Rapid assessment of clinical severity for salmonellosis cases via protein family domain analysis and machine learning by Aakash Bhattacharyya, Sudip Panday, David Ussery

“… Salmonella is a common pathogen, infecting more than a million people yearly. …”
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Natural Spillover Risk and Disease Outbreaks: Is Over-Simplification Putting Public Health at Risk? by David Bell, Jean von Agris, Blagovesta Tacheva, Garrett Wallace Brown

“…This picture is further complicated by rapidly and unevenly evolving capacity for pathogen detection and notification. Public health policy based on incorrect assumptions and overly simplified analyses is likely to lead to poorly designed interventions and poor outcomes. …”
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The Establishment of 3D Polarity-Reversed Organoids From Human Endometrial Tissue as a Model for Infection-Induced Endometritis by Xin Zhang, Li Zhang, Linyuan Fan, Zhaohui Liu

“…By preserving epithelial polarity, this approach offers enhanced physiological relevance, improves host–pathogen interaction studies, and provides a robust platform for evaluating potential therapeutic interventions.…”
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AI-Assisted Real-Time Monitoring of Infectious Diseases in Urban Areas by Mohammed M. Alwakeel

“…Experimental validation using real-world datasets demonstrated that SmartHealth-Track achieves high accuracy, with an outbreak detection accuracy of 92.4%, wearable-based fever detection accuracy of 93.5%, AI-driven contact tracing precision of 91.2%, and AI-enhanced wastewater pathogen classification accuracy of 94.1%. The findings confirm that AI-driven real-time surveillance significantly improves outbreak detection and forecasting, enabling timely public health interventions. …”
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Mechanisms and Emerging Regulators of Neuroinflammation: Exploring New Therapeutic Strategies for Neurological Disorders by Mi Eun Kim, Jun Sik Lee

“…While acute neuroinflammation plays a protective role by facilitating pathogen clearance and tissue repair, chronic and dysregulated inflammation contributes significantly to the progression of neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and Multiple Sclerosis. …”
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Seroepidemiology of human leptospirosis in the Dominican Republic: A multistage cluster survey, 2021. by Eric J Nilles, Cecilia Then Paulino, Renee Galloway, Michael de St Aubin, Helen J Mayfield, Angela Cadavid Restrepo, Devan Dumas, Salome Garnier, Marie Caroline Etienne, William Duke, Farah Peña, Naomi Iihoshi, Gabriela Abdalla, Beatriz Lopez, Lucia de la Cruz, Bernarda Henríquez, Kara Durski, Margaret Baldwin, Gideon Loevinsohn, Eleanor M Rees, Beatris Martin, Benn Sartorius, Ronald Skewes-Ramm, Emily Zielinski Gutiérrez, Adam Kucharski, Colleen L Lau

“…Our study highlights the need for targeted public health interventions informed by serogroup-specific dynamics, detailed spatial analyses, knowledge of local animal reservoirs, and strengthened laboratory surveillance to effectively control this pathogen.…”
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Embedding risk monitoring in infectious disease surveillance for timely and effective outbreak prevention and control by Marianne A B van der Sande, Niel Hens, Brecht Ingelbeen, Placide Mbala, Esther van Kleef, Ivalda Macicame, Kostas Danis, Eveline Cleynen

“…Monitoring One Health exposures, human behaviour, immunity, comorbidities, uptake of control measures or pathogen characteristics can complement facility-based surveillance in generating signals of imminent or ongoing outbreaks, and in targeting preventive/control interventions or epidemic preparedness to high-risk areas or subpopulations. …”
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Sialic Acids in Health and Disease by Gerardo N. Guerrero-Flores, Fayth M. Butler, Veronica L. Martinez Marignac, Guangyu Zhang, Fabio J. Pacheco, Danilo S. Boskovic

“…Further investigations encompass a variety of applications, including cell–cell interactions, signaling, host–pathogen interactions, and other biological functions associated with nutrition, metabolism, or genetic disorders. …”
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The PE/PPE family proteins of Mycobacterium tuberculosis: evolution, function, and prospects for tuberculosis control by Zhijing Zhang, Zhijing Zhang, Le Dong, Xin Li, Taibing Deng, Qinglan Wang

“…By integrating evolutionary, structural, and immunological insights, this review provides a roadmap for leveraging PE/PPE biology to develop next-generation TB interventions.…”
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Improving health literacy and stakeholder-directed knowledge of One Health through analysis of readability: a cross sectional infodemiology study by John E. Moore, Beverley C. Millar

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Urban pertussis epidemiological patterns in a highly vaccinated megacity: Policy impacts and control strategies in Chongqing, China, 2005-2024 by Rui Shen, Jiawei Xu, Yugang Li, Jianxing Yu, Na Sun, Zilu Xu, Xueying Xu, Xiao Liu, Yang Liu, Bosong Li, Li Qi, Luzhao Feng

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The TyphiNET data visualisation dashboard: unlocking Salmonella Typhi genomics data to support public health by Zoe A. Dyson, Louise Cerdeira, Vandana Sharma, Megan E. Carey, Kathryn E. Holt, Global Typhoid Genomics Consortium

“…Conclusions The TyphiNET dashboard provides an interactive platform for accessing genome-derived data on pathogen variant frequencies to inform typhoid control and intervention strategies. …”
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SIRT7 remodels the cytoskeleton via RAC1 to enhance host resistance to Mycobacterium tuberculosis by Fuxiang Li, Ximeng Zhang, Jinjin Xu, Yue Zhang, Guo Li, Xirui Yang, Guofang Deng, Youchao Dai, Baohua Liu, Christian Kosan, Xinchun Chen, Yi Cai

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Effectiveness of Bacterial Lysates as Immune-Boosting Supplements: Evaluating a Novel Approach to Immune Health by Gabriela Mąsior, Szymon Dowgiert, Zuzanna Ambroziewicz, Robert Siemiątkowski, Michał Łata, Joanna Chruściel, Hanna Grabowska, Jakub Kamiński, Katarzyna Więcław, Małgorzata Sikorska

“… The increasing prevalence of recurrent infections and immune-related disorders has intensified the search for effective immune-modulating interventions. Bacterial lysates, derived from inactivated bacterial components, have emerged as promising immune-boosting supplements. …”
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Staphylococcus aureus-associated post endoscopic retrograde cholangiopancreatography pancreatitis by Meshref Alshehri, Madhuri Duggirala, Uzoamaka Eke

“…Background: Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a recognized complication, often attributed to mechanical trauma, chemical injury, or bacterial contamination by enteric pathogens such as Escherichia coli, Enterococcus, and Klebsiella. …”
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Feasibility of modified surviving sepsis campaign guidelines in a resource-restricted setting based on a cohort study of severe S. aureus sepsis [corrected]. by Weera Mahavanakul, Emma K Nickerson, Pramot Srisomang, Prapit Teparrukkul, Pichet Lorvinitnun, Mingkwan Wongyingsinn, Wirongrong Chierakul, Maliwan Hongsuwan, T Eoin West, Nicholas P Day, Direk Limmathurotsakul, Sharon J Peacock

“…<h4>Methods and findings</h4>We undertook a detailed assessment of sepsis management in a prospective cohort of patients with severe sepsis caused by a single pathogen in a 1,100-bed hospital in lower-middle income Thailand. …”
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Pseudomonas-Enterobacter Co-Infection Drives Cellulitis and Lymphangitis in Equines: A Case Report by Xiangning Huang, Renjie Deng, Haoen Huang, Huisheng Xie, Aolei Chen

“…The case highlights the critical role of pathogen-directed antimicrobial selection and the potential benefits of combining conventional and holistic therapies. …”
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Outcomes of Selective Removals for Control of Pneumonia in a Bighorn Sheep Metapopulation by E. Frances Cassirer, Thomas E. Besser

“…Local elimination of M. ovipneumoniae in the two northern treatment populations within a year after removals was indicated by no further detection of the pathogen, waning antibody levels, and lack of antibody in animals born after removals. …”
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Interplay between autophagy and apoptosis in human viral pathogenesis by Qingqing Shao, Tong Liu, Bin Hu, Liuqing Chen

“…These pathways also act as key battlegrounds in host-pathogen interactions during viral infection. This comprehensive review explores the dual regulatory mechanisms controlling autophagy and apoptosis triggered by clinically significant human viruses. …”
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SEPSIS DUE TO LISTERIA MONOCYTOGENES IN AN IMMUNOCOMPROMISED PATIENT WITH PERITONEAL CARCINOMATOSIS: A CASE REPORT by İrem Unat, Kemal Tekin, Mehmet Ozan Durmaz, Musa Barış Aykan, Tuğrul Hoşbul

“…Local effects of intra-abdominal tumors, immune response suppression, and operations that disrupt the integrity of the peritoneal membrane and gastrointestinal tract may increase the risk of pathogen-induced invasive infection. Although cytoreductive surgical interventions, systemic and/or hyperthermic intraperitoneal chemotherapy (HIPEC) applied in the treatment of patients with abdominal and pelvic malignancies increase disease-free survival, they may predispose to infections caused by L. monocytogenes through gastrointestinal and systemic complications. …”
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