398 Phage Wars: Uncovering the resistance strategies of Escherichia coli O157:H7 by Edwin Rivera-Lope, Rivera-Lopez Edwin Omar, Moriniere Lucas, Kazakov Alexey, Deutschbauer Adam, Arkin Adam, Mutalik Vivek, Dudley G. Edward

“…The discovery of novel antiviral mechanisms offers promising targets for phage-based interventions, potentially enhancing strategies for controlling this dangerous pathogen.…”
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Zika virus induces monocyte recruitment in the immunocompetent adult brain driving chronic inflammation by Josefina Garcia Diaz, Josefina Garcia Diaz, Soo-Jeung Park, Lou Legouez, Tina Comlekoglu, Ashley Beck, Chia-Yi Kuan, Young S. Hahn, Young S. Hahn

“…Zika virus (ZIKV) is a neurotropic pathogen linked to neuropathogenesis in adults, causing conditions such as Guillain-Barré syndrome (GBS) and fatal encephalitis. …”
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Hidden in plain sight: the impact of human rhinovirus infection in adults by Tommaso Morelli, Anna Freeman, Karl J. Staples, Tom M. A. Wilkinson

“…Understanding the scope of this impact is essential for developing new, targeted interventions and improving patient outcomes in the face of this persistent and adaptable pathogen.…”
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Quorum sensing in Porphyromonas gingivalis and oral microbial interactions: a scoping review by Zelda Ziyi Zhao, Wenwen Shan, Lifeng Guo, Chun Hung Chu, Jing Zhang, Jing Zhang

“…ObjectivePorphyromonas gingivalis, a major periodontal pathogen, interacts with other oral microbes through quorum sensing, enhancing its growth and virulence, which contributes to periodontitis. …”
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Unveiling the Kadaknath Gut Microbiome: Early Growth Phase Spatiotemporal Diversity by Amruta Nair, Swapnil Prakash Doijad, Mangesh Vasant Suryavanshi, Anwesha Dey, Satya Veer Singh Malik, Bas E. Dutilh, Sukhadeo Baliram Barbuddhe

“…These findings provide critical insights into age-specific microbiome development and early life-stage susceptibility to pathogens, emphasizing the need for targeted interventions to optimize poultry health management and growth performance.…”
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Genes linked to schistosome resistance identified in a genome-wide association study of African snail vectors by Tom Pennance, Jacob A. Tennessen, Johannie M. Spaan, Tammie J. McQuistan, George Ogara, Fredrick Rawago, Kennedy Andiego, Boaz Mulonga, Meredith Odhiambo, Martin W. Mutuku, Gerald M. Mkoji, Eric S. Loker, Maurice R. Odiere, Michelle L. Steinauer

“…Interruption of transmission will require novel vector-focused interventions. We performed a genome-wide association study of African snails, Biomphalaria sudanica, exposed to Schistosoma mansoni in an endemic area of high transmission in Kenya. …”
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Sufficient reproduction numbers to prevent recurrent epidemics by Lorenzo Mari, Cristiano Trevisin, Andrea Rinaldo, Marino Gatto

“…Our theoretical framework may thus have important implications for human and non‐human diseases caused by emerging pathogens. Additional applications may be found in population ecology, particularly for the containment of transient outbreaks of invasive species.…”
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Escherichia coli in the T11-12 Thoracic Vertebrae: A Case Report by Weng D, Zhou H, Huang G, Cao Q, Wang H, Cao Z, Xie Q

“…With the prompt computed tomography (CT)-guided percutaneous biopsy of the thoracic vertebrae, Escherichia coli was identified as the causative pathogen using metagenomic next-generation sequencing (mNGS). …”
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Occurrence, risk factors and antimicrobial resistance of Campylobacter from poultry and humans in central Ethiopia: A one health approach. by Fikre Zeru, Haileeyesus Adamu, Yohannes Hagos Woldearegay, Tesfaye Sisay Tessema, Ingrid Hansson, Sofia Boqvist

“…<h4>Background</h4>Campylobacter is a leading foodborne pathogen posing a significant One Health challenge due to broad animal reservoirs and serious antibiotic resistance. …”
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Macrophage Dysfunction in Tuberculosis–Diabetes Mellitus Comorbidity: A Scoping Review of Immune Dysregulation and Disease Progression by Simone E. Barry, Alice Sawka, Antonietta Maldari, Joseph Inauen, Sam LaBroome, James B. Geake

“…Among these dysfunctions, macrophages—the primary immune cells responsible for pathogen recognition, phagocytosis, and bacterial clearance—exhibit profound alterations in TB-DM. …”
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Factors associated with ovine footrot lesions in Uruguayan flocks: a cross-sectional study by Waldemir Santiago Neto, Ana Crescionini, Ludmila Slimovich, Caroline da Silva Silveira, Sofía Salada, Martín Fraga, Sergio Fierro

“…Ovine footrot has Dichelobacter nodosus as the primary pathogen, and it is characterized by its infectious and multifactorial nature, such as environmental conditions, management practices, and host susceptibility, leading to variable prevalence and economic impacts across regions. …”
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From Livestock to Companion: Admission Causes, Diagnostics, and Clinical Findings in Chickens Admitted to the Avian Clinic of the Vetmeduni Vienna, 2009–2019 by Cornelia Konicek, Anja Joachim, Joachim Spergser, Barbara Richter, Michaela Gumpenberger

“…It also underscores the role of various diagnostic tools, such as imaging, pathogen detection, and histopathology, in addressing the health challenges of backyard chickens.…”
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Tropical infections and the gut microbiome: dysbiosis, recovery, and clinical implications by Biruk Demisse Ayalew, Muhammad Umar, Muhammad Saeed, Ahtisham Ali, Kaleb Assefa Berhane, Temesgen Mamo Sharew, Yonatan Abbawa Zewdie, Eskeatnaf Yosef Getachew, Zemichael Getu Alemayehu, Abate Bane Shewaye

“…The gastrointestinal (GI) microbiome, crucial for host health through its roles in digestion, immunity, and pathogen protection, is significantly disrupted by tropical infections. …”
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Year-round infectome profiling of acute febrile respiratory illness unveiled complex epidemiological dynamics postlifting of COVID-19 restrictions by Shisong Fang, Lin Zhu, Shaohui Bai, Weijian Tian, Yuanfei Pan, Shumiao Zhang, Rongjun Bi, Minqi Liang, Gengyan Luo, Xiaojing Chen, Minwu Peng, Hanlin Liu, Lu Xie, Runzi Zhang, Wudi Zhou, Shengze Zhang, Ting Xie, Haolu Zha, Chuming Luo, Xin Wang, Ying Sun, Hui Liu, Min Jiang, Weihua Wu, Xuan Zou, Yaoqing Chen, Jianhui Yuan, Ying Jiang, Nan Wu, Mang Shi, Yuelong Shu, Huanle Luo

“…Notably, we detected certain enterovirus subtypes (e.g., Coxsackievirus A6 and Echovirus 30), previously overlooked pathogens (e.g., redondovirus), and rare pathogens like Streptococcus pseudopneumoniae. …”
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Microbial metabolites and immune modulation by Hassan Ghasemi

“…Microbial metabolites serve as molecular mediators, orchestrating immune homeostasis and modulating responses to pathogens, inflammation, and diseases.1,2 Understanding these interactions has opened new avenues for therapeutic interventions targeting immune-related disorders. …”
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Infective endocarditis caused by Streptococcus sinensis diagnosed with next-generation sequencing: a case report and literature review by Rong Wang, Bin Niu, Jiaolong Ren, Liaoyun Zhang

“…Despite multiple diagnostic attempts, including blood cultures, no causative pathogen was identified. Blood mNGS revealed the presence of S. sinensis, a rare pathogen associated with IE. …”
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A Novel Innate Immune-Enhancement Strategy Combined with IVIG Rescues Mice from Fatal Staphylococcus aureus Septicemia by Gowrisankar Rajam, Gabrielle M. Hammons, George M. Carlone, Jacquelyn S. Sampson, Edwin W. Ades

“…Staphylococcus aureus (SA) is a major community-acquired pathogen. The emergence of drug-resistant strains like, methicillin-resistant SA (MRSA), poses stiff challenges to therapeutic intervention. …”
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Livestock abortion surveillance in Tanzania reveals disease priorities and importance of timely collection of vaginal swab samples for attribution by Felix Lankester, Tito J Kibona, Kathryn J Allan, William de Glanville, Joram J Buza, Frank Katzer, Jo E Halliday, Blandina T Mmbaga, Nick Wheelhouse, Elisabeth A Innes, Kate M Thomas, Obed M Nyasebwa, Emanuel Swai, John R Claxton, Sarah Cleaveland

“…Livestock abortion is an important disease syndrome affecting productivity and public health. Several pathogens are associated with livestock abortions but across Africa surveillance data rarely include information from abortions, little is known about aetiology and impacts, and data are not available to inform interventions. …”
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Severe Acute Respiratory Infection—Preparedness: Protocol for a Multicenter Prospective Cohort Study of Viral Respiratory Infections by Radu Postelnicu, MD, Avantika Srivastava, MS, Pavan K. Bhatraju, MD, MSc, Mark M. Wurfelc, MD, PhD, George L. Anesi, MD, MSCE, MBE, Martin Gonzalez, MS, Adair Andrews, RN, MATD, Karen Lutrick, PhD, Vishakha K. Kumar, MD, MBA, Timothy M. Uyeki, MD, MPH, Perren J. Cobb, MD, Leopoldo N. Segal, MD, David Brett-Major, MD, MPH, Janice M. Liebler, MD, Christopher J. Kratochvil, MD, Vikramjit Mukherjee, MD, M. Jana Broadhurst, MD, PhD, DTM&H, Richard Lee, MD, David Wyles, MD, Jonathan E. Sevransky, MD, MHS, Laura Evans, MD, MSc, Douglas Landsittel, PhD, the Society of Critical Care Medicine Discovery Network Investigators

“…This can lead to interventions to mitigate the clinical impact of respiratory virus infections associated with SARI.…”
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Concurrent invasive disseminated Nocardia farcinica and Candida infections in a patient undergoing long-term glucocorticoid therapy for autoimmune thrombocytopenia: a case report by Naiju Zhang, Hehe Dou, Pu Guo, Jiangtao Sun, Fan Zhang, Tianping Chen, Chunming Gao, Zhenjie Wang

“…A variety of diagnostic testing, including metagenomics next-generation sequencing, can help to identify the pathogen rapidly. Drug susceptibility test can guide the selection and adjustment of antibiotics, which should be in companion with surgical interventions to save lives in affected patients.…”
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