Inverse Vaccination for Autoimmune Diseases: Insights into the Role of B Lymphocytes by Moncef Zouali

“…In contrast to conventional vaccination, which aims to train the immune system to identify a pathogen as a potential threat that needs to be eradicated, inverse vaccination is designed to educate the immune system to recognize that an antigen is harmless and, consequently, extinguish the inflammatory attack of the tissues that contain the autoantigen. …”
Get full text

Fomite Transmission of Meticillin-Resistant <i>Staphylococcus aureus</i> in an Emergency Room Based on Real Touch Behaviors of Healthcare Workers and Patients by Mengting Wang, Bing Cao, Kaize Zhang, Yingying Geng, Jingchao Xie, Nan Zhang

“…MRSA mainly transferred via hand contact contributed over 89% of pathogen transmission. Therefore, disinfecting public surfaces or replacing them with antimicrobial surfaces was not effective. …”
Get full text

Prevention and Control of Human Salmonella enterica Infections: An Implication in Food Safety by Mwanaisha Mkangara

“…Salmonella is a foodborne zoonotic pathogen causing diarrhoeal disease to humans after consuming contaminated water, animal, and plant products. …”
Get full text

Genomic analysis of Salmonella enterica from cattle, beef and humans in the Greater Tamale Metropolis of Ghana. by Gabriel Temitope Sunmonu, Courage Kosi Setsoafia Saba, Erkison Ewomazino Odih, Opoku Bright, Eric Edem Y Osei, Alfred Mensah, Saeed Abdallah, Abdul-Razak Alhassan, Stephen Wilson Kpordze, Olabisi C Akinlabi, Anderson O Oaikhena, Beverly Egyir, Iruka N Okeke

“…Salmonella enterica is a bacterial foodborne pathogen that can infect humans and animals. Proper control of Salmonella requires routine surveillance and interventions across the food-production chain. …”
Get full text

Targeting HK3 in tumor-associated macrophages enhances antitumor immunity through augmenting antigen cross-presentation in cervical cancer by Hui Wang, Ying Chen, Min Wu, Jian Liu, Jingyu Wang, Yifan Yang, Chaoyang Sun, Shan He, Shen Qu, Xun Tian, Jinglan Chen, Han Jiang, Liting Liu, Yafei Huang

Get full text

Biological sex influences severity and outcomes in Acinetobacter baumannii pneumonia by Matthew S. Linz, Louis Collins, Emily Keenan, Ruchi Biswas, Dov Levine, Arun Mattappallil, Diana Finkel, Dane Parker

“…ABSTRACT Biological sex is known to affect the incidence and outcomes of infection, varying significantly by pathogen. The bacterial pathogen Acinetobacter baumannii is recognized as a serious global healthcare threat worldwide, yet understanding of how biological sex impacts its infection course is limited. …”
Get full text

Prediction of potential drug targets and key inhibitors (ZINC67974679, ZINC67982856, and ZINC05668040) against Rickettsia felis using integrated computational approaches by Sudais Rahman, Hsien Liu, Mohibuallah Shah, Mashal M. Almutairi, Iram Liaqat, Tetsuya Tanaka, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Abdulaziz Alouffi, Abid Ali

“…The rise in antibiotic-resistant strains of this pathogen underscores the urgent need for new therapeutic interventions. …”
Get full text

Analysis of Streptococcus dysgalactiae subspecies equisimilis gene transcripts during experimental primate necrotizing myositis by Jesus M. Eraso, Randall J. Olsen, S. Wesley Long, Ahmad Faili, Samer Kayal, James M. Musser

“…Collectively, our data provide new insights into the SDSE genes transcribed in vivo, thereby enhancing our understanding of the molecular basis of pathogen and primate host interactions. The SDSE genes identified in this study offer promising targets for future studies on molecular pathogenesis and therapeutic interventions.IMPORTANCEStreptococcus dysgalactiae subspecies equisimilis (SDSE) has emerged as an increasingly important bacterial pathogen causing serious invasive infections in humans worldwide. …”
Get full text

Coxiella burnetii infection in the lumbar vertebra: a rare case report and review of literature by Xingguo Tan, Xingguo Tan, Feng Li, Feng Li, Tao Zhang, Mingjia Song, Lian Zhang, Yuan Xing, Yizhe Wang, Yizhe Wang, Long Chen, Long Chen, Dashuai Huang, Yanpeng Lu, Yanpeng Lu, Songkai Li

“…Coxiella burnetii is a bacterial pathogen of Q fever. Coxiella burnetii infection in the lumbar vertebra is a rare form of chronic Q fever, which poses significant obstacles in both diagnostic processes and therapeutic interventions. …”
Get full text

Loss of Gst1 enhances resistance to MMS by reprogramming the transcription of DNA damage response genes in a Rad53-dependent manner in Candida albicans by Huaxin Cai, Yuting Feng, Jia Wang, Zhenyu Cao, Rui Lv, Jinrong Feng

“…These findings hold significant implications for understanding the mechanisms underlying the DNA damage response in this fungal pathogen and supply new potential targets for therapeutic intervention. …”
Get full text

Whole-genome sequencing as part of national and international surveillance programmes for antimicrobial resistance: a roadmap by Iruka N Okeke, Ben Taylor, Celia Carlos, Marietta Lagrada, Polle K. Macaranas, Agnettah M. Olorosa, June Gayeta, Melissa Ana Masim, Elmer M. Herrera, David M Aanensen, Khalil Abudahab, Monica Abrudan, Silvia Argimon, Harry Harste, Mihir Kekre, Ali Molloy, Dawn Muddyman, Anneke Schmider, Anthony Underwood, María del Pilar Donado Godoy, Johan Fabian Bernal Morales, Alejandra Arevalo, Maria Fernanda Valencia Guerrero, Erik Cristopher Dustin Osma Castro, Anderson O. Oaikhena, Ayorinde Oluwatobiloba Afolayan, Jolaade J Ajiboye, Ravikumar K. L., Geetha Nagaraj, Varun Shammana, Vandana Govindan, Akshata Prabhu, Darmavaram Sravani, Shincy M. R., Rajitha G. V., Carolin Vegvari, John Stelling

“…WGS provides insights into the genetic basis of resistance mechanisms, as well as pathogen evolution and population dynamics at different spatial and temporal scales. …”
Get full text

Identification and Characterization of Microsatellite Markers Derived from the Whole Genome Analysis of Taenia solium. by Mónica J Pajuelo, María Eguiluz, Eric Dahlstrom, David Requena, Frank Guzmán, Manuel Ramirez, Patricia Sheen, Michael Frace, Scott Sammons, Vitaliano Cama, Sarah Anzick, Dan Bruno, Siddhartha Mahanty, Patricia Wilkins, Theodore Nash, Armando Gonzalez, Héctor H García, Robert H Gilman, Steve Porcella, Mirko Zimic, Cysticercosis Working Group in Peru

“…A better understanding of the genetic diversity of T. solium will improve parasite diagnostics and transmission pathways in endemic areas thereby facilitating the design of future control measures and interventions. Microsatellite markers are useful genome features, which enable strain typing and identification in complex pathogen genomes. …”
Get full text

High-Dimensional Modeling of Huanglongbing Dynamics with Time-Varying Impulsive Control by Feiping Xie, Youquan Luo, Yan Zhang, Shujing Gao

“…The results provide a mathematical framework for optimizing intervention timing and intensity, offering actionable strategies for citrus growers.…”
Get full text

Epidemiology of Acinetobacter baumannii: analysis of hazard factors associated with positivity cases in Guizhou province, China from 2015 to 2023 by Zhongzhi Liang, Di Tian, Yanlan Huang, Shanjiang Dou, Anxin Yang, Zuyi Chen

“…IntroductionThe widely prevalent Acinetobacter baumannii is a gram-negative opportunistic pathogen, with the enormous potential to trigger multiple concurrent diseases. …”
Get full text

High prevalence of enterotoxigenic Escherichia coli strains in hospitalized diarrhea patients: a preliminary study from a cholera-endemic area in India (2022) by Hemant Kumar Khuntia, Prabir Manna, Deepak Kumar Barik, Subhojeet Biswas, Prasanta Kumar Bramha, Sanghamitra Pati, Manoranjan Ranjit, Madhusmita Bal, Anna Salomi Kerketta

“…These findings highlight the need for continued epidemiological monitoring and age-targeted interventions.…”
Get full text

Mass spectrometry‐based protein–protein interaction networks for the study of human diseases by Alicia L Richards, Manon Eckhardt, Nevan J Krogan

“…Abstract A better understanding of the molecular mechanisms underlying disease is key for expediting the development of novel therapeutic interventions. Disease mechanisms are often mediated by interactions between proteins. …”
Get full text

Application of Ecological Network Theory to the Human Microbiome by James A. Foster, Stephen M. Krone, Larry J. Forney

“…In healthy humans, many microbial consortia constitute rich ecosystems with dozens to hundreds of species, finely tuned to functions relevant to human health. Medical interventions, lifestyle changes, and the normal rhythms of life sometimes upset the balance in microbial ecosystems, facilitating pathogen invasions or causing other clinically relevant problems. …”
Get full text

Verification of Immune Debts in Children Caused by the COVID-19 Pandemic from an Epidemiological and Clinical Perspective by Masayuki Nagasawa

“…Resurges of infectious diseases vary depending on the biological characteristics of each infectious pathogen and differences in culture, lifestyle, and infection control mitigation policies by country or region. …”
Get full text

Assessing Antimicrobial Stewardship: A Survey of Distribution Practices in Dispensaries in Ghana by Ms Hannah Greene, Dr. Kinga Makovi, Rafiatu Abdul-Mumin, Dr. Akhil Bansal, Dr. Jemima Frimpong

“…Conclusion: Shopkeepers' understanding of clients' preferences and disincentives for purchase can inform interventions in the scope of user behaviors. Expanding the diagnostic, health surveillance, and treatment capacity of shopkeepers shows promise for public health interventions seeking to improve stewardship of antimicrobials at the community level.…”
Get full text

Multi-protomics analysis identified host cellular pathways perturbed by tick-borne encephalitis virus infection by Liyan Sui, Wenfang Wang, Xuerui Guo, Yinghua Zhao, Tian Tian, Jinlong Zhang, Heming Wang, Yueshan Xu, Hongmiao Chi, Hanxi Xie, Wenbo Xu, Nan Liu, Li Zhao, Guangqi Song, Zedong Wang, Kaiyu Zhang, Lihe Che, Yicheng Zhao, Guoqing Wang, Quan Liu

Get full text