Abdulrahman Alodaini

“…Besides, edifying the parents of paediatric patients about personal hygiene and sanitation practices would be the most important intervention strategy to emphasise.…”
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Perinatal factors and early neonatal outcomes of abnormal birthweight infants in Hangzhou, China, 2015–2021: a retrospective cohort study by Yan Jiang, Yiming Chen, Yanan Wang, Huimin Zhang, Lingling Huang, Wenwen Ning, Xuelian Chu

“…Close monitoring and intervention during pregnancy are essential to reduce the occurrence of ABW.…”
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Neutralizing the Th1 effector cytokines, IFN-γ and TNF-α, attenuates established experimental autoimmune anti-myeloperoxidase glomerulonephritis by Kei Nagai, Kei Nagai, Daniel Koo Yuk Cheong, Anne Cao Le, Diana Shu Yee Tan, Joshua Daniel Ooi, Poh-Yi Gan

“…However, in late, established GN (day 32), TNF-α blockade significantly attenuated kidney injury, indicating its pathogenic role in Th1-driven disease. At day 32, IFN-γ neutralization induced a Th2 phenotypic shift, increasing IL-4 production in ex vivo MPO-stimulated lymph node cells and upregulating alternatively activated M2 macrophages. …”
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Has-miR-30c-1-3p inhibits macrophage autophagy and promotes Mycobacterium tuberculosis survival by targeting ATG4B and ATG9B by Xianglin Peng, Feifei Pu, Fangzheng Zhou, Xiyong Dai, Feng Xu, Junwen Wang, Jing Feng, Ping Xia

“…Abstract Autophagy is a widespread physiological process in the body, which also protects the host by degrading invading pathogens and harmful substances during pathological conditions. …”
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Open-label pilot study using hydroxytyrosol as dietary supplements in patients with mitochondrial diseases by Tsz Sum Wong, Emily Man, Ian Chi Kei Wong, Shirley Xue Li, Hui Zhi, Ka Man Carmen Yeung, Ka Yee Yip, Anna Ka Yee Kwong, Kiran Moti Belaramani, Suet Na Wong, Anne Mei Kwun Kwok, Miu Mak, Toby Chun Hei Chan, Pui Yee Lau, Yee Ling Elaine Kan, Kwok Chun Wong, Freddie Poon, Vansie Kwok, Chun Yin Dick Li, Paul Lau, Sze Man Lam, Vanessa Chu, Chi Fung Godfrey Chan, Cheuk Wing Fung

“…Abstract Background Mitochondrial Diseases (MDs) refers to a heterogeneous group of inherited metabolic disorders resulting in defective cellular energy production due to abnormal oxidative phosphorylation (OXPHOS) caused by pathogenic mitochondrial DNA or nuclear DNA variants. …”
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Adolescent late-onset riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency manifesting with severe multi-organ failure: a case report by Yunhua Zhao, Yunhua Zhao, Zhichao Li, Zhichao Li, Lili Cui, Jun Chen, Jun Chen, Wangtao Zhong, Wangtao Zhong

“…Genetic testing identified a homozygous c.250G&gt;A (p.Ala84Thr) mutation in electron transfer flavoprotein dehydrogenase (ETFDH), inherited from her parents. Although this pathogenic mutation is known in MADD, it has not been associated with adolescent late-onset MADD with severe multi-organ failure. …”
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Holistic management of skin neglected tropical diseases through church networks in the Songololo Territory, the Democratic Republic of Congo: a retrospective evaluation by Delphin Mavinga Phanzu, Saidi Kashindi, César-Augustin Muaka Khoso, Frédéric Kitsasa Kamba, Pierre Soki-Kangi Mbombolo, George Gitau, Stefanie Weiland, Melissa Edmiston

“…Background: Neglected tropical diseases (NTDs) are a diverse group of conditions caused by a variety of pathogens mainly prevalent among impoverished communities in tropical areas. …”
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Selection of antibiotic-resistant bacterial populations in the dairy cow gut following intramuscular ceftiofur treatment for metritis by Karla A. Vasco, Bailey Bowcutt, Samantha Carbonell, Letícia Souza, Cara Robison, Angel Abuelo, Ronald Erskine, Bo Norby, Lixin Zhang, Pamela L. Ruegg, Shannon D. Manning

“…ABSTRACT: Third-generation cephalosporins such as ceftiofur are critically important antibiotics because human pathogens with resistance to these drugs contribute to high mortality rates. …”
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Gut microbiome and plasma metabolome alterations in ileostomy and after closure of ileostomy by Liang Xu, Xiaolong Li, Lang Chen, Haitao Ma, Ying Wang, Wenwen Liu, Anyan Liao, Liang Tan, Xiao Gao, Weidong Xiao, Hua Yang, Guangyan Ji, Yuan Qiu

“…The gut microbiota in the ileostomy effluent and defunctioned colon had lesser species diversity and richness, with an abundance of aerobic, gram-negative, and potentially pathogenic bacteria. After the intestinal continuity was restored with routine meal feeding, the gut microbes recovered to a standard composition within 1 month. …”
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Complex Medium-Chain Triglycerides Mitigate Porcine Epidemic Diarrhea Virus Infection in Piglets by Enhancing Anti-Inflammation, Antioxidation, and Intestinal Barrier Function by Tingting Hu, Yunhao Liu, Sihui Gao, Xiaonan Zhao, Huangzuo Cheng, Youjun Hu, Huaqiao Tang, Zhiwen Xu, Chunlin Fang

“…The shortage of effective PED vaccines emphasizes the need to explore potent natural compounds for therapeutic intervention. It has been shown that glycerol monolaurate (GML) effectively inhibits PEDV replication in vivo and in vitro. …”
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