Higher Dietary Fibre Increases the Faecal Microbiome Diversity of Golden Lion Tamarins (<i>Leontopithecus rosalia</i>) by Caitlin Lawless, Katrina Kovacs, Manijeh Mohammadi Dehcheshmeh, Esmaeil Ebrahimie, Yohannes E. Messele, Mark Snowball, Darren J. Trott, David J. McLelland

“…Additionally, both alpha and beta diversity increased significantly (<i>p</i> < 0.05) after the dietary fibre intervention. A significant reduction in Desulfobacterota (FDR-adjusted <i>p</i> < 0.05) following dietary fibre enrichment was observed, suggesting a shift away from microbial groups that may be associated with pathogenicity or pro-inflammatory effects. …”
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Hyperornithinemia–Hyperammonemia–Homocitrullinuria Syndrome in Vietnamese Patients by Khanh Ngoc Nguyen, Van Khanh Tran, Ngoc Lan Nguyen, Thi Bich Ngoc Can, Thi Kim Giang Dang, Thu Ha Nguyen, Thi Thanh Mai Do, Le Thi Phuong, Thinh Huy Tran, Thanh Van Ta, Nguyen Huu Tu, Chi Dung Vu

“…Genetic analyses revealed three pathogenic variants in the <i>SLC25A15</i> gene, with the c.535C>T (p.Arg179*) variant common in Vietnamese patients. …”
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Does paired genetic testing improve targeted therapy choices and screening recommendations for patients with upper gastrointestinal cancers and their families? A prospective cohort... by Colin Pritchard, William M Grady, Veena Shankaran, Kevin Tatunay, Stacey Cohen, Lorraine V Naylor, Cynthia L Handford, Angela Jacobson, Brant Oelschlager, Britta Sjoding, Everett Lally, Lauren Facchini, Qin Sun, Mercy Y Laurino, Eric Q Konnick, Marianne E Dubard-Gault

“…Another 11 did not have this biomarker, and 6 of them received immunotherapy. Six pathogenic variants were identified in four high-risk genes. …”
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Applications of bacteriophages in precision engineering of the human gut microbiome by Xiaoxian Kuang, Juntao Shen, Linggang Zheng, Yi Duan, Yingfei Ma, Elaine Lai-Han Leung, Lei Dai

“…Herein, we review the recent advances in bacteriophage-mediated modulation of the gut microbiome, discuss approaches at the ecological and genetic levels, and summarize the challenges and strategies pertinent to each level of intervention. Drawing on the structural attributes of bacteriophages in the context of precision engineering, we examined the latest developments in the field of phage administration. …”
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Comparative analysis of candidal carriage rates in long-term and short-term COVID-19 patients: An RT-PCR study by Ramya Sekar, Kavitha Bottu, Protyusha GB, Jeyaseelan Ramasamy, Bargavi Venkatesalu

“…However, current research shows that 10–20 % of the population, especially immunocompromised and elderly people, endure numerous adverse effects and multiple complications associated with different organs and systems during its pathogenic cycle. Also, many fungal coinfections are seen as post-COVID dysbiosis, the most common fungal organism being Candida. …”
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Animal Models in Rheumatoid Arthritis: Is There a Correlation Between Autoantibodies in Human Pathology and Animal Models? by Miguel Marco-Bonilla, Maria Fresnadillo, Macarena de la Riva-Bueno, Gabriel Herrero-Beaumont, Raquel Largo, Aránzazu Mediero

“…The early detection of ACPA provides a potential window for intervention, while anti-CarP antibodies correlate with severe disease progression and RF aids in diagnosis. …”
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Clinical correlation study of non-tuberculous mycobacterial isolates from bronchoalveolar lavage fluid by Hongye Ning, Guiqing He, Yanhong Mei, Jiandan Yu, Jichan Shi, Xiaoya Cui, Chaochao Qiu, Xiangao Jiang

“…The broth microdilution method assessed the drug sensitivity of isolated NTM pathogenic bacteria, determining their minimum inhibitory concentrations (MICs). …”
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Early diagnosed Zaki syndrome: identification of two novel WLS variants and a literature review by Anran Tian, Sujuan Li, Furong Liang, Minglan Yao, Niusha Mostafavi, Yingying Li, Xiaoping Luo, Cai Zhang

“…Abstract Background Zaki syndrome is an autosomal recessive disorder caused by pathogenic variants in the WLS gene, which is essential for Wnt signaling. …”
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Microbiota-derived butyrate alleviates asthma via inhibiting Tfh13-mediated IgE production by Baichao Yu, Chong Pei, Wenjun Peng, Yongkun Zheng, Ying Fu, Xueqi Wang, Wenjun Wang, Zhiqiang Wang, Yong Chen, Qi Wang, Kameina Zhuma, Yiyuan Gao, Yun Xing, Mengxia Jiao, Ronghua Liu, Feifei Luo, Dan Zhang, Jingbo Qie, Hui Yang, Meiling Jin, Luman Wang, Yiwei Chu

“…In this study, we identified that among SCFAs, butyrate uniquely alleviates asthma through specifically inhibiting a newly identified pathogenic T follicular helper (Tfh) cell subset, Tfh13 cells. …”
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Dual threat: Susceptibility mechanisms and treatment strategies for COVID-19 and bacterial co-infections by Keda Chen, Ruiqi Weng, Jiaxuan Li, Hao Wu, Xiaotian Tie, Hongyu Li, Yuanyuan Zhang

“…However, the rate increases significantly in severe cases (8.1 %) and reaches as high as 23.5 % among ICU patients. Common pathogens include Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella species. …”
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Heterozygosity in NPC may be associated with neurologic and systemic phenotypes by Tatiana Brémovà-Ertl, Sabina Tahirovic, Silva Katušić Hećimović, Kyriakos Martakis, Kyriakos Martakis, Marianne Rohrbach, Matthias Gautschi, Radhika Dhamija, Jaya Ganesh, Melinda Peters, Mark Walterfang, Susanne A. Schneider

“…Emerging biochemical, genetic, and clinical evidence challenges the traditional view that disease-associated variants in the genes associated with the typical phenotype NPC manifest as an exclusively autosomal recessive disorder. While biallelic pathogenic variants cause the NPC disease phenotype, heterozygous carriers may exhibit phenotypic traits attributable to a partial loss of NPC1 or NPC2 function.MethodsWe conducted a literature search of articles relevant to heterozygosity in NPC genes and genes associated with other lysosomal diseases. …”
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How to escape from sudden death: a challenging case of a rare cardiomyopathy with an unexpected twist by Luísa Pinheiro, Margarida de Castro, Filipa Cordeiro, Tamara Pereira, Francisco Ferreira, Víctor Sanfins, António Lourenço, Olga Azevedo

“…This was confirmed by low α-galactosidase A activity and detection of the pathogenic GLA p.F113L variant. Multisystemic evaluation revealed additional FD manifestations, and enzyme replacement therapy was initiated, later switched to oral migalastat. …”
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The Impact of Patent Ductus Arteriosus in Neonates with Late Onset Sepsis: A Retrospective Matched-Case Control Study by Pei-Jung Chiang, Jen-Fu Hsu, Ming-Horng Tsai, Reyin Lien, Ming-Chou Chiang, Hsuan-Rong Huang, Chiao-Ching Chiang, Hwey-Fang Liang, Shih-Ming Chu

“…The objective of this study was to determine the incidence, the distribution of pathogens, and the clinical features of LOS in neonates with PDA and analyze their outcomes. …”
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The role and mechanism of lung microbiota in coal mine dust-induced NLRP3 inflammasome upregulate and lung injury by Yao Zhang, Jiaju Yan, Yuan Ren, Lifang Li, Xiaojie You, Yujia Xie, Weihong Chen, Hui Zhao, Dongming Wang

“…Lung microbiota may serve as a key pathogenic mechanism in CWP.…”
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A point prevalence survey (PPS) of antimicrobial use amongst patients referred to tertiary care centre in Northern India by Dr Naveen Murali, Dr Nikhil Aravind, Prof Nusrat Shafiq, Dr Niveditha Krishnappa, Dr Ritin Mohindra, Dr Rishin Raj P, Dr Ashish Thomas George, Dr Asheema Khosla, Ms Himanshi Khera, Ms Rupamdeep Kaur, Mr Roop Kishor Soni

“…Also, a large number of patients have a very high risk for development of infections caused by MDR pathogens. The survey was efficient in identifying points for intervention for antimicrobial stewardship in the emergency unit.…”
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<i>Lactobacillus</i> Re-Engineers Gut Microbiota to Overcome <i>E. coli</i> Colonization Resistance in Mice by Jianlei Jia, Pengjia Bao, Qinran Yu, Ning Li, Hao Ren, Qian Chen, Ping Yan

“…The intestinal health and functionality of animals play pivotal roles in nutrient digestion and absorption, as well as in maintaining defense against pathogenic invasions. These biological processes are modulated by various determinants, including husbandry conditions, dietary composition, and gut microbial ecology. …”
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Diagnostic imaging confusion in infectious spondylitis by Zhihao Xu, Weijian Zhu, Sirui Zhou, Zhiying Yang, Liqiao Xiang, Jinming Zhang, Kangshou Liu

“…It can affect patients of all ages and is typically caused by bacterial, fungal, or other pathogens. The infection commonly targets the vertebral bodies and intervertebral discs. …”
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The role of DUOXA2 in the clinical diagnosis of paediatric congenital hypothyroidism by Jiani Du, Yanling Yang, Ding Wei, Jiajun Wu, Chunping Tian, Qianqian Hu, Hongyan Bian, Chen Cheng, Xiaoyan Zhai

“…Early identification through DUOXA2 gene screening could improve diagnostic accuracy, which facilitates early intervention and personalized treatment.Conclusions: DUOXA2 gene screening holds promise for enhancing diagnostic accuracy in CH. …”
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Dynamic changes of gut and skin microbiota in pancreatic cancer-induced skin injury by Siqi Yao, Xi Yan, Hao Chen, Shibo Lei, Jing Huang, Ke Guo, Zheng Yu

“…In the Epi group, the trend of increasing pathogenic bacteria and decreasing probiotics suggests a disrupted microbial environment that may contribute to skin injury through the gut–skin axis. …”
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Bifidobacterium longum JBLC-141 alleviates hypobaric hypoxia-induced intestinal barrier damage by attenuating inflammatory responses and oxidative stress by Xiang-Yang Li, Xiang-Yang Li, Xiang-Yang Li, Jin Shang, Jin Shang, Jin Shang, Xiao-Juan Wang, Xiao-Juan Wang, Xiao-Juan Wang, Hui-Ping Ma, Long-Fei Ren, Long-Fei Ren, Long-Fei Ren, Long-Fei Ren, Long-Fei Ren, Lei Zhang, Lei Zhang, Lei Zhang, Lei Zhang, Lei Zhang

“…In addition, B. longum JBLC-141 positively regulates the intestinal microbiota, increasing the relative abundance of beneficial bacteria while reducing that of pathogenic bacteria and maintaining intestinal flora homeostasis in rats.…”
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