Ferritin-NP-preS1 vaccine synergizes with siRNA for sustained seroconversion against chronic hepatitis B in mice by Wenjun Wang, Xiaoxiao Zhou, Tingting Guo, Qian Chai, Hongjun Wang, Mingzhao Zhu

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Tuberculosis preventive treatment among individuals with inactive tuberculosis suggested by untreated radiographic abnormalities: a community-based randomized controlled trial by Haoran Zhang, Henan Xin, Ying Du, Xuefang Cao, Shouguo Pan, Jianmin Liu, Ling Guan, Fei Shen, Zisen Liu, Bin Zhang, Dakuan Wang, Boxuan Feng, Jiang Du, Xueling Guan, Yijun He, Yongpeng He, Zhanjiang Zhang, Jiaoxia Yan, Qi Jin, Lei Gao

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First molecular detection and multilocus genotyping of Enterocytozoon bieneusi from pigs in Guangxi Zhuang Autonomous region, Southern China by Si-Ang Li, Yang Liu, Hui-Hong Lu, Ya-Fei Song, Meng-Jie Chu, Fei Huang, Shu-Yan Wang, Dong-Hui Zhou

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Epidemiological characteristics of eleven common respiratory viral infections in children by Suling Li, Zhengfeng Xue, Yuxin Feng, Xue Zhou, Yang Qi, Na Feng, Yuanxia Li

“…In this study, we aimed to describe the epidemiological characteristics of viral pathogens associated with LRTIs in hospitalized children in Yan’an; this has yet to be reported in the literature and may guide public health interventions and resource allocation in this region. …”
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Preserving Darwin’s fox: genomic tools for the conservation of South America’s most endangered canid by Cristóbal Valenzuela-Turner, José Horacio Grau, Jörns Fickel, Jörns Fickel, Daniel W. Förster

“…Here we highlight the potential of HTS to address these challenges, such as clarifying its taxonomy, demographic history, geographic distribution, population structure, genetic diversity, and pathogen exposure. Integrating molecular data into conservation planning will be pivotal in ensuring the long-term survival of Darwin’s fox by identifying priorities for targeted management interventions, highlighting areas of critical habitat for conservation, and guiding genetic rescue efforts to enhance genetic diversity and resilience.…”
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Holobiome Harmony: Linking Environmental Sustainability, Agriculture, and Human Health for a Thriving Planet and One Health by Gissel García, Martha Carlin, Raul de Jesus Cano

“…Microbial interactions drive nutrient cycling, pathogen suppression, and climate regulation. Soil microbiomes facilitate carbon sequestration and enhance soil fertility, while marine microbiomes contribute to carbon capture and climate stability. …”
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Intracerebral and interhemispheric abscesses as a complication of acute purulent polysinusitis by A. A. Krivopalov, D. V. Leiko, A. Yu. Shcherbuk, Yu. A. Shcherbuk, P. A. Shamkina, A. V. Chufistova

“…Despite the timely initiation of antibiotic therapy, the patient had intracranial purulent-inflammatory complica tions of acute purulent polysinusitis, which required the participation of a multidisciplinary team of medical specialists, the appointment of reserve antibiotics and repeated surgical interventions. The described clinical observation confirms that the influence on the course and outcome of the disease in patients with EnT-associated intracranial purulentinflammatory complications is exerted by: a multidisciplinary approach involving a neurosurgeon, otorhinolaryngologist, neurologist, radiologist, clinical pharmacologist, and anesthesiologist-resuscitator; early diagnosis, including computed tomography and/or magnetic resonance imaging of the brain and paranasal sinuses; early verification of the pathogen and determination of its sensitivity to antibiotics; timely etiotropic high-dose parenteral antibiotic therapy with drugs that penetrate the blood-brain barrier; radical rehabilitation of EnT-organs and intracranial foci of infection.…”
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Experimental dissection of tuberculosis protective immunity: a human perspective by Sarah Schmidiger, Sarah Schmidiger, Damien Portevin, Damien Portevin

“…Our knowledge gap in protective immunity in TB impedes the development of such new vaccines and host-directed interventions. Mtb is a pathogen highly adapted to humans and primarily infects the lungs. …”
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Genetic Engineering for Cereal Crop Yield Improvement and Disease Resistant Breeding by Asaye Demelash Limenie, Mastewal Alehegn

“…This not only reduces yield losses but also minimizes the development of pathogen resistance to single-gene interventions.…”
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The potential of genomic epidemiology: capitalizing on its practical use for impact in the healthcare setting by Nicole Pacchiarini, Caoimhe McKerr, Mari Morgan, Thomas R. Connor, Thomas R. Connor, Christopher Williams

“…Whole genome sequencing (WGS) has emerged as a powerful tool for tracking the transmission dynamics of pathogens and when used alongside traditional epidemiological methods it can better inform our understanding of the pathogen origin, pathway and extent of transmission. …”
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Can <i>Caenorhabditis elegans</i> Serve as a Reliable Model for Drug and Nutraceutical Discovery? by Opeyemi. O. Deji-Oloruntoba, Taiwo. O. Elufioye, Stephen Adeniyi Adefegha, Miran Jang

“…Additionally, its conserved stress response, apoptosis, and pathogen recognition pathways facilitate the study of pharmacological interventions for inflammation, oxidative stress, and infections. …”
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Impact of the gut microbiota-Th17 cell axis on inflammatory depression by Xiuzhi Jia, Xiuzhi Jia, Jiayi Wang, Dan Ren, Kaibo Zhang, Hongliang Zhang, Tengchuan Jin, Tengchuan Jin, Songquan Wu, Songquan Wu

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Development of a neutralization assay and bioluminescent imaging mouse model for Dehong virus (DEHV) using a pseudovirus system by Xuelian Wu, Fan Liu, Tao Li, Danfeng Li, Yanru Shen, Xiaoai Zhang, Shuo Liu, Qi Jiang, Chenyan Zhao, Jianhui Nie, Youchun Wang, Baomin Feng, Wei Liu, Weijin Huang

“…However, the mechanisms underlying the pathogenicity and transmission of DEHV remain poorly understood. …”
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Behavioral manipulation of Ixodes scapularis by Ehrlichia muris eauclairensis: implications for tick-borne disease transmission by Joseph Aspinwall, Barbara Weck, Larissa A. Martins, Clayton Jarrett, Motoshi Suzuki, Mina P. Peyton, Daniel E. Sonenshine, Tais B. Saito

“…This research provides the first evidence of behavioral manipulation by an Ehrlichia species, indicating that the tick nervous system is a site of bacterial influence and a potential target for interventions. These findings offer new insights into pathogen-vector dynamics that could lead to the development of transmission-blocking therapies, significantly impacting tick fitness and disease transmission.IMPORTANCETick-borne diseases (TBDs) are increasingly affecting humans, pets, and livestock, with cases rising in recent years. …”
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Epidemiological Genomics of Klebsiella pneumoniae isolates from hospitals across Colombia by Victor A. Medina, Angela S. García-Vega, Fernando Rodríguez, Enmanuel S. Triviño-García, Jaime A. Robledo, Aura L. Leal, Julián C. Galvis, Luis F. Reyes, Genomic Epidemiology of Antimicrobial Resistance Consortium (GEAR), Iruka N. Okeke, Natacha Couto, Emmanuelle A. Kumaran, Georgina Lewis-Woodhouse, Silvia Argimon, Stefany A. Arevalo, Anthony P. Underwood, Xavier Fargetton, David M. Aanensen, Maria P. Donado-Godoy

“…Abstract Klebsiella pneumoniae is one of the most important nosocomial pathogens worldwide. In Colombia, K. pneumoniae has been identified as the second most frequent microbial etiologic agent of healthcare-associated infections. …”
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Surveillance of avian influenza through bird guano in remote regions of the global south to uncover transmission dynamics by Dhammika Leshan Wannigama, Mohan Amarasiri, Phatthranit Phattharapornjaroen, Cameron Hurst, Charin Modchang, John Jefferson V. Besa, Kazuhiko Miyanaga, Longzhu Cui, Stefan Fernandez, Angkana T. Huang, Puey Ounjai, W. K. C. P. Werawatte, Ali Hosseini Rad S. M, Porames Vatanaprasan, Dylan John Jay, Thammakorn Saethang, Sirirat Luk-in, Phitsanuruk Kanthawee, Wanwara Thuptimdang, Ratana Tacharoenmuang, Bernadina Cynthia, S. P. H. Spencer Vitharana, Natharin Ngamwongsatit, Hitoshi Ishikawa, Takashi Furukawa, Yangzhong Wang, Andrew C. Singer, Naveen Kumar Devanga Ragupathi, Tanittha Chatsuwan, Kazunari Sei, Asuka Nanbo, Asada Leelahavanichkul, Talerngsak Kanjanabuch, Hiroshi Hamamoto, Paul G. Higgins, Daisuke Sano, Anthony Kicic, José O. Valdebenito, Jonas Bonnedahl, Sam Trowsdale, Parichart Hongsing, Aisha Khatib, Kenji Shibuya, Shuichi Abe

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The Expanding Threat of Crimean-Congo Haemorrhagic Fever Virus: Role of Migratory Birds and Climate Change as Drivers of <i>Hyalomma</i> spp. Dispersal in Europe by Melissa Alves Rodrigues, Paulina Lesiczka, Maria da Conceição Fontes, Luís Cardoso, Ana Cláudia Coelho

“…Crimean-Congo Haemorrhagic Fever Virus (CCHFV) is an emerging zoonotic pathogen with a high case fatality risk. Its primary vectors, <i>Hyalomma</i> spp. ticks, are expanding their geographic range, raising concerns about the increasing risk of Crimean-Congo Haemorrhagic Fever (CCHF) outbreaks in Europe. …”
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Transmission or Within-Host Dynamics Driving Pulses of Zoonotic Viruses in Reservoir-Host Populations. by Raina K Plowright, Alison J Peel, Daniel G Streicker, Amy T Gilbert, Hamish McCallum, James Wood, Michelle L Baker, Olivier Restif

“…Progress in combatting zoonoses that emerge from wildlife is often constrained by limited knowledge of the biology of pathogens within reservoir hosts. We focus on the host-pathogen dynamics of four emerging viruses associated with bats: Hendra, Nipah, Ebola, and Marburg viruses. …”
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Three-Dimensional Culture Modelling Reveals Divergent Mycobacterium tuberculosis Virulence and Antimicrobial Treatment Response by Magdalena K. Bielecka, Liku B. Tezera, Elena Konstantinopoulou, Nicola Casali, Orestis L. Katsamenis, Ximena Gonzalo, Francis Drobniewski, Paul T. Elkington

“…Mtb is an obligate human pathogen, and consequently utilizing models that are consistent with human disease is likely to be critical. …”
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Phage-mediated TLR2 signaling attenuates intracellular Mycobacterium abscessus survival in macrophages by Hannah Kapoor, Aaron M. Maves, Madeline A. Bowder, Lia Danelishvili

“…New therapeutic characteristics of phage, described in this study, will contribute to future phage-based therapeutic interventions.…”
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