Unveiling the Therapeutic Potential: Targeting Fibroblast-like Synoviocytes in Rheumatoid Arthritis by Siran Yue, Junyu Fan, Duoli Xie, Chunhao Cao, Zhuqian Wang, Jie Huang, Fang Qiu, Xu Yang, Dongyi He, Aiping Lu, Chao Liang

“…A deeper understanding of the molecular and functional heterogeneity of FLS may pave the way for more effective and precise therapeutic interventions in RA.…”
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Impact of point-of-care PCR testing on antibiotic prescribing in pediatric outpatients with acute respiratory infections: A randomized clinical trial by Ya-Nan Li, Juan Lv, Jun Zhou, Tian-Ming Chen, Yu-Chuan Li, Wei-Hua Zhang, Cheng-Feng Gao, Xiao-Lu Nie, Xiao-Xia Peng, Bing Hu, Ling-Yun Guo, Xue Ning, Zhen-Zhen Dou, Xin Guo, Lin-Lin Liu, Bing Liu, Yue Xie, Hai-Juan Xiao, Jing Liu, Cheng-Song Zhao, Gang Liu

“…Background: Respiratory pathogen diagnosis has been recommended as a core element of outpatient antibiotic stewardship in the United States since 2016, and it has shown effective results. …”
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Highly multiplexed molecular inversion probe panel in Plasmodium falciparum targeting common SNPs approximates whole-genome sequencing assessments for selection and relatedness by Karamoko Niaré, Karamoko Niaré, Rebecca Crudale, Abebe A. Fola, Abebe A. Fola, Neeva Wernsman Young, Victor Asua, Victor Asua, Melissa D. Conrad, Pierre Gashema, Anita Ghansah, Stan Hangi, Deus S. Ishengoma, Deus S. Ishengoma, Jean-Baptiste Mazarati, Ayalew Jejaw Zeleke, Philip J. Rosenthal, Abdoulaye A. Djimdé, Abdoulaye A. Djimdé, Jonathan J. Juliano, Jonathan J. Juliano, Jonathan J. Juliano, Jeffrey A. Bailey, Jeffrey A. Bailey

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Long noncoding RNA LINC00339 promotes osteoporosis development via modulating of regulator CDC42 by binding PARP1 by Dong-Li Zhu, Yan Zhang, Xiao-Yu Zhang, Zi-Han Qiu, Ke Li, Xiao-Rong Zhou, Zhen-Zhen He, Xiao-Feng Chen, Shan-Shan Dong, Wen Tian, Ya-Kang Wang, Tie-Lin Yang, Bo Yang, Yan Guo

“…Further investigation established that the LINC00339-PARP1 axis cooperatively modulates transcriptional programs critical to bone homeostasis, potentially driving pathogenic mechanisms underlying osteoporosis progression. …”
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Contribution of malnutrition to infant and child deaths in Sub-Saharan Africa and South Asia by Khatia Munguambe, Quique Bassat, Mahbubur Rahman, Sibone Mocumbi, Cynthia G Whitney, Amy Wise, Shams El Arifeen, Meerjady Sabrina Flora, Soter Ameh, Emily S Gurley, Mustafizur Rahman, Ariel Nhacolo, Cheick Bougadari Traore, Inacio Mandomando, Clara Menendez, Janet Agaya, Jane Juma, Shabir A Madhi, Tadesse Gure, George Aol, Hennie Lombaard, Ziyaad Dangor, James Bunn, Samba O Sow, Amara Jambai, Dickson Gethi, Sanwarul Bari, Natalia Rakislova, Tacilta Nhampossa, Maria Maixenchs, Mohammed Kamal, Joseph Oundo, Lola Madrid, Tahmina Shirin, Ikechukwu Udo Ogbuanu, Addisu Alemu, Hailemariam Legesse, Awa Traore, Portia C Mutevedzi, Helina Heluf, Victor Akelo, Dickens Onyango, Richard Omore, Yasmin Adam, Peter Otieno, Margaret Mannah, Karen L Kotloff, Milagritos D Tapia, Rima Koka, Mohammad Zahid Hossain, Dickens Kowuor, Tom Sesay, James Squire, Francis Moses, Kitiezo Aggrey Igunza, Andrew Moseray, Afruna Rahman, Nana Kourouma, Seydou Sissoko, Rosauro Varo, Sana Mahtab, Martin Hale, Jeanie du Toit, Zachary J Madewell, Dianna M Blau, Fatima Solomon, Gillian Sorour, Jeannette Wadula, Karen Petersen, Sanjay G Lala, Sithembiso Velaphi, Richard Chawana, Nellie Myburgh, Shahana Parveen, Mahbubul Hoque, Saria Tasnim, Ferdousi Islam, Farida Ariuman, Mohammad Mosiur Rahman, Dilruba Ahmed, Fikremelekot Temesgen, Melisachew Mulatu Yeshi, Mahlet Abayneh Gizaw, Stian MS Orlien, Solomon Ali, Peter Nyamthimba Onyango, Richard Oliech, Joyce Akinyi Were, Thomas Misore, Harun Owuor, Christopher Muga, Christine Ochola, Ashka Mehta, Brigitte Gaume, Adama Mamby Keita, Diakaridia Kone, Diakaridia Sidibe, Doh Sanogo, Kounandji Diarra, Tiéman Diarra, Kiranpreet Chawla, Zara Manhique, Fatmata Bintu Tarawally, Martin Seppeh, Ronald Mash, Julius Ojulong, Babatunde Duduyemi, Alim Swaray-Deen, Okokon Ita, Cornell Chukwuegbo, Sulaiman Sannoh, Princewill Nwajiobi, Erick Kaluma, Oluseyi Balogun, Carrie Jo Cain, Solomon Samura, Samuel Pratt, Joseph Kamanda Sesay, Osman Kaykay, Binyam Halu, Francis Smart, Sartie Kenneh, Ferdousi Begum, Priya Mehta-Gupta Das, Ogony Benard Oluoch, Caleb K Sagam, Ronita Luke, Milton Kincardett, Elisio G Xerinda, Markus Roos Breines, Ketema Degefa, J. Anthony G Scott, Kazi Munisul Islam, Parminder S Suchdev, Nelesh P. Govender, Peter J. Swart, Nawshad Uddin Ahmed, Alexander M. Ibrahim, Sharon M. Tennant, Carol L. Greene, J. Kristie Johnson, Karen D. Fairchild, Uma U. Onwuchekwa, Joseph Bangura

“…These findings highlight the need for integrated interventions addressing both malnutrition and infectious diseases to effectively reduce under-5 mortality.…”
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H2A.Z primes an epigenetic landscape for memory CD8+ T cell recall response by Wei Liang, Jiyu Ding, Qian Chai, Mengjie Lv, Shuting Zheng, Xiangxiang Cao, Zhimin Wang, Xiaoling Ying, Wenqi Wu, Guohong Li, Mingzhao Zhu

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Cutaneous anthrax rapidly progressed into septic anthrax resulting in death – A case report by Yufei Lyu, Shiyuan Li, Dongshu Wang, Meijie Feng, Wenjun Li, Xiankai Liu, Jia Zhou, Li Nie, Chao Pan, Shujuan Yu, Yan Guo, Hua Shao

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Rapid visual detection of Monkeypox virus by one-step LAMP-CRISPR/Cas12b assay by Jinlei Guo, Yunfeng Shan, Ge Hu, Xiaojuan Zhu, Kangchen Zhao, Tao Wu, Qiao Qiao, Ying Chi, Lunbiao Cui, Yiyue Ge

“…A rapid, sensitive, and accurate diagnostic method is urgently required to enable early intervention and effective management of MPXV outbreaks. …”
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FTO controls CD8+ T cell survival and effector response by modulating m6A methylation of Fas by Lina Sun, Tianzhe Zhang, Yao Ge, Zhihong Yao, Yanhong Su, Qianhao Wang, Yang Chen, Boxiao He, Renyi Ding, Cangang Zhang, Linbo Lan, Ruonan Liu, Huanxin Ping, Dan Zhang, Lin Shi, Xiaobo Zhou, Xiaoxuan Jia, Chenming Sun, Lingli Liang, Lianjun Zhang, Baojun Zhang

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A brief discussion on the impact of HIV-1 subtypes on virulence and immune reconstitution after antiviral therapy by LI Kang, SHAO Yiming

“…This is very unfavorable for prevention and control departments to grasp complete information on the prevalence and pathogenicity of the virus, making it difficult to formulate targeted intervention work. …”
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TBK1 phagosomal recruitment enhances antifungal immunity via positive feedback regulation with SRC by Yiting Feng, Xiaochen Cheng, Yuanzhe Yang, Chuanjin Liu, Yu Shi, Xiaopeng Qi, Wei Zhao, Bingyu Liu, Tian Chen, Chengjiang Gao

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Genotype/phenotype correlation in a patient with multiple abdominal and popliteal aneurysms by Mateus Picada Correa, MD, Camila Biedler Giordani, MD, Renan Camargo Puton, MD, Jaber Nashat Saleh, MD, Elizabeth Lemos Silveira Lucas, PhD

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Exploring current hypervirulent Klebsiella pneumoniae infections: insights into pathogenesis, drug resistance, and vaccine prospects by Qingjing Wang, Qingjing Wang, Haojie Yu, Xueer Pan, Weichang Huang, Jonathan Lalsiamthara, Saif Ullah, Yongchang Xu, Anwei Lu

“…Klebsiella pneumoniae is a significant pathogenic bacterium responsible for a range of infections. …”
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Analysis of Subtype, Molecular Clusters and Drug Resistance in Newly Diagnosed Individuals with HIV-1 Infection in Jiaxing City, Zhejiang Province, China in 2023 by Ganglin Ren, Xiaofei Zhang, Zhijian Ge, Yamei Zhou, Shencong Lv, Yin Song, Jimei Ji, Lina Li, Yong Yan, Guoying Zhu

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Gallstone disease and metabolic syndrome: before and after the cholecystectomy by Yu. P. Uspensky, S. V. Ivanov, A. V. Vovk, A. V. Koscheev, Kh. I. Ganbarova

“…The review article presents the main aspects of the pathogenic relationship between gallstone disease and metabolic syndrome, and the results of studies confirming its clinical significance. …”
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Cost-effectiveness of wastewater-based environmental surveillance for SARS-CoV-2 in Blantyre, Malawi and Kathmandu, Nepal: A model-based study. by Mercy Mvundura, Lucky G Ngwira, Kabita Bade Shrestha, Reshma Tuladhar, Jillian Gauld, Cliff Kerr, Kayla Barnes, Catherine Anscombe, Bhawana Sharma, Nicholas Feasey

“…Wastewater-based environmental surveillance (ES) has been demonstrated to provide an early warning signal to predict variant-driven waves of pathogens such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). …”
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Genetically Triggered Thoracic Aortic Disease: Who Should be Tested? by Valeria E. Duarte, Raman Yousefzai, Michael N. Singh

“…Diagnosing associated pathogenic gene variants and syndromes is critical, as the underlying genetics have an implication in medical management, surveillance, thresholds for surgical intervention, surgical risk, pregnancy risk, and risk of inheritance by the offspring. …”
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A case report of CHARGE syndrome caused by a de novo gene mutation by Yuan Zhang, Yu Lu, Xicui Long, Wenyu Xiong, Yuqing Liu

“…The clinical data of the patient as well as the whole-genome sequencing results of the child and parents were retrospectively analyzed to determine the pathogenicity of the gene mutation. Genetic testing revealed a heterozygous mutation of the CHD7 gene NM_017780.4: C.4853G >A (P.TP1618ter) in the child, which was identified as a de novo pathogenic mutation. …”
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Odontogenic brain abscess caused by Porphyromonas gingivalis and Streptococcus constellatus: a case report and review article by Siyu Sun, Rui He, Shan Chen, Jing Ren, Xinrong Ma, Junying Yang

“…Consequently, he was referred to the department of stomatology for further examination and treatment.Conclusions Our study found that major periodontal pathogens including P. gingivalis and S. constellatus were essential in the development of odontogenic brain abscesses; thus, timely intervention and preventive measures are important for treatment.…”
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Prevalence of molecular markers of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum isolates from West Africa during 2012–2022 by Ruimin Zhou, Suhua Li, Penghui Ji, Shucheng Ruan, Ying Liu, Chengyun Yang, Dan Qian, Zhiquan He, Dan Wang, Deling Lu, Hongwei Zhang, Yan Deng

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