Development and validation of a multiple myeloma diagnostic model based on systemic lupus erythematosus-associated genes and identification of specific genes by Yuepei Liu, Songshan Liu

“…By identifying the shared pathogenic mechanisms between SLE and MM, our research offers new perspectives for future clinical interventions and personalized therapies.…”
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Network analysis used to investigate the symptoms of cancer patients during chemotherapy: a scoping review by Xiaodan Shao, Na Wang, Ke Tang, Kunning Wang, Zhangyan Tan, Jiangxiu Xie, Zhiwei Shen, Yuting Jiang, Yan Zhang

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Clinical characteristics, antimicrobial resistance, and mortality of neonatal bloodstream infections in Northern Tanzania, 2022-2023. by Ganga S Moorthy, Matthew P Rubach, Anna Sechu, Ronald Mbwasi, Nyemo Peter, Ibukunoluwa C Kalu, John A Crump, Dorothy E Dow, Blandina T Mmbaga, Aisa Shayo

“…BSI was defined as the isolation of established neonatal pathogens, including yeast and coagulase-negative Staphylococcus spp. …”
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Integrated Serosurveillance of Infectious Diseases Using Multiplex Bead Assays: A Systematic Review by Selina Ward, Harriet L. S. Lawford, Benn Sartorius, Colleen L. Lau

“…Integrated serological surveillance (serosurveillance) involves testing for antibodies to multiple pathogens (or species) simultaneously and can be achieved using multiplex bead assays (MBAs). …”
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Molecular characterization of clinical non-typhoidal Salmonella isolates shows high antimicrobial resistance burden in Jiangsu, China by Hui Cao, Hui Cao, Yun Shen, Kai Ma, Dongyu Zheng, Yan Xu, Yan Xu, Xin Qiao, Xin Qiao

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Biogenic Amine Metabolism and Its Genetic Variations in Autism Spectrum Disorder: A Comprehensive Overview by Claudio Tabolacci, Angela Caruso, Martina Micai, Giulia Galati, Carla Lintas, Maria Elena Pisanu, Maria Luisa Scattoni

“…Despite its increasing prevalence globally, the underlying pathogenic mechanisms of this complex neurodevelopmental disorder remain poorly understood. …”
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Genetic Evaluation of Global Developmental Delay in Children: A Series of Seven Cases by Pramila Gopal Menon, Renuka Majjigudda, Sneha Sagarkar, Parag Tamhankar, Shailaja Vijay Mane

“…In two instances, novel variants of likely pathogenic or uncertain significance were identified in seven genes involved in neurodevelopment and immunity. …”
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AI-Driven Innovations for Early Sepsis Detection by Combining Predictive Accuracy With Blood Count Analysis in an Emergency Setting: Retrospective Study by Tai-Han Lin, Hsing-Yi Chung, Ming-Jr Jian, Chih-Kai Chang, Hung-Hsin Lin, Chiung-Tzu Yen, Sheng-Hui Tang, Pin-Ching Pan, Cherng-Lih Perng, Feng-Yee Chang, Chien-Wen Chen, Hung-Sheng Shang

“…Current diagnostic methods, including clinical assessments and laboratory tests, frequently lack the speed and specificity needed for timely intervention, particularly in vulnerable populations such as older adults, intensive care unit (ICU) patients, and those with compromised immune systems. …”
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Structural and functional changes in the oral microbiome of patients with craniofacial microsomia by Tianying Zang, Zhiyong Zhang, Wei Liu, Lin Yin, Shanbaga Zhao, Bingyang Liu, Lunkun Ma, Zhifeng Li, Xiaojun Tang

“…Upregulated pathways were primarily linked to biotin and amino acid metabolism, such as Tryptophan metabolism and Lysine degradation, and further underscored the need for focused oral health interventions in this population. This study is the first to indicate that CFM patients exhibit unique oral bacterial dysbiosis, marked by a higher presence of opportunistic pathogens and increased pathways related to oral and systemic health. …”
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Genetic Testing as a Source of Information Driving Diagnosis and Therapeutic Plan in a Multidisciplinary Case by Cristina Grippaudo, Concetta Cafiero, Nicola Maria Grande, Leonardo Dassatti, Raffaele Palmirotta, Raffaella Castagnola, Gaetano Isola

“…The results for bacterial load showed the presence of periodontal pathogenes. The first intervention was the intentional replantation of the incisor. …”
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Gastrointestinal inflammation and cancer: viral and bacterial interplay by Valentina Arrè, Roberto De Luca, Stella Mrmić, Sofia Marotta, Stefano Nardone, Sandra Incerpi, Gianluigi Giannelli, Roberto Negro, Pankaj Trivedi, Eleni Anastasiadou

“…Understanding these interactions is essential for developing targeted interventions for infection-driven GI malignancies.…”
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Unilateral Palpebral Edema as a Central Sign of Acute Enterobacter-Associated Rhinosinusitis in a 5-Year-Old: A Rare Pediatric Case by Andrei Osman, Irina Enache, Alice Elena Ghenea, Alexandra Bucătaru, Sidonia Cătălina Vrabie, Ovidiu Mircea Zlatian

“…<b>Conclusions</b>: Unusual pathogens like <i>Enterobacter</i> spp. can cause acute sinusitis in children without prior risk factors. …”
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Heart on Fire: Unmasking 'RyR2' Mutation in Stress-Induced Ventricular Arrhythmias by Vaibhav Sharma, Vishakha Maheshwari, Thirugnanasambandam Thayumanavan, Akshat Sahai, Surender Singh, Biswajit Kar

“…Comprehensive genetic testing identified a pathogenic mutation in the RyR2 gene, confirming the diagnosis of CPVT. …”
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Titanium surface functionalization with calcium-doped ZnO nanoparticles for hard tissue implant applications by Komel Tariq, Nosheen Fatima Rana, Sabah Javaid, Muneeba Khadim

“…Studies have shown that the cost of managing orthopaedic implant infections can range from USD 30,000 to over USD 100,000 per case, depending on severity and required surgical interventions. One of the primary pathogens responsible for these infections is Staphylococcus aureus, known for its potential to make biofilms on the surfaces of implants. …”
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Systematic review of extracellular vesicle-derived microRNAs involved in organ fibrosis: implications for arthrofibrosis therapy by Venkateswaran Ganesh, Rui He, James A. Martin, Aliasger K. Salem, Edward A. Sander, Kyungsup Shin, Dongrim Seol

“…Previous research and clinical observations on fibrosis across organ systems suggest that there are commonalities in pathogenic mechanisms that can be targeted in arthrofibrosis therapy. …”
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Anti-perilipin-1 autoantibodies in autoimmune Addison’s disease and related endocrine disorders by Muhammad O. Rahman, Andre Sulen, Lars Breivik, Silke Appel, Mark S. Anderson, Bergithe E. Oftedal, Anette S. B. Wolff, Eystein S. Husebye

“…In conclusion, PLIN1-autoAbs are found in subgroups of autoimmune endocrinopathies and indicate autoimmunity against adipose tissue, but their pathogenic role if any, remains to be defined. Investigating their role in disease progression and their potential as therapeutic targets could pave the way for novel interventions in autoimmune endocrine diseases.…”
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The Functions and Implications of MicroRNAs in Premature Ovarian Insufficiency by Hui Gao, Xi‐Xia Cao, Hua Hua, Hui Zhu

“…Despite considerable research, the exact pathogenic mechanisms underlying POI remain unclear. …”
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HACCP and antibiotic resistance in dairy products: The Armenian experience by Lilit Malkhasyan, Susanna Mirzabekyan, Haykush Batikyan, Astghik Pepoyan

“…Five distinct resistance profiles were identified among non-pathogenic bacteria, and up to two phenotypically different resistant isolates were recovered from some samples. …”
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Blockade of IL-1 family cytokines in the treatment of rheumatoid arthritis by Kexin Wang, Kexin Wang, Haoge Luo, Liping Liu, Hang Gao, Yanyan Song, Dong Li

“…However, late-stage interventions exhibit diminished therapeutic returns, largely due to irreversible joint damage and compensatory activation of redundant cytokine networks. …”
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The impact of household hygiene on the risk of bacterial diarrhea among Egyptian children in rural areas, 2004–2007 by Khaled E Hassan, Adel Mansour, Hind Shaheen, Mohamed Amine, Mark S Riddle, Sylvia YN Young, Peter Sebeny, Samuel Levin

“…Adjusted relative risk (aRR) of developing bacterial diarrhea was calculated for exposure to different hygiene variables and examined for specific bacterial pathogens. Results: Exclusive breastfeeding reduced the risk of bacterial diarrhea by 70%, while bacterial diarrhea cases were 2.6 times higher in the warm season. …”
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