MAN2B1 in immune system-related diseases, neurodegenerative disorders and cancers: functions beyond α-mannosidosis by Yuwen Han, Yuanshuai Zhou, Jinlin Pan, Minxuan Sun, Jiao Yang

“…Despite decades of research, its role in pathogenic infections, autoimmune conditions, cancers and neurodegenerative pathologies is highly ambiguous. …”
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Systems immunology integrates the complex endotypes of recessive dystrophic epidermolysis bullosa by Nell Hirt, Enzo Manchon, Qian Chen, Clara Delaroque, Aurelien Corneau, Patrice Hemon, Safaa Saker-Delye, Pauline Bataille, Jean-David Bouaziz, Emmanuelle Bourrat, Alain Hovnanian, Helene Le Buanec, Fawzi Aoudjit, Hicham El Costa, Nabila Jabrane-Ferrat, Reem Al-Daccak

“…Recessive dystrophic epidermolysis bullosa (RDEB) is a severe blistering disease caused by COL7A1 pathogenic variants. Although underscored by animal studies, the endotypes of human RDEB are poorly understood. …”
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Real-World Use, Effectiveness, and Safety of Intravenous Fosfomycin: The FORTRESS Study by Klaus-Friedrich Bodmann, Stefan Hagel, Alessandra Oliva, Stefan Kluge, Alessandra Mularoni, Valentina Galfo, Marco Falcone, Mathias W. Pletz, Simone Lindau, Nadja Käding, Jan T. Kielstein, Michael Zoller, Carlo Tascini, Sebastian Kintrup, Dirk Schädler, Claudia Spies, Francesco G. De Rosa, Szilvia Radnoti, Alessandra Bandera, Roberto Luzzati, Sam Allen, Loredana Sarmati, Antonio Cascio, Nikolaos Kapravelos, Chinari P. K. Subudhi, George Dimopoulos, Matthias G. Vossen, Abhijit M. Bal, Mario Venditti, Claudio M. Mastroianni, Thomas Borrmann, Christian Mayer

“…Abstract Introduction Intravenous fosfomycin (FOS) is a broad-spectrum antibiotic primarily used in combination therapy to treat severe infections caused by both Gram-positive (GP) and Gram-negative (GN) pathogens, including multi-drug resistant (MDR) bacteria. …”
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Interferons and Toxoplasma gondii shape PD-L1 regulation in retinal barrier cells: the critical role of proteases by Benjamin Geiller, Camila Cevallos, Iuliia Tsybenko, Lydia Arnoux, Marie-Paule Felder-Schmittbuhl, Alexander W. Pfaff, Alexander W. Pfaff

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Knowledge, attitudes, and practices of Native Americans in northern California regarding ticks and tick-borne diseases by Patricia Torres, Elizabeth F. Pienaar, Michelle A. Ritchie, Mourad W. Gabriel, Michael J. Yabsley

“…Reports of tick-borne diseases (TBDs) are increasing worldwide, particularly in North America where a diversity of endemic and exotic tick species and pathogens occur. Native American populations have unique outdoor cultural and occupational practices that may impact their exposure to ticks, yet this risk remains understudied in the context of TBD. …”
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Single-cycle, pseudotyped reporter influenza virus to facilitate evaluation of treatment strategies for avian influenza, Ebola and other highly infectious diseases in vivo by Tiong Kit Tan, Tiong Kit Tan, Pramila Rijal, Pramila Rijal, Kuan-Ying A. Huang, Stephen C. Hyde, Deborah R. Gill, Alain R. Townsend, Alain R. Townsend

“…The rapid spread of infectious diseases presents a significant global threat, with seasonal influenza viruses, leading to 290,000–650,000 deaths annually. Emerging high pathogenic influenza strains from animals such as H5N1 and H7N9 further exacerbates pandemic risks. …”
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Structural insights into terminal arabinosylation of mycobacterial cell wall arabinan by Yaqi Liu, Chelsea M. Brown, Satchal Erramilli, Yi-Chia Su, Shih-Yun Guu, Po-Sen Tseng, Yu-Jen Wang, Nam Ha Duong, Piotr Tokarz, Brian Kloss, Cheng-Ruei Han, Hung-Yu Chen, José Rodrigues, Kay-Hooi Khoo, Margarida Archer, Anthony A. Kossiakoff, Todd L. Lowary, Phillip J. Stansfeld, Rie Nygaard, Filippo Mancia

“…A critical factor in Mtb’s pathogenicity is its intricate cell envelope, which acts as a formidable barrier against immune defences and pharmacological interventions. …”
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For girls and women (4GW) HPV RCT protocol: a crowdsourced, pragmatic stepped-wedge cluster randomized trial to improve uptake of HPV vaccination and screening among mother-daughte... by Juliet Iwelunmor, Agatha E. Wapmuk, Ekenechukwu Kokelu, Temitope Ojo, Olufunto Olusanya, Titilola Gbaja-Biamila, Folahanmi T. Akinsolu, Adesola Z. Musa, Hong Xian, Olunike R. Abodunrin, Peter Kalulu, Angel Obiorah, Maria Afadapa, Nkiruka Obodoechina, Ucheoma Nwaozuru, Onyeka Anikamadu, Jennifer Smith, Benedict N. Azuogu, Kayode Ajenifuja, Mengmeng Jia, Assanatou Bamogo, Abdulhammed Babatunde, Jason J. Ong, Lei Zhang, Zhuoru Zou, Collins O. Airhihenbuwa, Joseph D. Tucker, Oliver C. Ezechi

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Rare Naegleria fowleri meningoencephalitis diagnosed via combined molecular biology and metagenomic sequencing techniques: a case report by Yuanjing Kou, Jiayao Zhang, Dan Wang, Lidan Cui, Qi Sun, Yanqi Lv, Ying Liu, Zhiquan He, Yuling Zhao, Hongwei Zhang, Jun Su, Yaobao Liu, Yan Deng

“…Abstract Background Naegleria fowleri, a pathogenic free-living amoeba, causes primary amoebic meningoencephalitis (PAM), a rare but devastating disease with acute onset, rapid progression, and > 95% mortality. …”
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Role of Inflammatory Markers as a Risk Factor for Community-Acquired Pneumonia Management by Ruta Nutautiene, Irmantas Aleksa, Ieva Janulaityte, Erika Skrodeniene, Kristina Bieksiene, Diana Zaliaduonyte, Darius Batulevicius, Astra Vitkauskiene

“…<i>Results</i>: Aetiology was identified in 87.8% of cases, with typical bacterial pathogens being more prevalent among older, smoking patients, while atypical pathogens were more common among younger, non-smoking patients. …”
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Probiotics Alleviated Nonalcoholic Fatty Liver Disease in High-Fat Diet-Fed Rats via Gut Microbiota/FXR/FGF15 Signaling Pathway by Minmin Luo, Junbin Yan, Liyan Wu, Jinting Wu, Zheng Chen, Jianping Jiang, Zhiyun Chen, Beihui He

“…We established a rat model of NAFLD fed with a high-fat diet (HFD) for 14 weeks, which was given different interventions (312 mg/kg/day probiotics or 10 mg/kg/day atorvastatin) from the 7th week. …”
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Seasonal patterns of infectious diseases in Riyadh Province, Saudi Arabia: a retrospective analysis by Mansour Almuqbil, Syed Imam Rabbani, Faisal Ghazi Alharbi, Meshari Hajed Alharbi, Rafiulla Gilkaramenthi, Amro Mohammed Sawadi Khormi, Mutlaq Eidhah M. Almalki, Walaa F. Alsanie, Abdulhakeem S. Alamri, Majid Alhomrani, Amal F. Alshammary, Syed Mohammed Basheeruddin Asdaq

“…This finding suggests that certain pathogens may exhibit heightened activity at certain times of the year. …”
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Diabetic kidney disease: from pathogenesis to multimodal therapy–current evidence and future directions by Hui Zhang, Keding Wang, Hairui Zhao, Bowen Qin, Xiaojing Cai, Manyi Wu, Junhua Li, Junhua Li, Jielian Wang

“…Despite recent therapeutic advances, current treatment strategies primarily alleviate symptoms rather than address the underlying pathogenic mechanisms, highlighting an urgent need for targeted, mechanism-based interventions. …”
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The Global Burden of Multidrug-Resistant Bacteria by Andrea Marino, Antonino Maniaci, Mario Lentini, Salvatore Ronsivalle, Giuseppe Nunnari, Salvatore Cocuzza, Federica Maria Parisi, Bruno Cacopardo, Salvatore Lavalle, Luigi La Via

“…We focused on the most clinically significant MDR pathogens, regional differences in resistance, and the effectiveness of containment strategies. …”
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Identification of TMEM53 as a novel SADS-CoV restriction factor that targets viral RNA-dependent RNA polymerase by Yu-Lin Yao, Yun Luo, Qi Wang, Rong Geng, Ying Chen, Mei-Qin Liu, Bei Li, Jing Chen, Chun-Guang Wu, Jing-Kun Jia, Jing-Yi Luo, Yan-Tong He, Ting-Ting Jiang, Yan Zhu, Ben Hu, Peng Zhou, Zheng-Li Shi

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Emerging antibiotic resistance in bacterial bloodstream infections: a clinical study at the Holy Family Hospital, Nkawkaw, Ghana by John Gameli Deku, Israel Bedzina, Prince Kwadade Amankwah, Lilian Kekeli Antor, Kenneth Ablordey, Madrid Alhassan, Akatwum Emmanuel Salifu, Robert Awupoli, Arnold Togiwe Luuse, Enoch Aninagyei, Innocent Afeke, Kwabena Obeng Duedu

“…Abstract Background Bacteraemia, a critical bloodstream infection caused by various bacterial pathogens, poses significant health challenges, particularly when compounded by antibiotic resistance. …”
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Molecular landscape of respiratory infection: A large-scale, multi-centre blood transcriptome dataset by Tracy Chew, Tiana M. Pelaia, Amy L. Phu, Sally Teoh, Ya Wang, Nandan Deshpande, Karan Kim, Velma Herwanto, Gunawan, Thomas Karvunidis, Yoann Zerbib, Kirsty R. Short, Stephen Macdonald, Irani Thevarajan, Darawan Rinchai, Win Sen Kuan, Ben Knippenberg, Jonathan Iredell, Philip N. Britton, Owen Hutchings, Warwick J. Britton, John-Sebastian Eden, Sam Orde, Benjamin Tang, Anthony McLean, Damien Chaussabel, Klaus Schughart, Maryam Shojaei

“…Understanding the molecular mechanisms underlying the pathogenicity of these infections is crucial for developing effective interventions. …”
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Gestational diabetes mellitus alters neonatal gut microbiota and increases infection susceptibility by Yifei Hu, Shunjie Zheng, Jing Xu, Yufang Zhao, Jianbao Wang, Zenghui Fang, Lanfang Zhou

“…These findings suggest that GDM-induced alterations in neonatal gut microbiota composition and metabolite production may compromise intestinal barrier function and increase susceptibility to infections, highlighting the potential for microbiome-targeted interventions to mitigate infection risk in GDM-exposed neonates.…”
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Study of antifungal susceptibility pattern of various Candida species with reference to conventional and automated methods in a tertiary care hospital by Paulami De, Rehena Sarkar, Raja Ray, Kumkum Bhattacharyya, Hasina Banu, Hirak Jyoti Raj

“…Introduction: The incidence of Candida infections is on the rise with the increase in number of immuno-compromised patients due to excessive use of immunosuppressive drugs as well as the use of medical and surgical interventions. Materials and Methods: A cross-sectional observational study was conducted in a tertiary care hospital from February 2021- August 2022. …”
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Integrative analysis identifies IL-6/JUN/MMP-9 pathway destroyed blood-brain-barrier in autism mice via machine learning and bioinformatic analysis by Cong Hu, Heli Li, Jinru Cui, Yunjie Li, Feiyan Zhang, Hao Li, Xiaoping Luo, Yan Hao

“…Growing evidence implicates neuroinflammation-induced blood-brain barrier (BBB) dysfunction as a key pathogenic mechanism in ASD, although the underlying molecular pathways remain poorly understood. …”
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