Advancements in Viral Genomics: Gated Recurrent Unit Modeling of SARS-CoV-2, SARS, MERS, and Ebola viruses by Abhishak Raj Devaraj, Victor Jose Marianthiran

“…The proposed study sheds light on their evolutionary dynamics, transmission patterns, and pathogenicity and contributes to the development of effective diagnostic and therapeutic interventions. …”
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Metabolic Syndrome and Schizophrenia: Adding a Piece to the Interplay Between the Kynurenine Pathway and Inflammation by Jacopo Sapienza, Giulia Agostoni, Federica Repaci, Marco Spangaro, Stefano Comai, Marta Bosia

“…Numerous efforts have been made over the years to disentangle the heterogeneity of the disease, gradually leading to a more detailed understanding of its underlying pathogenic mechanisms. Two cardinal elements in the pathophysiology of schizophrenia are neuroinflammation and alterations of neurotransmission. …”
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Current scenario of viral diseases and vaccination strategies of cattle in Turkey by Aysun Yilmaz, Sajid Umar, Nuri Turan, Abdullah Kayar, Juergen A Richt, Huseyin Yilmaz

“… The dairy and meat industry has rapidly developed in the last decade in Turkey and is playing a key role in supplying animal proteins for human consumption. Viral pathogens continue to threaten the dairy and meat industry leading to serious economic losses worldwide, including Turkey. …”
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Fatal Case Report of Methylmalonic Acidemia: Reflections on Organic Acidemias in Colombia by Ana María Zarante Bahamon, Juan Sebastián Rincón Redondo, Sandra Navarro Marroquin, Dairo Jesús Cera Cabarcas, Juan Carlos Prieto Rivera

“…This report presents the case of a 4-month-old Colombian female with MMA, diagnosed through whole-exome sequencing, which identified compound heterozygous pathogenic variants in the MMUT gene: c.607G>A (p.Gly203Arg) and c.1420C>T (p.Arg474Ter). …”
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Case Report: Practice of whole-course pharmaceutical care: a case in hypertrophic cardiomyopathy and a review of the pharmacist’s role by Liu-Cheng Li, Liu-Cheng Li, Su Zhang, Jia-Bin Sun, Jia-Bin Sun, Yao-Yao Xu, Yao-Yao Xu, Kai-Li Mao

“…Whole-blood exon sequencing revealed a pathogenic mutation in the beta-myosin heavy chain gene (MYH7, OMIM #160760), consistent with dominant inheritance. …”
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Assessing the Effect of Viral Coinfection on Pneumonia Diagnosis Odds in Children and Adolescents with Influenza by Oliver Mendoza-Cano, Ana Daniela Ortega-Ramírez, Efrén Murillo-Zamora

“…Coinfections with multiple pathogens exacerbate respiratory infections. This study assessed the effect of coinfections on pneumonia diagnosis in this population. …”
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Targeting Cellular Senescence: Pathophysiology in Multisystem Age-Related Diseases by Jinxue Liu, Hongliang Yu, Yuanyuan Xu

“…This disruption of tissue homeostasis induced by cellular senescence manifests as characteristic pathogenic mechanisms in distinct disease contexts. …”
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Microbial dysbiosis in periodontitis and peri-implantitis: pathogenesis, immune responses, and therapeutic by Ziwei Cui, Peng Wang, Weiyue Gao

“…When the microbial homeostasis in the periodontium is disrupted, pathogens within the biofilm can cause periodontitis and peri-implantitis, inducing host immune responses. …”
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Mapping the immune landscape in South Asian post kala-azar dermal leishmaniasis by Madhurima Roy, Ritika Sengupta, Mitali Chatterjee

“…Interventions via targeted immunomodulatory therapies aiming to restore effective immune responses could provide promising therapeutic strategies for management of PKDL.…”
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DNA methylation biomarkers of intellectual/developmental disability across the lifespan by Janine M. LaSalle

“…DNA methylation-based epigenetic signatures are becoming clinically useful in categorizing benign from pathogenic genetic variants following exome sequencing. …”
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Harnessing beta-cell replication: advancing molecular insights to regenerative therapies in diabetes by Rupangi C. Vasavada, Sangeeta Dhawan

“…Diminished functional beta-cell mass is a key pathogenic mechanism underlying both type 1 and type 2 diabetes (T1D and T2D), precipitated by the progressive impairment of insulin secretion, loss of cellular identity, and ultimately, beta-cell death. …”
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The role of reactive oxygen species in severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection-induced cell death by Jiufeng Xie, Cui Yuan, Sen Yang, Zhenling Ma, Wenqing Li, Lin Mao, Pengtao Jiao, Wei Liu

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Pathophysiological and clinical significance of mineral homeostasis disorders in the development of cardiovascular disease by A. G. Kutikhin

“…Here, we critically discuss the pathophysiological consequences of CPP formation, mechanisms of their pathogenic effects, and potential therapeutic interventions.…”
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Recent Advances in Detection and Control Strategies for Foodborne Bacteria in Raw and Ready‐to‐Eat Fruits and Vegetables by Asem M. Abdelshafy, Hala A. Younis, Ahmed I. Osman, Saleh M. Hussein, Amr S. Abou El‐Ela, Elsayed A. Mahmoud, Osama Elsherbiny, Ahmed K. Rashwan

“…This article extensively explores recent advancements in the detection of foodborne pathogens in uncooked and ready‐to‐eat fruits and vegetables, alongside potential prevention strategies. …”
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Case Report: Hereditary spastic paraplegia associated with monoallelic variant in the motor domain of KIF1A by Kathryn Sine, David Brodie-Mends, Wafae Chouhani, Lauren Massingham, Lauren Massingham, Saud Alhusaini, Saud Alhusaini

“…KIF1A pathogenic variants are associated with several neurological phenotypes, most commonly HSP. …”
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Lomentospora prolificans synthesizes several types of melanin by Livia C. Liporagi-Lopes, Christine Chrissian, Emma Camacho, Arlind Kacirani, Ruth E. Stark, Arturo Casadevall

“…Melanins are biological compounds with important functions that contribute to the virulence of many pathogenic fungi. Like many fungi, L. prolificans produces melanin, but little is known about its structure and composition. …”
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COPD risk due to extreme temperature exposure: combining epidemiological evidence with pathophysiological mechanisms by Jiayu Xu, Guogang Xu, Zehua Liu, Ruoyu Hou, John S. Ji, Cunrui Huang

“…Combining population-level findings with biomedical mechanistic insights, we proposed a framework illustrating how biomarkers bridge the gap between extreme temperature exposure and COPD, highlighting the pathophysiological mechanisms of prodromal symptoms, key pathogenic processes and early molecular events. The mechanisms and biomarkers identified in this study would provide critical information for elucidating the causal pathways through which extreme temperatures increase COPD risk, and thus inform preventive interventions. …”
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Efficacy of a Novel Two-sided Drop-through Photonic Decontamination System on Salmonella and Campylobacter Reduction on Broiler Parts by Abigail D. McConnell, Montana R. Riggs, Shijinaraj Manjankattil, Sabin Poudel, Madalyn M. Jennings, Matthew B. Hughes, Laura Huber, Jinquan Wang, Ian Rawson, S. Srikumar, R. Jeff Buhr, Dianna V. Bourassa

“…Antimicrobial intervention procedures are important in poultry processing to minimize foodborne pathogen contamination on raw meat. …”
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Context-dependent change in the fitness effect of (in)organic phosphate antiporter glpT during Salmonella Typhimurium infection by Noemi Santamaria de Souza, Yassine Cherrak, Thea Bill Andersen, Michel Vetsch, Manja Barthel, Sanne Kroon, Erik Bakkeren, Christopher Schubert, Philipp Christen, Patrick Kiefer, Julia A. Vorholt, Bidong D. Nguyen, Wolf-Dietrich Hardt

“…The dichotomy showcases the need to study the spatial and temporal heterogeneity of enteric pathogens’ fitness across distinct lifestyles and niches. …”
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Role of inflammasomes in cancer immunity: mechanisms and therapeutic potential by Vivek Singh, Saba Ubaid, Mohammad Kashif, Tanvi Singh, Gaurav Singh, Roma Pahwa, Anand Singh

“…Abstract Inflammasomes are multi-protein complexes that detect pathogenic and damage-associated molecular patterns, activating caspase-1, pyroptosis, and the maturation of pro-inflammatory cytokines such as IL-1β and IL-18Within the tumor microenvironment, inflammasomes like NLRP3 play critical roles in cancer initiation, promotion, and progression. …”
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