Refuse in order to resist: metabolic bottlenecks reduce antibiotic susceptibility by Orestis Kanaris, Frank Schreiber

“…The growth of pathogenic bacteria in the host is a prerequisite for infectious diseases. …”
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Transrenal DNA-based diagnosis of Strongyloides stercoralis (Grassi, 1879) infection: Bayesian latent class modeling of test accuracy. by Alejandro J Krolewiecki, Artemis Koukounari, Miryam Romano, Reynaldo N Caro, Alan L Scott, Pedro Fleitas, Ruben Cimino, Clive J Shiff

“…However, it has been demonstrated that cell-free DNA from pathogens and cancers can be readily detected in patient's urine which can be collected in the field, filtered in situ and processed later for analysis. …”
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Overview of Agrochemicals Application Practices on Tomato Farm by Smallholders at Koka, Meki and Ziway, Ethiopia by Dereje Haile, Bizuayehu Tesfaye, Fassil Assefa

“…Promoting the agricultural sector with up-to-date technologies and inputs is convenient to enhance productivity. Production intervention is needed by introducing and adopting proper agronomic practices. …”
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Treatment of extrasphincter rectal fistulas with bioplastic substance application by A. M. Kuzminov, Sh. T. Minbayev, V. Yu. Korolik, L. P. Orlova, O. Yu. Fomenko, N. A. Polyakova, A. A. Safoyan, S. M. Khermez

“…Surgical treatment of extrasphincter fistulas of rectum by formation of internal fistulous ostium by bioplastic substance «Collost» is pathogenicly proven. Its application allows to achieve permanent clinical effect, to decrease rate of postoperative morbidity, to reduce terms of rehabilitation of the operated patients.…”
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MicroRNAs in anthracycline cardiotoxicity: biomarkers, mechanisms, and therapeutic advances by Hongyun Mao, Hongyun Mao, Jing Hu, Chenshuo Yu, Sicong Xie, Cheng Chang, Juanjuan Peng, Yang Zhang

“…This network dynamically influences the onset and progression of AIC, affecting key processes including oxidative stress, autophagy, fibrosis, and apoptosis.ConclusionMiRNAs play a dual role in the pathomechanisms of AIC, acting as both pathogenic factors and protective agents. A deeper understanding of this regulatory network provides a solid theoretical foundation for developing novel miRNA-based diagnostic biomarkers and intervention strategies to manage AIC. …”
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Effects of dietary fiber on Chinese children with functional constipation and targeted modification of gut microbiota and related metabolites by Pei Xiao, Ting Song, Xiao Lu Li, Yong Mei Xiao, Rui Xue Wang, Fei Fei Song, Dan Li, Ai Hua Zhang, Ying Wang, Ting Zhang, Ting Zhang

“…These insights may enhance our understanding of the pathogenic mechanisms of FC and provide novel therapeutic perspectives.Clinical trials registrationChiCTR2400084125.…”
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Microbial Food Safety Risk to Humans Associated with Poultry Feed: The Role of Irradiation by Tahiru Mahami, Wellington Togby-Tetteh, Delali Isaac Kottoh, Leticia Amoakoah-Twum, Emmanuel Gasu, Sylvester Nana Yao Annan, Daniel Larbi, Isaac Adjei, Abraham Adu-Gyamfi

“…This study investigated the extent to which radiation can be used as an intervention to improve the safety and quality of poultry feed in terms of food borne pathogens and antibiotic resistant microbes. …”
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Focal Segmental Glomerulosclerosis Patient Baseline Characteristics in the Sparsentan Phase 3 DUPLEX Study by Howard Trachtman, Jai Radhakrishnan, Michelle N. Rheault, Charles E. Alpers, Jonathan Barratt, Hiddo J.L. Heerspink, Irene L. Noronha, Vlado Perkovic, Brad Rovin, Hernán Trimarchi, Muh Geot Wong, Alex Mercer, Jula Inrig, William Rote, Ed Murphy, Patricia W. Bedard, Sandra Roth, Stewart Bieler, Radko Komers

“…Thirty-three patients (9.4% of 352 evaluable samples) had pathogenic or likely pathogenic (P/LP) variants of genes essential to podocyte structural integrity and function, 27 (7.7%) had P/LP collagen gene (COL4A3/4/5) variants, and 14 (4.0%) had high-risk APOL1 genotypes. …”
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Water source, latrine type, and rainfall are associated with detection of non-optimal and enteric bacteria in the vaginal microbiome: a prospective observational cohort study neste... by Anna E Czapar, Souvik Paul, Garazi Zulaika, Fredrick Otieno, Walter Agingu, Adit Chaudhary, Runa Bhaumik, Anna Maria van Eijk, Stefan J Green, Elizabeth Nyothach, Penelope A Phillips-Howard, Supriya D. Mehta

“…Mixed effects multivariable longitudinal models were adjusted for intervention arm, age, socioeconomic status, sexual activity, and cluster-level school WASH and rainfall (in millimeters). …”
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iMeta Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health by Yao Wang, Huiyu Hou, Hao Luo, Jiani Xun, Chuang Ma, Haifei Yang, Defeng Bai, Salsabeel Yousuf, Hujie Lyu, Tianyuan Zhang, Xiulin Wan, Xiaofang Yao, Tengfei Ma, Yuanping Zhou, Zhihao Zhu, Meiyin Zeng, Sanqi An, Qing Bai, Yao Bai, Guodong Cao, Tingting Cao, Yongkai Cao, Chihmin Chang, Lijia Chang, Bo Chen, Dai Chen, Dijun Chen, Hanqing Chen, Jiali Chen, Jinfeng Chen, Wei‐Hua Chen, Xinhai Chen, Yue Chen, Zhangran Chen, Cheng Cheng, Quan Cheng, Xi‐Jian Dai, Chaowen Deng, Feilong Deng, Jingwen Deng, Chang‐Sheng Dong, Lei Dong, Lianhui Duan, Yi Duan, Qingjie Fan, Chao Fang, Tingyu Fang, Wensheng Fang, Zhencheng Fang, Min Fu, Minjie Fu, Cong Gao, Hao Gao, Weiwei Gao, Xinrui Gao, Yi‐Zhou Gao, Yan Geng, Wenping Gong, Shaohua Gu, Xia Gu, Zhengquan Gu, Jian‐Wei Guo, Junjie Guo, Qiuyan Guo, Xiang Guo, Xiaoqian Guo, Dongfei Han, Ziyi Han, Yanan Hao, Jiale He, Jianquan He, Jianyu He, Ruolin He, Guosen Hou, Bin Hu, Haibo Hu, Yi Hu, Yongfei Hu, Yucan Hu, Guanyin Huang, Haiyun Huang, Jiaomei Huang, Shenghui Huang, Baolei Jia, Xingxing Jian, Chao Jiang, Kun Jiang, Lanyan Jiang, Shuaiming Jiang, Jian‐Yu Jiao, Hao Jin, Jiajia Jin, Siyuan Kong, Xinxing Lai, Yuxin Leng, Bang Li, Bing Li, Fang Li, Hao Li, Huanjie Li, Jing Li, Kai Li, Lanqi Li, Leyuan Li, Minghan Li, Pengsong Li, Wei Li, Wei Li, Xianyu Li, Li Xuemeng, Yafei Li, Yuantao Li, Zhi Li, Liqin Liang, Rong Liang, Zhuobin Liang, Qingya Liu, Dejian Liu, Huiheng Liu, Jinchao Liu, Li Liu, Lihui Liu, Moyang Liu, Ran Liu, Shuai Liu, Tianyang Liu, Wei Liu, Wenjuan Liu, Xiaomin Liu, Yang Liu, Yichen Liu, Yina Liu, Yuan Liu, Zhe Liu, Zhipeng Liu, Zhiquan Liu, Chunhao Long, Yun Long, Changying Lu, Chao Lu, Cheng Lu, Qi Lu, Yaning Luan, Peng Luo, Sheng Luo, Ning Ma, Xiao‐Ya Ma, Yan Ma, Wenjun Mao, Yuanfa Meng, Yan Ni, Yawen Ni, Kang Ning, Dongze Niu, Kai Peng, Zhengwu Peng, Xubo Qian, Zhiguang Qiu, Hui Qu, Zepeng Qu, Yan Ren, Zhigang Ren, Youming Shen, Lin Shi, Linlin Shi, Wenxuan Shi, Yongpeng Shi, Tianyuan Song, Xiaohui Song, Xiaoming Song, Xiaowei Song, Qi Su, Yufan Su, Lifang Sun, Qiang Sun, Tiefeng Sun, Yunke Sun, Hua Tang, Wenjing Tang, Tao Yu, Simon Tian, Shuo Wang, Bowen Wang, Cheng Wang, Wang Jin, Leli Wang, Liangliang Wang, Lixiao Wang, Mingbang Wang, Ming‐Ke Wang, Pingyi Wang, Shaolin Wang, Shaopu Wang, Xinxia Wang, Xueqiang Wang, Mi Wei, Yan Wei, Yanxia Wei, Yongjun Wei, Chaoliang Wen, Xin Wen, Linkun Wu, Shengru Wu, Yuting Wu, Shuting Xia, Xiaodong Xia, Yu Xia, Xionggen Xiang, Chuanxing Xiao, Weihua Xiao, Yingping Xiao, Ruohan Xie, Rui Xing, Hui Xu, Wei Xu, Zhimin Xu, Hongliang Xue, Chao Yan, Qiu‐Long Yan, Shaofei Yan, Xiuchuan Yan, Mengli Yang, Yufan Yang, Zhipeng Yang, Ziyuan Yang, Guixiang Yao, Yanlai Yao, Xianfu Yi, Chong Yin, Mingliang Yin, Shicheng Yu, Ying Yu, Yongyao Yu, Fusong Yuan, Shao‐Lun Zhai, Bo Zhang, Chen Zhang, Fang Zhang, Feng‐Li Zhang, Hengguo Zhang, Jinping Zhang, Junya Zhang, Kun Zhang, Li Zhang, Lin Zhang, Lingxuan Zhang, Meng Zhang, Qian Zhang, Runan Zhang, Tongtong Zhang, Tongxue Zhang, Weipeng Zhang, Yong Zhang, Yuchao Zhang, Yujun Zhang, Zeng Zhang, Zhengxiao Zhang, Zhi‐Feng Zhang, Boxi Zhao, Yanyan Zhao, Yibing Zhao, Ziwei Zhao, Diwei Zheng, Ying Zheng, Wenqiang Zhi, Jixin Zhong, Xiangjian Zhong, Wei Zhou, Xin Zhou, Zhemin Zhou, Zhichao Zhou, Congmin Zhu, Feiying Zhu, Xiaodie Zhu, Yutian Zou, Hongling Zhou, Lei Lei, Yanliang Bi, Hubing Shi, Hui‐Zeng Sun, Shuangxia Jin, Wenkai Ren, Lei Dai, Xin Wang, Canhui Lan, Hongwei Liu, Shuang‐Jiang Liu, Yulong Yin, Chun‐Lin Shi, Ren‐You Gan, Fangqing Zhao, Jun Yu, Tong Chen, Xin Hong, Hua Yang, Bangzhou Zhang, Shifu Chen, Xiaodong Li, Yunyun Gao, Yong‐Xin Liu

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INFECTIONS AND FOLLICULAR LYMPHOMA: IS THERE A LINK? by Francesco Zallio, Giulia Limberti, Marco Ladetto

“…A classical model of infection-driven lymphoprolipherative disorder is Helicobacter pylori-induced gastric MALT lymphoma, where antibiotic therapy allows eradication of both the infectious agent and the clonal B-cell expansion;  following the footsteps of these example, several retrospective studies have found a correlation with other pathogens and B-cell Lymphomas, adding new important informations about pathogenesis and laying the groundwork for chemotherapy-free treatments. …”
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Fabrication of gelatine/fucoidan nanogel-coated silver nanoparticles for the treatment of wound healing therapy and nursing care by Jiao Hao, Xiaozhen Liu, Yaomiao Du

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Incidents of high tick load in injured cheetahs after reintroduction into a tropical ecosystem by Tamar A. Kendon, Carlos L. Pereira, Hugo Pereira, Kelsey Brown, David Gaynor, Willem D. Briers-Louw

“…Ixodid ticks are of veterinary importance for wildlife and domestic animals across Africa because of the associated direct damage and potential spread of tick-borne pathogens. This study investigates two cases of tick infestations in cheetahs recently reintroduced into a tropical environment. …”
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Microglial dynamics and neuroinflammation in prodromal and early Parkinson’s disease by Frida Lind-Holm Mogensen, Philip Seibler, Anne Grünewald, Alessandro Michelucci

“…As this loss of neurons starts decades before diagnosis, understanding the prodromal stages of the disease might offer novel strategies to curb its progression. While the precise pathogenic mechanisms underlying PD remain incompletely understood, growing evidence suggests that neuroinflammation and immune dysregulation play a central role in the development and progression of the disease. …”
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Acute pyelonephritis complicated by subcapsular and perinephric hematoma: Diagnostic role of CT scan and 6-month follow-up by Maryam Shahali Ramsheh, MD, Reza Zahedpasha, MD, Amin Ghaemi Amiri, Fereshte Maghsoudlou, MD

“…Acute pyelonephritis is a common renal infection that can become life-threatening when complicated by structural abnormalities, resistant pathogens, or systemic comorbidities such as diabetes mellitus. …”
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Biallelic Mutations in the Otogelin‐Like Gene (OTOGL) Associated With Congenital Non‐Syndromic Sensorineural Hearing Loss in a Chinese Family by Xiang Dai, Jun Li, Xijiang Hu, Wenqian Cai

“…These mutations are predicted to be pathogenic and may explain the observed phenotype. Single‐cell RNA sequencing revealed specific OTOGL expression in key auditory‐related cell types, providing insights into its developmental and functional roles in the inner ear. …”
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Periodontitis-related salivary microbiota aggravates Alzheimer’s disease via gut-brain axis crosstalk by Jiangyue Lu, Shuang Zhang, Yuezhen Huang, Jun Qian, Baochun Tan, Xueshen Qian, Jia Zhuang, Xihong Zou, Yanfen Li, Fuhua Yan

“…Increasing evidence indicates that periodontal pathogens and subsequent inflammatory responses to them contribute to the pathogenesis of Alzheimer’s disease (AD). …”
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Novel compound heterozygous OBSCN variants in Chinese children with congenital pulmonary airway malformation by Jiali Xu, Siyu Ma, Zhaocong Yang, Yang Xu, Jirong Qi, Min Da, Xuming Mo

“…Methods In this study, whole-exome sequencing (WES) technology was used to sequence 9 CPAM families to screen the pathogenic genes and their mutations for CPAM. Sanger sequencing was performed for verify the functions of these mutations. …”
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Nostoc commune Vauch. polysaccharide alleviates Pb-induced hepatorenal toxicity by changing gut bacteriome, mycobiome, and metabolome by Yue Liu, Ping Ren, Hailong Li, Yingying Liu, Yiting Yang, Wanting Wang, Jiaming Zhou, Ling Su, Lili Guan, Hongxia Ma

“…Specifically, Pb decreased the proportion of pathogenic species (g_Fusarium, p_Basidiomycota, g_Alternaria, g_Aspergillus, and g_Candida) while NCVP increased the abundance of probiotics species (g_Kazachstania and p_Ascomycota). …”
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The Effectiveness of Lactobacillus rhamnosus Administration on the Growth of Klebsiella pneumoniae in Mice (Mus musculus) by Izhar Fitrah Ahmad, Edward Pandu Wiriansya, Dwi Anggita, Rezky Pratiwi Lambang Basri, Yani Sodiqah, Nesyana Nurmadilla

“…Introduction: Klebsiella pneumoniae is a bacterium from the Enterobacteriaceae family and is considered one of the most dangerous pathogens. Antibiotics are crucial for treating acute bacterial infections. …”
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