Heterogeneity in recombination rates and accessory gene co-occurrence distinguish Pseudomonas aeruginosa phylogroups by Samara T. Choudhury, Kathryn R. Piper, Manuela Montoya-Giraldo, Odion O. Ikhimiukor, Jeremy R. Dettman, Rees Kassen, Cheryl P. Andam

“…This genomic variation partly explains its remarkable ability to exhibit diverse ecological and phenotypic traits, and thus contribute to circumventing clinical and public health intervention strategies to contain it. Our results may help inform efforts to control and prevent P. aeruginosa diseases, including managing transmission, therapeutic efforts, and pathogen circulation in non-clinical environmental reservoirs.…”
Get full text

Occurrence and antimicrobial susceptibility of Salmonella enterica in milk along the supply chain, humans, and the environment in Woliata Sodo, Ethiopia by Seblewengel Ayichew, Ashagrie Zewdu, Bekele Megerrsa, Teshale Sori, Fanta D Gutema

“…The alarming multidrug-resistant strains limit treatment options and complicate pathogen control. To prevent transmission and spread of antimicrobial resistant pathogen, proper hygiene practices, public education, and antimicrobial stewardship are essential. …”
Get full text

A single nucleotide polymorphism produces different transcription profiles in Campylobacter jejuni’s cysM by Nereus W. Gunther IV, Siddhartha Kanrar, Aisha Abdul-Wakeel, Michael J. McAnulty, John Renye, Joseph Uknalis, Gaylen A. Uhlich

Get full text

Emergence of mcr-8.1-bearing MDR-hypervirulent Klebsiella pneumoniae ST307 by Jie Sheng, Rory Cave, Mary M. Ter-Stepanyan, Siyu Lu, Yingxiong Wang, Taihang Liu, Hermine V. Mkrtchyan

“…Our study emphasises the importance of genomic surveillance of this emerging MDR-hypervirulent pathogen to provide early interventions.…”
Get full text

Discovery of natural CdnP inhibitors through structure-based virtual screening and molecular dynamics simulations by Xiaoxia Gu, Chaohu Xiong, Xinyu Wang, Hucheng Zhu, Weiguang Sun, Yan He, Jinwen Zhang

“…CdnP (Rv2837c) functions as a bifunctional oligoribonuclease and 3′(2′)-phosphoadenosine 5′-phosphate-phosphatase that impedes host immune responses by recognizing bacterial cyclic dinucleotides such as c-di-AMP, which serve as pathogen-associated molecular patterns. Despite its significance, strategies targeting CdnP remain limited. …”
Get full text

Bifidobacterium spp. and their metabolite lactate protect against acute pancreatitis via inhibition of pancreatic and systemic inflammatory responses by Han Li, Jinyan Xie, Xiuliu Guo, Guilian Yang, Bin Cai, Jingtianyi Liu, Mengjia Yue, Yixin Tang, Gan Wang, Shuxian Chen, Jialin Guo, Xuchen Qi, Donghai Wang, Huijun Zheng, Wei Liu, Hong Yu, Chunfeng Wang, Shu Jeffrey Zhu, Feng Guo

Get full text

Beyond the lungs: pulmonary embolism in a teenager with mycoplasma pneumoniae pneumonia by Supriya Adiody, Vishnu Narayanan S

“…Abstract Mycoplasma pneumoniae, commonly referred to as Eaton’s agent, is a frequent respiratory pathogen capable of causing diseases that vary from mild infections of the upper respiratory system to serious cases of atypical pneumonia. …”
Get full text

The forecasting power of the mucin-microbiome interplay in livestock respiratory diseases by Núria Mach

“…One of the first lines of pathogen defense combines the respiratory tract mucus, a highly viscous material primarily composed of mucins, and a thriving multi-kingdom microbial ecosystem. …”
Get full text

Lymphadenitis caused by Legionella sainthelensi infection: a case report and literature review by Cangjian Zhang, Minlei Zhao

“…He was diagnosed with L. sainthelensi lymphadenitis, which was treated with azithromycin and lymph node puncture and drainage.ConclusionFor patients with Legionella lymphadenitis, multiple etiological tests should be performed as early as possible to confirm the infectious pathogen. Early intervention with appropriate intravenous antibiotics and lymph node drainage is critical to improve the cure rate.…”
Get full text

Adynamic ileus as an atypical manifestation of meningitis confirmed by metagenomic next-generation sequencing: A case report by Tonger Liang, Junjie Situ, Hanqiao Qin, Jia Peng

“…Early recognition and intervention are essential to improving outcomes in such complex presentations.…”
Get full text

Investigation of multi-drug resistant Candida auris using species-specific molecular markers in immunocompromised patients from a tertiary care hospital in Quetta, Pakistan. by Hira Ejaz, Muhammad Mushtaq, Shereen Khan, Nasir Azim, Abrar Hussain, Kaleemullah Kakar, Muhammad Zubair Khan, Ayisha Hafeez, Syed Moeezullah

“…<h4>Introduction</h4>Candida auris is an emerging multidrug-resistant pathogen responsible for nosocomial infections worldwide, characterized by high mortality rates and significant challenges in detection due to frequent misidentification. …”
Get full text

The cell autonomous and non-autonomous roles of itaconate in immune response by Chao Chen, Xinjian Li

Get full text

Investigating the effects of dietary and management modifications on Salmonella enterica population in harvest-ready beef cattle by Yesica Botero, Kasi Schneid, Kendall L. Samuelson, John T. Richeson, Ty E. Lawrence, Gizem Levent

“…However, the high-starch diet demonstrated potential as a pre-harvest intervention, reducing Salmonella prevalence by 0.20 (95% CIs 0.02–0.43) in cattle lymph nodes, which may help mitigate and control Salmonella risks in beef products.IMPORTANCESalmonella is a leading foodborne pathogen, causing numerous infections, hospitalizations, and deaths annually in the United States. …”
Get full text

Intraventricular Empyema Features of Surgery and Conservative’s Outcome: A Scoping Review by Farhad Balafif, Donny Wardhana, Tommy Nazwar, Mustofa Mustofa

“…Cerebrospinal fluid analysis is crucial, highlighting increased leukocyte counts and commonly implicated pathogens like gram-negative organisms and Streptococcus species. …”
Get full text

Using mechanistic models to highlight research priorities for tick-borne zoonotic diseases: Improving our understanding of the ecology and maintenance of Kyasanur Forest Disease in... by Richard M J Hassall, Sarah J Burthe, Stefanie M Schäfer, Nienke Hartemink, Bethan V Purse

“…Neglected zoonotic diseases can have significant impacts on poor and marginalised populations in low-resource settings but ultimately receive less attention and funding for research and interventions. As such, effective control measures and interventions are often hindered by a limited ecological evidence base, which results in a limited understanding of epidemiologically relevant hosts or vectors and the processes that contribute to the maintenance of pathogens and spillover to humans. …”
Get full text

Managing Drug-resistant Acinetobacter baumannii Infection in Premature Infants by Fu-Ruei Zeng, Chia-Ning Chang, Sheng-Yuan Ho

“…Acinetobacter baumannii is a major pathogen in neonatal intensive care units, particularly affecting extremely premature infants and posing challenges due to its extensively drug-resistant (XDR) or pan-drug-resistant (PDR) profiles. …”
Get full text

Development and evaluation of optimized PCR and indirect ELISA for the detection of Morganella morganii in dairy cows by Meihua Zhang, Jiayi Li, Jianfeng Xue, Huiling Xu, Muzi Li, Yibo Xia, Changxi Qi, Pu Zhang, Yongxia Liu, Jianzhu Liu

“…IntroductionMorganella morganii (M. morganii) is a Gram-negative opportunistic pathogen, whose increasing virulence and antibiotic resistance negatively impact dairy cow health and productivity, raising concerns in livestock health management. …”
Get full text

Prognostic Role of SETDB2 in Clear Cell Renal Cell Carcinoma: Linking Immune Infiltration, Cuproptosis, and Tumor Suppression by Lu SH, Lui K, Qian Y, Zhou WY, Mu YY, Zhang W

“…Si Hao Lu,1,&ast; Kui Lui,1,&ast; Yue Qian,2 Wei ye Zhou,3 Ying Ying Mu,4 Wei Zhang2,3 1Department of Nephrology, Air Force Hospital of Western Theater Command, Chengdu, 610000, People’s Republic of China; 2Department of Pathogen Biology, Guizhou Nursing Vocational College, Guiyang, Guizhou, 550000, People’s Republic of China; 3Cell Biology Department, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, 214122, People’s Republic of China; 4Department of Pathology, Zunyi Hospital of Traditional Chinese Medicine, Zunyi, Guizhou, 563000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Wei Zhang, Department of Pathogen Biology, Guizhou Nursing Vocational College, Guiyang, Guizhou, 550000, People’s Republic of China, Email lawrence2013@163.comBackground: Clear cell renal cell carcinoma (ccRCC) is a relatively frequently diagnosed form of urological cancer that is highly malignant and associated with high rates of patient mortality. …”
Get full text

Dietary Qiwenghuangbo powder–enriched Limosilactobacillus reuteri protects the intestinal epithelium and alleviates inflammation via a strain‐specific mechanism by Qian Xu, Lei Xue, Zhenhua Wu, Shuaishuai Kang, Jia Li, Yifan Wu, Yujun Wu, Jinbiao Zhao, Rujuan Wu, Huiyuan Lv, Junjun Wang, Dandan Han

“…Furthermore, out of three isolated L. reuteri, two strains could alleviate pathogen infection and intestinal inflammation, respectively. …”
Get full text

Research progress on immunometabolism and gut microbiota in cryptococcal meningitis: mechanisms and therapeutic implications by Sha Wen, Sha Wen, Sha Wen, Sha Wen, Mu Liu, Mu Liu, Mu Liu, Chengyu Pan, Chengyu Pan, Chengyu Pan, Linhai Zhang, Linhai Zhang, Linhai Zhang, Rong Yan, Rong Yan, Rong Yan, Zucai Xu, Zucai Xu, Zucai Xu

“…We propose a combined therapeutic strategy of “immunomodulators + metabolic inhibitors + microbiota intervention,” moving beyond traditional single-factor research paradigms to establish a multi-omics integrated framework for the precise treatment of CM—spanning molecular mechanisms to clinical translation—and propelling the field of neuroinfectious diseases towards a host-pathogen-microenvironment systemic regulation paradigm.…”
Get full text