The impact of gut microbiome on neuro-autoimmune demyelinating diseases by Pouria Abolfazli, Cristina Nkene Apue Nchama, Brandon Lucke-Wold

“…Moreover, dysbiosis in MS involves more pathogenic bacteria and fewer beneficial taxa, further influencing disease progression. …”
Get full text

Growth Characteristics of Sheep-Derived <i>Bacteroides fragilis</i> and Preliminary Research on Effects in Mice and Lambs by Cheng Cheng, Jinye Du, Jianping Tao, Darong Cheng

“…In lamb trials, <i>Bacteroides fragilis</i> intervention stopped diarrhea in four out of five lambs, partially restored intestinal microbiota diversity, and reduced the abundance of potential pathogens such as <i>Aerococcus suis</i> and <i>Corynebacterium camporealensis</i>. …”
Get full text

Combining TNF-α silencing with Wnt3a overexpression: a promising gene therapy for particle-induced periprosthetic osteolysis by Ping Chen, Ping Chen, Long Wu, Shuai Zhang, Qunhua Jin, Kening Sun

Get full text

Prevalence and molecular insights into carbapenem resistance: a 2-year retrospective analysis of superbugs in South India by Rahul Harikumar Lathakumari, Leela Kakithakara Vajravelu, Jayaprakash Thulukanam, Dakshina M. Nair, Poornima Baskar Vimala, Vishnupriya Panneerselvam

“…Continuous surveillance and targeted interventions are vital to curbing the spread of CR-GNB in high-risk healthcare environments.…”
Get full text

Mastitis in goat: A review of etiology, epidemiology, economic impact, and public health concerns by Abebe Tibebu, Yechale Teshome, Habtamu Tamrat, Adane Bahiru

“…Dry period therapy and early interventions are the best options for mastitis treatment and control methods, while temporal milking stops can enhance immunity. …”
Get full text

Big Epidemiology: The Birth, Life, Death, and Resurgence of Diseases on a Global Timescale by Nicola Luigi Bragazzi, Thorsten Lehr

“…Modern genetic studies reveal the evolution and migration patterns of pathogens and human adaptations to diseases, offering insights into co-evolutionary dynamics. …”
Get full text

Vaccinia virus induces rapid necrosis in keratinocytes by a STAT3-dependent mechanism. by Yong He, Robert Fisher, Soma Chowdhury, Ishrat Sultana, Claudia P Pereira, Mike Bray, Jennifer L Reed

“…<h4>Rationale</h4>Humans with a dominant negative mutation in STAT3 are susceptible to severe skin infections, suggesting an essential role for STAT3 signaling in defense against cutaneous pathogens.<h4>Methods</h4>To focus on innate antiviral defenses in keratinocytes, we used a standard model of cutaneous infection of severe combined immunodeficient mice with the current smallpox vaccine, ACAM-2000. …”
Get full text

Successful treatment of extreme drug resistant Acinetobacter baumannii infection following a liver transplant by Muhammed Rasid Aykota, Tugba Sari, Sevda Yilmaz

“…Phosphomycin, used in combination therapy, may be an alternative in the treatment of XDR pathogens in organ transplant patients, due to its low side effect profile and lack of interaction with immunosuppressives. …”
Get full text

Risk factors of bloodstream infection after allogeneic hematopoietic cell transplantation in children/adolescent and young adults. by Daichi Sajiki, Hideki Muramatsu, Manabu Wakamatsu, Daiki Yamashita, Ryo Maemura, Yusuke Tsumura, Masayuki Imaya, Ayako Yamamori, Kotaro Narita, Shinsuke Kataoka, Rieko Taniguchi, Atsushi Narita, Nobuhiro Nishio, Yoshiyuki Takahashi

“…In patients receiving tandem HCT, the pathogens isolated from blood cultures were all gram-positive bacteria, with Streptococcus mitis/oralis accounting for up to 67% of the isolated pathogens. …”
Get full text

Tradition and Innovation in Raw Meat Products with a Focus on the Steak Tartare Case by Giovanni D’Ambrosio, Francesca Maggio, Annalisa Serio, Antonello Paparella

“…This review analyses the regulations, the safety, and technological advances in steak tartare manufacturing, focusing on microbiological risks due to potential contamination by pathogens like <i>Salmonella</i> spp., <i>Listeria monocytogenes</i>, and <i>Escherichia coli</i> O157:H7. …”
Get full text

Analysis of Complications and Risk Factors Other than Bleeding before and after Endoscopic Treatment of Esophagogastric Variceal Bleeding in Patients with Liver Cirrhosis by Xiaowei Duan, Xing He, Hezhong Yan, Haiqing Li, Jiaoxue Wang, Shicun Guo, Zhengwei Zha, Qianqian Zhang, Yuchuan Bai, Jiayi Zhang, Jun Tang, Derun Kong

“…Cirrhotic patients complicated with EGVB, who underwent interventional endoscopic treatments in our hospital from November 2017 to August 2020, were enrolled in this study. …”
Get full text

Viral Impact on Male Fertility: Current Insights and Implications for SARS-CoV-2 by Falah Hasan Obayes Al-Khikani

“…This review calls for increased awareness among healthcare providers, routine screening for viral pathogens in men presenting with infertility, and further research into the long-term effects of viral infections on male reproductive health. …”
Get full text

Epidemiological changes in Chlamydia pneumoniae molecular detections before, during and after the COVID-19 pandemic in 27 European sites and Taiwan, 2018 to 2023 by on behalf of the ESCMID Study Group for Mycoplasma and Chlamydia infections (ESGMAC)

“…Background During the COVID-19 pandemic, non-pharmaceutical interventions (NPIs) such as social distancing, lockdowns and enhanced hygiene led to a decrease in respiratory pathogens. …”
Get full text

Normal-Tension Glaucoma: Epidemiology, Pathogenesis, Diagnosis and Treatment. Literature Review. Part 2. Role of Vascular Dysregulation in the Pathogenesis. Treatment of Normal Ten... by N. I. Kurysheva, V. E. Kim, H. M. Plieva, V. Yu. Kim

“…Insufficient blood supply, vascular dysregulation, perfusion pressure and endothelial dysfunction may account for the pathogenic mechanism. OCT angiography (OCTA) measurements have been reported to be useful for glaucoma diagnostics. …”
Get full text

Aryl hydrocarbon receptor facilitates HSV-1 lytic infection by enhancing viral gene transcription and receptor expression by Pu Huang, Pu Huang, Xiaohong Pan, Hongli Chen, Hongli Chen, Mengyue Lei, Ying Ma, Xiaomei Guo, Xiaomei Guo, Jiaxin Xie, Jixiong Li, Jixiong Li, Jing Sun, Yunzhang Hu, Jiandong Shi, Jiandong Shi

“…Herpes simplex virus type 1 (HSV-1) is a major human pathogen with significant morbidity in neonates and immunocompromised individuals. …”
Get full text

Human respiratory organoids sustained reproducible propagation of human rhinovirus C and elucidation of virus-host interaction by Cun Li, Yifei Yu, Zhixin Wan, Man Chun Chiu, Jingjing Huang, Shuxin Zhang, Xiaoxin Zhu, Qiaoshuai Lan, Yanlin Deng, Ying Zhou, Wei Xue, Ming Yue, Jian-Piao Cai, Cyril Chik-Yan Yip, Kenneth Kak-Yuen Wong, Xiaojuan Liu, Yang Yu, Lin Huang, Hin Chu, Jasper Fuk-Woo Chan, Hans Clevers, Kwok Yung Yuen, Jie Zhou

“…Abstract The lack of a robust system to reproducibly propagate HRV-C, a family of viruses refractory to cultivation in standard cell lines, has substantially hindered our understanding of this common respiratory pathogen. We sought to develop an organoid-based system to reproducibly propagate HRV-C, and characterize virus-host interaction using respiratory organoids. …”
Get full text

Near-source wastewater surveillance of SARS-CoV-2, norovirus, influenza virus and RSV across five different sites in the UK. by Jay C Bullen, Mina Mohaghegh, Fatima Tahir, Charlotte Hammer, Jacob Sims, Frederico Myers, Lucas Eisinger, Ali Reza Kasmati, Claire F Trant

“…By tracking infectious diseases through sewage, municipal-scale wastewater surveillance has provided early warnings of future COVID-19 hospitalisations, identified biases in diagnostic testing, and is rapidly expanding to a broader array of pathogens. Despite applications in the targeted delivery of local interventions, near-source wastewater surveillance has received less attention and we know little about the near-source time series dynamics of contrasting pathogens. …”
Get full text

Heterogeneity of Checkpoint Inhibitor–Associated Pneumonitis: A Multicenter Study on Inflammatory Subtypes and Clinical Outcomes by Tingyue Luo, Tiantian Liu, Weisheng Chen, Wei Lei, Shuquan Wei, Yan Wang, Shudong Ma, Li Lin, Junjie Xi, Zeyu Fu, Jingze Guo, Qiang Xiao, Xiaodan Chang, Danhui Huang, Shifang Yang, Laiyu Liu, Shaoxi Cai, Hangming Dong

“…Methods This multicenter retrospective study included 113 CIP patients without pathogen infection, aiming to classify CIP based on peripheral blood immune cell percentages. …”
Get full text

Giardiavirus infection alleviates growth restriction and intestinal damage caused by the intestinal parasite Giardia duodenalis by Lu Li, Lili Cao, Qiankun Yang, Zhiteng Zhao, Jianqi Yuan, Shaoxiong Liu, Qinqin Jin, Jianhua Li, Xin Li, Xiaocen Wang, Nan Zhang, Weina Jiang, Pengtao Gong

“…Abstract Background Giardia duodenalis is a prevalent intestinal pathogen causing giardiasis, a condition characterized by diarrhea and frequently linked to malnutrition and growth impairments in children. …”
Get full text

Multi-omics driven biomarker discovery and pathological insights into Pseudomonas aeruginosa pneumonia by Zhiwei Lin, Mingshan Xue, Mingqing Lu, Shuang Liu, Yueting Jiang, Qianyue Yang, Honghui Cui, Xia Huang, Zeguang Zheng, Baoqing Sun

“…Our findings highlight the dual role of NETs in both pathogen containment and tissue damage, as well as the metabolic reprogramming required to sustain immune activity. …”
Get full text