Microbial Dynamics in Endodontic Pathology—From Bacterial Infection to Therapeutic Interventions—A Narrative Review by Klara Wieczorkiewicz, Anna Jarząbek, Estera Bakinowska, Kajetan Kiełbowski, Andrzej Pawlik

“…Furthermore, it is considered that different types of pathogens could play a major role in primary and secondary endodontic infections. …”
Get full text

Emerging highly pathogenic H5N1 influenza triggers fibrotic remodeling in human airway organoids by Hussin Rothan, Ahmed Mostafa, Mahmoud Bayoumi, Chengjin Ye, Ramya S. Barre, Anna Allué-Guardia, Aitor Nogales, Jordi B. Torrelles, Luis Martinez-Sobrido

“…The ongoing outbreak of highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b has affected at least 989 dairy herds across 17 states in the United States (U.S.) and resulted in 70 confirmed human infections, underscoring the urgent need to understand the pathogenesis and therapeutic interventions of emerging H5N1 viruses. …”
Get full text

Complex-mediated evasion: modeling defense against antimicrobial peptides with application to human-pathogenic fungus Candida albicans by Yann Bachelot, Anastasia Solomatina, Marc Thilo Figge

“…Abstract Understanding the complex interplay between host and pathogen during infection is critical for developing diagnostics and improving therapeutic interventions. …”
Get full text

The Effects of Vitamins and Micronutrients on Helicobacter pylori Pathogenicity, Survival, and Eradication: A Crosstalk between Micronutrients and Immune System by Ali Nabavi-Rad, Mahsa Azizi, Shaghayegh Jamshidizadeh, Amir Sadeghi, Hamid Asadzadeh Aghdaei, Abbas Yadegar, Mohammad Reza Zali

Get full text

Introduction of Vector-Borne Infections in Europe: Emerging and Re-Emerging Viral Pathogens with Potential Impact on One Health by Jacopo Logiudice, Maria Alberti, Andrea Ciccarone, Benedetta Rossi, Giorgio Tiecco, Maria Antonia De Francesco, Eugenia Quiros-Roldan

Get full text

Molecular Detection and Characterization of Tick-Borne Pathogens in <i>Ixodes ricinus</i> Ticks Collected from Humans by Marina Žekić, Tjaša Cerar Kišek, Vesna Cvitković-Špik, Eva Ružić-Sabljić, Vladimir Gajdov, Aleksandar Potkonjak, Aleksandar Jurišić, Sara Savić

“…Regular surveillance of tick populations, with molecular identification of pathogens, offers insight into transmission dynamics, allowing for monitoring and public health interventions to be created if needed due to increased risk.…”
Get full text

Exploring shared pathogenic mechanisms and biomarkers in hepatic fibrosis and inflammatory bowel disease through bioinformatics and machine learning by Shangkun Li, Haoyu Li, Mingran Qi

“…BackgroundThe coexistence of hepatic fibrosis (HF) and inflammatory bowel disease (IBD) represents a significant clinical concern due to their poorly characterized shared pathogenic mechanisms. Current limitations in identifying common biomarkers for comorbid cases impede early dual diagnosis and therapeutic interventions.MethodsDifferentially expressed genes (DEGs) were screened, followed by Weighted Gene Co-expression Network Analysis (WGCNA) to identify disease-associated modules. …”
Get full text

Evolution of pathogenic Escherichia coli harboring the transmissible locus of stress tolerance: from food sources to clinical environments by Maxsueli Machado, Pedro Panzenhagen, Flávia Figueira Aburjaile, Bertram Brenig, Mateus Matiuzzi da Costa, Vasco Ariston de Carvalho Azevedo, Eduardo Eustáquio de Souza Figueiredo, Carlos Adam Conte-Junior

“…This study demonstrated the historical background of E. coli with tLST genes dating back more than 100 years, and the acquisition of a wide range of virulence and resistance genes that allow it to circulate in different environments: from food to clinic or from clinic to food, making this bacterium a pathogen that requires rigorous surveillance and strategic interventions to mitigate potential risks.…”
Get full text

Impact of prostate cancer screening in European ancestry un‐affected men with germline DNA repair pathogenic variants by Vittorio Fasulo, Giuseppe Chiarelli, Giuseppe Garofano, Carla Barbara Ripamonti, Monica Barile, Paolo Bianchi, Emanuela Morenghi, Alessio Benetti, Muhannad Aljoulani, Alessio Finocchiaro, Marco Paciotti, Pier Paolo Avolio, Edoardo Beatrici, Paola Arena, Alberto Saita, Rodolfo Hurle, Federica Maura, Giorgio Da Rin, Rosanna Asselta, Anita Capalbo, Giulia Soldà, Paolo Casale, Nicolò Maria Buffi, Giovanni Lughezzani, Massimo Lazzeri

“…Genetic factors, particularly germline pathogenic variants (PVs) in DNA repair genes (DRGs), play a crucial role in PCa predisposition. …”
Get full text

Respiratory pathogens detected in children aged <5 years hospitalized with severe respiratory illness, South Africa, 2017 by Malefu Moleleki, Malefu Moleleki, Cayla Reddy, Cayla Reddy, Kedibone Ndlangisa, Kedibone Ndlangisa, Mignon du Plessis, Mignon du Plessis, Orienka Hellferscee, Orienka Hellferscee, Omphe Mekgoe, Sibongile Walaza, Sibongile Walaza, Stefano Tempia, Stefano Tempia, Stefano Tempia, Cheryl Cohen, Cheryl Cohen, Anne von Gottberg, Anne von Gottberg, Nicole Wolter, Nicole Wolter

“…IntroductionThe burden of morbidity and mortality of severe respiratory illness (SRI) remains disproportionately high among young children, and in low-and middle-income countries. We used a multi-pathogen respiratory PCR assay to detect pathogens in children aged &lt;5 years hospitalized with SRI.MethodsProspective syndromic surveillance for SRI was performed at two sentinel hospitals in South Africa between January and December 2017. …”
Get full text

Model-guided development of pharmacokinetic/pharmacodynamic cut-offs and evaluation of sitafloxacin dosing regimens against target pathogens by Hailan Wu, Hailan Wu, Hailan Wu, Yi Li, Yi Li, Yi Li, Xin Li, Xin Li, Xin Li, Yaxin Fan, Yaxin Fan, Yaxin Fan, Beining Guo, Beining Guo, Beining Guo, Xiaofen Liu, Xiaofen Liu, Xiaofen Liu, Wanzhen Li, Wanzhen Li, Wanzhen Li, Mengting Chen, Mengting Chen, Mengting Chen, Yan Chen, Yan Chen, Yan Chen, Jing Zhang, Jing Zhang, Jing Zhang, Jing Zhang

“…IntroductionThe establishment of clinical breakpoints for antimicrobial drug is crucial for guiding appropriate therapeutic interventions. This study aims to identify the pharmacokinetic/pharmacodynamic (PK/PD) cut-offs for using sitafloxacin against target pathogens to support clinical breakpoint establishment for antimicrobial drug sensitivity testing.MethodsA population PK (PopPK) model was built (342 subjects) to calculate the dosing-regimen-dependent (50 mg q12 h, 100 mg q24 h and 100 mg q12 h) PK parameters of sitafloxacin-infected patients, which were combined with in vitro PD data and PK/PD target data. …”
Get full text

Highly pathogenic avian influenza H5N1 in the United States: recent incursions and spillover to cattle by Ahmed Mostafa, Aitor Nogales, Luis Martinez-Sobrido

Get full text

Diabetic Kidney Disease: Disease Progression Driven by Positive Feedback Loops and Therapeutic Strategies Targeting Pathogenic Pathways by Mo GP, Zhu Y, You Y, Chen H, Zhang J, Ku B, Yu H, Peng Z

Get full text

Cryo-EM structure of ribosome from pathogenic protozoa Entamoeba histolytica reveals unique features of its architecture by Shivani Sharma, Shalini Mishra, Samudrala Gourinath, Prem S. Kaushal

Get full text

Pathogenic aspects of fructose consumption in metabolic dysfunction-associated steatotic liver disease (MASLD): A narrative review by Katharina Burger, Michael Trauner, Ina Bergheim

“…Evidence from human (intervention) studies regarding the effects of sugar and especially fructose intake is limited and contradictory with respect to the development of MASLD. …”
Get full text

Early and Accurate Pathogen Identification Based on mNGS: Key to Timely Therapy for Mycoplasma Prosthetic Joint Infection by Zhenyuan Lin, Yang Chen, Zhenggui Yu, Zeyu Zhang, Yiming Lin, Wenming Zhang, Wenbo Li, Yufeng Guo, Xinyu Fang

“…This multimodal diagnostic approach significantly enhances pathogen identification accuracy, minimizes diagnostic oversights, and provides essential guidance for effective therapeutic intervention.…”
Get full text

Hyperbaric oxygen-induced acute lung injury: A mouse model study on pathogenic characteristics and recovery dynamics by Shu Wang, Shu Wang, Hong Chen, Zhi Li, Guangxu Xu, Xiaochen Bao

Get full text

Periodontal Pathobionts and Respiratory Diseases: Mechanisms of Interaction and Implications for Interdisciplinary Care by Byeongguk Kim, Nana Han

“…These pathobionts contribute to respiratory diseases by facilitating pathogen adhesion, inducing epithelial cell apoptosis, and promoting inflammation. …”
Get full text

Epidemiological characteristics of acute respiratory infectious diseases in the first year after COVID-19 pandemic in Guangdong Province, China by Ting Hu, Yali Zhuang, Lirong Zou, Zhencui Li, Yihong Li, Yan Li, Min Kang, Aiping Deng

“…Continuous multi-pathogen surveillance is essential for understanding their epidemiological characteristics and formulating effective prevention and control measures, including vaccination strategies, clinical interventions.…”
Get full text

Mathematical assessment of the optimal intervention strategy for Cercospora fungal disease in orange plants by Omowumi Fatimah Lawal, Anthony Kodzo Hunkpe, Afeez Abidemi, Pius Olanrewaju Ogunjobi

“…Cercospora fragariae is a fungal plant pathogen. Citrus trees and shrubs are particularly vulnerable to Cercospora infections, which can result in significant crop losses. …”
Get full text