Exploration of shared pathogenic factors and causative genes in early-stage endometrial cancer and osteoarthritis by Yiyun Bai, Sang Luo, Ruzhen Shuai, Xiaomei Zhang, Liwei Yuan, Dan Liu

“…Abstract Osteoarthritis (OA) has been implicated in the development and progression of early-stage endometrial cancer (EC), suggesting shared pathogenic factors between the two diseases. This study aimed to investigate the causal relationship between OA and EC and to identify causative genes common to both early-stage EC and OA. …”
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Pathogenic variants identification in primary congenital glaucoma patients using whole exome sequencing by Shahzad Ahmad, Muhammad Saleem Gandapur, Musharraf Jelani, Anees Muhammad, Ihtisham Ul Haq, Yousaf Jamal Mahsood, Sajjad Ahmad, Wadi B. Alonazi, Nousheen Bibi, Muhammad Tahir Sarwar, Taj Ali Khan

“…Whole exome sequencing revealed four pathogenic homozygous variants in six PCG families. …”
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A Comparison of Causative Pathogens in Bone and Prosthetic Joint Infections: Implications for Antimicrobial Therapy by Annalise Unsworth, Bernadette Young, Matthew Scarborough, Martin McNally

“…<b>Conclusions</b>: Causative pathogens are similar across bone and joint infections and are independent of the presence of prosthetic material.…”
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A novel method for estimating pathogen presence, prevalence, load, and dynamics at multiple scales by John F. Grider, Bradley J Udell, Brian E. Reichert, Jeffrey T. Foster, William L. Kendall, Tina L. Cheng, Winifred F. Frick

“…Our findings demonstrate that accounting for pathogen load and prevalence at multiple scales changes our understanding of Pd dynamics, potentially allowing earlier conservation intervention. …”
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Application of Multimodal Anesthesia in Surgical Interventions for Lung Cancer by S. V. Kachur, V. T. Dolgikh, O. V. Korpacheva, O. V. Leonov

“…Objective. To prove pathogenically the reasonability of multimodal anesthesia in patients with lung cancer to improve the efficacy of pain management.Materials and methods. 74 patients (59 men and 15 women) aged 46 to 60 years with lung cancer were examined and treated. 42 patients (the main group) underwent surgery under multimodal anesthesia accompanied with epidural blockade, and 32 patients (the comparison group) were subjected to a surgical intervention under inhalation and intravenous anesthesia with mechanical ventilation. …”
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Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy by Su Zhang, Yang Meng, Lian Zhou, Lei Qiu, Heping Wang, Dan Su, Bo Zhang, Kui‐Ming Chan, Junhong Han

“…Abstract Emerging evidence indicates that resolution of inflammation is a critical and dynamic endogenous process for host tissues defending against external invasive pathogens or internal tissue injury. It has long been known that autoimmune diseases and chronic inflammatory disorders are characterized by dysregulated immune responses, leading to excessive and uncontrol tissue inflammation. …”
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Intervention strategies for Parkinson’s disease: the role of exercise and mitochondria by Ganggang Xu, Chunlian Ma, Chunlian Ma, Yi Yang, Yi Yang

“…Parkinson’s disease (PD), a progressive neurodegenerative disorder with complex pathogenic mechanisms, exhibiting rising prevalence alongside global population aging. …”
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Odyssey of environmental and microbial interventions in maize crop improvement by Alok Kumar Singh, Alok Kumar Singh, Alok Kumar Srivastava, Parul Johri, Manish Dwivedi, Radhey Shyam Kaushal, Mala Trivedi, Tarun Kumar Upadhyay, Nadiyah M. Alabdallah, Nadiyah M. Alabdallah, Irfan Ahmad, Mohd Saeed, Sorabh Lakhanpal

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Epidemiological and health economic implications of symptom propagation in respiratory pathogens: A mathematical modelling investigation. by Phoebe Asplin, Matt J Keeling, Rebecca Mancy, Edward M Hill

“…For parameters corresponding to three respiratory pathogens-seasonal influenza, pandemic influenza and SARS-CoV-2-we explored how symptom propagation impacted the relative epidemiological and health-economic performance of three interventions, conceptualised as vaccines with different actions: symptom-attenuating (labelled SA), infection-blocking (IB) and infection-blocking admitting only mild breakthrough infections (IB_MB). …”
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Lewy body dementia: exploring biomarkers and pathogenic interactions of amyloid β, tau, and α-synuclein by Jingfeng Liang, Rongzhen Li, Garry Wong, Xiaobing Huang

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Refining Unfavorable Vaginal Microbial Community in Infertile Women Subjected to Precision Probiotic Intervention: An Exploratory Single-Arm, Prospective, Open-Label, Interventiona... by Giovanna Cocomazzi, Viviana Contu, Silvia De Stefani, Lino Del Pup, Matteo Buccheri, Monica Antinori, Lodovico Parmegiani, Daniele De Ruvo, Francesco Marino, Edy Virgili, Christine Allen, Simone Palini, Walter Ciampaglia, Matteo Cerboneschi, Domenico Baldini, Giorgio Maria Baldini, Valerio Pazienza

“…Conclusions: Although CST-III and CST-IV are generally considered detrimental, gynecologists should not refrain from performing IVF in these women if they have been previously subjected to a consortium of precision probiotics treatments, as the administration of specific probiotics reduces the presence of pathogenic bacteria promoting the increase in lactobacilli associated with a healthy vaginal ecosystem, which could impact pregnancy success.…”
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The impact of a single HIIT intervention on the mobilization of NK cells and ILCs in adolescents and young adults (AYA) undergoing cancer treatment: an interventional controlled tr... by Isabella Deppe, Ronja Beller, Fabian Kiehl, Nico De Lazzari, Sabrina B. Bennstein, Dirk Reinhardt, Uta Dirksen, Miriam Götte

“…Blood was taken at three timepoints during the intervention. Once immediately before (T0), once immediately after the intervention (T1), and after one-hour of recovery (T2). …”
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Dual regulatory effects of gut microbiota and their metabolites in rheumatoid arthritis: balancing pathogenic and protective mechanisms by Xingwen Xie, Xingwen Xie, Xin Chen, Xuetao Wang, Sunli Wang, Peng Qi

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Exploring the c.406 C > T variant in TNNI3 gene: pathogenic insights into restrictive cardiomyopathy by Tannaz Masoumi, Hamed Hesami, Majid Maleki, Samira Kalayinia

“…Further studies are warranted to explore therapeutic interventions targeting TNNI3-related pathologies.…”
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Viral Pathogenic Spectrum and Epidemiological Characteristics of Febrile Rash Illness in China From 2009 to 2021 by Zhen Zhu, Naiying Mao, Xujing Chi, Pengbo Yu, Fangcai Li, Jianxing Wang, Binzhi Ren, Yingying Liu, Min Mu, Runan Zhu, Bing Zhao, Zhenguo Gao, Kongxin Hu, Aili Cui, Yan Zhang

“…EV, MV, RuV, and VZV were found to be the main causal pathogens of FRI among patients in China, and their epidemic levels and seasonal patterns changed during the COVID-19 pandemic, because of large-scale implementation of non-pharmacological interventions.…”
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Decoding the Bite: Sensory cues, host heterogeneity, and pathogen manipulation in mosquito host-seeking behavior by Ran Zhang, Rui Han, Shuairu Jiao, Xiuyun Wang, Guizhi Xu, Fanghang He, Chengsheng Peng, Qilong Wu, Shengqun Deng

“…Mosquito host preference exhibits plasticity, shifting due to host availability (e.g., bird migration for West Nile vectors) or interventions (e.g., bed nets). Understanding these mechanisms (sensory cues, host factors, pathogen manipulation, and plasticity) is vital for developing targeted interventions (personal protection, odor masking, housing modifications, and microbiota management) to reduce bites and disease transmission.…”
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Caught in the ESKAPE: Wildlife as Key Players in the Ecology of Resistant Pathogens in a One Health Context by Vanessa Silva, Sara Araújo, Manuela Caniça, José Eduardo Pereira, Gilberto Igrejas, Patrícia Poeta

“…Wildlife may act as both sentinels and reservoirs for resistant pathogens, contributing to their persistence and dissemination across ecosystems. …”
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Aerial remote sensing system to control pathogens and diseases in broccoli crops with the use of artificial vision by Darwin Laura, Elsa Pilar Urrutia, Franklin Salazar, Jeanette Ureña, Rodrigo Moreno, Gustavo Machado, Maria Cazorla-Logroño, Santiago Altamirano

“…The system's autonomous drone efficiently covered large crop areas, providing precise geolocation data for targeted interventions. The collected data, stored in a centralized database, facilitated continuous improvement of the detection algorithm, ensuring reliable pathogen control and maintaining high production quality.…”
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Prevalence and antimicrobial resistance of Salmonella and pathogenic E. coli in broiler farms, Wakiso district, Uganda. by Thomas Ssemakadde, Nalumaga Pauline Petra, Jude Collins Busingye, Joel Bazira, Kabanda Taseera

“…<h4>Results</h4>A total of 40 (18.5%) Salmonella and 120 (55.6%) pathogenic E. coli were isolated while extended beta-lactamase (ESBL) production was detected in 18 Salmonella and 57 pathogenic E. coli isolates. …”
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Combating Antibiotic Resistance: Mechanisms, Multidrug-Resistant Pathogens, and Novel Therapeutic Approaches: An Updated Review by Mostafa E. Elshobary, Nadia K. Badawy, Yara Ashraf, Asmaa A. Zatioun, Hagar H. Masriya, Mohamed M. Ammar, Nourhan A. Mohamed, Sohaila Mourad, Abdelrahman M. Assy

“…The escalating global health crisis of antibiotic resistance, driven by the rapid emergence of multidrug-resistant (MDR) bacterial pathogens, necessitates urgent and innovative countermeasures. …”
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