Surveillance of Pediatric Invasive Bacterial Diseases in the Veneto Region: Epidemiological Trends and Outcomes over 17 Years (2007–2023) by Silvia Cocchio, Claudia Cozzolino, Andrea Cozza, Patrizia Furlan, Enrica Frasson, Sara Tarantino, Elisabetta Conte, Lorenzo Chiusaroli, Irene Amoruso, Francesca Zanella, Davide Gentili, Michele Tonon, Francesca Russo, Tatjana Baldovin, Vincenzo Baldo

“…<b>Results:</b> A total of 535 pediatric IBD cases were reported, with <i>Streptococcus pneumoniae</i> (54.6%), <i>Neisseria meningitidis</i> (19.6%), and <i>Streptococcus agalactiae</i> (13.5%) being the most common pathogens. <i>Haemophilus influenzae</i> infections were more commonly represented in infants under 1 year (41.5%), whereas <i>S. pneumoniae</i> and <i>N. meningitidis</i> were more frequent in the 1–4-year age group (40.8% and 37.1%, respectively). …”
Get full text

Innovative use of gram-positive enhancer matrix particles and affinity peptides in a vaccine against Coxsackievirus B3 by Shaoju Qian, Ruixue Li, Guanyu Chen, Yinghua Ma, Xuehan Zhang, Zhou Tang, Yihang Song, Zhishan Xu, Zihan Zhang, Yeqing He, Xingyi Zhang, Shuao Lu, Zishan Yang, Xiangfeng Song, Wenfa Yu, Lili Yu

“…No specific therapeutic interventions for VM exist, and vaccine development has encountered substantial challenges. …”
Get full text

Modeling healthcare resource dynamics and its application based on interregional population mobility by Jiaming Guo, Beibei Yan, Yanli Yang, Yifei Ning, Yan Zhou, Rui Zhang, Yifei Ma, Jiantao Li, Hongmei Yu, Hongmei Yu, Hongmei Yu, Hongmei Yu, Jun Xie, Jun Xie, Jun Xie

Get full text

Noncompact Myocardium with Dilated Phenotype: Manifestations, Treatment and Outcomes in Comparison with Other Forms of Dilated Cardiomyopathy Syndrome by O. V. Blagova, E. V. Pavlenko, N. V. Varionchik, V. P. Sedov, N. V. Gagarina, E. A. Mershina, M. E. Polyak, E. V. Zaklyazminskaya, A. V. Nedostup

“…NCM is an independent form of DCM syndrome, which is characterized by higher frequency of pathogenic mutations, arrhythmic events, worse response to cardiotropic therapy, higher frequency of intracardiac thrombosis. …”
Get full text

Hyodeoxycholic acid modulates gut microbiota and bile acid metabolism to enhance intestinal barrier function in piglets by Jie Chong, Jie Chong, Yongming Zhou, Zhi Li, Xiaokai Li, Jinwei Zhang, Jinwei Zhang, Haoran Cao, Jideng Ma, Liangpeng Ge, Liangpeng Ge, Hang Zhong, Hang Zhong, Jing Sun, Jing Sun

“…HDCA significantly altered gut microbiota composition in SPF piglets, markedly increasing the Lactobacillus abundance (37.97% vs. 5.28% in SPF-CON) while decreasing the proportion of Streptococcus (28.34% vs. 38.65%) and pathogenic family Erysipelotrichaceae (0.35% vs. 17.15%). …”
Get full text

Identification of circulating metabolites associated with chronic rhinosinusitis using Mendelian randomization analysis by Fan Jiang, Junhao Tu, Wenqi Luo, Yizhen Jia, Qing Luo, Jing Ye

“…Objective: This study aims to employ Mendelian Randomization (MR) analysis to investigate causal relationships between serum metabolites and CRS, identifying key pathogenic and protective factors and analyzing their mechanisms of action. …”
Get full text

Cadmium induced ferroptosis and inflammation in sheep via targeting ACSL4/NF-κB axis by Zimeng Ma, Zimeng Ma, Shuo Yan, Shuo Yan, Huimin Zhang, Huimin Zhang, Ruilin Du, Ruilin Du, Xinyue Cheng, Xinyue Cheng, Siqin Bao, Siqin Bao, Xihe Li, Xihe Li, Xihe Li, Yongli Song, Yongli Song

“…IntroductionCadmium, a major environmental contaminant, induces progressive intestinal damage through bioaccumulation in vivo. Elucidating its pathogenic mechanisms is crucial for developing therapeutic interventions.MethodsThis study employed multi-omics approaches to systematically investigated cadmium-induced ileal dysfunction in Hu sheep and the intervention mechanisms of sodium octanoate.ResultsPhenotypic assessment revealed cadmium exposure caused intestinal barrier impairment and histopathological changes. …”
Get full text

Effect of newborn genomic screening for lysosomal storage disorders: a cohort study in China by Xin Wang, Yun Sun, Xian-Wei Guan, Yan-Yun Wang, Dong-Yang Hong, Zhi-Lei Zhang, Ya-Hong Li, Pei-Ying Yang, Tao jiang, Zheng-feng Xu

“…Of these, 4 were excluded, 15 were diagnosed as LSD-presymptomatic individuals based on enzyme deficiency and pathogenic variants conforming to inheritance patterns, and 11 remain under follow-up. …”
Get full text

IL‐37 Mitigates the Inflammatory Response in Macrophages Induced by SARS‐CoV‐2 Omicron Infection Through the NF‐κB Signaling Pathway by Feifei Qi, Yiwei Yan, Mingya Liu, Qi Lv, Yanfeng Xu, Ming Liu, Fengdi Li, Ran Deng, Xujian Liang, Shuyue Li, Guocui Mou, Linlin Bao

“…Treatment with interleukin‐37 (IL‐37), an anti‐inflammatory factor, has unique anti‐inflammatory and antiviral effects on infections caused by various pathogens. In this study, we investigated the effect of IL‐37 treatment on the SARS‐CoV‐2 Omicron‐infection induced inflammatory response and its molecular mechanism. …”
Get full text

The spatiotemporal and paradoxical roles of NRF2 in renal toxicity and kidney diseases by Yiying Bian, Jize Dong, Zhengsheng Zhou, Hua Zhou, Yuanyuan Xu, Qiang Zhang, Chengjie Chen, Jingbo Pi

“…However, if persistently activated, NRF2-induced transcriptional cascade may disrupt normal cell signaling and contribute to numerous chronic pathogenic processes such as fibrosis. In this concise review, we assembled experimental evidence to reveal the cell- and pathophysiological condition-specific roles of NRF2 in renal chemical toxicity, AKI, and chronic kidney disease (CKD), all of which are closely associated with oxidative stress and inflammation. …”
Get full text

Single-cell transcriptome-wide Mendelian randomization and colocalization reveals immune-mediated regulatory mechanisms and drug targets for COVID-19Research in context by Hui Ying, Xueyan Wu, Xiaojing Jia, Qianqian Yang, Haoyu Liu, Huiling Zhao, Zhihe Chen, Min Xu, Tiange Wang, Mian Li, Zhiyun Zhao, Ruizhi Zheng, Shuangyuan Wang, Hong Lin, Yu Xu, Jieli Lu, Weiqing Wang, Guang Ning, Jie Zheng, Yufang Bi

“…We also carried out additional validations including colocalization, linkage disequilibrium check and host–pathogen interactome predictions. We integrated MR findings with clinical trial evidence from several drug gene related databases to identify drugs with repurposing potential. …”
Get full text

Antimicrobial Resistance and Migration: Interrelation Between Two Hot Topics in Global Health by Sergio Cotugno, Elda De Vita, Luisa Frallonardo, Roberta Novara, Roberta Papagni, Muhammad Asaduzzaman, Francesco Vladimiro Segala, Nicola Veronese, Emanuele Nicastri, Anna Morea, Ferenc Balázs Farkas, Botond Lakatos, Roberta Iatta, Giovanni Putoto, Annalisa Saracino, Francesco Di Gennaro

“…Studies reveal higher rates of AMR colonization and infection among migrants compared with native populations, with specific pathogens such as MRSA and multidrug‑resistant gram‑negative bacteria posing significant risks. …”
Get full text

Effect of an In-Home Palivizumab Administration Program for Children with Medical Complexity by Hina Emanuel, Aravind Yadav, Julie C. Eapan, Maria Caldas-Vasquez, Tomika S. Harris, Katrina McBeth, Fatima Boricha, Janice John, Ivan G. Magana Ceballos., Giuseppe N. Colasurdo, Maria E. Tellez, Tina Reddy, Wilfredo De Jesús-Rojas, Ricardo A. Mosquera

“…These programs may be particularly beneficial for children with medical complexity (CMC) by limiting their exposure to healthcare-associated infections (HAIs) from non-RSV-related pathogens during transportation and visits to medical facilities. …”
Get full text

Temporal network analysis of gut microbiota unveils aging trajectories associated with colon cancer by Ziqi Chen, Zhipeng Zhang, Bei Ning Nie, Wei Huang, Ying Zhu, Long Zhang, Meng Xu, Mengfei Wang, Chenyue Yuan, Ningning Liu, Xinyi Wang, Jianhui Tian, Qian Ba, Ziliang Wang

“…Understanding these microbial dynamics could also inform interventions targeting gut microbiota to mitigate CRC risk and progression.…”
Get full text

The improvement path of depression and anxiety among adult women in Shanxi Province, China: a fuzzy-set qualitative comparative analysis by Dahong Wu, Dahong Wu, Dahong Wu, Guangxian Zeng, Guangxian Zeng, Guangxian Zeng, Jing Cheng, Jing Cheng, Jing Cheng, Jie Liu, Jie Liu, Jie Liu, Sitian Li, Sitian Li, Sitian Li, Mengxia Qin, Mengxia Qin, Mengxia Qin, Lu He, Lu He, Lu He, Qilong Feng

Get full text

Clinical and genetic features of CNGA3 achromatopsia in preschool children: novel insights into retinal architecture and therapeutic window for clinical trials by Yanting Lai, Yanting Lai, Aohan Hou, Aohan Hou, Linyan Zhang, Linyan Zhang, Limei Sun, Limei Sun, Miner Yuan, Miner Yuan, Xiaoyan Ding, Xiaoyan Ding

“…This study aims to provide a comprehensive phenotyping of the retinal structure and identify novel genetic variants in a preschool cohort with ACHM in China.MethodsWe recruited patients with pathogenic genes (CNGA3, CNGB3, GNAT2, PDE6C, PDE6H, and ATF6) known to cause ACHM, all of whom had an age of symptom onset before 6 years of age. …”
Get full text

Child Health, Agriculture and Integrated Nutrition (CHAIN): protocol for a randomised controlled trial of improved infant and young child feeding in rural Zimbabwe by Paul Kelly, Lisa Langhaug, Robert Ntozini, Kuda Mutasa, Bernard Chasekwa, Andrew Prendergast, Batsirai Mutasa, Naume V Tavengwa, Tim Brown, Laura E Smith, Dexter. T Chagwena, Claire Bourke, Ruairi Robertson, Shamiso Fernando, Jill Cairns, Thokozile Ndhlela, Exhibit Matumbu, Kavita Datta, Alice Tengende, Dzivaidzo Chidhanguro, Maggie Makanza, Jonathan Swann

“…Redesigning current infant and young child feeding (IYCF) interventions using locally available foods to improve intake, uptake and utilisation of nutrients could ameliorate underlying pathogenic pathways and improve infant growth during the critical period of complementary feeding, to reduce the global burden of stunting.Methods and analysis Child Health Agriculture Integrated Nutrition is an open-label, individual household randomised trial comparing the effects of IYCF versus ‘IYCF-plus’ on nutrient intake during infancy. …”
Get full text

A pan-genotypic indirect competitive ELISA for serological detection of pigeon circovirus antibodies by Weifan Wang, Weifan Wang, Sa Xiao, Man Zhang, Jinming Liu, Jianxia Tian, Chuanyu Chang, Yuzhen Li, Yajie Zhang, Fuliang Zhang, Fuliang Zhang, Guiming Li, Guiming Li, Xiaoyuan Yuan, Xiaoyuan Yuan, Wenbin Wang, Wenbin Wang

“…The icELISA method exhibited no cross-reactivity with antibodies against other common pigeon pathogens, such as pigeon paramyxovirus type 1 (PPMV-1), avian influenza (H9N2), avian adenovirus type 4 (FAdV-4) or rotavirus (RV). …”
Get full text

Age-based host response to turkey arthritis reovirus in commercial turkeys in the presence of maternally derived antibodies by Saroj Khatiwada, John Ngunjiri, Patricia A. Boley, Kush K. Yadav, Amir Ghorbani, Michael Abundo, Carolyn M. Lee, Jelmer W. Poelstra, Chang-Won Lee, Saad Gharaibeh, Gireesh Rajashekara, Scott P. Kenney

“…Since 2011, highly pathogenic TARV strains have caused significant economic losses in the turkey industry due to increased culling, reduced market weights, and decreased carcass quality, necessitating more effective control measures. …”
Get full text

Untargeted proteomics enables ultra-rapid variant prioritisation in mitochondrial and other rare diseases by Daniella H. Hock, Nikeisha J. Caruana, Liana N. Semcesen, Nicole J. Lake, Luke E. Formosa, Sumudu S. C. Amarasekera, Tegan Stait, Simone Tregoning, Leah E. Frajman, Adam M. Bournazos, David R. L. Robinson, Megan Ball, Boris Reljic, Bryony Ryder, Mathew J. Wallis, Anand Vasudevan, Cara Beck, Heidi Peters, Joy Lee, Natalie B. Tan, Mary-Louise Freckmann, MitoMDT Diagnostic Network for Genomics and Omics, Vasiliki Karlaftis, Chantal Attard, Paul Monagle, Amanda Samarasinghe, Rosie Brown, Weimin Bi, Monkol Lek, Robert McFarland, Robert W. Taylor, Michael T. Ryan, Sandra T. Cooper, Zornitza Stark, John Christodoulou, Alison G. Compton, David R. Thorburn, David A. Stroud

“…A genetic diagnosis allows access to appropriate care, restores reproductive confidence and reduces the number of potentially unnecessary interventions. A major barrier is the lack of disease agnostic functional tests suitable for implementation in routine diagnostics that can provide evidence supporting pathogenicity of novel variants, especially those refractory to RNA sequencing. …”
Get full text