Exploring the Microbial Landscape of Bone and Joint Infections: An Analysis Using 16S rRNA Metagenome Sequencing by Maimaiti Z, Liu L

“…This emerging diagnostic approach can enhance the accuracy and speed of pathogen identification, enabling more effective interventions in the management of BJIs.Keywords: bone and joint infections, 16S rRNA gene sequencing, microbial complexity, diagnostic tool, clinical management…”
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Evaluation of European severe acute respiratory infection (SARI) surveillance, 27 European countries, 2022/23 by Angela MC Rose

“…Background Between 2020 and 2023, ECDC has supported 21 of 30 EU/EEA and six Western Balkan countries by enhancing severe acute respiratory infection (SARI) surveillance to monitor trends, detect unexpected events, evaluate public health interventions, identify risk factors and support vaccine effectiveness studies. …”
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Case Report: Mycoplasma pneumoniae-induced rash and mucositis in a child by Xiaoying Mo, Meihua Wang, Xue Jiang, Li Jin, Li Jin

“…RationaleMycoplasma pneumoniae (MP) is a common pathogen responsible for pediatric community-acquired pneumonia. …”
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Pentamidine inhibition of streptopain attenuates Streptococcus pyogenes virulence by Keya Trivedi, Christopher N. LaRock

“…ABSTRACT The obligate human pathogen Streptococcus pyogenes (also known as GAS; Group A Streptococcus) carries high morbidity and mortality, primarily in impoverished or resource-poor regions. …”
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Integrated evaluation of lung disease in single animals. by Pratyusha Mandal, John D Lyons, Eileen M Burd, Michael Koval, Edward S Mocarski, Craig M Coopersmith

“…Pulmonary failure in SARS-CoV2-infected hospitalized COVID-19 patients is one such prominent example. Intervention strategies require characterization of the host-pathogen interaction by accurately assessing all of the above-mentioned disease parameters. …”
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Uniportal endoscopic decompression and debridement for infectious diseases of spine with neurological deficits: a retrospective study in China by Hui Lv, Jianhong Zhou, Yuan Guo, Sheng Liao, Hui Chen, Fei Luo, Jianzhong Xu, Zhongrong Zhang, Zehua Zhang

“…UEDD offers a dual therapeutic-diagnostic advantage during the initial admission phase, enabling simultaneous debridement, neurological decompression, and targeted biopsy in a single intervention. Compared with traditional tissue culture, mNGS enables rapid microbiological diagnosis and extensive pathogen coverage.…”
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Clinical presentation, treatment, and antimicrobial susceptibility of 155 sequential Staphylococcus lugdunensis infections by Kurt D. Palumbo, Natasia F. Jacko, Michael Z. David

“…The findings also improve upon our understanding of the incidence of each infection syndrome and variability in antimicrobial susceptibilities of isolates to guide the design of future studies on the genomic epidemiology of this important pathogen.…”
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Development of a robust FT-IR typing system for Salmonella enterica, enhancing performance through hierarchical classification by Diego Fredes-García, Javiera Jiménez-Rodríguez, Alejandro Piña-Iturbe, Pablo Caballero-Díaz, Tamara González-Villarroel, Fernando Dueñas, Aniela Wozniak, Aiko D. Adell, Andrea I. Moreno-Switt, Patricia García

“…This study supports its implementation as a cost-effective, high-throughput tool for pathogen typing, enhancing real-time epidemiological surveillance, and guiding treatment strategies for salmonellosis. …”
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Small RNA CjNC110 regulates the activated methyl cycle to enable optimal chicken colonization by Campylobacter jejuni by Brandon Ruddell, Alan Hassall, Orhan Sahin, Paul J. Plummer, Qijing Zhang, Amanda J. Kreuder

“…As a growing body of evidence suggests that maintenance of L-met homeostasis appears to be critical for C. jejuni colonization, interventions targeting the AMC could provide a critical control point for therapeutic drug options to combat this zoonotic pathogen. …”
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Genomic insights into the population structure, antimicrobial resistance, and virulence of Brachyspira hyodysenteriae from diverse geographical regions by Maria Hakimi, Fangshu Ye, Anugrah Saxena, Xiao Hu, Huigang Shen, Paarthiphan Elankumaran, Chloe C. Stinman, Nubia Macedo, Orhan Sahin, Eric R. Burrough, Ganwu Li

“…Virulence factor analysis identified genes linked to hemolysin production, iron uptake, and survival in host environments in most isolates, with a subset of genes demonstrating lineage-specific associations that are further linked to pathogenic potential. This comprehensive genomic epidemiological analysis elucidates the genetic diversity, antimicrobial resistance, and virulence of B. hyodysenteriae globally, enhancing understanding of its epidemiology and guiding interventions to mitigate swine dysentery.IMPORTANCEBrachyspira hyodysenteriae, the primary causative agent of swine dysentery, remains a less-studied pathogen than other bacterial species that impact animal health. …”
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Enteroaggregative Escherichia coli foodborne outbreak in Shandong Province, China (2023): comprehensive epidemiology and genomic resistance profiling by Lu Liu, Lu Liu, Shuang Wang, Shuang Wang, Xiaolin Yu, Xiaolin Yu, Yuzhen Chen, Yuzhen Chen, Yanru Chen, Yanru Chen, Gaoxiang Sun, Gaoxiang Sun, Ziqing Liu, Ziqing Liu, Lixiao Cheng, Lixiao Cheng, Huaning Zhang, Huaning Zhang, Zengqiang Kou, Zengqiang Kou

“…IntroductionEnteroaggregative Escherichia coli (EAEC) is an emerging and intricate diarrheagenic bacterial pathogen responsible for acute and persistent diarrhea in children, adults, and travelers. …”
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Clinical Characteristic and Prevalence of Invasive Candidiasis Patient in Cipto Mangunkusumo Hospital by Kemal Fariz Kalista, Lie Khie Chen, Retno Wahyuningsih, Cleopas Martin Rumende

“…Mortality due to IC was high and C. albicans was the most common etiologic pathogen.…”
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Invasive Mucormycosis in a Chronic Lymphocytic Leukemia Patient on Zanubrutinib: A Case Report by Bilal H, Li X, Lv QL, Qiu H, Qiu YA, Xu B

“…Delayed identification of the fungal pathogen significantly hindered timely antifungal intervention, underscoring the importance of appropriate empirical therapies in hematological patients treated with zanubrutinib. …”
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Impact of the COVID-19 Pandemic on Pediatric Pneumonia Outcomes: A Five-Year Retrospective Cohort Study by Heinige P, Slováková L, Vočková J, Leová LN, Tašková A, Kripnerová K, Prchlík M, Doležalová K

“…Pavel Heinige,1 Lea Slováková,2 Jitka Vočková,2 Lan Ngoc Leová,3 Alice Tašková,4 Kateřina Kripnerová,5 Martin Prchlík,1 Karolína Doležalová2 1Department of Pediatric Intensive Care, Thomayer University Hospital, Prague, Czech Republic; 2Clinic of Paediatrics of the First Faculty of Medicine, Charles University, Thomayer University Hospital, Prague, Czech Republic; 3Department of Radiology, Thomayer University Hospital, Prague, Czech Republic; 4Clinic of Thoracic Surgery 3rd Faculty of Medicine, Charles University and Thomayer University Hospital, Prague, Czech Republic; 5Department of Clinical Microbiology, Thomayer University Hospital, Prague, Czech RepublicCorrespondence: Karolína Doležalová, Clinic of Paediatrics of the First Faculty of Medicine, Charles University, Thomayer University Hospital, Prague, Czech Republic, Email karolina.dolezalova@ftn.czBackground: Pneumonia remains a leading cause of pediatric morbidity globally, with Streptococcus pneumoniae (SP) as the primary bacterial pathogen. Despite vaccination programs and modern antibiotics, complicated cases requiring surgical intervention present ongoing challenges for healthcare providers. …”
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Metabolic fluxes for nutritional flexibility of Mycobacterium tuberculosis by Khushboo Borah, Tom A Mendum, Nathaniel D Hawkins, Jane L Ward, Michael H Beale, Gerald Larrouy‐Maumus, Apoorva Bhatt, Martine Moulin, Michael Haertlein, Gernot Strohmeier, Harald Pichler, V Trevor Forsyth, Stephan Noack, Celia W Goulding, Johnjoe McFadden, Dany J V Beste

“…However, the metabolic plasticity of this pathogen and the complexity of the metabolic networks present a major obstacle in identifying those nodes most amenable to therapeutic interventions. …”
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The multiple functions of CD5 in diseases related to immune disorders by Jiawen Dong, Kaibo Zhang, Jinhui Hong, Jialu Ye, Leping Wang, Qiang Ke, Yuyang Ye, Keting Jin, Yalun Chen, Jing Wu

“…Beyond these functions, CD5 also plays a role in immunotherapy, recognition of pathogen-associated molecular patterns, regulation of inflammatory processes, prediction of poor tumour prognosis, and clearance of macromolecules. …”
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Multi-Year Analysis of Respiratory Viral Dynamics Reveals Significance of Rhinovirus in Young Children with Severe Respiratory Illness by Juan Raphael Caldera, Tawny Saleh, Trevon Fuller, Shangxin Yang, Karin Nielsen-Saines

“…<b>Conclusions</b>: RV was the most common viral pathogen in young children, even during the height of the COVID-19 pandemic, and was an independent driver of moderate-to-severe disease, particularly in children with comorbidities. …”
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Distribution and Antibiotic Resistance Analysis of 13,048 Clinically Common Isolates by Zhao J, Yue P, Li ZJ, Xu T, Xing GZ, Shao Y, Yu HY

“…Timely and effective interventions targeting pathogenic bacteria are essential for controlling and mitigating nosocomial infection risks.Keywords: multidrug-resistant organisms, monitoring, hospital infection, prevention and control, CRE…”
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The Sero-epidemiology of Coxiella burnetii in Humans and Cattle, Western Kenya: Evidence from a Cross-Sectional Study. by Nicola A Wardrop, Lian F Thomas, Elizabeth A J Cook, William A de Glanville, Peter M Atkinson, Claire N Wamae, Eric M Fèvre

“…Evidence suggests that the intracellular bacterial pathogen Coxiella burnetii (which causes Q fever) is widespread, with a near global distribution. …”
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The growing concern of MDR/XDR bacteria in patients undergoing dialysis: a cross-sectional study by Noor S. Kadhem, Ahmed Khassaf Atya

“…This study aims to determine the prevalence, risk factors, and antimicrobial resistance patterns of these pathogens to enhance patient care and infection control strategies. …”
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