Recent advances in targeting LRRK2 for Parkinson’s disease treatment by Mahsa Karami, Pantea Majma Sanaye, Atousa Ghorbani, Roshanak Amirian, Pouya Goleij, Mehregan Babamohamadi, Zhila Izadi

“…Furthermore, research results have suggested inhibiting LRRK2 as a therapeutic intervention targeting pathogenic mechanisms with varying degrees of efficacy. …”
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Risk factors for bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli in a Turkish hospital by Onur Kaya, Fusun Zeynep Akcam, Ibak Gonen, Onur Unal, Tennure Ceylan

“… Introduction: Bloodstream infection caused by extended-spectrum beta-lactamase (ESBL)-producing pathogens has become a serious concern worldwide. The purpose of this study was to identify risk factors for bacteremia due to ESBL-producing Escherichia coli in a Turkish hospital. …”
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Th17/Treg Cell Imbalance May Contribute to Spontaneous Preterm Labor by Meiyi Xu, Cunling Zhang, Dan Wu, Liying Yao, Mengyuan Geng, Shanshan Li, Yuling Guo, Qiushui Wang, Zhuo Wei, Wen Li

“…Although predictive models and interventional strategies related to SPTL have been explored, there is currently insufficient evidence to establish a direct causal relationship between Th17/Treg imbalance and the onset of SPTL.…”
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Using molecular methods to diagnose, classify, and treat neonatal sepsis: a scoping review by Catherine Y. Lee, Sidney E. Zven, Shreyas A. Sathya, Danielle Abukhalaf, Sneha Sahoo, Pratyusha Samal, Stephanie M. Prescott

“…Of 1,043 articles screened, 30 were included in the final review.ResultsThe gut microbiome is associated with both pathogenicity and protection in the setting of neonatal sepsis, while expression levels of immune response and regulation help classify neonatal response to septic events. …”
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Adjacent segment disease induced by spinal tophus: a case report by Chenglong Wang, Hongjun Liu, Shuangquan Gong, Yu Ye, Liqiang Cui, Dengshang Liu, Sen Li, Shiming Xie

“…This report details the clinical presentation, imaging characteristics, pathological findings, surgical management, and potential pathogenic mechanisms underlying this rare complication.…”
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Aerosol Dynamics in the Respiratory Tract of Food-Producing Animals: An Insight into Transmission Patterns and Deposition Distribution by Longhuan Du, Mohan Qiu, Zengrong Zhang, Chenming Hu, Li Yang, Zhuxiang Xiong, Jiangxian Wang, Xia Xiong, Han Peng, Jialei Chen, Shiliang Zhu, Xiaoyan Song, Chunlin Yu, Chaowu Yang

“…Aerosols facilitate the spread of pathogens, introducing external infections to farms and enabling cross-transmission within barns. …”
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Disinfection impacts: Effects of different disinfection treatments on common polymer types to guide the identification of polymers of concern in the water industry by Kala Senathirajah, Raji Kandaiah, Logeshwaran Panneerselvan, Kyana Young, Thava Palanisami

“…While disinfection is helpful for treating pathogenic microorganisms, the risks of generating microplastics below detection limits are highlighted. …”
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Advances in the structures, mechanisms and targeting of molecular chaperones by Jinying Gu, Yanyi He, Chenxi He, Qiuyue Zhang, Qifei Huang, Shangjun Bai, Ruoning Wang, Qidong You, Lei Wang

“…In addition, how molecular chaperones affect diseases by regulating pathogenic proteins has been thoroughly analyzed. Furthermore, we focus on molecular chaperones to systematically discuss recent clinical advances and various drug design strategies in the preclinical stage. …”
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Enhancing protection against vector-borne diseases in forcibly displaced communities: evaluating the efficacy of spatial repellents for cutaneous leishmaniasis control in North-Eas... by Richard Allan, Ramona Scherrer, Ozge Erisoz Kasap, Laura Paris, Thomas Scott, Hendrik Sauskojus, Olivia Wetherill, Sara Estecha-Querol, Zaid Alkhalaf, Mehmet Karakus, Ayda Yilmaz, Bülent Alten, Louisa A. Messenger

“…Conclusions Trial findings provide the first demonstrable impact of spatial repellents on CL transmission, strengthening the growing evidence basis for the effectiveness of this intervention against multiple vector species and their associated pathogens. …”
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Treatment of non-healing sternum wound after open-heart surgery with allogenic platelet-rich plasma and fibrin glue-preliminary outcomes by Mohammad Abbasi Tashnizi, Mohammad Esmail Khayami, Hamid Reza Rahimi, Aliasghar Moeinipour, Ahmad Amouzeshi, Alexander M. Seifalian, Daryoush Hamidi Alamdari

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The prospects of employing probiotics in combating COVID-19 by Moutoshi Chakraborty, Saurab Kishore Munshi

“…Unanticipated pathogenic risk and emerging transmittable diseases can result from interspecies exchanges of viruses among animals and humans. …”
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Reducing bias in coronary heart disease prediction using Smote-ENN and PCA. by Xinyi Wei, Boyu Shi

“…This study employs machine learning techniques to analyze CHD-related pathogenic factors and proposes an efficient diagnostic and predictive framework. …”
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FMRFamide-like peptides (FLPs) enhance voltage-gated calcium currents to elicit muscle contraction in the human parasite Schistosoma mansoni. by Ekaterina Novozhilova, Michael J Kimber, Hai Qian, Paul McVeigh, Alan P Robertson, Mostafa Zamanian, Aaron G Maule, Tim A Day

“…Schistosomes are amongst the most important and neglected pathogens in the world, and schistosomiasis control relies almost exclusively on a single drug. …”
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Efficacy of Mouthrinsing in Reducing Aerosol Contamination in the Dental Environment: A Systematic Review by Eun-Mi Choi, Eun-Bi Sim

“…Background: Aerosols generated during dental procedures can contaminate dental devices and trigger microbial and pathogenic propagation in dental clinics. Pre-procedural use of chlorhexidine gluconate, essential oils, or povidone-iodine can reduce the number of oral microorganisms in aerosols and the splatter produced during dental procedures. …”

Antibiotic Resistance Surveillance and Control in the Mediterranean Region: report of the ARMed Consensus Conference by Michael A. Borg, Barry D. Cookson, Peter Zarb, Elizabeth A. Scicluna, ARMed Steering Group & Collaborators

“…There was general agreement on the need for surveillance and audit to underpin any intervention to tackle antimicrobial resistance, both to monitor changing epidemiological trends in critical pathogens as well as to identify antibiotic consumption practices and effectiveness of prevention and control of health care associated infections. …”
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Inadequate empirical antibiotics following debridement for orthopedic infections do not increase therapy failures by S. M. Maurer, M. S. Maurer, M. Schmid, S. Dossi, S. Dossi, L. Gautier, A. E. Boyd, M. Farshad, I. Uçkay, I. Uçkay

“…<p><strong>Introduction</strong>: Empirical antibiotics should only target the most likely pathogens if antibiotic stewardship is being heeded. …”
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Visceral adipose tissue area and proportion provide distinct reflections of cardiometabolic outcomes in weight loss; pooled analysis of MRI-assessed CENTRAL and DIRECT PLUS dietary... by Hadar Klein, Hila Zelicha, Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Alon Kaplan, Yoash Chassidim, Yftach Gepner, Matthias Blüher, Uta Ceglarek, Berend Isermann, Michael Stumvoll, Ilan Shelef, Lu Qi, Jun Li, Frank B. Hu, Meir J. Stampfer, Iris Shai

“…Abstract Background Visceral adipose tissue (VAT) is well established as a pathogenic fat depot, whereas superficial subcutaneous adipose tissue (SAT) is associated with either an improved or neutral cardiovascular state. …”
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Epidemiology, clinical characteristics, and outcome in candidemia: a retrospective five-year analysis from two tertiary general hospitals by Tingting Liu, Shuhong Sun, Xiaosong Zhu, Hui Wu, Zhiqing Sun, Shanxin Peng

“…Abstract Background Candidemia is linked with high mortality, highlighting the critical importance of timely empirical antimicrobial therapy and precise medical intervention before a definite etiologic diagnosis. The current study aimed to investigate the prevalence of pathogens in patients with candidemia and evaluate the potential independent risk factors for Candida albicans bloodstream infections (BSI), as well as the prognosis of candidemia. …”
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Intestinal phages interact with bacteria and are involved in human diseases by Han Shuwen, Ding Kefeng

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Impact of Omicron BA.5 infection on maternal and neonatal outcomes by Lu Li, Lu Li, Ruitian Hou, Ruitian Hou, Zan Mai, Li Liang, Zheng Li, Bin Long, Lin Chen, Ping Feng, Baojun Yang, Lijie Yang, Lianhua Tang, Peizhi Wang, Fan Zhong, Mei Chu, Huichao Liang, Xiaoping Tang, Xiaoping Tang, Xiaoping Tang

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