Accessible viral metagenomics for public health and clinical domains with Jovian by Dennis Schmitz, Florian Zwagemaker, Sam Nooij, Thierry K. S. Janssens, Jeroen Cremer, Robert Verhagen, Harry Vennema, Annelies Kroneman, Marion P. G. Koopmans, Jeroen F. J. Laros, Miranda de Graaf

“…Comparison with a commercial online reference tool using viral gastroenteritis samples confirmed the identification of the same pathogens. Jovian provides comparable results to a commercially available online reference tool and generates identical results at different institutes with different IT architectures, proving it is portable and reproducible. …”
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Exploring the Impact of Chemotherapy on the Emergence of Antibiotic Resistance in the Gut Microbiota of Colorectal Cancer Patients by Mutebi John Kenneth, Chin-Chia Wu, Chuan-Yin Fang, Tsui-Kang Hsu, I-Ching Lin, Shih-Wei Huang, Yi-Chou Chiu, Bing-Mu Hsu

“…This toxicity triggers the bacterial SOS response and loss of microbial diversity, leading to bacterial mutations and dysbiosis. Consequently, pathogenic overgrowth and systemic infections increase, necessitating broad-spectrum antibiotics intervention. …”
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Association between guidelines and medical practitioners’ perception of best management for patients attending with an apparently uncomplicated acute sore throat: a cross-sectional... by Alastair D Hay, Mark H Ebell, Ronny Gunnarsson, Pär-Daniel Sundvall, Katarina Hedin, Hannelore Wächtler, Naveen Manchal, Lynne Reid, Stefan Malmberg, Sean Hawkey

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Surfactin from Bacillus subtilis enhances immune response and contributes to the maintenance of intestinal microbial homeostasis by Junpeng Jia, Mei Fu, Wenxin Ji, Ningna Xiong, Peng Chen, Jian Lin, Qian Yang

“…., has emerged as a promising bioactive compound due to its potent inhibitory effects on bacterial and viral pathogens. This showcases its potential as a non-antibiotic strategy for managing infectious diseases. …”
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Using Nano-Luciferase Binary (NanoBiT) Technology to Assess the Interaction Between Viral Spike Protein and Angiotensin-Converting Enzyme II by Aptamers by Meng-Wei Lin, Cheng-Han Lin, Hua-Hsin Chiang, Irwin A. Quintela, Vivian C. H. Wu, Chih-Sheng Lin

“…This interaction is crucial for viral entry and serves as a key target for therapeutic interventions against coronavirus disease 2019 (COVID-19). …”
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Targeting SARM1 as a novel neuroprotective therapy in neurotropic viral infections by Sheng He, Yanyan Zhu, Xinyue Wang, Gaofeng Zhang, Kaijian Hou, Xianzhu Xia, Zhenyou Jiang, Xiaoqian Gong, Pingsen Zhao

“…Consequently, these interventions ameliorated neuropathological damage and enhanced survival outcomes in mice. …”
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Profiling the Enterobacterales Community Isolated from Retail Foods in England by Richard Harding-Crooks, Amanda L. Jones, Darren L. Smith, Séamus Fanning, Edward M. Fox

“…Enterobacterales include foodborne pathogens of importance to public health and are often targeted in food surveillance programs as both safety and hygiene indicators. …”
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Molecular characterization of human respiratory syncytial virus strains circulating among hospitalized children in Jordan by Ashraf I. Khasawneh, Nisreen Himsawi, Ashraf Sammour, Hazem Abu Safieh, Salma Burayzat, Hafez Al-Momani, Moureq R. Alotaibi, Sofian Al Shboul, Tareq Saleh

“…All samples were screened for common viral and bacterial respiratory pathogens using PCR. A partial segment of the G gene of RSV was amplified for molecular characterization and phylogenetic tree analysis. …”
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Multidrug-Resistant Infections and Metabolic Syndrome: An Overlooked Bidirectional Relationship by Carlo Acierno, Riccardo Nevola, Fannia Barletta, Luca Rinaldi, Ferdinando Carlo Sasso, Luigi Elio Adinolfi, Alfredo Caturano

“…Over the past two decades, metabolic syndrome (MetS) and infections caused by multidrug-resistant (MDR) pathogens have emerged as converging global health challenges. …”
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Profiling the diversity of the village chicken faecal microbiota using 16S rRNA gene and metagenomic sequencing data to reveal patterns of gut microbiome signatures by Mxolisi Nene, Mxolisi Nene, Nokuthula Winfred Kunene, Rian Pierneef, Rian Pierneef, Rian Pierneef, Khanyisile Hadebe

“…Taxonomic profiles and functional gene annotations were derived, focusing on microbial diversity, antibiotic resistance genes (ARGs), and potential zoonotic pathogens.ResultsTaxonomic analysis showed that the predominant phyla in both provinces were Firmicutes, Bacteroidota, Proteobacteria, and Actinobacteria. …”
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Infectious diseases during pregnancy in Brazil: seroprevalence and risk factors by Galileu Barbosa Costa, Mário Cézar de Oliveira, Sandra Rocha Gadelha, George Rego Albuquerque, Marcel Teixeira, Monica Regina da Silva Raiol, Sandra Mara Bispo Sousa, Lauro Juliano Marin

“… Introduction: Vertically transmitted infections are caused by a diversity of pathogenic microorganisms. Pregnant women are routinely screened to evaluate the risks and reduce the burden of disorders in their unborn children. …”
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Prevalence and clinical impact of bacterial co-infection in chronic pulmonary aspergillosis by Fatma Tokgöz Akyıl, Sida Gösterici, Hülya Abalı, Derya Hırçın Cenger, Çiğdem Sabancı, Sinem Sökücü, Sedat Altın

“…The most common bacterial pathogens at diagnosis were Pseudomonas aeruginosa (n = 6), Klebsiella pneumoniae (n = 5), Escherichia coli (n = 4), and Serratia marcescens (n = 4). …”
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Distribution of vectors and arboviruses, and healthcare workers’ knowledge of vector-borne diseases in Armenia by Lilit Babayan, Arsen Manucharyan, Lusine Paronyan, Haykuhi Vardanyan, Ruben Danielyan, Gayane Melik-Andreasyan, Jenna E Achenbach

“…Methodology: In 2021, we conducted fieldwork, combining morphological identification of vectors with polymerase chain reaction (PCR) analysis of pathogens to map the distribution of potential arbovirus vectors across Armenia. …”
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Enterotype-stratified gut microbial signatures in MASLD and cirrhosis based on integrated microbiome data by Heng Yuan, Heng Yuan, Junyu Zhou, Junyu Zhou, Xuangao Wu, Shiwei Wang, Sunmin Park, Sunmin Park

“…Enterotype classification was performed using principal component analysis, with advanced bioinformatics tools, including Linear Discriminant Analysis Effect Size (LEfSe), eXtreme Gradient Boosting (XGBoost), and Deep Cross-Fusion Networks for Genome-Scale Identification of Pathogens (DCiPatho), to identify differentially abundant microbes and potential pathogens. …”
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Characterization of Salmonella adaptation in response to phage treatment in broiler chickens by Lorna Agapé, Pierrette Menanteau, Florent Kempf, Madeline Morinet, Marianne Nicolas, Olivier Boulesteix, Mickaël Riou, Isabelle Virlogeux-Payant, Catherine Schouler, Philippe Velge

“…Overall, our findings suggest that phage-induced evolutionary pressure may be harnessed not only to control bacterial populations but also to attenuate their pathogenicity. Therefore, bacterial resistance what is often view as a limitation of phage therapy may be leveraged as a functional advantage in phage cocktail design.…”
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Evaluating the effect of virgin coconut oil pulling on viral load, bacterial load and inflammatory mediator levels in chronic periodontitis – A clinical study by Monika M, Rudhra K, Vennila K, Elanchezhiyan, Sri Harini P, S. Shakeron

“…Chronic periodontitis is driven by a consortium of pathogenic microorganisms. This study aimed to evaluate the efficacy of virgin coconut oil (VCO) pulling in reducing the microbial load and inflammatory mediators responsible for chronic periodontitis, in comparison to chlorhexidine (CHX) mouthwash and distilled water. …”
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HLA alleles and dengue susceptibility across populations in the era of climate change: a comprehensive review by Amit Gourav Ghosh, Amit Gourav Ghosh, Hie Lim Kim, Hie Lim Kim, Hie Lim Kim, Seik-Soon Khor, Seik-Soon Khor

“…The Human Leukocyte Antigen (HLA) genes encode proteins essential for an effective immune response against pathogens, and their genetic variations influence susceptibility to severe dengue. …”
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Comparison of hospital- and community-onset central line associated bloodstream infections by Tuğba Yanık Yalçın, Ali Can, Alperen Sümer, Ahmet Habib Mert Satıcı, Ece Ceylan, Mehmet Cüneyt Narin, Ege Can Cılız, Nurefşan Tuba Kurt

“…BACKGROUND-AIM: Central venous catheters are one of the frequently used interventions in recent years. The aim of this study was to compare community-and hospital-onset central line associated bloodstream infections (CLA-BSI). …”
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Prevalence of Enterococcus faecalis and Candida albicans in endodontic retreatment Cases: A comprehensive study by Siddiq Ahmed, Sami Jehad Hassan, Shaiq Gajdhar, Lama Saleh Alhazmi, Rawan Yahya Khalifah, Juman Alhusain Alrifai, Shymaa Salem Aljhdali, Muazam Sheriff Maqbul

“…Microbiological analysis unveiled a significant prevalence of E. faecalis and C. albicans, establishing a robust association between these pathogens and retreatment failure. These findings underscore the critical need for targeted antimicrobial interventions to enhance the overall success rates of endodontic retreatment procedures. …”
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A human-induced pluripotent stem cell (iPSC) line (SMUSHi006-A) from an ALS patient carrying a mutation c.1126C > T in the FUS gene by Chunyan Huang, Liying Qiu, Wenyan Zhou, Congwen Shao, Xichun Wang, Qiwen Zhang, Weilin Chen, Min Xiong, Min Huang, Mei Tang, Liangyu Zou, Xueqing Xu

“…The objective of this study is to create another iPS cell line featuring the pathogenic c.1126C > T mutation in the FUS gene. This research aims not only to establish a disease model for ALS linked to FUS mutations but also to pave the way for potential therapeutic interventions.…”
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