IL-17A drives a fibroblast-neutrophil-NET axis to exacerbate immunopathology in the lung with diffuse alveolar damage by Duo Su, Duo Su, Lu Li, Hao Xie, Lingli Ai, Yuqing Wang, Bo Yang, Dongsheng Zhou, Lingfei Hu, Huiying Yang

“…This finding delineates a pathogenic IL-17A-neutrophil-NET axis that amplifies lung immunopathology after ricin-induced DAD, a deeper understanding of these relationships may pave the way for mitigate DAD immunopathology and other lung inflammatory disorders.…”
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Reviewing the ecological evidence base for management of emerging tropical zoonoses: Kyasanur Forest Disease in India as a case study. by Sarah J Burthe, Stefanie M Schäfer, Festus A Asaaga, Natrajan Balakrishnan, Mohammed Mudasssar Chanda, Narayanaswamy Darshan, Subhash L Hoti, Shivani K Kiran, Tanya Seshadri, Prashanth N Srinivas, Abi T Vanak, Bethan V Purse

“…New frameworks identify the hierarchical series of barriers that a pathogen needs to overcome before human spillover occurs and demonstrate how ecological interventions may strengthen these barriers and complement human-focused disease control. …”
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Functional Verification of Differentially Expressed Genes Following DENV2 Infection in <i>Aedes aegypti</i> by Xiaoli Chen, Xinyu Zhou, Xiaoxue Xie, Bo Li, Teng Zhao, Haotian Yu, Dan Xing, Jiahong Wu, Chunxiao Li

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A Roadmap of Primary Pandemic Prevention Through Spillover Investigation by Emily S. Gurley, Raina K. Plowright

“…Although there are many valiant plans around pandemic preparedness, they typically involve slowing the spread or mitigating the effects of a pathogen after it has already entered the human population. …”
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Interplay Between Viral Shedding, Age, and Symptoms in Individual Infectivity of COVID-19 Breakthrough Infections in Households by Shuaibing Dong, Ying Sun, Shuyu Ni, Yi Tian, Zhaomin Feng, Lei Jia, Xiaoli Wang, Daitao Zhang, Quanyi Wang, Tim K. Tsang, Peng Yang

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Microbiota, chronic inflammation, and health: The promise of inflammatome and inflammatomics for precision medicine and health care by Huan Zhang, Bing Jun Yang Lee, Tong Wang, Xuesong Xiang, Yafang Tan, Yanping Han, Yujing Bi, Fachao Zhi, Xin Wang, Fang He, Seppo J. Salminen, Baoli Zhu, Ruifu Yang

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A review of occupational exposure to blood and blood products in medical students in a South African university by Andrew Ross, Sear Cheevers, Laura Campbell

“…Internationally and nationally, interventions have been implemented in medical schools to reduce students’ risk of acquiring a blood-borne pathogen. …”
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Spatializing zoonotic disease dynamics from a political ecology perspective: Reconceptualizing spillover as structure by Ekaterina Gladkova, Francis Masse

“…This framework is intended to: 1. give critical attention to spatialities of animal-human-pathogen relations; 2. examine how and what political-economic, socio-cultural and other structural processes drive changes in these spatialities; and 3. investigate how changes in these spatialities intensify (or de-intensify) animal-human-pathogen relations and zoonotic risks. …”
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Kinetics of Neutralizing Antibody Response Underscores Clinical COVID-19 Progression by Qing Lei, Hongyan Hou, Caizheng Yu, Yandi Zhang, Jo-Lewis Banga Ndzouboukou, Xiaosong Lin, Zongjie Yao, Hui Fu, Ziyong Sun, Feng Wang, Xionglin Fan

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Metabolic modelling uncovers the complex interplay between fungal probiotics, poultry microbiomes, and diet by Montazar Al-Nijir, Christopher J. Chuck, Michael R. Bedford, Daniel A. Henk

“…However, the complexity of the interactions between probiotics, gut microbiome, and the host hinders the development of effective probiotic interventions. This study explores metabolic modelling to examine the possibility of designing informed probiotic interventions within poultry production. …”
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Multi-scale wastewater surveillance at a Bangkok tertiary care hospital: A potential sentinel site for real-time COVID-19 surveillance at hospital and national levels. by Quinton Hayre, Supaporn Wacharapluesadee, Piyapha Hirunpatrawong, Ananporn Supataragul, Opass Putcharoen, Leilani Paitoonpong

“…While most sampling focuses on municipal wastewater treatment plants, emerging evidence suggests wastewater collected from hospital settings can lead to targeted clinical interventions. To investigate wastewater pathogen surveillance in hospital settings further, we tracked the presence and concentration of SARS-CoV-2 RNA in wastewater across multi-scale sample sites within a large, public tertiary care hospital in Bangkok, Thailand. …”
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Vaccination as a Game: Behavioural Dynamics, Network Effects, and Policy Levers—A Comprehensive Review by Pedro H. T. Schimit, Abimael R. Sergio, Marco A. R. Fontoura

“…Papers are organised along five methodological axes: (i) population topology (well-mixed, static and evolving networks, multilayer systems); (ii) decision heuristics (risk assessment, imitation, prospect theory, memory); (iii) additional processes (information diffusion, non-pharmacological interventions, treatment, quarantine); (iv) policy levers (subsidies, penalties, mandates, communication); and (v) pathogen complexity (multi-strain, zoonotic reservoirs). …”
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Changing Concepts of “Latent Tuberculosis Infection” in Patients Living with HIV Infection by Stephen D. Lawn, Robin Wood, Robert J. Wilkinson

“…However, the nature of the host-pathogen relationship in those with “latent TB infection” and how this is affected by HIV coinfection are poorly understood. …”
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Precision Diagnosis of Helicobacter pylori Infection and Its Drug Resistance by Bin Tang, Pu Li, Xuhu Mao

“…By critically evaluating existing methods and exploring innovative approaches, this review aims to support future progress in the effective management of this globally prevalent pathogen.…”
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Pendekatan Edukasi dan Pelatihan dalam Upaya Mengatasi Tantangan Pembangunan Berkelanjutan di Nagari Ampek Koto Palembayan by Haiyyu Darman Moenir, Maryam Jamilah, Muhammad Farhan, Fatimah Azzahra

“…As a form of empowerment, the research team conducted a series of interventions designed to increase community awareness and knowledge on these issues. …”
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National serosurvey and risk mapping reveal widespread distribution of Coxiella burnetii in Kenya by Lillian Wambua, Bernard Bett, Hussein M. Abkallo, Mathew Muturi, Daniel Nthiwa, Richard Nyamota, Enock Kiprono, Lynn Kirwa, Francis Gakuya, Andrew W. Bartlow, Earl A. Middlebrook, Jeanne Fair, Kariuki Njenga, John Gachohi, Athman Mwatondo, James M. Akoko

“…The evidence generated on the potential role of environmental factors can also be used to design nature-based interventions, such as replacement of vegetation in denuded areas, to reduce potential for the aerosolization of the pathogen. …”
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Probiotics in Disease Management for Sustainable Poultry Production by Gelana Urgesa Ayana, Robert Kamutambuko

“…This review provides a comprehensive analysis of the scientific rationale behind probiotic interventions in poultry, highlighting their ability to modulate the gut microbiota, enhance immune function, and mitigate pathogen proliferation and the mechanisms by which probiotics influence poultry health. …”
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Etiologies of influenza-like illness and severe acute respiratory infections in Tanzania, 2017-2019. by Maria Ezekiely Kelly, Radhika Gharpure, Sabrina Shivji, Miriam Matonya, Solomon Moshi, Ambele Mwafulango, Vumilia Mwalongo, Janneth Mghamba, Azma Simba, S Arunmozhi Balajee, Wangeci Gatei, Marcelina Mponela, Grace Saguti, Toni Whistler, Nyambura Moremi, Vida Mmbaga

“…Continued respiratory surveillance in Tanzania, and globally, can provide valuable data, particularly in the context of emerging respiratory pathogens such as SARS-CoV-2, and guide public health interventions to reduce the burden of respiratory illnesses.…”
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Emerging anthropozoonotic threat in amphibian aquaculture: First report of Trichosporon asahii-induced epidemic with cross-species virulence by Hongbing Wang, Guangwei Kuang, Jie Zhang, Yao Tian, Yazhou Hu, Sha Wang, Xiaoming Tang, Yanxia Jiang, Lifei Du, Jiaxing Wei, Junqi Liu

“…These findings redefine T. asahii as a transboundary pathogen requiring coordinated veterinary-medical interventions and provide epidemiological benchmarks for developing biosecurity protocols in intensive frog farming systems.…”
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Identification of neutralizing nanobodies protecting against poxvirus infection by Xuehua Yang, Li Guo, Huarui Duan, Miao Fan, Fengwen Xu, Xiaojing Chi, Shengnan Pan, Xiuying Liu, Xinhui Zhang, Peixiang Gao, Fangyuan Zhang, Xinyi Wang, Fei Guo, Jiwan Ge, Lili Ren, Wei Yang

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