HDAC4: an emerging target in diabetes mellitus and diabetic complications by Yiqi Lin, Yuetong Li, Caiying Ke, Ying Jin, Wanwen Lao, Yiling Wu, Yang Liu, Xinyi Kong, Jie Qiao, Aixia Zhai, Changlong Bi

“…Abstract Diabetes mellitus (DM) is a metabolic disease with complex pathogenic mechanisms. Histone deacetylase 4 (HDAC4) is a member of an important family of epigenetic modifications. …”
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Exploring the systemic impacts of urinary tract infection-specific antibiotic treatments on the gut microbiome, metabolome, and intestinal morphology in rats by Hao Guo, Xiang Zhou, Zhou Li, Junjie Zhi, Chaowei Fu, Xinwei Liu, Yufan Wu, Fengping Liu, Ninghan Feng

“…The gut microbiota is a dynamic ecosystem that plays a crucial role in host metabolism, immune system regulation, and protection against pathogens. An imbalanced gut microbiota has been associated with various diseases such as inflammatory bowel disease, metabolic disorders, and autoimmune diseases. …”
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Predictive modeling of multidrug resistance in female genital infections: implications for early urinary tract infection detection by Francis Chukwuebuka Ihenetu, Chinyere I. Okoro, Emeka Henry Okechukwu, Makuochukwu Maryann Ozoude, Farirai Melania Farirai

“…HVS was chosen to detect urogenital pathogens before ascending infections occur. Data on age and clinical signs were collected via structured questionnaires. …”
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Lactiplantibacillus plantarum Lp05 protects against ethanol-induced liver injury in zebrafish through metabolic and microbiota modulation by Yixuan Fan, Yao Dong, Zhonghui Gai, Yanyan Zhang, Mei Han

“…Lp05 also altered gut microbiota, increasing beneficial bacteria such as Fluviicola and Delftia, while decreasing pathogenic bacteria like Acinetobacter and Aeromonas. …”
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Clinical evaluation of chitosan/polycaprolactone nanofibrous scaffolds releasing tetracycline hydrochloride in periodontal pockets of patients with chronic periodontitis by Janet Moradi Haghgoo, Parviz Torkzaban, Parisa Hashemi, Rana Sarvari, Sana Hashemi, Elahe Fakhri, Behnaz Alafchi

“…The role of bacteria in the initiation and progression of periodontitis has led to a great interest in using antibiotics to suppress pathogenic microbiota. Considering the drawbacks of systemic antibiotics’ application, local delivery systems directly in the periodontal pocket can be helpful. …”
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The impact of enhanced cleaning on bacterial contamination of the hospital environmental surfaces: a clinical trial in critical care unit in an Egyptian hospital by Nermine Mahmoud Hassan Hamed, Osama Ahmed Deif, Aleya Hanafy El-Zoka, Magda Mohamed Abdel-Atty, Mohamed Fakhry Hussein

“…Abstract Background Contaminated environmental surfaces play an important role in the transmission of pathogens that cause healthcare acquired infection (HAI). …”
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Maternal benzo[a]pyrene exposure during critical gestational periods impairs offspring neurological development in rats: a mechanistic study of the Wnt/β-catenin signaling pathway by Nan Zhang, Nan Bo, Yuanhao Wang, Wenlin Bai, Wen Sun, Zhenlin Zhao, Yuanbao Zhang, Yingying Zhang, Lijian Lei, Lijian Lei, Lijian Lei, Jianjun Zhou, Wenping Zhang, Wenping Zhang, Wenping Zhang, Wenping Zhang

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Clinical Case of Echinococcosis of the Orbit. Modern Approaches to Diagnosis and Treatment by D. S. Gorbachev, A. N. Kulikov, S. S. Kozlov, A. A. Kolbin, A. V. Voronov, A. V. Kudryavtseva, I. S. Kovalevskaya, A. I. Yakovenko, M. A. Burnasheva, N. N. Haritonova, N. V. Zemlyanukhin

“…The article presents the epidemiology of echinococcosis in Russia, its strains, their pathogenicity for humans. The ways of spread and infection of the parasite, as well as the features of invasion into the human body, are indicated. …”
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Direct Disk Diffusion Testing and Antimicrobial Stewardship for Gram-Negative Bacteremia in the Context of High Multidrug Resistance by Wantin Sribenjalux, Pawarit Kulwongroj, Waewta Kuwatjanakul, Lumyai Wonglakorn, Kanuengnit Srisak, Natapong Manomaiwong, Atibordee Meesing

“…<i>Escherichia coli</i> (36.5%) and <i>Klebsiella pneumoniae</i> (27.6%) were the most frequently isolated pathogens, with intra-abdominal and urinary tract infections being the most common sources. …”
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Effects of polyphosphates with different chain lengths on digestive organ weight, carcass quality, and immune response, and intestinal microflora in broilers by Yi-Qiang Chang, Seung-Gyu Moon, Yan-Qing Wang, Sang-Woo Jeon, Ah-Ran Lee, Soo-Hyun Kim, Won-Uk Hwang, Soo-Ki Kim

“…MCPP and LCPP produced bacteriostatic properties against four pathogenic bacteria, Shigella sonnei, Pseudomonas aeruginosa, Salmonella enterica serovar. …”
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Bilateral sequential bacterial dacryoadenitis with abscess– a case report by Lydia Lam, James Pietris, Clare Quigley, Garry Davis, James Slattery, Dinesh Selva

“…Bacterial dacryoadenitis is rare, with Staphylococcus and Streptococcus species being the most common pathogens. The bilateral sequential onset of dacryoadenitis has not been described in the literature to date. …”
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Targeting early diagnosis and treatment of pancreatic cancer among the diabetic population: a comprehensive review of biomarker screening strategies by Jie Yang, Chengming Wen, Hongkai Guo, Yahui Chai, Guodong Sun, Huijuan Cheng

“…Diabetes mellitus, marked by altered glucose metabolism, has emerged as a significant risk factor for PDAC development, highlighting a complex, bidirectional pathogenic relationship. This review systematically examines the intricate interactions between diabetes and PDAC, emphasizing their shared pathophysiological mechanisms. …”
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Infective Endocarditis Complicated by Severe Mitral Regurgitation and Markedly Elevated Troponin Levels as A Prognostic Marker: A Case Report by Dahir OF, Hassan MO, Adan AS, Abdi AE, Abdi IA

“…Persistent troponin elevation, despite appropriate antibiotic treatment, indicates ongoing myocardial injury and suggests the need for urgent surgical intervention. Severe MR in IE contributes to hemodynamic instability and increases the risk of heart failure, necessitating prompt surgical correction. …”
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Risk factors of lower respiratory tract infection after general anesthesia for maxillofacial trauma in elderly patients by LI Yi, HU Haolei, ZHANG Pengzhen

“…Forty-seven strains of pathogens were isolated from the lower respiratory tract secretions, including 13 strains of Gram-positive bacteria, accounting for 27.66%, 31 strains of Gram-negative bacteria, accounting for 65.96%, and 3 strains of fungi, accounting for 6.38% respectively. …”
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Hyper-induction of IL-6 after TLR1/2 stimulation in calves with bovine respiratory disease. by Cian Reid, John Donlon, Aude Remot, Emer Kennedy, Giovanna De Matteis, Cliona O'Farrelly, Conor McAloon, Kieran G Meade

“…It is a polymicrobial syndrome resulting from a complex interplay of viral and bacterial pathogens with environmental factors. Despite the availability of vaccines, incidence and severity in young calves remains unabated. …”
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Microbial biofilm root canals and new approaches to the diagnosis and treatment of the chronic forms of pulpitis using a photoactivatable disinfection and ultrasonic treatment

“…In subgroups, where it was used the standard method of treatment, the percentage of re-treatment and surgical intervention prevails compared to the study group. According to the results of clinical and microbiological studies have observed a positive trend to reduce the number of the designated pathogens and the use of complex interaction of ULTRASOUND and PDT was the most successful method compared to traditional method of treatment…”
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Atherosclerosis Induced by Chlamydophila pneumoniae: A Controversial Theory by Hamidreza Honarmand

“…Both viral and bacterial pathogens have been proposed to be associated with the inflammatory changes found in atherosclerosis. …”
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A fully humanized IgG-like bispecific antibody for effective dual targeting of CXCR3 and CCR6. by Remy Robert, Laurent Juglair, Ee X Lim, Caroline Ang, Carl J H Wang, Gregor Ebert, Olan Dolezal, Charles R Mackay

“…The use of two or more receptors by pathogenic cells may explain why targeting of individual receptors has proven disappointing in the clinic. …”
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New Insights into the Pathogenesis of Alcohol-Induced ER Stress and Liver Diseases by Cheng Ji

“…Dissecting ER stress signaling pathways leading to tumorigenesis will uncover potential therapeutic targets for intervention and treatment of human alcoholics with liver cancer.…”
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Pulmonary Arteriovenous Malformations Unmasked by Refractory Hypoxia: An Unusual Presentation in Hereditary Hemorrhagic Telangiectasia by Sharmila Sankar, P. S. Rajakumar, S. Shuba, Vimalnath Shanmugam, Sabarish Sekar, Jebaraj Rathinasamy

“…Genetic analysis confirmed a likely pathogenic variant in the ENG gene. Coil embolization of the pulmonary AVMs was done in stages, following which saturations improved and the child became asymptomatic. …”
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