Epidemiology of Burkholderia pseudomallei, Streptococcus suis, Salmonella spp., Shigella spp. and Vibrio spp. infections in 111 hospitals in Thailand, 2022. by Charuttaporn Jitpeera, Somkid Kripattanapong, Preeyarach Klaytong, Chalida Rangsiwutisak, Prapass Wannapinij, Pawinee Doungngern, Papassorn Pinyopornpanish, Panida Chamawan, Voranadda Srisuphan, Krittiya Tuamsuwan, Phairam Boonyarit, Orapan Sripichai, Soawapak Hinjoy, John Stelling, Paul Turner, Wichan Bhunyakitikorn, Sopon Iamsirithaworn, Direk Limmathurotsakul

“…Specific public health interventions are warranted.…”
Get full text

High mortality amongst adolescents and adults with bacterial meningitis in sub-Saharan Africa: an analysis of 715 cases from Malawi. by Emma C Wall, Katharine Cartwright, Matthew Scarborough, Katherine M Ajdukiewicz, Patrick Goodson, James Mwambene, Eduard E Zijlstra, Stephen B Gordon, Neil French, Brian Faragher, Robert S Heyderman, David G Lalloo

“…<h4>Unlabelled</h4>Mortality from bacterial meningitis in African adults is significantly higher than those in better resourced settings and adjunctive therapeutic interventions such as dexamethasone and glycerol have been shown to be ineffective. …”
Get full text

RNA Splicing Aberrations in Hereditary Cancer: Insights from Turkish Patients by Seda Kilic, Ozge Sukruoglu Erdogan, Seref Bugra Tuncer, Betul Celik Demirbas, Zubeyde Yalniz Kayim, Hulya Yazici

“…Three of the seven variants demonstrated no discernible effect on RNA, while four exhibited pathogenic characteristics. Specifically, the variants <i>APC</i> c.532-1G>A rs1554072547, <i>BRCA1</i>c.4358-3A>G rs1567779966, <i>BRCA2</i>c.7436-1G>C rs81002830 and <i>MSH3</i>c.1897-1G>A rs1744149615 were identified as pathogenic, while the variants <i>BLM</i>c.4076+4T>G rs183176301, <i>RB1</i>c.2489+2T>C rs1555294636 and <i>RB1</i>c.1050-2A>G rs? …”
Get full text

Metagenomic evaluation of food hygiene practices in the National School Nutrition Programme in KwaZulu Natal, South Africa by Sithembile S. Madlala, Nokuthula Mchunu, Monica Dalasile, Rian Pierneef, Poovendhree Reddy

“…Aim: To assess compliance of school kitchens with general hygiene requirements (R638 of 2018) and detect food pathogens on food contact surfaces using amplified metagenomics. …”
Get full text

Expanding the Clinical and Genetic Spectrum of Mitochondrial Short‐Chain Enoyl‐CoA Hydratase 1 Deficiency: Insights From Two Unrelated Chinese Families by Jihua Wu, Xuehui Hu, Zhongli Zhao, Zhen Zhao, Bin Yang

“…Methods This study aimed to investigate the clinical and genetic characteristics of ECHS1D in two unrelated Chinese families and identify novel pathogenic variants. Clinical and genetic data were collected, and whole‐genome sequencing was performed to identify pathogenic variants in the ECHS1 gene. …”
Get full text

Lipoprotein(a) and panvascular disease by Ruiyan Xu, Zhenwei Wang, Jiayu Dong, Miao Yu, Yue Zhou

“…This review systematically outlines the structure, genetic determinants, and pathogenic mechanisms of Lp(a), and synthesizes current clinical evidence regarding its role in various PVD subtypes. …”
Get full text

BLIS Fingerprinting as a Tool to Investigate the Distribution and Significance of Bacteriocin Production and Immunity in <i>Streptococcus pyogenes</i> and <i>Streptococcus salivari... by John R. Tagg, John D. F. Hale, Liam K. Harold

“…The potential for harnessing bacteriocin-producing streptococci in antimicrobial interventions, particularly in combating antibiotic-resistant pathogens, underscores the translational relevance of these findings. …”
Get full text

Management and outcome of whole-spine epidural abscesses – institutional case series and systematic review by Erik Schulz, Linda Bättig, Felix C. Stengel, Lorenzo Bertulli, Nader Hejrati, Maximilian Wegener, Carol Strahm, Benjamin Martens, Martin N. Stienen, Stefan Motov

“…Staphylococcus aureus was the most common pathogen (67 %). Five patients (10.4 %) received only conservative antibiotic treatment, primarily those with mild neurological deficits or severe comorbidities. …”
Get full text

Outer membrane vesicles in gram-negative bacteria and its correlation with pathogenesis by Fatemeh Sadat Abolhasani, Nasim Vaghefinanekaran, Aref Yarahmadi, Sousan Akrami, Solmaz Mirmahdavi, Solmaz Mirmahdavi, Mohammad Hasan Yousefi, Mohammad Hasan Yousefi, Mohammad Hasan Yousefi, Hamed Afkhami, Hamed Afkhami, Hamed Afkhami, Hamed Afkhami, Morvarid Shafiei

“…The illnesses they cause can be localized and systemic, and these bacteria possess several key virulence factors that contribute to their pathogenicity. In recent years, several distinct mechanisms of pathogenesis have evolved that remain largely unknown to scientists and medical experts. …”
Get full text

Grain-sized moxibustion activates dendritic cells to enhance the antitumor immunity of cancer vaccines by Weiming Shen, Dan Hu, Chenyuan Gong, Cheng Fang, Jiaojiao Luo, Lixin Wang, Chao Yao, Huangan Wu, Chen Zhao, Shiguo Zhu

“…Guided by the TCM principle of fu zheng qu xie (“fortify the host to dispel pathogens”), this study investigated whether gM augments cancer vaccine efficacy and validate the mechanistic basis of thermal acupoint stimulation in amplifying adaptive antitumor immunity. …”
Get full text

Gut-eye axis by Weixin Zheng, Mingzhi Su, Ningxi Hong, Panpan Ye

“…By elucidating the putative pathogenic mechanisms underlying these ocular conditions, we offer novel perspectives to inform future diagnostic and therapeutic interventions in ophthalmology. …”
Get full text

Oxidative Stress in People Living With HIV: Are Diverse Supplement Sources the Solution? by Esimebia Adjovi Amegashie, Ruth Oyawole Sikeola, Emmanuel Ayitey Tagoe, Elijah Paintsil, Kwasi Torpey, Osbourne Quaye

Get full text

Bloodstream infections at a tertiary hospital in the Gambia - a one-year retrospective study by Paul Rahden, Ebrima Barrow, Haddy Bah, Sheikh Omar Bittaye, David Nygren, Abdoulie Badjan

“…Blood culture positivity-rates and pathogens were described. Antimicrobial susceptibility testing was performed using disk diffusion following the Clinical & Laboratory Standards Institute guidelines. …”
Get full text

Mechanism of electroacupuncture treating detrusor-bladder neck dyssynergia after suprasacral spinal cord injury by proteomics by Liya Tang, Qirui Qu, Jincan Liu, Ming Xu, Lu Zhou, Qiong Liu, Kun Ai

“…Methods: A total of 52 specific pathogen-free (SPF) grade famale Sprague-Dawley (SD) rats (10 – 12 weeks, 250 – 280 g) were randomly assigned to either a sham group (n = 12) or a spinal cord injury model group (n = 40). …”
Get full text

Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances by Qiu Jiang, Jie Liu, Shan Huang, Xuan-Yue Wang, Xiaowei Chen, Guang-Hui Liu, Keqiang Ye, Weihong Song, Colin L. Masters, Jun Wang, Yan-Jiang Wang

“…Consequently, we propose that the prevention and treatment of neurodegenerative diseases should be grounded in holistic antiageing and rejuvenation means complemented by interventions targeting disease-specific pathogenic events. …”
Get full text

Stenosing Crohn’s disease patients display gut autophagy/oxidative stress imbalance by Leonardo Schirone, Maria Carla Di Paolo, Daniele Vecchio, Cristina Nocella, Alessandra D’Amico, Riccardo Urgesi, Lorella Pallotta, Gianfranco Fanello, Giuseppe Villotti, Maria Giovanna Graziani, Mariangela Peruzzi, Elena De Falco, Roberto Carnevale, Sebastiano Sciarretta, Giacomo Frati, Cristiano Pagnini

“…Our results highlight the importance of exploring the interactions between autophagy, the fibrotic process, and the inflammatory cascade, opening avenues for potential therapeutic interventions in CD management.…”
Get full text

Advancing lodging resistance in maize: Integrating genetic, hormonal, and agronomic insights for sustainable crop productivity by Shumila Ishfaq, Yi Ding, Xiaoyan Liang, Wei Guo

“…Concurrently, agronomic interventions, such as optimized planting density and nutrient management, have improved stem integrity and mitigated lodging risk. …”
Get full text

Whole Exome Sequencing Facilitates Early Diagnosis of Lesch–Nyhan Syndrome: A Case Series by Hung-Hsiang Fang, Chung-Lin Lee, Hui-Ju Chen, Chih-Kuang Chuang, Huei-Ching Chiu, Ya-Hui Chang, Yuan-Rong Tu, Yun-Ting Lo, Hsiang-Yu Lin, Shuan-Pei Lin

“…Results: All three patients had hyperuricemia, hypotonia, spasticity, and motor developmental delay. Pathogenic variants in the <i>HPRT1</i> gene were identified in two patients, while the third was confirmed by biochemical testing. …”
Get full text

IUPHAR themed review: The gut microbiome in schizophrenia by Srinivas Kamath, Elysia Sokolenko, Kate Collins, Nicole S.L. Chan, Natalie Mills, Scott R. Clark, Francine Z. Marques, Paul Joyce

“…Gut microbial dysbiosis or altered gut microbial consortium, in schizophrenia suggests a pathogenic role through the gut-brain axis, influencing neuroinflammatory and neurotransmitter pathways critical to psychotic, affective, and cognitive symptoms. …”
Get full text

Epigenetic Shifts in Preterm Neonatal Microbiome by Agnieszka Buliszak, Piotr Marcjasz, Anna Bioły, Monika Babczyńska, Agnieszka Borończyk, Piotr Zając

“…., bifidobacteria) are reduced, while pathogens (e.g., Staphylococcus, Enterobacteriaceae) increase, linked to NEC and sepsis. …”
Get full text