Bacteria Fight Back, Also in Indonesia! by Pratiwi Sudarmono

“…That simple, sensible, and often life-saving intervention, repeated myriad times, has triggered an ever-escalating war between humans and microbes—a war the microbes seem to be winning. …”
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Updates on the development of vaccines and therapeutic options against rabies by Roshan Arjun Ananda, Hooi-Leng Ser, Vengadesh Letchumanan

“…Further studies on the pathogenic mechanism of RABV and therapeutic approaches are still required to prevent the deathly infection following clinical manifestation. …”
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Nanotechnology for effective bovine mastitis treatment: Applications in biosensors and vaccines by Soheil Sadr, Babak Khoramian, Zahra Yousefsani, Ahad Jafari Rahbar Alizadeh, Abbas Rahdar, Hassan Borji

“…Mastitis occurs due to many different pathogens, such as bacteria, fungi, and algae, and antibiotics are the first line of treatment and control. …”
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Prognostic and clinical indicators of sepsis outcomes in hospitalized patients: a cross-sectional study by Javad Moazen, Fatemeh Riyahi Zaniani, Aziz Kassani, Parisa Akhondshushtari, Zeynab Ahmadi

“…Abstract Background Sepsis is a life-threatening medical emergency that necessitates immediate attention and intervention. Without prompt treatment, it can lead to organ failure, tissue damage, and death. …”
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OCNDS core features are conserved across variants, with loop-region mutations driving greater symptom burden by Elena D. Bagatelas, Maahin Manzoor Khan, Gabrielle V. Rushing

“…Although prior reports have described considerable phenotypic variability, the relationship between specific CK2α variant locations and symptom presentation remains poorly defined.MethodsWe analyzed natural history data from 48 individuals with pathogenic or likely pathogenic CSNK2A1 missense variants enrolled in Simons Searchlight. …”
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Diversity and antibiotic susceptibility profiles of bacterial isolates from wound infections in patients at the surgical unit of Kisii teaching and referral hospital, Kenya. by Samson Onsando, Wycliffe Masanta, Andrew Nyerere, Moses Njire, Gervason Moriasi

“…Understanding the socio-demographic, clinical, and microbiological characteristics of wound infections is critical for effective intervention strategies in resource-limited settings. …”
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Dopamine Receptor D3 Induces Transient, mTORC1-Dependent Autophagy That Becomes Persistent, AMPK-Mediated, and Neuroprotective in Experimental Models of Huntington’s Disease by Diego Luis-Ravelo, Felipe Fumagallo-Reading, Alejandro Febles-Casquero, Jonathan Lopez-Fernandez, Daniel J. Marcellino, Tomas Gonzalez-Hernandez

“…Autophagy activation and its effects on mHTT/polyQ clearance were studied in R6/1 mice (a genetic model of HD), their wild-type littermates, and <i>DRD2</i>- and <i>DRD3</i>-HEK cells expressing a pathogenic (Q74) and a non-pathogenic (Q23) polyQ fragment of mHTT treated with the DRD2/DRD3 agonist pramipexole. …”
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The effect of vitamin D and vitamin A supplementation on T cell levels of patients with pneumosepsis: A double-blind, randomized clinical trial by Abolfazl Jokar, Alireza Sistani, Ghasem Mosayebi, Atefeh Poyandeh

“…Its pathogenesis involves intricate interactions among host factors, pathogens, and immune dysregulation. Vitamins A and D are crucial for immune function, acting as regulators and cofactors in immune cell development and function. …”
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Selective Digestive Decontamination in Hemato-Oncological Patients Colonized with Carbapenem-Resistant Enterobacterales by Sara de Abreu Luís, Carla Mimoso Santos

“…Selective digestive decontamination is a prophylactic intervention with the purpose of reducing or eliminating gut colonization by pathogenic agents, preserving beneficial endogenous flora but its application remains controversial due to great heterogeneity amongst studies. …”
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Whispers of the polycystic ovary syndrome theater: Directing role of long noncoding RNAs by Xiuying Lin, Xinyu Nie, Ping Deng, Luyao Wang, Cong Hu, Ningyi Jin

“…By integrating findings from recent studies, we illuminate the potential of lncRNAs as biomarkers for PCOS and highlight their contribution to the disorder, offering a detailed perspective on the lncRNA-mediated modulation of gene expression and pathogenic pathways. Understanding targeted lncRNA interactions with PCOS proposes novel avenues for therapeutic intervention to ameliorate the reproductive and metabolic disturbances characteristic of the syndrome.…”
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Duplication of the autism-related gene Chd8 leads to behavioral hyperactivity and neurodevelopmental defects in mice by Atsuki Kawamura, Kazuki Fujii, Kota Tamada, Yoshifumi Abe, Kenta Nitahara, Tomoya Iwasaki, Sho Yagishita, Kenji F. Tanaka, Toru Takumi, Keizo Takao, Masaaki Nishiyama

“…Furthermore, pharmacological intervention partially ameliorates the hyperactivity of Chd8 KI mice. …”
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First ATG101-recruiting small molecule degrader for selective CDK9 degradation via autophagy–lysosome pathway by Ye Zhong, Jing Xu, Huiying Cao, Jie Gao, Shaoyue Ding, Zhaohui Ren, Huali Yang, Yili Sun, Maosheng Cheng, Jia Li, Yang Liu

“…These dates validated the existence of non-proteasomal degradation pathway of hydrophobic driven protein degradation strategy for the first time, which might provide research ideas for chemical induction intervention on other types of pathogenic proteins.…”
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Non-Thermal Treatment Mediated by Curcumin for Enhancing Food Product Quality by Ziyuan Wang, Haihong Yang, Zhaofeng Li, Jie Liu

“…The antimicrobial mechanism of the synergistic interaction and the inhibitory efficacy against foodborne pathogens (bacteria in both vegetative form and spore, as well as in biofilms) are discussed. …”
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IS IT POSSIBLE TO PREDICT TUMOR PROGRESSION THROUGH GENOMIC CHARACTERIZATION OF MONOCLONAL GAMMOPATHY AND SMOLDERING MULTIPLE MYELOMA? by Ugo Testa, Giuseppe Leone, Elvira Pelosi, Germana Castelli, Valerio De Stefano

“…MGUS and SMM are heterogeneous conditions with the presence of tumors with distinct pathogenic phenotypes and clinical outcomes. The identification of MGUS and SMM patients with a molecularly defined high risk of progression to MM offers the unique opportunity of early intervention with a therapeutic approach on a low tumor burden.   …”
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Fosfomycin in the treatment of extended spectrum beta-lactamase-producing Enterobacteriaceae- related urinary tract infections by Ayhanim Tumturk, Senol Tonyali, Ayse Yasemin Tezer Tekce, Levent Isikay, Hakan Cime

“…The isolated pathogens included Escherichia Coli (n = 32), Klebsiella spp. …”
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Genetic variants and molecular profiling of 46,XY gonadal dysgenesis using whole-exome sequencing by Ning Zhang, Ning Zhang, Ning Zhang, Shuoming You, Shuoming You, Jingjing Guo, Jingjing Guo, Xingyu Chang, Xingyu Chang, Junjun Qiu, Junjun Qiu, Keqin Hua, Keqin Hua

“…Furthermore, we performed in-silico protein structural analysis and protein thermodynamic analysis to further explore the pathogenicity of these variants. GATA4 variants in patients with 46,XY GD with/without CHD and patients with cardiac disease alone were also analyzed.ResultsWe identified three novel pathogenic variants in GATA4:c.725G&gt;C(p.Cys242Ser), NR5A1:c.370_380del(p.Pro124Glyfs*21), and DHX37:c.2020C&gt;T(p.Arg674Trp), as well as one previously reported MAP3K1:c.1016G&gt;A(p.Arg339Gln) variant. …”
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Beyond insecticide treated bed nets coverage to heterogeneous human behaviors and spatial realities by Merveille Koissi Savi, Merveille Koissi Savi, Lauren M. Childs, Lauren M. Childs, Christian Borgemeister

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An inevitable bewilderment before choosing a psychotherapeutic model by Pablo Población

“…“What for replacing the why”, the purpose therapy, strengthen up as an independent model more than as a technical formalization of the therapist's attention, focusing not so much in the historical origin of pathological pictures, paying attention to the subject’s internal world factors that links with the struggle between the pathogenic and the salutogenic positions. When the psychodramatist on a brave impulse can transgress the time and dares to take a tremendous step forward, the extension of what psychodrama deals with breakdowns the usual spaces’ barriers of the nowadays, introducing his intervention in what we call transpersonal and also in the transcendent realm. …”
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Yi-Shen-Hua-Shi regulates intestinal microbiota dysbiosis and protects against proteinuria in patients with chronic kidney disease: a randomized controlled study by Xingtong Dong, Jialing Zhang, Wen Li, Yinping Li, Linpei Jia, Zhaohui Liu, Wenjing Fu, Aihua Zhang

“…After 4 months of the YSHS intervention, the relative abundance of bacteria that have beneficial effects on the body, such as Faecalibacterium, Lachnospiraceae, Lachnoclostridium, and Sutterella increased significantly, while pathogenic bacteria such as the Eggerthella and Clostridium innocuum group decreased. …”
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Efficacy of deep brain stimulation in treating monogenic dystonia symptoms: protocol for a systematic review by Sylvia Boesch, Rocio Rodriguez-Lopez, Beatriz Carmona-Hidalgo, Javier Quintero, Juan Antonio Blasco-Amaro, Carola Reinhard

“…The outcomes will be assessed using generic and specific scales to measure the efficacy and safety of the intervention. The search will be performed in generic and specific databases and bibliographic resources from 2000. …”
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