Systemic Sclerosis Presenting as Osteomyelitis of the Finger: Physicians Must Maintain a High Index of Suspicion for Systemic Sclerosis when Evaluating Patients with Fingertip Ulce... by Logan Van Poucke, Jared B Hinton, Holly C Heck, Benjamin E Heck, Bruce E Heck

“…Introduction: Osteomyelitis is a serious bone infection commonly caused by bacterial pathogens, with Staphylococcus aureus being the most prevalent. …”
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Pathways to optimising antibiotic use in rural China: identifying key determinants in community and clinical settings, a mixed methods study protocol by Helen Lambert, Rui Feng, Jing Chai, Caroline Coope, Jing Cheng, Isabel Oliver, DeBin Wang, Alasdair MacGowan, Matthew Hickman, Christie Cabral, Linhai Zhao, Rachel Marie Kwiatkowska, Meixuan Chen, Karen Bowker, Jilu Shen, XingRong Shen, Paul Kadetz

“…Clinical isolates from 1550 sputum, throat swab and urine samples taken from consenting patients at village and township health centres will be analysed to identify bacterial pathogens and ascertain antibiotic susceptibilities. …”
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Bilateral neonatal suppurative parotitis: A case report and review of the literature by Marialida Farah, Mikhael Makhoul, Adib Moukarzel, Simon Rassi

“…A review of 80 reported cases revealed Staphylococcus aureus as the predominant pathogen, often linked to breastfeeding. This case underscores the critical importance of early diagnosis and tailored antibiotic therapy in managing NSP, which is essential for preventing complications and avoiding the need for surgical intervention.…”
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Microbial Influences on Amyotrophic Lateral Sclerosis: The Gut–Brain Axis and Therapeutic Potential of Microbiota Modulation by Victòria Ayala, Laia Fontdevila, Santiago Rico-Rios, Mònica Povedano, Pol Andrés-Benito, Pascual Torres, José C. E. Serrano, Reinald Pamplona, Manuel Portero-Otin

“…The potential changes in microbiota would sustain the rationale for therapeutic strategies such as probiotics, prebiotics, fecal microbiota transplantation (FMT), and dietary interventions. Results: ALS patients exhibit gut dysbiosis, characterized by reduced SCFA-producing bacteria and an increase in potentially pathogenic genera. …”
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Case Report: Novel truncating PPM1D variant in a dichorionic diamniotic (DCDA) twin with Jansen-de Vries syndrome. an updated perspective by Francisco Javier Merida De la Torre, Javier Porta Pelayo, Inmaculada Ortiz-Martín

“…Trio-whole-exome sequencing revealed a de novo frameshift mutation (c.1411_1412del) in PPM1D in the proband, classified as pathogenic. The brother had no such variant.Interventions and outcomesThe proband received multidisciplinary interventions including behavioral therapy and speech support. …”
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Induction of CD4 T cell memory responses following BCG vaccination in cattle by Haley M. Sterle, Haley M. Sterle, Ellie J. Putz, Steven C. Olsen, Paola M. Boggiatto

“…Mycobacterium bovis, the causative agent of bovine tuberculosis (bTB), is a zoonotic pathogen that contributes to economic losses in the cattle industry and poses a public health risk worldwide. …”
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Causal inference regarding infectious aetiology of chronic conditions: a systematic review. by Sofia Orrskog, Emma Medin, Svetla Tsolova, Jan C Semenza

“…<h4>Conclusions</h4>Prevention and treatment of these five pathogens lend themselves as effective public health intervention entry points. …”
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Accurate influenza forecasts using type-specific incidence data for small geographic units. by James Turtle, Pete Riley, Michal Ben-Nun, Steven Riley

“…Simple mechanistic models will likely improve forecast accuracy when applied at small spatial scales to pathogen-specific data before being scaled to larger geographical units and broader syndromic data. …”
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Assessment Of The Anti-Fungal Activity Of Trichoderma harzianum Against Seed-Borne Chickpea Ascochyta Blight Under Field Conditions by Qasim A Marzani, Kamalaldeen M. Fatah

“… Ascochyta rabiei (Pass.) Labr., the fungal pathogen that causes ascochyta blight, is a serious global danger to chickpea crops, especially in the Mediterranean and other colder, wetter climates. …”
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Serological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenya. by Mathew Muturi, James Akoko, Daniel Nthiwa, Bernard Chege, Richard Nyamota, Mathew Mutiiria, Josphat Maina, S M Thumbi, Mutono Nyamai, Samuel Kahariri, Rinah Sitawa, Joshua Kimutai, Wilson Kuria, Athman Mwatondo, Bernard Bett

“…We found 27.5% (95% CI: 19.5-35.5%) of the animals were seropositive for at least one pathogen and 13.3% (95% CI: 7.2-19.4%) were seropositive for at least two pathogens. …”
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In vivo expressed biologics for infectious disease prophylaxis: rapid delivery of DNA-based antiviral antibodies by Chasity D. Andrews, Yaoxing Huang, David D. Ho, Rachel A. Liberatore

“…Furthermore, the development of mAb cocktails can provide a faster route to developing a robust medical intervention than searching for a single, outstanding mAb. …”
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Current approaches to the ongoing challenges of mycotoxins in poultry diets: Understanding and combating mycotoxins for sustainable poultry production by Revathi Shanmugasundaram

“…Additionally, potential intervention strategies, including probiotics, mycotoxin deactivating enzymes, and mycotoxin binders, were discussed to mitigate mycotoxin impacts in poultry.…”
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Targeting Enterotoxins: Advancing Vaccine Development for Enterotoxigenic <i>Escherichia coli</i> ETEC by Josune Salvador-Erro, Yadira Pastor, Carlos Gamazo

“…This review explores the temporal and spatial coordination of ETEC virulence factors, focusing on the interplay between adherence mechanisms and toxin production as critical targets for therapeutic intervention. Advancements in molecular biology and host–pathogen interaction studies have uncovered species-specific variations and cross-reactivity between human and animal strains. …”
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Correlating Cleaning Thoroughness with Effectiveness and Briefly Intervening to Affect Cleaning Outcomes: How Clean Is Cleaned? by Robert Clifford, Michael Sparks, Eve Hosford, Ana Ong, Douglas Richesson, Susan Fraser, Yoon Kwak, Sonia Miller, Michael Julius, Patrick McGann, Emil Lesho

“…<h4>Conclusion</h4>At this facility, a minor intervention or minimally more aggressive cleaning may reduce pathogen-specific contamination, but not without unintended consequences.…”
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A scoping review on bio-aerosols in healthcare and the dental environment. by Charifa Zemouri, Hans de Soet, Wim Crielaard, Alexa Laheij

“…<h4>Background</h4>Bio-aerosols originate from different sources and their potentially pathogenic nature may form a hazard to healthcare workers and patients. …”
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Prevalence and transmission of Salmonella collected from farming to egg processing of layer production chain in Jiangsu Province, China by Chuang Meng, Fan Wang, Chen Xu, Bowen Liu, Xilong Kang, Yunzeng Zhang, Xinan Jiao, Zhiming Pan

“…Salmonella is a common foodborne pathogen found in poultry production systems. Contaminated poultry products are a major source of human salmonellosis. …”
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Contemporary Approach to Antibiotic Therapy of Urinary Tract Infection by M. V. Zhuravleva, S. K. Yarovoy, A. B. Prokofiev, N. G. Berdnikova, T. M. Ponomarenko, B. A. Rodionov, T. R. Kameneva, N. B. Lazareva, S. Yu. Serebrova, I. V. Sukhobrus

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Differential Regulation of the Immune Response in the Spleen and Liver of Mice Infected with Leishmania donovani by Rashmi Bankoti, Simona Stäger

“…Immunity to pathogens requires generation of effective innate and adaptive immune responses. …”
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Distinct virologic trajectories in chronic hepatitis B identify heterogeneity in response to nucleos(t)ide analogue therapy by Tingyan Wang, Cori Campbell, Alexander J. Stockdale, Stacy Todd, Karl McIntyre, Andrew Frankland, Jakub Jaworski, Ben Glampson, Dimitri Papadimitriou, Luca Mercuri, Erik Mayer, Christopher R. Jones, Hizni Salih, Gail Roadknight, Stephanie Little, Theresa Noble, Kinga A. Várnai, Cai Davis, Ashley I. Heinson, Michael George, Florina Borca, Louise English, Luis Romão, David Ramlakhan, Kerrie Woods, Jim Davies, Eleni Nastouli, Salim I. Khakoo, William Gelson, Graham S. Cooke, Eleanor Barnes, Philippa C. Matthews, Eleanor Barnes, Philippa C. Matthews, William Gelson, Graham S. Cooke, Salim I. Khakoo, Eleni Nastouli, Jim Davies, Kerrie Woods, Alexander J. Stockdale, Stephen Ryder, Ahmed Elsharkawy, Nicholas Easom, William Bernal, Shazaad Ahmad, Douglas Macdonald, Tingyan Wang, Cori Campbell, Simon Stanworth, Suzanne Maynard, Gail Roadknight, Stephanie Little, Kinga A. Várnai, Ben Glampson, Dimitri Papadimitriou, Luca Mercuri, Christopher R. Jones, Jakub Jaworski, Cai Davis, Florina Borca, Ashley Heinson, Michael George, Heidi MacNaughton, Yun Kim, Josune Olza Meneses, Louise English, Timothy Roberts, Luis Romão, David Ramlakhan, Stacy Todd, Heather Rogers, Karl McIntyre, Andrew Frankland, Hizni Salih, Theresa Noble, Lara Roberts, Finola Higgins, Javier Vilar, Ruth Norris, George Tilston, Ilina Serafimova, Sarah Montague, Juliette Verheyden, Irene Juurlink, Kathryn Jack, Alex Waldren-Glenn, Lizzie Poole, Victoria Day, Berit Reglar

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Extracellular vesicles: the “Trojan Horse” within breast cancer host microenvironments by Yue Kang, Ling’ao Meng, Shi Bai, Shenglong Li

“…This scholarly inquiry delves into the pathogenic mechanisms of EVs in breast cancer and delves into prospective therapeutic interventions, offering a groundwork for forthcoming precision-guided therapies tailored to breast cancer.…”
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