Systematic analysis of genetic and phenotypic characteristics reveals antisense oligonucleotide therapy potential for one-third of neurodevelopmental disorders by Kim N. Wijnant, Nael Nadif Kasri, Lisenka E.L.M. Vissers

“…Abstract Background Neurodevelopmental disorders (NDDs) are a challenging group of disorders to treat, but promising therapeutic interventions in the form of antisense oligonucleotides (AONs) have emerged in recent years. …”
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Respiratory Microbiota and Health Risks in Children with Cerebral Palsy: A Narrative Review by Pavlina Peneva, Rouzha Pancheva, Silviya P. Nikolova

“…Future research should focus on longitudinal studies to track microbiota changes over time and identify interventions that optimize respiratory health in CP.…”
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Hematopoietic stem cell state and fate in trained immunity by Weinian Liao, Xiaodong Zai, Jun Zhang, Junjie Xu

“…It enhances resistance to pathogens and augments immunosurveillance under physiological conditions. …”
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Hereditary spastic paraplegia due to NIPA1 gene mutation: Case report by Dary Jizeth Parra-Párraga, Eugenia Espinosa-García

“…Conclusion: This is a rare case of complex HSP, associated with epilepsy, due to the mutation of the NIPA1 gene (SPG6), the most common pathogenic variant within this type of mutation. The present case demonstrates the importance of making an early diagnosis of GSP6 to perform timely interventions in these patients, prevent complications, and avoid a higher level of disability. …”
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Biomarkers in Systemic Sclerosis by Claudio Karsulovic, Lia Hojman

“…These biomarkers reflect diverse pathogenic mechanisms such as endothelial injury, fibroblast activation, immune signaling, and extracellular matrix remodeling. …”
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Fracture-Related Infection of the Proximal Femur – Diagnostics and Treatment by Moritz Riedl MD, Josina Straub MD, Nike Walter PhD, Susanne Baertl MD, Florian Baumann MD, Volker Alt MD, PhD, Markus Rupp MD

“…Antimicrobial therapy plays a pivotal role in FRI management, with empirical regiments targeting common pathogens and local delivery systems offering sustained antibiotic release. …”
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Beyond antibiotics: leveraging microbiome diversity to combat antimicrobial resistance by Ali Al-Kuwari, Hamad Al-Karbi, Abdulla Al-Khuzaei, Dounia Baroudi, Ghizlane Bendriss

“…This perspective paper calls for a shift in the approach to AMR, advocating for microbiome-based solutions as a sustainable alternative to traditional pharmaceutical interventions.…”
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Comparison of the antibacterial efficacy of 810 nm diode laser and photodynamic therapy in reducing microbial flora in patients with peri-implant mucositis – An in vivo study by Poonam Siwach, Reshu Sanan, Abhishek Nagpal, Omkar Krishna Shetty, Amit Bhardwaj, Mukesh Sharma

“…Conclusion: Within the limitations of the study, it can be concluded that there is a definitive reduction in pathogenic bacteria with both interventions and PDT offers clinically visible benefits in the treatment of peri-implant mucositis.…”
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Intra-specific variations in Schistosoma mansoni and their possible contribution to inconsistent virulence and diverse clinical outcomes. by Tim A Dannenhaus, Franziska Winkelmann, Cindy Reinholdt, Miriam Bischofsberger, Jan Dvořák, Christoph G Grevelding, Micha Löbermann, Emil C Reisinger, Martina Sombetzki

“…In contrast, the strains from Liberia and Belo Horizonte had a less pathogenic profile with less liver fibrosis. We found further variations in granuloma formation, cytokine expression and T-cell dynamics, indicating different immune responses.…”
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Strategies for the Prevention and Containment of Antibiotic Resistance by S.Y. Essack

“…Risk factors unique to South African communities (poverty, HIV) and hospitals (duration of hospitalisation, location within the hospital, intensive care unit stay, surgery, wounds, previous and current antimicrobial therapy, mechanical ventilation, urinary catherterisation, nasogastric intubation, central venous and peripheral catheters, previous hospitalisation and transfer from another unit or hospital) must be determined and due vigilance exercised in patients exhibiting classical risk factors for the acquisition of or colonisation with resistant pathogens. Hygiene and sanitation (in communities) and infection control (in hospitals) status must be determined and interventions initiated to prevent the spread of resistance. …”
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Prevalence and antimicrobial susceptibility profiles of Staphylococcus aureus from raw bovine milk in dairy and pastoral farms in Morogoro region, Tanzania by Nancy Kalee, Noel Gahamanyi, Abubakar Hoza

“…Of the 124 S. aureus isolates, 80 (64.5%) possessed spa gene, with 76/80(95.0%) being pathogenic. One of the S. aureus isolates, 1/124 (0.8%), harbored a mecA resistance gene. …”
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Spatial and seasonal dynamics of mosquito species in Harris County, Texas, highlight risk of arbovirus introduction and transmission by Morgan Jibowu, Maximea Vigilant, Andre Luis Costa-da-Silva, Alisa Nelson, Heather T. Essigmann, Eric L. Brown, Sarah M. Gunter

“…Notably, three of the five most abundant species are primary vectors of human pathogens, highlighting the urgent need for targeted interventions. …”
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Early Severe Cortical Involvement and Novel FUCA1 Mutations in a Pediatric Fucosidosis Case by Mar Jiménez de laPeña, Sara López‐Martín, Daniel Martín Fernández‐Mayoralas, Ana Laura Fernández‐Perrone, Ana Jiménez de Domingo, Pilar Tirado, Beatriz Calleja‐Pérez, Sara Álvarez, Jacobo Albert, Alberto Fernández‐Jaén

“…ABSTRACT Background Biallelic pathogenic variants in the FUCA1 gene are associated with fucosidosis. …”
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Mitochondrial Dysfunction in Atrial Fibrillation: The Need for a Strong Pharmacological Approach by Alfredo Mauriello, Adriana Correra, Riccardo Molinari, Gerardo Elia Del Vecchio, Viviana Tessitore, Antonello D’Andrea, Vincenzo Russo

“…Despite great progress in treating atrial fibrillation (AF), especially with the development of increasingly effective invasive techniques for AF ablation, many unanswered questions remain regarding the pathogenic mechanism of the arrhythmia and its prevention methods. …”
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Bioactive Sphingolipids, Complement Cascade, and Free Hemoglobin Levels in Stable Coronary Artery Disease and Acute Myocardial Infarction by T. Jadczyk, K. Baranski, M. Syzdol, E. Nabialek, W. Wanha, R. Kurzelowski, M. Z. Ratajczak, M. Kucia, B. Dolegowska, M. Niewczas, J. Zejda, W. Wojakowski

“…Acute myocardial infarction (AMI) and coronary artery bypass graft (CABG) surgery are associated with a pathogen-free inflammatory response (sterile inflammation). …”
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Enterovirus Detection Trends Based on Respiratory Specimens from a Single Tertiary Hospital in Korea (2018–2024): A Retrospective Study Using Multiplex PCR Data by Jeong Su Han, Sung Hun Jang, Jae-Sik Jeon, Jae Kyung Kim

“…Hence, EVs may act as atypical respiratory pathogens, underscoring the need for integrated public health surveillance and seasonal prevention strategies.…”
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Gut Microbiota Dysbiosis and Its Impact on Type 2 Diabetes: From Pathogenesis to Therapeutic Strategies by Yonghua Yu, Yilan Ding, Shuangyuan Wang, Lei Jiang

“…Additionally, we explore potential therapeutic strategies, including probiotics and dietary interventions, to modulate the gut microbiota and its metabolites, providing insights for future clinical research and the development of novel treatments for T2DM.…”
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Synergistic Effect of Combined Antibiotic and Methanolic Extracts of Withania somnifera and Catharanthus roseus against MDR Salmonella enterica Serovar Typhi by Neha Chauhan, Azhar Khan, Umar Farooq

“…The present study also suggests that in the future, combined treatment with the antibiotics and the bioactive compounds can enhance the immune system to perform better action against the external pathogens as well as in the treatment of internal pathogens, and the combinations will be the successful immune modulators.…”
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Clinico-epidemiological characteristics of the biliary samples and their antibiotic susceptibility pattern at a teaching hospital in Northern India by Mitra Kar, Akanksha Dubey, Romya Singh, Chinmoy Sahu, Sangram Singh Patel, Ankita Tiwari

“…Introduction: Bile is deemed a sterile fluid, with the presence of clinical conditions like cholelithiasis, cholecystitis, previous biliary interventions, biliary strictures, and so on, leading to bile stasis, and increases the chances of bacteriobilia. …”
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Features of a Systematic Approach to the Prevention of Healthcare-Associated Infections in the Russian Federation and abroad by M. A. Davydova, G. D. Bryukhanova, V. N. Gorodin

“…Health care-associated infections (HAIs) are one of the global problems of modern healthcare with a negative trend in the growth of this pathology throughout the world, which is due to a complex of reasons, among which the resistance of pathogens of hospital infections to antimicrobials is important, as well as gaps in organization of epidemiological surveillance due to a number of objective and subjective factors (complication of technologies and expansion of the practice of invasive medical interventions, turnover and shortage of personnel in medical institutions, etc.).The purpose of the work is to study the experience of organizing measures for the prevention of HCAI from the standpoint of a systematic approach in Russia and in foreign countries that have the best practices in this area. …”
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