Prevalence and Antibiotics Susceptibility Pattern of Salmonella and Shigella Species among Diarrheal Patients Attending Nekemte Referral Hospital, Oromia, Ethiopia by Alemayehu Terfassa, Mulissa Jida

“…This study revealed 9.2% prevalence of Salmonella and Shigella sp. which were resistant to commonly prescribed antibiotics. Thus, intervention measures such as health education, provision of safe drinking water, improvement of waste disposal systems, and surveillance of antibiotics susceptibility of the pathogens should be done regularly.…”
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Integrative metagenomic, transcriptomic, and proteomic analysis reveal the microbiota-host interplay in early-stage lung adenocarcinoma among non-smokers by Yaohui Sun, Zhiming Gan, Xiaojin Wang, Jian Liu, Wei Zhong, Zhiyan Zhang, Jiebin Zuo, Hang Zhong, Xiuting Huang, Zhixiang Yan, Qingdong Cao

“…Patients with ES-LUAD exhibited local microbial dysbiosis, suggesting the potential pathogenicity of certain microbial species. Through multi-omics correlations, intricate local crosstalk between the host and local microbial communities was observed. …”
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Syndromic Diagnostics of Respiratory Infections in Children As One of Antibiotic Management Tools in a Hospital by A. V. Vlasova, P. V. Berezhanskiy, A. B. Malakhov, A. E. Angel, Yu. F. Shubina, E. V. Smirnova, L. V. Dymnova, A. A. Sharshakova, S. B. Asalkhanova

“…An observational, ambispective, non-interventional study was conducted to compare the effectiveness of introducing syndromic diagnostic according to the RP-2021 protocol on the basis of the pediatric departments of the Morozov Children's City Clinical Hospital. …”
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Case Report: Two children with factor XII deficiency caused by novel F12 compound heterozygous variants by Rui-Xue Ma, Rui-Xue Ma, Hai-Yan Li, Yi-Hang Zhang, Xue-Min Zhang, Xue-Min Zhang, Yan-Juan Chen, Yan-Juan Chen, Yi-Lin Dai, Yi-Lin Dai, Gui-Xian Li, Gui-Xian Li, Wen-Hai Luo, Wen-Hai Luo, Jie Zhang, Yun-Fen Tian

“…BackgroundFactor XII (FXII) deficiency (OMIM 234000) is a rare hereditary coagulation disorder caused by pathogenic variants within the F12 gene. It causes prolonged activated partial thromboplastin time without bleeding diathesis. …”
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Compound Heterozygous MRPS14 Variants Associated With Leigh Syndrome by Maria Gabriela Otero, Christina Freeman, Ruchi Shah, Renkui Bai, Hong Cui, Marian Castro, Zachary Myers, Eric Choy, Derek Chan, Molly Easter, Sophia Y. Zhao, Madeline Babros, Ruchi Garg, Matthew Deardorff, Franklin Moser, Tyler Mark Pierson

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C1q reprograms innate immune memory by Inge Jonkman, Maaike M. E. Jacobs, Yutaka Negishi, Yutaka Negishi, Julia I. P. van Heck, Vasiliki Matzaraki, Joost H. A. Martens, Marijke Baltissen, Michiel Vermeulen, Zahi A. Fayad, Abraham J. P. Teunissen, Abraham J. P. Teunissen, Abraham J. P. Teunissen, Abraham J. P. Teunissen, Willem J. M. Mulder, Willem J. M. Mulder, Willem J. M. Mulder, Willem J. M. Mulder, Luuk B. Hilbrands, Leo A. B. Joosten, Leo A. B. Joosten, Mihai G. Netea, Mihai G. Netea, Musa M. Mhlanga, Musa M. Mhlanga, Nils Rother, Raphaël Duivenvoorden, Raphaël Duivenvoorden, Raphaël Duivenvoorden

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FapR regulates HssRS-mediated heme homeostasis in Bacillus anthracis by Hualiang Pi, Owen S. Burroughs, Sophia M. Carlin, William N. Beavers, Gideon H. Hillebrand, Evan S. Krystofiak, Devin L. Stauff, Eric P. Skaar

“…This study uncovers the role of the transcriptional regulator FapR in maintaining membrane integrity and facilitating the proper function of the HssRS two-component signaling system, which is essential for managing heme toxicity in B. anthracis, as well as other Gram-positive pathogens. By elucidating the connection between FapR and HssRS, our findings provide new insights into the molecular adaptation of bacteria to heme stress and expand our knowledge of bacterial physiology and pathogenicity. …”
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Atypical bilateral papilledema during the puerperium: a case report by Ligang Jiang, Xin Jiang, Ailian Li, Mengting Liu, Zhe Zhang, Yuhua Tong

“…BackgroundTo analyze a case of atypical bilateral papilledema in a puerperium woman, and to explore the pathogenic mechanism of pregnancy-related physiological changes, blood hypercoagulable state, immune abnormalities and abnormal structure of intracranial venous sinus, so as to provide reference for early diagnosis and intervention of similar cases.Case reportA 28-year-old woman, 3 days post-operative from a cesarean section, presented at the hospital with decreased vision in her right eye. …”
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Sulfated dietary fiber protects gut microbiota from antibiotics by Fuqing Wu, Xiaoqian Annie Yu, David Angeles-Albores, Susan E. Erdman, Eric J. Alm

“…Abstract Background Antibiotics, while essential for combating pathogens, also disrupt commensal bacteria, leading to gut microbiota imbalance and associated diseases. …”
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The Role of Microglia and Macrophages in CNS Homeostasis, Autoimmunity, and Cancer by Jie Yin, Katherine L. Valin, Michael L. Dixon, Jianmei W. Leavenworth

“…We believe that a better understanding of the biology of these macrophage subsets offers new exciting paths for therapeutic intervention.…”
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Pycnodysostosis: a case series of eight Saudi patients with cathepsin K gene mutation and a literature review by Afaf Alsagheir, Raghad Alhuthil, Ahmad T. Alissa, Faisal Joueidi, Ahmed G. Sayed, Waleed Al-Amoudi, Alanoud S. Alabdulhadi, Bassam Bin-Abbas, Bassam Bin-Abbas

“…Pycnodysostosis, a rare osteopetrosis subtype, is mainly caused by homozygous or compound heterozygous biallelic pathogenic mutation of the cathepsin K (CTSK) gene. …”
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A versatile platform based on matrix metalloproteinase-sensitive peptides for novel diagnostic and therapeutic strategies in arthritis by Mingyang Li, Tao Deng, Quan Chen, Shenghu Jiang, Hang Li, Jiayi Li, Shenglan You, Hui-qi Xie, Bin Shen

“…Matrix metalloproteinases (MMPs), coupled with other proteinases and glycanases, can degrade proteoglycans, collagens, and other extracellular matrix (ECM) components in inflammatory and non-inflammatory arthritis, making them important pathogenic molecules and ideal disease indicators and pharmaceutical intervention triggers. …”
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Fibrous dysplasia in the alveolar crest of edentulous site and the curettage for future implant placement: a case report by Hao Chen, Yuting Wen, Xueqi Guo, Shiyong Zhao

“…Conclusion We described an unreported pathogenic site of FD that occurred at the alveolar ridge of the edentulous site, which ended up with satisfactory oral implant rehabilitation through 5-year sequential diagnosis and treatment.…”
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Decoding Colon Cancer Heterogeneity Through Integrated miRNA–Gene Network Analysis by Qingcai He, Zhilong Mi, Tianyue Liu, Taihang Huang, Mao Li, Binghui Guo, Zhiming Zheng

“…Our findings underscore the critical need for heterogeneity-aware clinical decision-making, providing a roadmap for stratified intervention paradigms in precision oncology.…”
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Assessing a Novel Method to Reduce Anesthesia Machine Contamination: A Prospective, Observational Trial by Chuck J. Biddle, Beverly George-Gay, Praveen Prasanna, Emily M. Hill, Thomas C. Davis, Brad Verhulst

“…In a prospective, experimental research design, the AMW was used in 11 surgical cases (intervention group) and not used in 11 control surgical cases. …”
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A Retrospective Study of Respiratory Viruses in a Four-Year Study of Nasal Swabs from Patients with Severe Influenza-like Symptoms in the Lazio Region, Italy by Giuseppe Sberna, Licia Bordi, Cosmina Mija, Enrico Girardi, Fabrizio Maggi, Eleonora Lalle

“…The global outbreak of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and the strategies adopted by different nations have affected and altered the transmission of different respiratory pathogens around the world. We examined the impact of SARS-CoV-2 on the spread of respiratory viruses in the period between 2021 and 2024 in patients with severe influenza-like symptoms in the Lazio region using multiplex PCR tests for the identification of common seasonal respiratory viruses. …”
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Dissecção espontânea de artéria carótida interna com paralisia de nervos cranianos inferiores: relato de caso Spontaneous internal carotid artery dissection with paralysis of lower... by Vera L.F. Vieira, Daniel C. Pereira, Vinícius T. Ribeiro, Alex B.C. Leite, Iran Emerique

“…<br>Spontaneous internal carotid artery dissection is a rare event that strikes patients at their productive age. As early intervention frequently determines a significant improvement, it is important to broaden the knowledge of the clinical, pathogenic and pathophysiological aspects of this disease. …”
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The Anti-AGEing and RAGEing Potential of Isothiocyanates by Bradley A. Krisanits, Bhoomika Kaur, Jed W. Fahey, David P. Turner

“…This review summarizes the current evidence supporting the observation that the antioxidant and anti-inflammatory activities of ITCs temper the pathogenic effects of a group of reactive metabolites called advanced glycation end products (AGEs). …”
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The chemosensory world of mosquitoes: olfactory receptors and their role in blocking mosquito-borne disease transmission by Sitian Xiong, Jingjing Liang, Shuyang Gao, Zhilong Liu, Hong Zheng, Xuesen Yang, Ying Wang, Shasha Yu

“…The mosquito olfactory system, which mediates a wide range of behaviors throughout the mosquito's life cycle, including host-seeking, foraging, oviposition, mating, avoidance behavior, and social communication, offers a promising avenue for intervention. Specifically, olfactory receptors play a crucial role in enabling female mosquitoes to locate human hosts through odor recognition, a process that facilitates the transmission of pathogens responsible for diseases such as malaria and dengue fever. …”
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<i>PRKAG2</i> Syndrome: Clinical Features, Imaging Findings and Cardiac Events by Maria Sudomir, Przemysław Chmielewski, Grażyna Truszkowska, Mariusz Kłopotowski, Mateusz Śpiewak, Marta Legatowicz-Koprowska, Monika Gawor-Prokopczyk, Justyna Szczygieł, Joanna Zakrzewska-Koperska, Mariusz Kruk, Jolanta Krzysztoń-Russjan, Jacek Grzybowski, Rafał Płoski, Zofia T. Bilińska

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