A metagenome-wide association study of gut microbiota in hepatitis B virus-related cirrhosis in northwest China by Meirong Feng, Yan Chai, Jinna Li, Qi Wang, Dekui Zhang

“…These findings highlight the potential of gut microbiome-targeted interventions for regional precision medicine of HBV-LC.…”
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Comprehensive characterization of high-risk coding and non-coding single nucleotide polymorphisms of human CXCR4 gene. by Bonoshree Sarkar, Muhammad Safiul Alam Mondal, Taibur Rahman, Md Ismail Hosen, Atiqur Rahman

“…In the mostly annotated variant (ENSP00000241393) of the CXCR4 gene, we found 23 highly deleterious and pathogenic nsSNPs and these were selected for in-depth analysis. …”
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Comprehensive bioinformatics analysis identifies hub genes associated with immune cell infiltration in early-onset schizophrenia by Shasha Wu, Tailian Xue, Yilin Li, Weikang Chen, Yan Ren

“…This study employs immune infiltration analysis and bioinformatics to unveil the pathogenic mechanisms of EOS and identify potential diagnostic biomarkers, aiming for more precise clinical interventions. …”
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Risk factors for weight gain after risk reducing salpingo-oophorectomy in premenopausal patients with hereditary ovarian cancer risk by Surabhi Tewari, Karen Hurley, Meng Yao, Snehi Shah, Melissa Yurch, Anna Chichura, Mariam AlHilli

“…Methods: We analyzed data from premenopausal patients (age ≤ 51 years) with pathogenic variants in BRCA1/2, ATM, BRIP1, PALB2, RAD51C/D, MLH1, MSH2, MSH6, or PMS2 who underwent RRSO between 2009–2016. …”
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Adult-capture assays as a tool to measure insecticide resistance in Anopheles malaria vectors: a modeling comparison with larval-capture assays by Inga Holmdahl, Inga Holmdahl, Caroline O. Buckee, Caroline O. Buckee, Lauren M. Childs

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Bacteriological and Mycological Assessments of Second-Hand Wears Procured From Girei And Jimeta Markets, Adamawa State, Nigeria by Halima Isa, Halima Isa, Nafisat Kachalla Adamu, Mohammed Bashir, Adamu Aliyu Usman, Simon Anthony, Blessing Wayeh

“… • The findings underscore the need for public health interventions, including the washing and disinfection of second-hand clothing to mitigate the risk of spreading antibiotic-resistant pathogens. …”
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Risk factors for the progression from pulmonary tuberculosis to spinal tuberculosis: a logistic regression analysis by Di Xue, Xiaolei Chen, Lufei Shao, Qinfu Liu, Jia Chen, Yajing Su, Chen Zhang, Zhirong Chen, Min Su, Zhiqiang Wu, Yiqiang Yang, Xue Lin

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HIV risk perception, trust and PrEP adherence among participants in an HIV prevention trial: a qualitative longitudinal study, South Africa by Giuseppe Pantaleo, Glenda Gray, Pontiano Kaleebu, Said Aboud, David Dunn, Merlin Robb, Janet Seeley, Sheena McCormack, Julie Fox, Jim Rooney, Tom Miller, Agricola Joachim, Ilesh Jani, Mary Amondi, Peter Hughes, Sarah Joseph, Eugene Ruzagira, Vincent Basajja, Jonathan Weber, Cherry Kingsley, Eligius Lyamuya, Lucas Maganga, Doreen Pamba, Edna Viegas, Charlotta Nilsson, Arne Kroidl, Angela Crook, Anne Gumbe, Phindile Khanyile, Jennifer Serwanga, Carter Lee, Kundai Chinyenze, Song Ding, Muhammad Bakari, Neetha Morar, Ayoub Kakande, Tumaini Nagu, Henry Bern, Sylvia Kusemererwa, Patricia Munseri, Lwitiho Sudi, Jorge Ribeiro, Igor Capitine, Diana Faini, Edna Nhacule, Kubashni Woeber, Yolanda Manganhe, Abisai Kisinda, Wiston William, Rujeko Samanthia Chimukuche, Londiwe Shandu, Silindile Zulu, Nishanta Singh, Zakir Gaffoor, Rachel Kawuma, Thandiwe Sithole, Samantha Siva, Eldinah Hwengwere, Rujeko Samanthia Chidawanyika, Nteboheleng Mahapa, Isabel Remane, Odete Bule, Patricia Ramgi, Raquel Chissumba, Eduardo Namalango, Carmelia Massingue, Emmanuel Kapesa, Elizabeth Danstan, Marco Missanga, Amani Kway, Lilian Njovu, Revocatus Kunambi, Frank Msafiri, Edith Tarimo, Deus Buma, Freddie Mukasa Kibengo, Christian Hansen Holmes, Sheila Kansiime, Sylvia Masawi, Tobias Vudriko, Shamim Nabukenya, Gertrude Mutonyi, Rita Nakiboneka, Susan Mugaba, Aminata Sy, Liz Brodnicki, Claire Wenden, Jacqueline Musau, Mabela Matsoso, Paramesh Chetty, Gustavo Doncel, Allison Matthews

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Ultrasound-mediated nanomaterials for the treatment of inflammatory diseases by Kai Zhang, Tingting Wang, Xingyong Huang, Peng Wu, Lufan Shen, Yuanyuan Yang, Wenyu Wan, Siyu Sun, Zhan Zhang

“…Conventional drug therapies often entail significant drawbacks, such as the risk of drug overdose, the development of drug resistance in pathogens, and systemic adverse reactions, all of which can undermine the effectiveness of treatments for these conditions. …”
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Probiotic L. reuteri treatment in stressed rats improves maternal care and corrects corticosterone-BDNF-oxytocin balance offering insights for maternal postpartum distress treatmen... by Ryma Benlakehal, Alessandra Gaetano, Rogatien Charlet, Hammou Bouwalerh, Virginie Cogez, Anne Harduin-Lepers, Boualem Sendid, Ferdinando Nicoletti, Stefania Maccari, Sara Morley-Fletcher

“…Additionally, L. reuteri restored gut microbiota balance, increasing Lactobacillus spp. while reducing pathogenic strains in fecal pellets of stressed dams during lactation and post-weaning, correlating with both maternal oxytocin and corticosterone plasma levels. …”
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Povetacicept (ALPN-303; TACI vTD-Fc), an enhanced, potent dual inhibitor of BAFF and APRIL, ameliorates experimental autoimmune myasthenia gravis in C57BL/6N mice by Elena Rinaldi, Elisa Puleo, Alessandra Consonni, Martina Miglietti, Renato Mantegazza, NingXin Wang, Stanford L. Peng, Katherine E. Lewis, Stacey R. Dillon, Fulvio Baggi

“…Povetacicept treatment also reduced the number of total B220+ and Ki67+ proliferating cells in draining lymph node follicles and resulted in modifications of splenic T and B cell subset frequencies, compared to controls.DiscussionThe potent, dual BAFF/APRIL inhibitor povetacicept significantly improves clinical disease activity in EAMG, associated with reductions in pathogenic anti-AChR autoantibodies and superior to comparator therapeutic interventions based on WT TACI-Fc, CD20 depletion, or FcRn inhibition. …”
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Genomic epidemiology and public health implications of zoonotic monophasic Salmonella Typhimurium ST34 by Xiaolei Wu, Jiaxin Du, Xiao Zhou, Xianqi Peng, Chenghao Jia, Baikui Wang, Beibei Wu, Yan Li, Yan Li, Min Yue, Min Yue, Min Yue

“…This study addresses critical gaps in our understanding of mSTM ST34 prevalence, highlighting the importance of whole genome sequencing in surveilling zoonotic pathogens.…”
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A comprehensive strategy for the development of a multi-epitope vaccine targeting Treponema pallidum, utilizing heat shock proteins, encompassing the entire process from vaccine de... by Jing Jiang, Jing Jiang, Linglan Xu, Linglan Xu, Xuefeng Wang, Ming Wang, Youde Cao, Ranhui Li, Kang Zheng, Xian Wu

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Norovirus molecular trends in Harbin preschoolers Post-NPI easing by Yuan Tian, Xiqiao Du, Hong Gao, Mingyue Yuan, Yingchen Wang, Lei Shang, Yuhui Pan, Tuo Dong, Zhe Zhang

“…Background: Noroviruses (NoV) are key pathogens causing acute gastroenteritis (AGE) in children, with a significant disease burden, especially in developing nations. …”
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CKD in Bardet-Biedl Syndrome: Evidence Supporting Multifactorial Etiology by Miriam Zacchia, Floriana Secondulfo, Andrea Melluso, Francesca Del Vecchio Blanco, Valentina Di Iorio, Anna Laura Torella, Giulio Piluso, Giovanna Capolongo, Francesco Trepiccione, Francesca Simonelli, Vincenzo Nigro, Alessandra Perna, Giovambattista Capasso

“…Early diagnosis and intervention are essential for improving patient outcomes. …”
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Clonal expansion of chromosome-borne CTX-M-55 extended-spectrum β-lactamase-producing Salmonella enterica serovar Agona, Taiwan by Ying-Shu Liao, Yu-Ping Hong, Bo-Han Chen, You-Wun Wang, Ru-Hsiou Teng, Yung-Chen Chien, Shiu-Yun Liang, Hsiao Lun Wei, Jui-Hsien Chang, Ming-Hao Yang, Chi-Sen Tsao, Chien-Shun Chiou

“…These findings underscore the urgent need for enhanced surveillance, targeted interventions, and global antimicrobial stewardship to curb the spread of MDR pathogens and safeguard public health.…”
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Metabolic Profiling Reveals Potential Prognostic Biomarkers for SFTS: Insights into Disease Severity and Clinical Outcomes by Zhuo-Min Zhu, Huan-Yu Liu, Na An, An-Ling Li, Jia Li, Sai-Jun Wang, Gui Yang, Yong-Wei Duan, Ying Yang, Mei Zhang, Quan-Fei Zhu, Song-Mei Liu, Yu-Qi Feng

“…Despite its increasing prevalence, the underlying pathogenic mechanisms remain poorly understood, limiting the development of effective therapeutic interventions. …”
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Acceptance of a computer vision facilitated protocol to measure adherence to face mask use: a single-site, observational cohort study among hospital staff by Giovanni Traverso, Adam B Landman, Peter R Chai, Hen-Wei Huang, Jack Chen, Farah Dadabhoy, Phillip Rupp, Clint Vaz, Anjali Sinha, Claas Ehmke, Akhil Thomas, Jia Y Liang, George Player, Kevin Slattery

“…Objectives Mask adherence continues to be a critical public health measure to prevent transmission of aerosol pathogens, such as SARS-CoV-2. We aimed to develop and deploy a computer vision algorithm to provide real-time feedback of mask wearing among staff in a hospital.Design Single-site, observational cohort study.Setting An urban, academic hospital in Boston, Massachusetts, USA.Participants We enrolled adult hospital staff entering the hospital at a key ingress point.Interventions Consenting participants entering the hospital were invited to experience the computer vision mask detection system. …”
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Whole exome sequencing and polygenic risk assessment for kidney functions and clinical management in both hospital-based cohort and population-based Asian cohorts by Min-Rou Lin, I-Wen Wu, Wan-Hsuan Chou, Yung-Feng Lin, Kuan-Yu Hung, Kaname Kojima, Kosuke Shido, Kengo Kinoshita, Wei-Chiao Chang, Mai-Szu Wu

“…Beyond previously reported genes, we identified novel rare pathogenic variants in PEX1, GANAB, DYNC2H1, and PROKR2. …”
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Differential expression of TLR and CXCR genes in mammary HC11 cells challenged with Bacillus cereus and Bacillus subtilis: Implications for mastitis resistance by Nova Dilla Yanthi, Anneke Anggraeni, Syahruddin Said, Sugiyono Saputra, Retno Damayanti Soejoedono, Muladno Muladno, Nina Herlina, Ima Fauziah, Herjuno Ari Nugroho, Mukh Fajar Nasrulloh, Rida Tiffarent

“…Background and Aim: Mastitis remains a major health challenge in dairy cattle, often caused by Gram-positive pathogens. Toll-like receptors (TLRs) and chemokine receptors (CXCRs) play essential roles in the innate immune response of mammary epithelial cells (MECs). …”
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