A tombus-like virus in patients with lower respiratory tract infection: an observational study based on meta-transcriptomic sequencing by Run-Ze Ye, Jia-Qi Zhao, Hui Xie, Lin Zhao, Cheng Gong, Zhen-Fei Wang, Ning Yue, Luo-Yuan Xia, Ke Song, Bao Dong, Ning Wang, Wan-Ying Gao, Yu-Yu Li, Xiao-Ming Cui, Jiao-Jiao Pang, De-Dong Ma, Hao Wang, Jia-Fu Jiang, Yule Liu, Ye Feng, Na Jia, Wen-Qing Sun, Xiao-Peng Qi, Lu-Tao Du, Yuguo Chen, Tao Jiang, Fang Huang, Wu-Chun Cao

“…Identification of the pathogens for acute respiratory tract infections is essential for timely public health interventions and clinical management. …”
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The spatial resolution of epidemic peaks. by Harriet L Mills, Steven Riley

“…The emergence of novel respiratory pathogens can challenge the capacity of key health care resources, such as intensive care units, that are constrained to serve only specific geographical populations. …”
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Vaxtherapy, a Multiphase Therapeutic Protocol Approach for Longvax, the COVID-19 Vaccine-Induced Disease: Spike Persistence as the Core Culprit and Its Downstream Effects by Jose Crespo-Barrios

“…<b>Conclusions:</b> This hypothesis driven framework outlines a biologically plausible roadmap for longvax research. By matching interventions to specific mechanisms (fibrinolysis, spike neutralisation, pathogen clearance and regeneration), it aims to guide controlled trials and compassionate pilot programs directed at durable recovery rather than chronic symptom management.…”
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Prevalence, distribution, and antibiotic resistance of bacterial isolates in daycare centers in Ile-Ife, Nigeria by Eunice Damilola Wilkie, Jude Oluwapelumi Alao, Oluwakemi Abike Thonda, Anthonia Olufunke Oluduro

“…This study investigates bacterial pathogen prevalence in daycare centers in Ile-Ife, Nigeria, highlighting significant contamination and high antibiotic resistance rates, particularly among Staphylococcus aureus. …”
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Patient-centric analysis of Orientia tsutsugamushi spatial diversity patterns across Hainan Island, China. by Chuanning Tang, Yi Huang, Gaoyu Wang, Liying Xue, Xiaoyuan Hu, Ruoyan Peng, Jiang Du, Jinyan Yang, Yi Niu, Wanxin Deng, Yibo Jia, Yijia Guo, Siqi Chen, Nan Ge, Liyuan Zhang, Fahui Wang, Yongguo Du, Yueping Wang, Long Sun, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Biao Wu, Feifei Yin

“…<h4>Conclusions/significance</h4>These findings emphasize the urgent need for targeted public health interventions, particularly focusing on vulnerable populations in rural and agricultural areas of nine key administrative regions where high genetic diversity and pathogen spread were observed. …”
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The use of stem cells and organoids for modeling host-microbe interactions in low-biomass tissues by Claire A. Shaw, Claire A. Shaw, Margo Verstrate, Kinga Graniczkowska, Katie R. Risoen, Katie R. Risoen, Pouya Dini, Bart C. Weimer, Bart C. Weimer

“…Therefore, a comprehensive understanding of how pathogens and the microbiome interact with stem cells and organoids is relevant for developing safe and effective regenerative medicine interventions. …”
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Optimisation of aetiological examination processes for enhanced quality and efficiency in hospitalised patients prior to antimicrobial therapy: a multicentre quasi-experimental stu... by Yan Liu, Mei Lin, Xiao Zhong, Li-Hua Xiao, Lan-Fang Mo, Shan-Wen Yang, Lan-Fang He, Qin-Fei Wu, Xiao-Feng Luo

“…Objectives This study aimed to optimise the aetiological examination process in hospitalised patients to enhance pathogen detection quality and efficiency. The hypothesis was that process management strategies would improve specimen submission rates, quality, timeliness and antimicrobial use adjustment.Design A multicentre quasi-experimental pre–post comparison design was used, with baseline and postoptimisation phases.Setting Two hospitals in Guangming District, Shenzhen, China.Participants 34 790 inpatients in the baseline and 34 361 in the postoptimisation phase, across all departments.Interventions Implemented process clarification, standardisation of specimen collection/submission and multidisciplinary collaboration, with comprehensive staff training.Primary and secondary outcome measures The primary outcome measures were the pathogen submission rate before antimicrobial therapy. …”
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Stable topical application of antimicrobials using plumbing rings in an ex vivo porcine corneal infection model. by Daniel M Foulkes, Keri Mclean, Tarunima Sharma, David G Fernig, Stephen B Kaye

“…Infection models are vital tools in understanding host-pathogen interactions and the development of novel therapies. …”
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Long term sequelae from childhood pneumonia; systematic review and meta-analysis. by Karen Edmond, Susana Scott, Viola Korczak, Catherine Ward, Colin Sanderson, Evropi Theodoratou, Andrew Clark, Ulla Griffiths, Igor Rudan, Harry Campbell

“…Evaluation of childhood pneumonia interventions should include potential impact on long term respiratory sequelae.…”
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Perspectives on Microbiome Therapeutics in Infectious Diseases: A Comprehensive Approach Beyond Immunology and Microbiology by Hoonhee Seo, Sukyung Kim, Samuel Beck, Ho-Yeon Song

“…These findings underscore the potential of microbiome-based interventions to promote physiological function alongside existing strategies aimed at enhancing host immune responses and pathogen destruction. …”
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The role of KLF4 in phagocyte activation during infectious diseases by Toni Herta, Toni Herta, Aritra Bhattacharyya, Stefan Hippenstiel, Janine Zahlten

“…Additionally, potential implications for therapeutic interventions targeting KLF4 are discussed.…”
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Virulence factors released by extracellular vesicles from Cryptococcus neoformans by Wenhao Xiao, Huiqiang Lu, Bowei Jiang, Yaqi Zheng, Puwen Chen, Xiaotong Liu, Junyun Huang

“…Ssa1) associated with pathogenicity factors. Furthermore, we discuss the implications of these findings for developing therapeutic interventions. …”
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Competing microorganisms with exclusion effects against multidrug-resistant Salmonella Infantis in chicken litter supplemented with growth-promoting antimicrobials by María Alejandra Ospina Barrero, Maryeimy Varón-López, Lina M. Peñuela-Sierra

“…Salmonella enterica serovar Infantis (Salmonella Infantis [S.I]), a prevalent zoonotic pathogen, has demonstrated increasing resistance in poultry systems. …”
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Unveiling viral diversity and dynamics in mosquitoes through metagenomic analysis in Guizhou Province, China by Yan Linghu, Rui-Si Hu, Xiao-Min Tang, Rong-Ting Li, Wei-Yi Li, Jia-Hong Wu

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Comparative Genomic Analysis of <i>Campylobacter</i> Plasmids Identified in Food Isolates by Yiping He, Gretchen Elizabeth Dykes, Siddhartha Kanrar, Yanhong Liu, Nereus W. Gunther, Katrina L. Counihan, Joe Lee, Joseph A. Capobianco

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A live attenuated NS1-deficient vaccine candidate for cattle-origin influenza A (H5N1) clade 2.3.4.4.b viruses by Ahmed Mostafa, Chengjin Ye, Ramya S. Barre, Vinay Shivanna, Reagan Meredith, Roy N. Platt, Ruby A. Escobedo, Mahmoud Bayoumi, Esteban M. Castro, Nathaniel Jackson, Anastasija Cupic, Aitor Nogales, Timothy J. C. Anderson, Adolfo García-Sastre, Luis Martinez-Sobrido

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AI-Based Treatment Recommendations Enhance Speed and Accuracy in Bacteremia Management: A Comparative Study of Molecular and Phenotypic Data by Juan C. Gomez de la Torre, Ari Frenkel, Carlos Chavez-Lencinas, Alicia Rendon, José Alonso Cáceres, Luis Alvarado, Miguel Hueda-Zavaleta

“…Escherichia coli was the most frequently isolated pathogen, with a 95% concordance in suggested therapy. …”
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Enhanced hierarchical attention networks for predictive interactome analysis of LncRNA and CircRNA in oral herpes virus by Pradeep Kumar Yadalam, Carlos M. Ardila

“…Conclusion: This study provides insights into lncRNA-circRNA interactions in herpes viral infections, enhancing therapeutic development, disease progression monitoring, and understanding host-pathogen interactions, paving the way for targeted interventions and improved outcomes.…”
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Disseminated Ureaplasma infection: A case report of septic polyarthritis in a patient on Rituximab therapy by Michael Axenhus, Jesper Ericson, Agata Rysinska, Annelie Petterson, Desiree Friis

“…Accurate pathogen identification using PCR assays is crucial for optimizing therapeutic outcomes in such cases. …”
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Epizootic Activity and Epidemic Manifestation of Natural Fod of Tularemia in Voronezh Region by T. V. Mikhaylova, T. N. Demidova, M. I. Kormilitsyna, D. A. Kvasov, A. V. Kozorezov, D. B. Trankvilevsky

“…Tularemia natural foci were investigated in the 15 districts of the Voronezh region. 1533 small mammals of 11 species were captured in 2011, 2014 and 2015 to identify antigen and/or DNA of tularemia pathogen. In all the studied areas there are continuous epizootic of tularemia among small mammals. …”
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