The diagnostic potential of extracellular vesicles in virus-related diseases by Qing Gao, Qing Gao, Yuqing Zhan, Yuqing Zhan, Jianhao Zhang, Jianhao Zhang, Dongyu Sun, Dongyu Sun, Huayuan Xiang, Huayuan Xiang, Chenxuan Bao, Chenxuan Bao, Qianqian Gao, Mengyu Zhang, Jianjun Wang, Lingxiang Mao, Lingxiang Mao

“…Recent advances reveal their dual functionality in viral pathogenesis: while facilitating viral dissemination through transport of pathogenic components, they simultaneously orchestrate host antiviral defense mechanisms. …”
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Carbapenem-resistant Enterobacterales colonisation in a tertiary PICU, Cape Town, South Africa by Elri du Plooy, Angela Dramowski, Pieter Nel, Noor M. Parker, Helena Rabie

“…Background: Carbapenem-resistant Enterobacterales (CRE) are important healthcare-associated pathogens in resource-limited paediatric intensive care units (PICUs). …”
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Antimicrobial resistance of Staphylococcus spp. isolated from canine specimens submitted to a veterinary diagnostic laboratory in South Africa by Themba Titus Sigudu, James W. Oguttu, Daniel N. Qekwana

“…Conclusion: The high prevalence of AMR and MDR among canine Staphylococcus isolates, particularly in skin infections and among younger dogs, underscores the urgent need to strengthen antimicrobial stewardship, enhance surveillance systems, and target interventions in veterinary practice. These findings serve as critical baseline data for future assessments of AMR trends and can be used to inform strategies to mitigate the dissemination of resistant pathogens between animals and humans.…”
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Changes in Gut Microbiota and Serum Metabolites in Patients with Extreme Obesity by Libuša Kubáňová, Adela Penesová, Ivan Hric, Jana Babjaková, Eva Baranovičová, Marián Grendár, Viktor Bielik

“…Consequently, weight loss interventions and non-invasive manipulation of gut microbiota composition in these patients could offer a novel strategy for managing obesity and related disorders.…”
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Microbial alterations in the lungs of children with chronic pulmonary aspiration by Nadine Freitag, Tobias Wienemann, Thi Minh Thao Lea Nguyen, Thomas Höhn, Julia Kristin, Dirk Schramm

“…While the presence of mixed upper respiratory flora did not differ significantly between groups, pathogenic bacteria were more frequently detected in CPA patients. …”
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LDHB suppresses the PDCoV proliferation by targeting viral nucleocapsid protein for autophagic degradation by Xiaohan Wu, Shijin Lan, Ying Wang, Shixing Yang, Quan Shen, Xiaochun Wang, Yuwei Liu, Hongfeng Yang, Likai Ji, Wen Zhang

“…The findings not only expand our understanding of how PDCoV manipulates host cell pathways to its advantage but also open up new avenues for therapeutic interventions that could mitigate the impact of this and similar viral pathogens.…”
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The Global Challenge of Antimicrobial Resistance: Mechanisms, Case Studies, and Mitigation Approaches by Abubakar Nazir, Awais Nazir, Varisha Zuhair, Shafaq Aman, Safi Ur Rehman Sadiq, Abdul Haseeb Hasan, Maryam Tariq, Latif Ur Rehman, Mubarak Jolayemi Mustapha, Deusdedith Boniphace Bulimbe

“…Notably, resistance to last‐resort antibiotics (e.g., colistin, carbapenems) is rising in pathogens such as Klebsiella pneumoniae and Acinetobacter baumannii, with treatment failure rates exceeding 50% in some regions. …”
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Rift Valley fever virus and Coxiella burnetii infections among febrile patients, Eastern Ethiopia. by Dadi Marami, Adane Mihret, Nega Assefa, Alemseged Abdissa, Mahlet Osman, Gizachew Gemechu, Jacob S Witherbee, Adargachew Mulu, Rea Tschopp

“…However, the prevalence of these pathogens among febrile patients in Ethiopia remains unknown. …”
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Gut Microbiota Differences in Infants with Cow-Milk-Induced Allergic Proctocolitis: A Comparative Cross-Sectional Study by Zeliha Haytoglu, Dilek Ozcan, Derya Ufuk Altintas

“…Understanding its pathophysiology is crucial for microbiota-based interventions. <i><b>Methods</b></i>: We enrolled 32 exclusively breastfed infants—16 with confirmed cases of CMIAP and 16 age-matched healthy controls. …”
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Seroprevalence and risk factors of hantavirus and hepatitis E virus exposure among wildlife farmers in Vietnam. by Ha Thi Thanh Nguyen, Hu Suk Lee, Bernard Bett, Jiaxin Ling, Thang Nguyen-Tien, Sinh Dang-Xuan, Hung Nguyen-Viet, Fred Unger, Steven Lâm, Vuong Nghia Bui, Tung Duy Dao, Åke Lundkvist, Genevieve Cattell, Johanna F Lindahl

“…<h4>Conclusions</h4>This study highlights behavioural and environmental risk factors associated with wildlife farming and zoonotic pathogens exposure. Public health interventions should focus on biosecurity, proper hygiene practices, and risk communication to reduce the transmission in wildlife farming settings.…”
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Systematic Review and Meta-Analysis of the Efficacy and Safety Profile of Belimumab in Combination with Standard Therapy for Adults with Systemic Lupus Erythematosus by Mochamad Rangga Alif Dharmawan, Maftuchah Rochmanti, Awalia, Citrawati Dyah Kencono Wungu

“…Introduction: Systemic lupus erythematosus (SLE) is a multi-system autoimmune disorder marked by pathogenic autoantibodies, resulting in considerable morbidity and mortality. …”
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Social dynamics influencing cholera risk in the City of Goma, Democratic Republic of Congo: a qualitative study by Felicien Masanga Maisha, Ndemo Mumbere Mbasa, Kennedy Mumbere Ulikuwe, Serge Kahatwa, Connie J. Mulligan, J. Glenn Morris, Kevin Bardosh

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Percutaneous pedicle screw fixation in the surgical treatment of monosegmental pyogenic spondylodiscitis by Zhen-Zhong Chen, Ke-Jun Zhu, Bin Pan, Chao Lou, Wei-Yang Yu, Deng-Wei He

“…Results The mean duration of PPSF among all patients was 73.9 ± 13.9 min, with an average intraoperative blood loss of 52.4 ± 18.4 mL. Pathogenic bacteria were identified in 17 out of 38 cases, representing a detection rate of 44.7%. …”
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Aseptic Vertebral Body Necrosis in Unstable Traumatic Injuries of the Thoracolumbar Spine by Oleksii S. Nekhlopochyn, Vadim V. Verbov, Ievgen V. Cheshuk, Milan V. Vorodi

“…The data and proposed pathogenic mechanisms emphasize the importance of early stabilization for unstable injuries from both neurological and orthopedic perspectives.…”
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Bacterial profile and antimicrobial resistance patterns among pediatrics patients with suspected bloodstream infections in Ethiopia: a systematic review and meta-analysis by Bekele Sharew, Mihret Tilahun

“…The most frequently isolated pathogens were Klebsiella species (30.6%), coagulase-negative staphylococci (CoNS), and Staphylococcus aureus, with Gram-negative bacteria comprising 56.65% of isolates. …”
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Impact of a Heterozygous C1R^R301P/WT Mutation on Collagen Metabolism and Inflammatory Response in Human Gingival Fibroblasts by Chengjuan Qu, Cecilia Koskinen Holm

“…Periodontal Ehlers–Danlos syndrome arising from heterozygous pathogenic mutation in <i>C1R</i> and/or <i>C1S</i> genes is an autosomal-dominant disorder characterized by early-onset periodontitis. …”
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Evolution and taxonomic classification of human papillomavirus 16 (HPV16)-related variant genomes: HPV31, HPV33, HPV35, HPV52, HPV58 and HPV67. by Zigui Chen, Mark Schiffman, Rolando Herrero, Rob Desalle, Kathryn Anastos, Michel Segondy, Vikrant V Sahasrabuddhe, Patti E Gravitt, Ann W Hsing, Robert D Burk

“…Viral variants of these HPVs differ in evolutionary history and pathogenicity. Moreover, a comprehensive nomenclature system for HPV variants is lacking, limiting comparisons between studies.…”
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Impact of anthelminthic treatment in pregnancy and childhood on immunisations, infections and eczema in childhood: a randomised controlled trial. by Juliet Ndibazza, Harriet Mpairwe, Emily L Webb, Patrice A Mawa, Margaret Nampijja, Lawrence Muhangi, Macklyn Kihembo, Swaib A Lule, Diana Rutebarika, Barbara Apule, Florence Akello, Hellen Akurut, Gloria Oduru, Peter Naniima, Dennison Kizito, Moses Kizza, Robert Kizindo, Robert Tweyongere, Katherine J Alcock, Moses Muwanga, Alison M Elliott

“…<h4>Background</h4>Helminth infections may modulate immune responses to unrelated pathogens and allergens; these effects may commence prenatally. …”
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Differential approach to the diagnosis and treatment of appendicular peritonitis in children by I. Yu. Karpova, D. S. Strizhenok, D. A. Myasnikov, V. V. Parshikov, E. D. Pyatova, T. E. Potemina

“…Analysis of the results of bacteriological studies allowed us to identify the leading pathological pathogens belonging to Gram-negative or Gram-positive flora. …”
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Prevalence and Risk Factors of Hepatitis B and C Virus Co-Infection among Women Attending Antiretroviral Therapy Clinic in Yola, Nigeria by Maryam Adam Ibrahim1*, James Hamuel Doughari2

“…Women living with HIV are at heightened risk of coinfection with hepatitis B and C due to their increased risk of exposure to bloodborne pathogens through medical interventions, potentially leading to severe health outcomes, including increased morbidity and mortality, and public health impacts through maternal transmission. …”
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