Efficacy and safety of SH003 on immune function: study protocol for a randomized, double-blind placebo-controlled clinical trial by Chunhoo Cheon, Seong-Gyu Ko

“…Abstract Background The immune system is essential for defending the body against pathogens and maintaining homeostasis. Recent global public health challenges have increased interest in natural products that enhance immune function. …”
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Goat-derived Lactobacillus amylovorus improved floppy kid syndrome via regulating gut microflora by Cheng Cheng, Yan Zheng, Xin Wang, Jianping Tao, Darong Cheng

“…These findings support its promise as a novel probiotic intervention for preventing and treating Floppy Kid Syndrome.…”
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Recurrent Wunderlich syndrome in systemic lupus erythematosus: a case report by Yingzi Zhu, Lingli Dong

“…Given that most WS cases are life-threatening and require prompt intervention, timely identification and resolution are essential. …”
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The Influence of Working in Stone Crushing Factories on Specific Respiratory Parameters by Belal Rahhal, Raya Sinnokrot, Omar Abuzant, Samah Shahin, Amany Masalmeh, Wala Jarrar

“…Working in stone-cutting factories is a known source for silica dust exposure, which has pathogenic effects on the respiratory system resulting finally in silicosis which may end in malignancy. …”
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Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042. by Roy R Chaudhuri, Mohammed Sebaihia, Jon L Hobman, Mark A Webber, Denisse L Leyton, Martin D Goldberg, Adam F Cunningham, Anthony Scott-Tucker, Paul R Ferguson, Christopher M Thomas, Gad Frankel, Christoph M Tang, Edward G Dudley, Ian S Roberts, David A Rasko, Mark J Pallen, Julian Parkhill, James P Nataro, Nicholas R Thomson, Ian R Henderson

“…In addition, by using Biolog Phenotype Microarrays we have provided a full metabolic profiling of E. coli 042 and the non-pathogenic lab strain E. coli K-12. We have highlighted the genetic basis for many of the metabolic differences between E. coli 042 and E. coli K-12.…”
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Ameliorative action of probiotics on the neurotoxicological effect of Aluminium chloride and D-galactose by Vaishali Lekchand Dasriya, Manorama Kumari, Soniya Ranveer, Pradip Behare, Shilpa Vij, Anil Kumar Puniya

“…This finding provides insights into the effect of L. fermentum NCDC701 intervention on the gut–microbiome–brain axis and should assist future understanding of probiotics for improved host health.…”
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Concurrent uveitis in monozygotic twins in the context of systemic sarcoidosis by Doaa Maamoun Ashour, Reem Mohsen, Rahma A. Elziaty, Omnia Bahaa Attia, Haytham Samy Diab, Caroline Atef Tawfik

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Pyogenic Liver Abscess: Contemporary Trends in a Tertiary Institute by Elad Boaz, Eli Ben-Chetrit, Yonathan Bokhobza, Shlomo Yellinek, Menahem Ben-Haim, Petachia Reissman, Amir Dagan

“…Patients diagnosed with PLA are older, the male predominance is less pronounced, and the offending pathogens are likely to originate from the biliary tract. …”
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Salmonella serotypeTyphi, Shigella, and intestinal parasites among food handlers at Bahir Dar University, Ethiopia by Bayeh Abera, Gashaw Yitayew, Hiwot Amare

“…Typhi should be considered as intervention measures. …”
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How is the human microbiome linked to kidney stones? by Xin Pei, Miao Liu, Shanshan Yu

“…Microbiome-based diagnostic markers (e.g., elevated abundance of Aspergillus phylum) and targeted intervention strategies (e.g., probiotic supplementation, faecal bacteria transplantation) show potential for clinical application. …”
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Epidemiology, microbiology and mortality associated with community-acquired bacteremia in northeast Thailand: a multicenter surveillance study. by Manas Kanoksil, Anchalee Jatapai, Sharon J Peacock, Direk Limmathurotsakul

“…CAB was defined in patients who had pathogenic organisms isolated from blood taken within 2 days of hospital admission without a prior inpatient episode in the preceding 30 days. …”
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Targeted plasma metabolomics reveals potential biomarkers of the elderly with mild cognitive impairment in Qingdao rural area by Yuchi Meng, Murong Cheng, Hongyan Qu, Zhenxue Song, Ling Zhang, Yuanjun Zeng, Dongfeng Zhang, Suyun Li

“…Random forest analysis was used to further evaluate the ability of the metabolic data to distinguish effectively between the two groups.ResultsA total of 14 differential metabolites were identified, leading to the discovery of a biomarker panel consisting of three plasma metabolites including uric acid, pyruvic acid and isolithocholic acid that effectively distinguished MCI patients from healthy subjects.DiscussionThese findings have provided a comprehensive metabolic profile, offering valuable insights into the early prediction and understanding of the pathogenic processes underlying MCI. This study holds the potential for advancing early detection and intervention strategies for MCI.…”
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Synbiotics in caries prevention: A scoping review. by Mohammed Nadeem Bijle, Manikandan Ekambaram, Edward C M Lo, Cynthia Kar Yung Yiu

“…Future studies are needed to examine the combination of amino acids (esp. arginine) with probiotics as a potential synbiotic against cariogenic pathogens.…”
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Rare and novel variant load threshold for KIF7, GJA1 and PDE1C genes elevates the risk of severity of congenital heart defects in Down syndrome. by Agnish Ganguly, Samudra Pal, Srilagna Chatterjee, Madhusudan Das, Sumantra Sarkar, Sujay Ghosh

“…In-silico analyses indicated that these variants are pathogenic. The frequencies of the heterozygous genotypes for KIF7 rs138354681, GJA1 rs778110855, and PDE1C PP785745 were recorded as 0.027, 0.016, and 0.032, respectively. …”
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Mirtazapine for gastrointestinal and neuropsychological symptoms in older adults with irritable bowel syndrome by Ayesha Khan, Raakhi Menon, Brooke Corning, Steven Cohn, Cecil Kumfa, Mukaila Raji

“…These neurological and psychiatric comorbidities reflect shared pathogenic mechanisms and bidirectional crosstalk of high inflammation, alteration of gut microbiota, and dysregulation of multiple gastrointestinal and central nervous system-active neurotransmitters (e.g., serotonin, neuropeptides). …”
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The Role of RYR2 in Atrial Fibrillation by Bernhard M. Boehm, Jochen Gaa, Petra Hoppmann, Eimo Martens, Dominik S. Westphal

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Improvement of antibiotic use in sore throat, tonsillitis and acute otitis media in Palestine: a prospective full cycle audit by Haytham AbuMohsen, Mohammad Abusheikha

“… Introduction: Antibiotics are commonly prescribed for upper respiratory tract infections (URTIs) which are generally caused by viral pathogens and do not require antibiotics under most circumstances. …”
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IoMT Architecture for Fully Automated Point-of-Care Molecular Diagnostic Device by Min-Gin Kim, Byeong-Heon Kil, Mun-Ho Ryu, Jong-Dae Kim

“…The emergence of infectious diseases, including COVID-19, underscores the need for rapid and decentralized diagnostics to facilitate early intervention. Traditional centralized laboratory testing introduces delays, limiting timely medical responses. …”
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Antibiotic resistance of uropathogens in patients with nephrolithiasis and concomitant coronary heart disease by R. V. Royuk, S. K. Yarovoy, I. B. Shikina

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Periplaneta americana extract (L.) promotes hair regrowth in Alopecia areata mice by reducing inflammation and modulating skin microbiota by Tangfei Guan, Tangfei Guan, Tangfei Guan, Xin Yang, Xin Yang, Canhui Hong, Canhui Hong, Jiali Zhu, Jiali Zhu, Peiyun Xiao, Peiyun Xiao, Yongshou Yang, Yongshou Yang, Chenggui Zhang, Chenggui Zhang, Zhengchun He, Zhengchun He

“…Transcriptomics, metabolomics, and 16S rRNA sequencing explored the hair-growth-promoting mechanisms.ResultsNetwork pharmacology showed PA-011 could regulate AA-related targets and pathways. PA-011 intervention promoted hair follicle cell proliferation and hair growth in AA mice, reduced skin TNF-α, IL-23, and VCAM-1 expression. …”
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