Successful management of a multi-species outbreak of carbapenem-resistant organisms in Fiji: a prospective genomics-enhanced investigation and responseResearch in context by Tracey Young-Sharma, Courtney R. Lane, Rodney James, Mathilda Wilmot, Sanjeshni Autar, Kylie Hui, Aneley Getahun Strobel, Jake A. Lacey, Savneel Kumar, Ashlyn Datt, Alvina Lata, Donna Cameron, Norelle L. Sherry, Sisilia Genaro, Timaima Ditukana, Ilisapeci Nabose, Apaitia Goneyali, Elizabeth Bennett, Anisi Kavoa, Shammi Prasad, Alipate Vakamocea, Ana Suka, Prinika Prasad, Farheen Hussein, Chantel Lin, Adam WJ. Jenney, Kirsty Buising, Ravi Naidu, Benjamin P. Howden

“…Interpretation: Carbapenem-resistant pathogens pose a major threat to the health system in Fiji. …”
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Editorial: Interaction between virus and host cell: how do viruses cause cellular dysregulation? by Ahmed Mostafa, Ahmed Mostafa

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Successful Treatment of Lomentospora Prolificans Infection Following Allogeneic Hematopoietic Stem Cell Transplantation: A Case Report and Literature Review by Yang YH, Di C, Zheng H, Luo Y, Zhang AR, Su T, Mo XD, Sun YQ, Wang Y, Lv M

“…This pathogen poses a significant challenge in immunocompromised individuals, particularly patients with hematologic malignancies. …”
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Surgical Management of Septic Arthritis of the Wrist: An Analysis of Short- and Long-Term Functional and Clinical Outcomes by Yonca Steubing, Felix Reinkemeier, Flemming Puscz, Sonja Verena Schmidt, Jannik Hinzmann, Marcus Lehnhardt, Mehran Dadras

“…Data analysis examined correlations between comorbidities, surgical interventions and long-term outcomes. <i>Staphylococcus aureus</i> was identified in 61.4% of cases, thus being the most common pathogen. …”
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Experimental evidence rules out mosquitoes as vectors of Lyme disease by Miriama Pekľanská, Kateřina Kuníková, Romana Vlčková, Hana Slabová, David Hartmann, Karolina Volfová, Ivo Rudolf, Silvie Šikutová, Ryan O. M. Rego, Fernando Gabriel Noriega, Ondřej Hajdušek, Jan Perner, Jan Votýpka, Marcela Nouzová, Radek Šíma

“…Methods Mosquitoes (Aedes aegypti, Culex quinquefasciatus, and Culex pipiens biotype molestus) were fed on Borrelia-infected mice to assess pathogen acquisition. Additional experiments involved ex vivo feeding on Borrelia-enriched blood to examine spirochete persistence in the mosquito gut. …”
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Small but mighty: targeted antifungal liposomes of a smaller size are superior in treating cryptococcal meningitis by Tuyetnhu Pham, Peter Zhang, Suresh Ambati, Richard B. Meagher, Xiaorong Lin

“…In our previous work, we generated DectiSomes, dectin-decorated liposomes loaded with AmB that more effectively deliver the drug to the pathogen and enhance antifungal efficacy. However, the improvement in treating systemic cryptococcosis, compared with candidiasis and aspergillosis, is modest. …”
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Pilaralisib inhibits the replication of enteroviruses by targeting the PI3K/AKT signaling pathway by Jie Zhou, Yanping Wang, Guangyan Zhu, Mingzhe Yan, Zhengnan Li, Lin Li, Jingwen Kuang, Wenyuan Zhang, Chaolin Huang, Fuli Ren, Qingyu Yang

“…Abstract Enterovirus 71 (EV71) is a significant pathogen responsible for hand, foot, and mouth disease (HFMD), which poses a substantial public health concern, particularly in the Asia-Pacific region. …”
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Antiprotozoal agents – Integration of drug discovery, medicinal chemistry, and advanced computational approaches: An in-depth review by Aviral Kaushik, Naureenbanu Makarani, Krupanshi Bharadava, Jeetaram Gehlot, Bhukya Vishnu Naik, Ankita Singh, Sumit Govil, Radhey Shyam Kaushal

“…Challenges include limited healthcare access in endemic areas, inadequate NTD funding, adaptive pathogen evolution and an underdeveloped antiprotozoal drug pipeline. …”
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Tropical diseases and the gastrointestinal tract: an overlooked connection by Ramy Mohamed Ghazy, Ramy Mohamed Ghazy, Saleh Ahmed Alshaikhi, Hassan Ahmed Hassan Assiri, Adel Ahmed Almozaini, Abdullah Faisal Alhazmi, Heba Elsaeed Mohammed Elhasaneen, Sarah M. Abdo

“…BackgroundTropical infectious diseases continue to impose a significant public health burden, particularly in regions with poor sanitation, limited healthcare access, and favorable environmental conditions for pathogen transmission. Gastrointestinal (GI) involvement is a key clinical feature across many of these diseases, contributing significantly to global morbidity and mortality. …”
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Can a diet rich in Brassicaceae help control Helicobacter pylori infection? A systematic review by Sara Properzi, Fabrizio Stracci, Margherita Rosi, Chiara Lupi, Anna Villarini, Alessio Gili

“…Animal studies, cell line experiments, reviews unrelated to the research objectives, and studies on Hp-related gastric cancer were excluded.ResultsAvailable evidence indicates that Brassicaceae consumption exhibits the potential to reduce Hp colonization but achieving complete eradication of the pathogen remains challenging. Conflicting results regarding the efficacy of broccoli in Hp treatment emerge, with certain investigations suggesting limited effectiveness. …”
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Proteomic, metabolomic and lipidomic profiles in community acquired pneumonia for differentiating viral and bacterial infections by Samuel Rischke, Robert Gurke, Ann-Sophie Zielbauer, Nicole Ziegler, Lisa Hahnefeld, Michaela Köhm, Aimo Kannt, Maria JGT Vehreschild, Gerd Geisslinger, Gernot Rohde, Carla Bellinghausen, Frank Behrens, CAPNETZ Study group

“…Through comparison of the bacterial and viral pathogen groups, distinct signatures were observed in the plasma profiles. …”
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The Response Regulator OmpR Negatively Controls the Expression of Genes Implicated in Tilimycin and Tilivalline Cytotoxin Production in <i>Klebsiella oxytoca</i> by Ramón G. Varela-Nájera, Miguel A. De la Cruz, Jorge Soria-Bustos, Carmen González-Horta, Ma Carmen E. Delgado-Gardea, Jorge A. Yáñez-Santos, María L. Cedillo, Hidetada Hirakawa, James G. Fox, Blanca Sánchez-Ramírez, Miguel A. Ares

“…This research deepens our understanding of the mechanisms of toxigenic <i>K. oxytoca</i> and opens promising avenues for targeting OmpR for new therapeutic interventions. By focusing on this innovative approach, we can develop more effective solutions to combat this pressing health challenge, ultimately improving patient outcomes against this pathogen.…”
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The role of machine learning in infectious disease early detection and prediction in the MENA region: A systematic review by Radwan Qasrawi, Ghada Issa, Suliman Thwib, Razan AbuGhoush, Malak Amro, Raghad Ayyad, Stephanny Vicuna, Eman Badran, Yousef Khader, Raeda Al Qutob, Faris Al Bakri, Hana Trigui, Elie Sokhn, Emmanuel Musa, Jude Dzevela Kong

“…The findings reveal a predominance of deep learning approaches, particularly Convolutional Neural Networks (CNNs), achieving mean accuracy rates of 96.3 % in pathogen detection from medical imaging. Random Forest algorithms demonstrated superior performance in disease outbreak prediction, with mean ACC scores of 0.85. …”
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The Vaginal Microbiome: Associations with Vaginal pH, Menopause and Metabolic Parameters by Yi-Chun Chen, Yi-Fen Chiang, Ko-Chieh Huang, Kai-Lee Wang, Yun-Ju Huang, Tzong-Ming Shieh, Mohamed Ali, Shih-Min Hsia

“…Use of sodium–glucose cotransporter-2 (SGLT2) inhibitors in postmenopausal women was associated with a higher prevalence of protective CST-I + II (57.14% vs. 8.33%, <i>p</i> < 0.05), though no significant impact on pathogen presence was observed. This study highlights the dynamic interplay between menopausal status, metabolic interventions, and vaginal microbiota composition. …”
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Immunoregulation in Fungal Infections: A Review and Update on the Critical Role of Myeloid-Derived Suppressor Cells by Valéria de Lima Kaminski, Ana Luiza Oliveira Menezes, Kauan Gonçalves de Lima, Stephani Leonelo de Almeida, Diego Vinícius Alves da Silva, Filipe Nogueira Franco, Nycolas Willian Preite, Flávio Vieira Loures

“…Their recruitment is mediated by pathogen recognition receptors, particularly Dectin-1 and CARD9 signaling, which promote the production of reactive oxygen species (ROS) and IL-1β. …”
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Isolation and Determination of Antibacterial Sensitivity Characteristics of Staphylococcus aureus from Lactating Cows in West Shewa Zone, Ethiopia by Negassa Feyissa, Tesfaye Alemu, Dagim Jirata Birri, Asnake Desalegn, Melaku Sombo, Shubisa Abera

“…Therefore, research-based interventions need to be taken in action to combat the pathogen.…”
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Emerging role of N-acetyltransferase 10 in diseases: RNA ac4C modification and beyond by Lin Jiao, Yanjun Si, Yushan Yuan, Xinxing Lei, Qian Jiang, Lijun Yang, Wenhao Mao, Binwu Ying, Liwei Ma, Ting Sun

“…In infectious contexts, NAT10 influences sepsis progression and viral pathogenesis by stabilizing pathogen-related RNAs, while in cardiovascular diseases, it exacerbates myocardial injury and heart failure through ac4C-dependent and independent pathways. …”
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A rare waterborne outbreak of Bacillus paranthracis in Shandong province, China, 2020: epidemiologic survey, genomic insights, and virulence characteristics by Shuang Wang, Hengjie Xie, Lu Liu, Lei Du, Fang Yin, Yuzhen Chen, Ziqing Liu, Gaoxiang Sun, Xiaomei Zhang, Dapeng Sun, Ming Fang, Lixiao Cheng, Yanru Chen, Zengqiang Kou, Beiwen Zheng

“…The findings highlight the usefulness of B. paranthracis genomes in understanding genetic diversity within specific environments and in tracing the source of pathogens during outbreak situations, thereby enabling targeted infection control interventions.…”
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Quantification of Salmonella in Raw Poultry Using Droplet Digital PCR With a Whole Cell, Enrichment-free Approach by Cheryl M. Armstrong, Chin-Yi Chen, Yicheng Xie, Javier Atencia, Sophie Pierre, Yiping He, Joe Lee, Gretchen E. Dykes, Kathleen Johnson, Brice Froment, Sean Martinos, Joseph Capobianco

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Effectiveness of the use of immune complex vaccine “Novamune” in the prevention of Gamboro's disease in egg poultry farming by V. V. Marchenko, A. V. Kolechko

“…Therefore, today specialists face key questions, such as effectiveness against variations of a specific microorganism distributed in different parts of the world; compatibility between vaccines; increasing the resistance or preventing (reducing) the isolation and spread of the pathogen in the environment, which are of crucial importance for reducing the risk of the persistence of the pathogen or preventing the spread of the disease; influence or intervention of passive immunity, advantages of using one category of vaccines over others, etc.…”
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