Community-led intensive trapping reduces abundance of key plague reservoir and flea vector by Marcela P. A. Espinaze, Soanandrasana Rahelinirina, Todisoa Radovimiandrinifarany, Fehivola Mandanirina Andriamiarimanana, Alain Berthin Andrianarisoa, Voahangy Soarimalala, Kathryn Scobie, Mireille Harimalala, Minoarisoa Rajerison, Steven R. Belmain, Sandra Telfer

“…Abstract Background Zoonotic pathogens transmitted by rodents are highly prevalent in low-middle income countries and effective control measures that are easily implemented are urgently needed. …”
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Comorbidity of hypertension and lung cancer: interplay of genetics and environment by Jingtong Zeng, Difang Shi, Daqian He, Wenxun Dong, Zhenghong Yang, Ying Chen

“…The relationship between hypertension and lung cancer is complex, with shared risk factors and common pathogenic mechanisms, including inflammation, oxidative stress, and metabolic dysregulation. …”
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Efgartigimod following plasma exchange in the treatment of subjects with generalised myasthenia gravis: study protocol for a multicentre, three-arm, open-label study by Lu Zhang, Kan Wang, Yong Hao, Yangtai Guan, Jing Peng, Li Gao, Song Gao, Qiuju Li, Chong Xie, Yuhui Wang, Yanan Wu, Mengze Zhang, Xiaokun Wang, Chunran Xue, Yiwei Yang

“…Plasma exchange (PLEX) transiently depletes pathogenic mediators, while neonatal Fc receptor antagonists (eg, efgartigimod) offer novel therapeutic potential. …”
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Targeting EGR1-ATF3 signaling mitigates paravertebral muscle degeneration by regulating cell death and inflammaging by Xuke Wang, Qingfeng Wang, Zhe Wang, Yingjie Zhou, Xiaobing Jiang, Yongjin Li

“…Age-related cellular death further accelerates chronic, low-grade inflammation termed “inflammaging” and disrupts the extracellular matrix (ECM), representing a key pathogenic mechanism driving paravertebral muscle degeneration (PMD). …”
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Bone mineral density and microarchitecture improvement in a young patient with Hajdu-Cheney syndrome and autosomal dominant polycystic kidney disease treated with alendronate by André Silva Franco, Valeria de Falco Caparbo, Elieser Hitoshi Watanabe, Rosa Maria Rodrigues Pereira, Luiz Fernando Onuchic

“…Whole exome sequencing revealed a pathogenic variant in NOTCH2, confirming the diagnosis of HCS, and a very likely causative variant in PKD1, supporting the diagnosis of ADPKD.The treatment regimen included weekly alendronate, impact exercise, a calcium-rich diet, and vitamin D supplementation. …”
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IL-6 signaling is required for the development and regeneration of ear cartilage in microtia by Wenkang Luan, Shujun Fan, Hanyi Jiang, Dongwen Jiang, Jinxiu Yang, Leren He

“…IntroductionCongenital microtia is a birth defect characterized by auricular underdevelopment, with unclear pathogenesis and unidentified pathogenic genes.MethodsDifferential expression analysis, weighted co-expression network analysis (WGCNA), protein-protein interaction (PPI) networks and support vector machine recursive feature elimination (SVM-RFE) identified the key biomolecules in microtia. …”
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Investigating the Utility of Leukocyte Sialic Acid Measurements in Lysosomal Free Sialic Acid Storage Disorder by Marya S. Sabir, Laura Pollard, Lynne Wolfe, David R. Adams, Carla Ciccone, Petcharat Leoyklang, Frances M. Platt, Marjan Huizing, William A. Gahl, May Christine V. Malicdan

“…ABSTRACT Lysosomal free sialic acid storage disorder (FSASD) is a rare, multisystem neurodegenerative disease caused by biallelic pathogenic variants in SLC17A5, encoding sialin. FSASD is characterized by aberrant accumulation of unconjugated “free” sialic acid (Neu5Ac) within lysosomes. …”
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Necrotising Soft-tissue Infection of the Breast: Case Series of a Rare but Fatal Entity by Sabyasachi Hazra, Meghraj Kundan, Karan Barat, MS Hrishikesh, Aman Jawwad

“…Blood cultures revealed pathogens such as Enterococcus, E. coli and Proteus mirabilis. …”
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Mitochondria-targeted nanovesicles for ursodeoxycholic acid delivery to combat neurodegeneration by ameliorating mitochondrial dysfunction by Shizheng Zhang, Mengmeng Li, Yuan Li, Shike Yang, Jian Wang, Xiaoxiang Ren, Xiuhui Wang, Long Bai, Jianping Huang, Zhen Geng, Guosheng Han, Yibin Fang, Jiacan Su

“…It is well-established that mitochondrial dysfunction constitutes a fundamental pathogenic mechanism in neurodegeneration, especially in the context of Parkinson’s disease (PD), this represents a promising target for therapeutic intervention. …”
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Longitudinal detection of somatic mutations in the saliva of head and neck squamous cell carcinoma–affected patients: a pilot study by Chiara Dal Secco, Alessandro Tel, Lorenzo Allegri, Federica Baldan, Francesco Curcio, Francesco Curcio, Salvatore Sembronio, Salvatore Sembronio, Flavio Faletra, Massimo Robiony, Massimo Robiony, Giuseppe Damante, Giuseppe Damante, Catia Mio

“…Overall, 29.2% of samples harbored at least a pathogenic variant (n=21/72). The most frequently mutated genes were TP53 (80%), FBXW7 (8%), PDGFRA (4%) and PTEN (4%). …”
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Case Report: Whole genome sequencing identifies a novel deep intronic COL4A5 variant of uncertain significance in X-linked Alport syndrome by Hoon Seok Kim, Hoon Seok Kim, Myungshin Kim, Myungshin Kim, Jin-Soon Suh, Yeonhee Lee

“…Diagnosing Alport syndrome can be particularly challenging when targeted sequencing methods, such as panel-based next-generation sequencing (NGS), fail to identify pathogenic variants, especially deep intronic mutations. …”
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Integrated bioinformatics analysis to develop diagnostic models for malignant transformation of chronic proliferative diseases by Hua Liu, Sheng Lin, Pei-Xuan Chen, Juan Min, Xia-Yang Liu, Ting Guan, Chao-Ying Yang, Xiao-Juan Xiao, De-Hui Xiong, Sheng-Jie Sun, Ling Nie, Han Gong, Xu-Sheng Wu, Xiao-Feng He, Jing Liu

“…The combined analysis of dual diseases can provide new insights into pathogenic mechanisms, identify novel biomarkers, and develop targeted therapeutic strategies. …”
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Predicting biomarkers of progressive pulmonary fibrosis: morphological, cytokine profile, and clinical portrait by Nicol Bernardinello, Federica Pezzuto, Lauren D’Sa, Luca Vedovelli, Chiara Giraudo, Anamaria Chelu, Anamaria Chelu, Cecilia de Chellis, Francesca Lunardi, Francesco Fortarezza, Francesca Boscaro, Elisabetta Cocconcelli, Paolo Spagnolo, Elisabetta Balestro, Fiorella Calabrese

“…ObjectiveThe term progressive pulmonary fibrosis (PPF) refers to a specific disorder that becomes worse despite optimal treatment. The pathogenic explanation of this progressive worsening is still to be found. …”
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Lung-specific CRBN knockout attenuates influenza a virus-induced acute lung injury in mice: a potential therapeutic approach by Lifang Zhang, Qingchao Zhang, Jiahui Chang, Yunyi Zhou, Wei Wang, Xiliang Wang, Chengyu Jiang, Yanli Zhang

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Development and validation of a high-throughput qPCR platform for the detection of soil-transmitted helminth infections. by Nils Pilotte, Victor Omballa, Monica Voss, Leah Padgett, Malathi Manuel, Jeanne L Goodman, Tim Littlewood, Zayina Zondervenni Manoharan, Lisette van Lieshout, Jaco J Verweij, Manigandan Sekar, Ajith Kumar Muthukumar, Gretchen Walch, Abriana Warren, Mariyam Sheikh, Andrew Gonzalez, Sean R Galagan, Sitara Swarna Rao Ajjampur, Moudachirou Ibikounlé, Steven A Williams, Doug Rains, Ushashi Dadwal, Judd L Walson

“…While these efforts have succeeded in reducing morbidity associated with STH infection, recent modeling efforts have suggested that expanding intervention to treatment of the entire community could achieve transmission interruption in some settings. …”
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Predicting cancer-related mycobiome aspects in gastrointestinal cancers: a systematic review by György Szklenarik, Peter Kiraly, Gabor Szegvari, David Dora, Zoltan Lohinai

“…BackgroundColonization of the human gut and tumor tissue by non-pathogenic fungi has emerged as a potential risk factor associated with cancer epidemics. …”
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Comparison of ultraviolet C light and isopropyl alcohol for the disinfection of cellular phones in a paediatric intensive care unit setting by L Thomas, J John, H Lochan

“…A considerable proportion of cellular phones (cell phones) used by healthcare workers (HCWs) have been shown to be contaminated with pathogenic micro-organisms, making these devices reservoirs to infect susceptible patients. …”
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Modulation of gut microbiota and immune response by soy peptides mitigates irinotecan induced intestinal toxicity by Yongfa Jing, Dongli Yan

“…Fecal samples were subjected to 16S rRNA sequencing to analyze gut microbiota composition.ResultsSPs intervention significantly reduced the incidence of diarrhea (P < 0.05) and attenuated body weight loss (P < 0.05) in mice. …”
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Factors influencing uptake of protective behaviours by healthcare workers in England during the COVID-19 pandemic: A theory-based mixed-methods study. by Carly Meyer, Elise Crayton, Abigail Wright, Moira Spyer, Nina Vora, Catherine Houlihan, Naomi F Walker, Eleni Nastouli, Susan Michie, Fabiana Lorencatto, SAFER investigators

“…<h4>Background</h4>Hospital infection control policies protect patients and healthcare workers (HCWs) and limit the spread of pathogens, but adherence to COVID-19 guidance varies. …”
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A Web Geographic Information System to share data and explorative analysis tools: The application to West Nile disease in the Mediterranean basin. by Lara Savini, Susanna Tora, Alessio Di Lorenzo, Daniela Cioci, Federica Monaco, Andrea Polci, Massimiliano Orsini, Paolo Calistri, Annamaria Conte

“…The collection, storage and distribution of information on the spread of the disease becomes important for a shared intervention and control strategy. To this end, a Web Geographic Information System has been developed and disease data, climatic and environmental remote sensed data, full genome sequences of selected isolated strains are made available. …”
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