Non-antibiotic therapies for multidrug-resistant gastrointestinal infections: an overview of the use of probiotics, natural compounds, and bacteriophages by Manuela Oliveira, Manuela Oliveira, Áurea Madureira-Carvalho, Áurea Madureira-Carvalho, Ricardo Jorge Dinis-Oliveira, Ricardo Jorge Dinis-Oliveira, Ricardo Jorge Dinis-Oliveira, Ricardo Jorge Dinis-Oliveira, Diana Dias da Silva, Diana Dias da Silva, Diana Dias da Silva, Diana Dias da Silva

“…The worldwide increasing frequency and severity of multidrug-resistant gastrointestinal (MDR-GI) infections not only raises awareness of the debilities of conventional antibiotic treatments but also highlights the demand for alternative interventions. One of these alternatives is probiotics, harmless bacteria that compete with pathogenic species, which have been considered beneficial due to their therapeutic potential since they strengthen the mucosal barrier and modulate the host immune response. …”
Get full text

A Senomorphlytic Three‐Drug Combination Discovered in Salsola collina for Delaying Aging Phenotypes and Extending Healthspan by Jiqun Wang, Wenwen Liu, Yunyuan Huang, Guangwei Wang, Xiaobo Guo, Donglei Shi, Tianyue Sun, Chaojiang Xiao, Chao Zhang, Bei Jiang, Yuan Guo, Jian Li

Get full text

Slow virologic control but strong immune and metabolic recovery with dolutegravir-anchored therapy in an HIV cohort in Ghana by Mark Appeaning, Edwin Magomere, Alberta Mawulawoe Abotsi, Nana Ama Yeboaa Amoako, Kirk Elorm Kouffie, Becky Ewurama Tetteh, Bridget Nana Darkoa Quist, Christèle Nguepou Tchopba, Gloria Akosua Ansa, Evelyn Yayra Bonney, Peter Kojo Quashie

Get full text

Unveiling the therapeutic potential of natural products in Alzheimer’s disease: insights from in vitro, in vivo, and clinical studies by Nahida Aktary, Yerim Jeong, Seungji Oh, Yeju Shin, Yoonsoo Sung, Muntajin Rahman, Livia Ramos Santiago, Jinwon Choi, Han Gyeul Song, Fahrul Nurkolis, Rosy Iara Maciel Azambuja Ribeiro, Moon Nyeo Park, Bonglee Kim

“…Emerging evidence highlights the therapeutic potential of natural products, particularly herbal medicines, as versatile modulators of key pathogenic processes in AD. These compounds exert neuroprotective effects by mitigating oxidative stress, suppressing neuroinflammation, inhibiting tau hyperphosphorylation, and reducing amyloid-beta aggregation. …”
Get full text

Optical genome mapping: Unraveling complex variations and enabling precise diagnosis in dystrophinopathy by Jiahui Mai, Jing Duan, Xiaoyu Chen, Liqin Liu, Dachao Liang, Tao Fu, Gang Lu, Wai Yee Chan, Xufeng Luo, Feiqiu Wen, Jianxiang Liao, Zhuo Li, Xinguo Lu

“…Results Conventional methods (MLPA and NGS) failed to detect pathogenic mutations in six out of eight individuals (four males and two females). …”
Get full text

UV radiation at 222, 254, and 282 nm inhibits sporulation and suppresses infectivity of Eimeria acervulina oocysts by Aaron A. Baumann, Addison K. Myers, Niloofar Khajeh-Kazerooni, Ashley Wise-Mitchell, Benjamin M. Rosenthal, Mark C. Jenkins, Celia O'Brien, Lorraine Fuller, Samuel Tremaine, Mark Morgan, Scott C. Lenaghan

“…It is also a valuable model for exploring interventions capable of reducing the public health risks posed by the related foodborne parasite Cyclospora cayetanensis. …”
Get full text

Multiomics comparative analysis of feces AMRGs of Duroc pigs and Tibetan and the effect of fecal microbiota transplantation on AMRGs upon antibiotic exposure by Tao Wang, Yuheng Luo, Xiangfeng Kong, Ling Fang, Liping Zhu, Bing Yu, Ping Zheng, Zhiqing Huang, Xiangbing Mao, Yu Jie, Junqiu Luo, Hui Yan, Jun He

“…Given the escalating antimicrobial resistance crisis, novel therapeutic interventions are imperative to mitigate gut colonization by pathogens and AMRGs. …”
Get full text

Placental transfer of SARS-CoV-2 antibodies in mother-neonate pairs: a prospective nested cohort study by Alex G. Mugo, Angela Koech, Liberty Cantrell, Moses Mukhanya, Isaac Mwaniki, Joseph Mutunga, Merryn Voysey, Rachel Craik, Peter von Dadelszen, Kirsty Le Doare, Marleen Temmerman, Geoffrey Omuse, periCOVID-Africa, The PRECISE Network

“…Abstract Background Newborns depend on the transfer of IgG across the placenta to acquire protection against pathogens. We assessed the placental transfer of SARS-CoV-2 antibodies, primarily derived from infection, from seropositive pregnant women enrolled in a pregnancy cohort in Kilifi, Kenya. …”
Get full text

Assessing Wolbachia circulation in wild populations of phlebotomine sand flies from Spain and Morocco: implications for control of leishmaniasis by Andrés Torres-Llamas, Victoriano Díaz-Sáez, Manuel Morales-Yuste, Patricia Ibáñez-De Haro, Arturo Enrique López-López, Victoriano Corpas-López, Francisco Morillas-Márquez, Joaquina Martín-Sánchez

“…The increasing threat of insecticide-resistant vectors entails incorporating more vector control interventions to eliminate these diseases. Introduction of Wolbachia into wild vector populations has been suggested as a potential vector control measure that would require extensive regional knowledge. …”
Get full text

Innate cells and STAT1-dependent signals orchestrate vaccine-induced protection against invasive Cryptococcus infection by Keyi Wang, Vanessa Espinosa, Yina Wang, Alexander Lemenze, Yosuke Kumamoto, Chaoyang Xue, Amariliz Rivera

“…ABSTRACT Fungal pathogens are underappreciated causes of significant morbidity and mortality worldwide. …”
Get full text

Limited Diagnostic Value of Blood Cultures in Patients with Soft Tissue Infections Transferred to a Quaternary Care Center by Mira H. Ghneim, Gregory M. Schrank, William Teeter, Brooke Andersen, Anna Brown, Quincy K. Tran

“…However, when patients require transfer to tertiary/quaternary-level care for more advanced surgical interventions, blood cultures are often repeated despite patients being on broad-spectrum antibiotics. …”
Get full text

Corneal sensory nerve loss induced by repeated subconjunctival and topical bupivacaine disrupts tear secretion and enhances bacterial adhesion via neuropeptide modulation. by Ananya Datta, Grace Kelly Orallo, Nahomy Nelson

“…Beyond infection models, this subconjunctival injection strategy serves as a versatile platform for studying ocular drug pharmacokinetics, neuroprotective interventions, and immune modulation.…”
Get full text

Metagenomics Analysis of Altered Gut Microbiome in Psoriasis and the Mediation Analysis: A Case-Control Study by Xiao Y, Jing D, Xiao H, Mao M, Kuang Y, Shen M, Lv C, Jian X, Peng C, Chen X

“…This study provides new insights for adjuvant treatments of psoriasis through dietary and intestinal microbiota interventions.Keywords: psoriasis, gut microbiome, metagenomics, diet, mediator…”
Get full text

Blood Pressure Indices and Associated Risk Factors in a Rural West African Adult Population: Insights from an AWI-Gen Substudy in Ghana by Godfred Agongo, Engelbert A. Nonterah, Lucas Amenga-Etego, Cornelius Debpuur, Michael B. Kaburise, Stuart A. Ali, Nigel J. Crowther, Michèle Ramsay, Abraham R. Oduro

Get full text

Shifts in Influenza and Respiratory Syncytial Virus Infection Patterns in Korea After the COVID-19 Pandemic Resulting From Immunity Debt: Retrospective Observational Study by Minah Park, Won Suk Choi, Benjamin J Cowling

“…As NPIs were stopped, concerns emerged about “immunity debt,” which suggests that limited natural exposure to pathogens may have increased susceptibility and severity, particularly among young children. …”
Get full text

The TgAMPK-TgPFKII axis essentially regulates protein lactylation in the zoonotic parasite Toxoplasma gondii by Chenghuan Li, Yang Zhao, Qilong Li, Ran Chen, Ying Feng, Xiaoyu Sang, Xiangrui Li, Bang Shen, Ning Jiang, Qijun Chen

“…These findings highlight TgPFKII as a crucial regulator of lactylation and underscore the importance of the AMPK pathway in T. gondii’s pathogenic mechanisms, offering potential targets for therapeutic intervention.IMPORTANCEUnderstanding the intricate mechanisms by which Toxoplasma gondii invades and proliferates within host cells is essential for developing novel therapeutic strategies against toxoplasmosis. …”
Get full text

Crimean-Congo haemorrhagic fever virus screening among African individuals in Spain: Lessons to learn by Helena Miriam Lorenzo Juanes, Amparo López-Bernus, Belen Vicente, Montserrat Alonso-Sardón, Beatriz Rodríguez Alonso, Josue Pendones Ulerio, Pedro Fernandez Soto, Juan Luis Muñoz Bellido, Antonio Muro, Moncef Belhassen-García

“…Although the risk is considered very low in these collectives, clinicians should be alert to the possibility of new CCHF cases, given the high pathogenicity of CCHFV and the risk of transmission.…”
Get full text

Promise and Peril of a Genotype‐First Approach to Mendelian Cardiovascular Disease by Babken Asatryan, Brittney Murray, Rafik Tadros, Marina Rieder, Ravi A. Shah, Ghaith Sharaf Dabbagh, Andrew P. Landstrom, Stephan Dobner, Patricia B. Munroe, Christopher M. Haggerty, Argelia Medeiros‐Domingo, Anjali T. Owens, Iftikhar J. Kullo, Christopher Semsarian, Tobias Reichlin, Andreas S. Barth, Dan M. Roden, Cynthia A. James, James S. Ware, C. Anwar A. Chahal

“…This approach could transform health care by diagnostic refinement and facilitating prevention or therapeutic interventions. Yet, potential benefits must be weighed against the potential risks, which include evolving variant pathogenicity assertion or identification of variants with low disease penetrance; costly, stressful, and inappropriate diagnostic evaluations; negative psychological impact; disqualification for employment or of competitive sports; and denial of insurance. …”
Get full text

Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides by Ka Kiu Lee, Urszula Łapińska, Giulia Tolle, Maureen Micaletto, Bing Zhang, Wanida Phetsang, Anthony D Verderosa, Brandon M Invergo, Joseph Westley, Attila Bebes, Raif Yuecel, Paul A O'Neill, Audrey Farbos, Aaron R Jeffries, Stineke van Houte, Pierluigi Caboni, Mark AT Blaskovich, Benjamin E Housden, Krasimira Tsaneva-Atanasova, Stefano Pagliara

“…Antimicrobial resistance threatens the viability of modern medical interventions. There is a dire need to develop novel approaches to counter resistance mechanisms employed by starved or slow-growing pathogens that are refractory to conventional antimicrobial therapies. …”
Get full text

Novel oral compound Z526 mitigates cancer-associated cachexia via intervening NF-κB signaling and oxidative stress by Xiaofan Gu, Shanshan Lu, Shuang Xu, Yiwei Li, Meng Fan, Guangyu Lin, Yiyuan Liu, Yun Zhao, Weili Zhao, Xuan Liu, Xiaochun Dong, Xiongwen Zhang

“…Thus, oral Z526, which exhibited potent anti-CAC activities in vitro and in vivo, multiple interventions in diverse pathogenic mechanisms (NF-κB signaling and oxidative stress), and a favorable preclinical safety profile, holds the promise to be developed into a novel and beneficial therapeutic option for CAC.…”
Get full text