Suppression of inflammatory arthritis by the parasitic worm product ES-62 is associated with epigenetic changes in synovial fibroblasts. by Marlene Corbet, Miguel A Pineda, Kun Yang, Anuradha Tarafdar, Sarah McGrath, Rinako Nakagawa, Felicity E Lumb, Colin J Suckling, William Harnett, Margaret M Harnett

“…Such protection is associated with functional suppression of "pathogenic" hyper-responsive synovial fibroblasts (SFs), which exhibit an aggressive inflammatory and bone-damaging phenotype induced by their epigenetic rewiring in response to the inflammatory microenvironment of the arthritic joint. …”
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HIV, asymptomatic STI, and the rectal mucosal immune environment among young men who have sex with men. by Vanessa E Van Doren, S Abigail Smith, Yi-Juan Hu, Gregory Tharp, Steven Bosinger, Cassie G Ackerley, Phillip M Murray, Rama R Amara, Praveen K Amancha, Robert A Arthur, H Richard Johnston, Colleen F Kelley

“…Our results suggest that asymptomatic bacterial STI may contribute to inflammation particularly among YMSM with HIV, and that future research should examine potential harms and interventions to reduce the health impact of these syndemic infections.…”
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Deep analysis of CD4 T cells in the rhesus CNS during SIV infection. by Sonny R Elizaldi, Anil Verma, Zhong-Min Ma, Sean Ott, Dhivyaa Rajasundaram, Chase E Hawes, Yashavanth Shaan Lakshmanappa, Mackenzie L Cottrell, Angela D M Kashuba, Zandrea Ambrose, Jeffrey D Lifson, John H Morrison, Smita S Iyer

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Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection. by Matthias Hoffmann, Nikos Pantazis, Genevieve E Martin, Stephen Hickling, Jacob Hurst, Jodi Meyerowitz, Christian B Willberg, Nicola Robinson, Helen Brown, Martin Fisher, Sabine Kinloch, Abdel Babiker, Jonathan Weber, Nneka Nwokolo, Julie Fox, Sarah Fidler, Rodney Phillips, John Frater, SPARTAC and CHERUB Investigators

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Reversible host cell surface remodelling limits immune recognition and maximizes survival of Plasmodium falciparum gametocytes. by Priscilla Ngotho, Kathleen Dantzler Press, Megan Peedell, William Muasya, Brian Roy Omondi, Stanley E Otoboh, Jahiro Gomez, Lorena Coronado, Karl B Seydel, Melissa Kapulu, Miriam Laufer, Terrie Taylor, Teun Bousema, Matthias Marti

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Stunting is associated with persistent and transferable alterations in the gut microbiome by Joshua O. Amimo, C. N. Kunyanga, S. A. Raev, M. Kick, H. Micheal, L. J. Saif, Anastasia N. Vlasova

“…This information and the Gn pig model are vital for developing and testing targeted interventions for malnourished/stunted populations, consequently advancing microbiome-based diagnosis and personalized medicine.…”
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Determinants of Campylobacter species diversity in infants and association with family members, livestock, and household environments in rural Eastern Ethiopia by Amanda Ojeda, Loïc Deblais, Bahar Mummed, Mussie Brhane, Kedir A. Hassen, Belisa Usmael Ahmedo, Yenenesh Demisie Weldesenbet, Dehao Chen, Xiaolong Li, Cyrus Saleem, Mark J. Manary, Luiz F. W. Roesch, Sarah L. McKune, Arie H. Havelaar, Gireesh Rajashekara, the CAGED Research Team

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Exploring the effects of probiotics on olanzapine-induced metabolic syndrome through the gut microbiota by Syed Mushraf, Kiran Chawla, Shaik Mohammed Abdul Fayaz, Aranjani Jesil Mathew, Gayam Prasanna Kumar Reddy, Mohandas Rao Kappettu Gadahad, Padmaja A. Shenoy, Vasudha Devi, Shalini Adiga, Veena Nayak

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The effects of probiotic treatment with Bifidobacterium breve, Bif195 for small intestinal Crohn’s disease and the gut microbiome: results from a randomised, double-blind, placebo-... by Ida Marie Bruun Grønbæk, Sofie Ingdam Halkjær, Sarah Mollerup, Esben Holm Hansen, Sarah Juel Paulsen, Sara Engel, Klaus Theede, Rune Wilkens, Trine Boysen, Andreas Munk Petersen

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Mathematical models of drug-resistant tuberculosis lack bacterial heterogeneity: A systematic review. by Naomi M Fuller, Christopher F McQuaid, Martin J Harker, Chathika K Weerasuriya, Timothy D McHugh, Gwenan M Knight

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Mitogen and stress activated kinases act co-operatively with CREB during the induction of human cytomegalovirus immediate-early gene expression from latency. by Verity G Kew, Jinxiang Yuan, Jeffery Meier, Matthew B Reeves

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A pan-orthohantavirus human lung xenograft mouse model and its utility for preclinical studies. by Melanie Rissmann, Danny Noack, Thomas M Spliethof, Vincent P Vaes, Rianne Stam, Peter van Run, Jordan J Clark, Georges M G M Verjans, Bart L Haagmans, Florian Krammer, Marion P G Koopmans, Judith M A van den Brand, Barry Rockx

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Staphylococcus aureus blocks host autophagy through circSyk/miR-5106/Sik3 axis to promote progression of bone infection. by Zhihao Chen, Qiyuan Jin, Jinqi Zhong, Zonggang Xie, Qi Chen, Liubing Li, Jijie Li, Chenhao Zhao, Junfeng Wang, Xiaoying Tang, Mingxiao Han, Ru Li, Ziyuan Li, Zelei Tong, Min Wang, Hong Du, Haifang Zhang

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HIV control: Is getting there the same as staying there? by Philip Goulder, Steven G Deeks

“…We then describe the evidence from longitudinal studies of controllers who fail and studies of biologic sex (male versus female), age (children versus adults), and simian immunodeficiency virus (SIV) (pathogenic/experimental versus nonpathogenic/natural infection). …”
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Stage-Specific Changes in Plasmodium Metabolism Required for Differentiation and Adaptation to Different Host and Vector Environments. by Anubhav Srivastava, Nisha Philip, Katie R Hughes, Konstantina Georgiou, James I MacRae, Michael P Barrett, Darren J Creek, Malcolm J McConville, Andrew P Waters

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8-Oxoguanine DNA Glycosylase1 conceals oxidized guanine in nucleoprotein-associated RNA of respiratory syncytial virus. by Lang Pan, Ke Wang, Wenjing Hao, Yaoyao Xue, Xu Zheng, Ritwika S Basu, Tapas K Hazra, Azharul Islam, Yashoda Hosakote, Bing Tian, Matthieu G Gagnon, Xueqing Ba, Istvan Boldogh

“…Respiratory syncytial virus (RSV), along with other prominent respiratory RNA viruses such as influenza and SARS-CoV-2, significantly contributes to the global incidence of respiratory tract infections. These pathogens induce the production of reactive oxygen species (ROS), which play a crucial role in the onset and progression of respiratory diseases. …”
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Is "pre-sepsis" the new sepsis? A narrative review. by Rémy Gerard, Antoine Dewitte, Fridolin Gross, Thomas Pradeu, Maël Lemoine, Julien Goret, Maria Mamani-Matsuda

“…Currently, there is no formal definition of "pre-sepsis", but this phase could be defined on the basis of early biological pathways in host-pathogen interactions, such as those involving endogenous carbon monoxide. …”
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Intranasal gene therapy to prevent infection by SARS-CoV-2 variants. by Joshua J Sims, Jenny A Greig, Kristofer T Michalson, Sharon Lian, R Alexander Martino, Rosemary Meggersee, Kevin B Turner, Kalyani Nambiar, Cecilia Dyer, Christian Hinderer, Makoto Horiuchi, Hanying Yan, Xin Huang, Shu-Jen Chen, James M Wilson

“…SARS-CoV-2 variants have emerged with enhanced pathogenicity and transmissibility, and escape from pre-existing immunity, suggesting first-generation vaccines and monoclonal antibodies may now be less effective. …”
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Eating the brain - A multidisciplinary study provides new insights into the mechanisms underlying the cytopathogenicity of Naegleria fowleri. by Ronald Malych, Filipe Folgosa, Jana Pilátová, Libor Mikeš, Vít Dohnálek, Jan Mach, Magdaléna Matějková, Vladimír Kopecký, Pavel Doležal, Robert Sutak

“…Taken together, our findings provide important new insights into the pathogenic mechanisms of N. fowleri and highlight potential targets for therapeutic intervention against PAM.…”
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Isoferulic acid facilitates effective clearance of hypervirulent Klebsiella pneumoniae through targeting capsule. by Tingting Wang, Huaizhi Yang, Qiushuang Sheng, Ying Ding, Jian Zhang, Feng Chen, Jianfeng Wang, Lei Song, Xuming Deng

“…Hypervirulent Klebsiella pneumoniae (hvKP) poses an alarming threat in clinical settings and global public health owing to its high pathogenicity, epidemic success and rapid development of drug resistance, especially the emergence of carbapenem-resistant lineages (CR-hvKP). …”
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