Wetland-to-Meadow Transition Alters Soil Microbial Networks and Stability in the Sanjiangyuan Region by Guiling Wu, Jay Gao, Zhaoqi Wang, Yangong Du

“…Particularly, the collapse of methane-oxidizing archaea (−100%) and emergence of pathogenic fungi (+28.6%) highlight functional thresholds in degradation processes. …”
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An integrative analysis of functional consequences of PKD2 missense variants on RNA and protein structures: a computational approach by Chandra Devi, Prashant Ranjan, Parimal Das

“…It lays the groundwork in identifying high-impact variants in terms of pathogenicity and prioritizing these for further implications in understanding disease heterogeneity and eventually contributing to the development of targeted therapeutic interventions for ADPKD. …”
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Epigenetic Biomarkers and the Wnt/β-Catenin Pathway in Opisthorchis viverrini-associated Cholangiocarcinoma: A Scoping Review on Therapeutic Opportunities. by Alok Kafle, Sutas Suttiprapa, Mubarak Muhammad, Jan Clyden B Tenorio, Roshan Kumar Mahato, Norhidayu Sahimin, Shih Keng Loong

“…Considering the distinct etiological agent, pathogenic mechanisms, and pathological manifestations, epigenetic research plays a pivotal role in uncovering markers and potential targets related to the cancer-promoting and morbidity-inducing liver fluke parasite prevalent in the Great Mekong Subregion (GMS). …”
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Mendelian randomization and transcriptomic analysis reveal a positive cause-and-effect relationship between Alzheimer's disease and colorectal cancer by Wei Du, Xueming Xia, Qiheng Gou, Yan Qiu

“…The identification of COLEC11 as a potential link between AD and CRC offers new avenues for research and therapeutic interventions. These findings contribute to a deeper understanding of the interplay between neurodegenerative and oncologic diseases, highlighting the importance of exploring common pathogenic mechanisms.…”
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CARDIAL-MS (CArdio-Renal-DIAbetes-Liver-Metabolic Syndrome): a new proposition for an integrated multisystem metabolic disease by Amélio F. Godoy-Matos, Cynthia Melissa Valério, Wellington S. Silva Júnior, João Marcello de Araujo-Neto, Andrei C. Sposito, José Hermógenes Rocco Suassuna

“…This model emphasizes early interventions targeting adipose tissue health and ectopic fat deposition to mitigate the progression of metabolic cardiorenal diseases. …”
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Idiopathic epilepsy in dogs is associated with dysbiotic faecal microbiota by Marco Silvestrino, Mattia Pirolo, Angelica Bianco, Stefano Castellana, Laura Del Sambro, Viviana Domenica Tarallo, Luca Guardabassi, Andrea Zatelli, Floriana Gernone

“…Conclusions Idiopathic epileptic dogs exhibit dysbiosis, with reduced bacterial diversity, loss of beneficial genera, and overgrowth of opportunistic pathogens. These alterations in microbiota diversity and composition may contribute to epilepsy via the gut-brain axis, highlighting the need for further research to explore dietary or probiotic interventions targeting gut microbiota modulation as adjunctive therapies for managing epilepsy in dogs.…”
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Eye and bone involvement is not always osteogenesis imperfecta: unravelling the second case of spondyloocular syndrome from India by Ajaz Qadir, Ankit Chhabra, Shahid Ahmad Ganie, Mohd Rafi Mir

“…Whole-exome sequencing was subsequently performed, identifying a pathogenic variant, c.2401A > T(p.Thr801Ser), in exon 11 of the XYLT2 gene (NM_022167), which confirmed the diagnosis of spondyloocular syndrome. …”
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Quantitative multi-pathway assessment of exposure to Escherichia coli for infants in Rural Ethiopia. by Yuke Wang, Yang Yang, Crystal M Slanzi, Xiaolong Li, Amanda Ojeda, Fevi Paro, Loïc Deblais, Habib Yakubu, Bahar Mummed Hassen, Halengo Game, Kedir Teji Roba, Elizabeth Schieber, Abdulmuen Mohammed Ibrahim, Jeylan Wolyie, Jemal Yusuf Hassen, Gireesh Rajashekara, Sarah L McKune, Arie H Havelaar, Christine L Moe, Song Liang

“…However, understanding the specifics of when, where, and how young children in LMICs are exposed to enteric pathogens and the roles of animal reservoirs, environmental media, and human hosts play during exposure remains limited. …”
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Epidemiology of curable sexually transmitted infections among women at increased risk for HIV in northwestern Tanzania: inadequacy of syndromic management. by Suzanna C Francis, Trong T Ao, Fiona M Vanobberghen, Joseph Chilongani, Ramadhan Hashim, Aura Andreasen, Deborah Watson-Jones, John Changalucha, Saidi Kapiga, Richard J Hayes

“…<h4>Background</h4>Curable, non-viral pathogens account for a significant burden of sexually transmitted infections (STIs), and there is established evidence that STIs increase both HIV acquisition and transmission. …”
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Clinical and Laboratory Profiles of Rhinovirus-Infected Preschool Children: Identifying Risk Factors for Subsequent Asthma by Kunc P, Fabry J, Istvankova K, Neuschlova M, Pecova R

“…This personalized approach allows for more intensive medical surveillance and targeted therapeutic interventions in high-risk individuals, potentially improving the long-term outcomes.Keywords: rhinovirus, bronchial asthma, children, wheezing, atopy…”
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Visual analysis of research trends in diabetes-associated dry eye via bibliometrics by Zhe Yang, Jia-Yi Jiang, Xiao-Hui Zhang

“…Precisely the oxidative stress seemed to surge into the research spotlight presently. The key pathogenic mechanisms of DADE include inflammation, oxidative stress and corneal neuropathy, contributing to the development of dry eye symptoms. …”
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Knowledge, attitudes, and practices regarding malaria transmission and prevention in an indigenous Maijuna community: a qualitative study in the Peruvian Amazon by Kathryn M. Hogan, Michael Gilmore, Graziella P. McCarron, Brian M. Griffiths, Jeffrey W. Koehler, Guillermo A. García, Michael E. von Fricken

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Clinical research progress on pathogenesis and treatment of Patent Foramen Ovale-associated stroke by Wenyao Li, Jianjun Zhang, Yier Zhang, Yier Zhang, Wuyue Shentu, Sicheng Yan, Qiulu Chen, Song Qiao, Qi Kong

“…Furthermore, significant research progress has been made in elucidating the pathogenic PFO gene. Nonetheless, additional in-depth research is still required to better elucidate the precise mechanisms underlying PFO-AS. …”
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Prevalence, identification of virulence genes, and antibiotic resistance properties of Shiga-toxin producing Escherichia coli (STEC) strains isolated from ice cream and juice in sa... by Elyas Shahrivar, Ebrahim Rahimi, Faham Khamesipour

“…Results Among the 500 samples, 52 (10.42%) were E. coli positive, with the highest prevalence found in traditional juice (20%) and traditional ice cream (15%). The pathogenic subtype, particularly enterohemorrhagic E. coli (EHEC), was most common in traditional juice (75% of positive samples) and traditional ice cream (66.66%). …”
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Self-consistency and congruence, perceived social support, and psychological resilience as predictors of professional identity of male nursing students among consecutive secondary... by Li Ma, Li Ma, Xu Sun, Wei Zhou, Zhenpeng Lin, Anqi Li, Fanqun Kong, Yuchen Xue, Zhouyan Dong, Yulong Wu, Mei Cheng

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Biocontrol of Two Escherichia coli O157:H7 Strains and a Nonpathogenic Surrogate E. coli in Wheat Grains and Wheat Milling Operations Using a Lytic Bacteriophage Cocktail by Amit Vikram, Kristen McCarty, Mary T. Callahan, Joanne Sullivan, Alexander Sulakvelidze

“…These findings confirm that phage applications effectively reduce foodborne pathogens on wheat without compromising product quality.…”
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The impact of school water, sanitation, and hygiene improvements on infectious disease using serum antibody detection. by Anna N Chard, Victoria Trinies, Delynn M Moss, Howard H Chang, Seydou Doumbia, Patrick J Lammie, Matthew C Freeman

“…<h4>Background</h4>Evidence from recent studies assessing the impact of school water, sanitation and hygiene (WASH) interventions on child health has been mixed. Self-reports of disease are subject to bias, and few WASH impact evaluations employ objective health measures to assess reductions in disease and exposure to pathogens. …”
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Prevalence and associated factors of syphilis among female sex workers in East Africa: a systematic review and meta-analysis by Solomon Gedfie, Woldeteklehymanot Kassahun, Abdu Jemal, Muluken Gashaw, Alembante Bazezew, Marye Nigatie, Getinet Kumie, Tadesse Misganaw, Zewdu Tefera, Bewuketu Belete Alemu, Bahriew Mezgebu, Brhanu Kassanew, Ephrem Tamrat, Wagaw Abebe, Agenagnew Ashagre, Assefa Sisay, Yalewayker Gashaw, Melese Abate Reta, Melese Abate Reta

“…BackgroundSyphilis is the most common sexually transmitted infection caused by Treponema pallidum, a pathogen that is exclusive to humans. Syphilis is a highly treatable infection, but if left untreated, it can result in serious health complications, including adverse reproductive outcomes, diminished quality of life, and an increased risk of Human Immunodeficiency Virus (HIV) transmission. …”
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Anxiolytic Effects of <i>Cichorium intybus</i> L. Oligo-Polysaccharides by Modulating Gut Microbiota, Neuronal Signaling Pathways, and Neuroinflammation in Chronic Sleep Deprivatio... by Yongzhi Zhao, Yiwen Zhang, Yanqin Luo, Fang Chen, Meng Qiang, Mengchao Liu, Ruile Pan, Qi Chang, Ning Wang, Muhammad Wasim Usmani, Ning Jiang, Xinmin Liu

“…The 16S rRNA sequencing indicated that JSO intervention increased Bacteroidetes abundance while reducing Actinobacteria. …”
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Confirmation of Tuberculous Meningitis Using Metagenomic Next-Generation Sequencing: A Case Report by Liu C, Cai Y, Yuan K, Lu M, Deng Y, Chen X, Ye L, Cui S, Lyu J, Ling Y

“…Traditional diagnostic methods, such as smear microscopy and tuberculosis culture, often yield low positive rates, delaying timely diagnosis and intervention. Early detection, accurate diagnosis, and prompt treatment are crucial for improving patient outcomes. mNGS of CSF has proven to be a powerful tool in TBM diagnosis, enabling early and precise identification of the pathogen, thereby facilitating timely treatment and reducing TBM-related mortality.Keywords: tuberculous meningitis, metagenomic next-generation sequencing, diagnosis…”
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