Rapid diagnostic testing combined with an immediate infectious disease consultation increases the rate of septic intensive care unit patients on targeted antibiotic therapy by Evelyn Kramme, Nadja Käding, Nadja Käding, Tobias Graf, Karolin Schmoll, Heidi Linnen, Katharina Nagel, Esther Grote-Levi, Susanne Hauswaldt, Dennis Nurjadi, Dennis Nurjadi, Jan Rupp, Jan Rupp, Jan Rupp

“…The control group underwent routine laboratory testing, and for the intervention group, RDT was applied with immediate ID consultation.ResultsIn 77 out of the 91 patients in the intervention group, the pathogen was identified by RDT. …”
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Signaling pathways and molecular mechanisms involved in the onset and progression of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CAD... by Parasta Heidari, Motahareh Taghizadeh, Omid Vakili

“…Pathogenic mutations alter the number of cysteine residues in the extracellular domain of NOTCH3, leading to the abnormal accumulation of granular osmiophilic material in the vessels of affected individuals. …”
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Effects of livestock related gender roles on pastoral children and their implication to RVF risk exposure by Irene N. Mutambo, Bernard Bett, Salome A. Bukachi

“…Abstract Background: Children in pastoral communities play a significant role in herding livestock, placing them at a high risk of exposure to zoonotic pathogens such as the Rift Valley fever (RVF) virus. …”
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Ubiquitination regulates autophagy in cancer: simple modifications, promising targets by Yihui Wu, Yifei Chen, Xianyan Tian, Genbao Shao, Qiong Lin, Aiqin Sun

“…Abstract Autophagy is an important lysosomal degradation process that digests and recycles bio-molecules, protein or lipid aggregates, organelles, and invaded pathogens. Autophagy plays crucial roles in regulation of metabolic and oxidative stress and multiple pathological processes. …”
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Engineered neutrophil, an emerging immune therapeutic strategy by Jingyi Wang, Teng Deng, Ruisi Chen, Lu Yang, Yan Teng, Junming Miao

“…Neutrophils play a pivotal role in the host immune system, serving as the frontline defense against microbial infections. They eradicate pathogens through diverse mechanisms, encompassing degranulation, phagocytosis, and the release of reactive oxygen species. …”
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Pulmonary lymphoid tissue induced after SARS-CoV-2 infection in rhesus macaques by Zhong-Min Ma, Katherine J. Olstad, Katherine J. Olstad, Koen K. A. Van Rompay, Koen K. A. Van Rompay, Smita S. Iyer, Smita S. Iyer, Smita S. Iyer, Christopher J. Miller, Christopher J. Miller, Christopher J. Miller, J. Rachel Reader, J. Rachel Reader

“…Pulmonary immunity plays a vital role against lung pathogens, including SARS-CoV-2 infection. Understanding the pathogenesis, including the development of local immune responses to infection, is fundamental for developing interventions to control the viral infection.MethodsUsing immunohistochemistry, we investigated the distribution of immune cells in the lungs of rhesus macaques experimentally infected with SARS-CoV-2 and euthanized 11–14 days later.ResultsTertiary lymphoid tissue was found in all SARS-CoV-2 infected animals. …”
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The reverse transsulfuration pathway affects the colonic microbiota and contributes to colitis in mice by Alain P. Gobert, Yvonne L. Latour, Kara M. McNamara, Caroline V. Hawkins, Kamery J. Williams, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Alberto G. Delgado, Ginger L. Milne, Shilin Zhao, M. Blanca Piazuelo, M. Kay Washington, Lori A. Coburn, Keith T. Wilson

“…We reported that CTH supports gastritis induced by the pathogen Helicobacter pylori. Herein our aim was to investigate the role of CTH in colonic inflammation. …”
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Understanding Post-Translational Modifications in Porcine Reproductive and Respiratory Syndrome Virus Infection by Xiaoyong Chen, Jianlong Zhang

“…This review highlights the significance of PTMs in shaping viral pathogenicity and host antiviral mechanisms and provides valuable insights for future research aimed at developing effective interventions against PRRSV infections.…”
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Virucidal Approaches for Hemorrhagic Fever Viruses by Raymond W. Nims, M. Khalid Ijaz

“…As each of these HFVs are large, lipid-enveloped RNA viruses, their susceptibilities to virucidal agents are informed by the so-called hierarchy of susceptibility of pathogens to microbicides. The unique susceptibility of lipid-enveloped viruses to most classes of microbicides is based on the common mechanisms of action of envelope-disrupting microbicides. …”
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A mini review of the pathogenesis of acute rheumatic fever and rheumatic heart disease by Shuting Zhuang, Danchun Guo, Dingle Yu

“…A central hypothesis is that autoimmune responses are triggered by molecular mimicry, but alternate pathogenic mechanisms are continuously being explored. …”
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Revealing the complexity of depression configurations in HIV-positive men who have sex with men: a fuzzy-set qualitative comparative analysis by Songli Mei, Chengbin Zheng, Leilei Liang, Jian Zhang, Marhaba Kiyum, Junsong Fei, Tongshuang Yuan, Huimin Wang, Jiaying Gao, Xiaoying Liu, Na Du

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The role of 6-phosphogluconate dehydrogenase in vascular smooth muscle cell phenotypic switching and angioplasty-induced intimal hyperplasia by Amy L. Lu, Li Yin, PhD, Yitao Huang, BS, Zain Husain Islam, Rohan Kanchetty, Campbell Johnston, Kaijie Zhang, MD, Xiujie Xie, PhD, Ki Ho Park, PhD, Charles E. Chalfant, PhD, Bowen Wang, PhD

“…Using gain-of-function (dCas9-mediated transcriptional activation) and loss-of-function (small interfering RNA-mediated) silencing, we were able to demonstrate the pathogenic role of 6PGD in driving VSMC hyperproliferation, migration, dedifferentiation, and inflammation. …”
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An AI-Based Digital Scanner for <i>Varroa destructor</i> Detection in Beekeeping by Daniela Scutaru, Simone Bergonzoli, Corrado Costa, Simona Violino, Cecilia Costa, Sergio Albertazzi, Vittorio Capano, Marko M. Kostić, Antonio Scarfone

“…However, honey bees face numerous threats, including exotic parasites, large-scale transportation, and common agricultural practices that may increase the risk of parasite and pathogen transmission. A major threat is the <i>Varroa destructor</i> mite, which feeds on honey bee fat bodies and transmits viruses, leading to significant colony losses. …”
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Postbiotics Regulate Intestinal Microbiota and Reduce Amyloid β-Protein Deposition in the Brain, Thereby Ameliorating Cognitive Impairment in Rats with Alzheimer’s Disease by XIAO Ling, TANG Linlin, SONG Xiaoyan, ZHANG Yihua, HAN Xuemei, LÜ Houjiao, LIANG Wu, WANG Yanping, GENG Weitao, JIA Longgang

“…At 1 h following the last injection and oral gavage, the intervention groups were orally administered with donepezil hydrochloride or postbiotics, whereas the Ctrl and AD groups were given an equivalent volume of normal saline. …”
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cGAS-STING Targeting Offers Novel Therapeutic Opportunities in Liver Diseases by Wang Y, Yang R, Cao Y, Li Y, Zhu Y, Zhang Z, Fleishman JS, Chen J, Ding M

“…John’s University, Queens, NY, 11439, USA; 3Department of Peripheral Vascular Intervention, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing, 100049, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Mingchao Ding, Department of Peripheral Vascular Intervention, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing, 100049, People’s Republic of China, Email dmc_zxl@vip.sina.com Joshua S Fleishman, Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. …”
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Microbiological Profiles, Antibiotic Susceptibility Patterns and the Role of Multidrug-Resistant Organisms in Patients Diagnosed with Periprosthetic Joint Infection over 8 Years: R... by Serban Dragosloveanu, Rares-Mircea Birlutiu, Bogdan Neamtu, Victoria Birlutiu

“…This study examines temporal patterns in pathogens isolated from prosthetic joint infection (PJI) cases and antimicrobial resistance patterns at a Romanian orthopedic center. …”
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Development and evaluation of a triplex real-time PCR assay for enhanced plague diagnostics in Madagascar. by Beza Ramasindrazana, Zoé A Rahalison, Philippe Gauthier, Guillain Mikaty, Zaina I Bodoarison, Lanto A Maminirina, Soloandry Rahajandraibe, Mamy G Randriamanantsoa, Gilbert Kayoko, Jean-Claude Manuguerra, Anne-Sophie Le Guern, Andriamiliharison J Rasamindrakotroka, Minoarisoa Rajerison

“…Rapid and accurate detection of this pathogen is essential for effective outbreak management and timely intervention. …”
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Monitoring of the dynamics of antimicrobial resistance among wounded in the conditions of armed conflict by L. K. Sorokoumova, A. A. Kozhokaru, S. Yu. Yaremin, О. І. Zhorniak

“…Bacteriological examination of biological material using Vitek-2 Biomerieux automated pathogen systems and classic, followed by determination of sensitivity using the disk-diffusion method. …”
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Systems Biology-Driven Discovery of Host-Targeted Therapeutics for Oropouche Virus: Integrating Network Pharmacology, Molecular Docking, and Drug Repurposing by Pranab Dev Sharma, Abdulrahman Mohammed Alhudhaibi, Abdullah Al Noman, Emad M. Abdallah, Tarek H. Taha, Himanshu Sharma

“…<b>Background:</b> Oropouche virus (OROV), part of the Peribunyaviridae family, is an emerging pathogen causing Oropouche fever, a febrile illness endemic in South and Central America. …”
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Functional immunopeptides: advancing prevention and therapeutic strategies against animal diseases by Aldryan Cristianto Pratama, Xudong Yin, Jinwei Xu, Fang He

“…These approaches utilize innovative functional immunopeptides—such as antigenic peptides, antimicrobial, immune modulation, and delivery peptides derived from pathogens or hosts—to target specific immune mechanisms. …”
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