Elucidating the Pathogenic Mechanism of Spinal Muscular Atrophy Through the Investigation of UTS2 by Xu Zhang, Liqi Yang

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RNA-binding proteins in ALS and FTD: from pathogenic mechanisms to therapeutic insights by Jens Rummens, Sandrine Da Cruz

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The pathogens and curative effects analysis of perianal abscess of infants under 3 months by Yimin Zhu, Fuying Xu

“… In order to guide clinical treatment for perianal abscess of young infants, the characteristics of pathogens and curative effects analysis were conducted. …”
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Unraveling the role of STAT3 in Cancer Cachexia: pathogenic mechanisms and therapeutic opportunities by Xinyi Lv, Xinyi Lv, Shengguang Ding

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Epidemiology, antimicrobial resistance, and risk factors of infection among liver transplant patients: a retrospective study 2010–2023 by Lei Liu, Zhongyi Jiang, Huanjin Liao, Zhiwei Xu, Yang Yu, Lin Zhong, Pusen Wang

“…Furthermore, pre-transplant interventions targeting reduction in jaundice could potentially mitigate the risk of post-transplant sepsis.IMPORTANCEThis study elucidates the recent pathogen spectrum associated with infections in liver transplantation and compares it with the pathogen spectrum from previous periods. …”
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Outbreak of Highly Pathogenic Avian Influenza in Commercial Poultry Farms, Kwahu-West Municipality, Ghana by Francis Sena Nuvey, Basil Benduri Kaburi, Esther Dsani, Pascal Kingsley Mwin, Eli Dzandu, Timothy Wekura, Joseph Kofi Abuh, Donne Kofi Ameme, Ernest Kenu

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Negative effects of lifespan extending intervention on resilience in mice. by Katelynn M Corder, Jessica M Hoffman, Anamarija Sogorovic, Youfeng Yang, Anisha Banerjee, Yi Sun, Michael B Stout, Steven N Austad

“…The challenges were: (1) anesthesia recovery, (2) restoration of hemoglobin levels after a blood draw, (3) speed of wound healing, and (4) survival after pathogen exposure. We evaluated how each changed with age and with interventions known to extend health in males only (17α-estradiol) or both sexes (calorie restriction). …”
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Communicating hydrocephalus following eosinophilic meningitis is pathogenic for chronic Viliuisk encephalomyelitis in Northeastern Siberia. by Alexander Storch, Jan Kassubek, Hayrettin Tumani, Vsevolod A Vladimirtsev, Andreas Hermann, Vladimir L Osakovsky, Vladimir A Baranov, Vadim G Krivoshapkin, Albert C Ludolph

“…<h4>Conclusions and significance</h4>Our data showed that pressure by the communicating hydrocephalus as a mechanical factor is the major pathogenic mechanism in chronic VE, most likely triggered by eosinophilic meningitis. …”
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Evaluation of pathogenicity islands in uropathogenic Escherichia coli isolated from patients with urinary catheters by Farzaneh Firoozeh, Leila Soleimani-Moorchekhorti, Mohammad Zibaei

“… Introduction: Uropathogenic Escherichia coli (UPEC), an important causative agent of urinary tract infections (UTIs), carries virulence factors which are clustered on pathogenicity islands (PAIs). The goal of this study was to characterize the PAIs among the UPEC isolated from patients with urinary catheters. …”
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Silent spread of pathogens in hospital settings: a one-week molecular epidemiologic study by Elif S Tanriverdi, Yusuf Yakupogullari, Deste Ceylan, Yucel Duman, Baris Otlu

“…Such data may indicate unnoticed breaks in infection control measures and guide in determining targeted interventions or reinforcements. The study aimed to analyze the clonal relatedness of pathogens isolated from HAIs during a period when the facility}'s HAI rate remained stable. …”
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Trends in Antimicrobial Resistance of Major Mastitis‐Causing Pathogens: A Nine‐Year Study by Amir Moradi, Behnam Bidarian, Fatemeh Mohammadian, Farideh Akbarian, Hamideh Kalateh Rahmani, Niloufar Tashakkori, Babak Khoramian

“…Conclusions This study highlighted key factors contributing to MDR in mastitis pathogens. The findings emphasised the complex nature of antimicrobial resistance and the necessity for tailored strategies—such as improved farm management, seasonal interventions, and targeted antimicrobial use—to effectively mitigate resistance.…”
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Microbiome-Based Interventions for Food Safety and Environmental Health by Blessing Oteta Simon, Nnabueze Darlington Nnaji, Christian Kosisochukwu Anumudu, Job Chinagorom Aleke, Chiemerie Theresa Ekwueme, Chijioke Christopher Uhegwu, Francis Chukwuebuka Ihenetu, Promiselynda Obioha, Onyinye Victoria Ifedinezi, Precious Somtochukwu Ezechukwu, Helen Onyeaka

“…Unlike traditional broad-spectrum approaches, these tools enable precise interventions, such as detecting foodborne pathogens and remediating polluted soils for safer agriculture. …”
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Co-detection of respiratory pathogens in children with Mycoplasma pneumoniae pneumonia: a multicenter study by Xiaoyan Dong, Rui Li, Yingxue Zou, Lina Chen, Hailin Zhang, Fangfang Lyu, Wenhao Yang, Yanhua Niu, Haojie Wang, Run Guo, Xu Wang, Li Li, Zihao Lin, Li Luo, Danli Lu, Quan Lu, Hanmin Liu

“…Severe cases were further subdivided into an MP alone group and a multi-pathogen co-detection group. Receiver operating characteristic (ROC) curve analysis was performed to assess the predictive performance of inflammatory biomarkers for multi-pathogen co-detection.ResultsA total of 266 children were enrolled. …”
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Biofilms by bacterial human pathogens:Clinical relevance - development, composition and regulation - therapeutical strategies by Adina Schulze, Fabian Mitterer, Joao P. Pombo, Stefan Schild

“…In this review we will focus on bacterial biofilms formed by human pathogens and high-light their relevance for diverse diseases. …”
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Progress in the pathogenic mechanism, histological characteristics of hereditary dentine disorders and clinical management strategies by Qing Xue, Zhina Wu, Yinuo Zhao, Xiaoxi Wei, Min Hu

“…In this review, we summarize the clinical features, pathogenic genes, histomorphological characteristics and therapy of hereditary dentine disorders. …”
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A Global Comparative Genomic Analysis of Major Bacterial Pathogens in Bovine Mastitis and Lameness by Szilvia Kusza, Zoltán Bagi

“…Our findings provide crucial insights into pathogen adaptation and host–microbe interactions, suggesting the need for region-specific intervention strategies. …”
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HOST/PATHOGEN INTERACTIONS AND THE ROLE OF THE BARRIERS: ON THE EDGE BETWEEN HEALTH AND MULTIFACTORIAL/COMPLEX DISEASES

“… Microbial agents, whether pathogens, pathobionts, or commensals, have a multifaceted role in the pathogenesis of multifactorial diseases, with a particular emphasis on immune cell activation, antigen recognition, and trafficking through distinct tissues’ barriers. …”
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Analysis of the Primary Pathogenic Bacteria in Abscess Disease of Musk Deer Using Metagenomic Approaches by Jingyao Hu, Xian An, Pengcheng Yang, Rongzeng Tan, Taoyue Chen, Jiatong Chen, Yifan Tao, Xuxin Li, Runbin Sun, Shouyun Zhang, Shuqiang Liu, Liangliang Yang

“…<i>Fusobacterium</i> and <i>Trueperella</i> were the main pathogenic bacteria responsible for the occurrence of abscess diseases in forest musk deer in this study. …”
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Utilizing Viral Metagenomics to Characterize Pathogenic and Commensal Viruses in Pediatric Patients with Febrile Neutropenia by Anielly Sarana da Silva, Gabriel Montenegro de Campos, Gabriela Marengone Altizani, Enéas de Carvalho, Alice Chagas Barros, Eleonora Cella, Simone Kashima, Sandra Coccuzzo Sampaio, Maria Carolina Elias, Marta Giovanetti, Carlos Alberto Scrideli, Svetoslav Nanev Slavov

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Immune dysregulation in ulcerative colitis: pathogenic mechanisms and therapeutic strategies of traditional Chinese medicine by Xudong Tang, Yilin Huang, Ying Zhu, Yin Xu

“…This article reviews the pathogenic mechanisms underlying immune dysregulation in UC and the advances in research on TCM’s role in immune regulation, anti-inflammatory repair, and flora modulation, encompassing the mechanisms of action of individual active ingredients and classic TCM compound formulas. …”
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