HIV-1 epitopes presented by MHC class I types associated with superior immune containment of viremia have highly constrained fitness landscapes. by Aleksandr M Gorin, Yushen Du, Franklin Y Liu, Tian-Hao Zhang, Hwee L Ng, Christian Hofmann, William G Cumberland, Ren Sun, Otto O Yang

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Mycobacterial mutants with defective control of phagosomal acidification. by Graham R Stewart, Janisha Patel, Brian D Robertson, Aaron Rae, Douglas B Young

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Histone Deacetylase Inhibitors Enhance CD4 T Cell Susceptibility to NK Cell Killing but Reduce NK Cell Function. by Matthew Pace, James Williams, Ayako Kurioka, Andrew B Gerry, Bent Jakobsen, Paul Klenerman, Nneka Nwokolo, Julie Fox, Sarah Fidler, John Frater, CHERUB Investigators

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IFITM3 restricts influenza A virus entry by blocking the formation of fusion pores following virus-endosome hemifusion. by Tanay M Desai, Mariana Marin, Christopher R Chin, George Savidis, Abraham L Brass, Gregory B Melikyan

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Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection in Collaborative Cross mice. by Jessica B Graham, Jessica L Swarts, Sarah R Leist, Alexandra Schäfer, Vineet D Menachery, Lisa E Gralinski, Sophia Jeng, Darla R Miller, Michael A Mooney, Shannon K McWeeney, Martin T Ferris, Fernando Pardo-Manuel de Villena, Mark T Heise, Ralph S Baric, Jennifer M Lund

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Rice ragged stunt virus Pns10 induces mitochondrial-mediated apoptosis to promote viral infection in Nilaparvata lugens through disrupting the NlNDUFS1-NlPHB2 interaction. by Lianshun Zheng, Shuai Fu, Ming Zeng, Liyan Li, Dan Wang, Shibo Gao, Yunge Zhang, Cui Zhang, Shifang Fei, Xuan Ye, Lele Chen, Qianhui Chen, Yaqin Wang, Xueping Zhou, Yan Xie, Boli Hu, Jianxiang Wu

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APOE protects against severe infection with Mycobacterium tuberculosis by restraining production of neutrophil extracellular traps. by Dong Liu, Dat Mai, Ana N Jahn, Tara A Murray, John D Aitchison, Benjamin H Gern, Kevin B Urdahl, Alan Aderem, Alan H Diercks, Elizabeth S Gold

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Lymph node colonization dynamics after oral Salmonella Typhimurium infection in mice. by Patrick Kaiser, Emma Slack, Andrew J Grant, Wolf-Dietrich Hardt, Roland R Regoes

“…An understanding of how pathogens colonize their hosts is crucial for the rational design of vaccines or therapy. …”
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Genome-wide association studies reveal the role of polymorphisms affecting factor H binding protein expression in host invasion by Neisseria meningitidis. by Sarah G Earle, Mariya Lobanovska, Hayley Lavender, Changyan Tang, Rachel M Exley, Elisa Ramos-Sevillano, Douglas F Browning, Vasiliki Kostiou, Odile B Harrison, Holly B Bratcher, Gabriele Varani, Christoph M Tang, Daniel J Wilson, Martin C J Maiden

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High-throughput, single-copy sequencing reveals SARS-CoV-2 spike variants coincident with mounting humoral immunity during acute COVID-19. by Sung Hee Ko, Elham Bayat Mokhtari, Prakriti Mudvari, Sydney Stein, Christopher D Stringham, Danielle Wagner, Sabrina Ramelli, Marcos J Ramos-Benitez, Jeffrey R Strich, Richard T Davey, Tongqing Zhou, John Misasi, Peter D Kwong, Daniel S Chertow, Nancy J Sullivan, Eli A Boritz

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Differential contribution of PBP occupancy and efflux on the effectiveness of β-lactams at their target site in clinical isolates of Neisseria gonorrhoeae. by Silvia López-Argüello, Eva Alcoceba, Paula Ordóñez, Biel Taltavull, Gabriel Cabot, Maria Antonia Gomis-Font, Antonio Oliver, Bartolome Moya

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Sustained immune activation and impaired epithelial barrier integrity in the ectocervix of women with chronic HIV infection. by Mathias Franzén Boger, Tyra Hasselrot, Vilde Kaldhusdal, Gisele H B Miranda, Paulo Czarnewski, Gabriella Edfeldt, Frideborg Bradley, Genta Rexaj, Julie Lajoie, Kenneth Omollo, Joshua Kimani, Keith R Fowke, Kristina Broliden, Annelie Tjernlund

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The pharmacokinetics and drug-drug interactions of ivermectin in Aedes aegypti mosquitoes. by Urs Duthaler, Michael Weber, Lorenz Hofer, Carlos Chaccour, Marta Maia, Pie Müller, Stephan Krähenbühl, Felix Hammann

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Staphylococcus aureus infection dynamics. by Eric J G Pollitt, Piotr T Szkuta, Nicola Burns, Simon J Foster

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EV-D68 cleaves LARP1 and PABPC1 by 3Cpro to redirect host mRNA translation machinery toward its genomic RNA. by Ruyang Tan, Yuling Zhang, Mengqian Huang, Honghua Chen, Zixiang Liu, Zining Wang, Xiaoyan Li, Tao Wang, Zhiyun Wang

“…Enterovirus D68 (EV-D68) is an emerging pathogen associated with severe respiratory diseases and neurological complications, such as acute flaccid myelitis. …”
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Dengue virus reduces AGPAT1 expression to alter phospholipids and enhance infection in Aedes aegypti. by Thomas Vial, Wei-Lian Tan, Benjamin Wong Wei Xiang, Dorothée Missé, Eric Deharo, Guillaume Marti, Julien Pompon

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Detecting differential transmissibilities that affect the size of self-limited outbreaks. by Seth Blumberg, Sebastian Funk, Juliet R C Pulliam

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Comparison of HIV-1 A6 dispersal dynamics in Poland before and after the war in Ukraine. by Karol Serwin, Kaja Mielczak, Anna Urbańska, Bogusz Aksak-Wąs, Malwina Karasińska-Cieślak, Piotr Ząbek, Ewa Siwak, Iwona Cielniak, Elżbieta Jabłonowska, Paweł Jakubowski, Błażej Rozpłochowski, Aleksandra Szymczak, Bartosz Szetela, Anna Kalinowska-Nowak, Monika Bociąga-Jasik, Elżbieta Mularska, Adam Witor, Anita Olczak, Władysław Łojewski, Maria Hlebowicz, Miłosz Parczewski

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Broad coverage of neutralization-resistant SIV strains by second-generation SIV-specific antibodies targeting the region involved in binding CD4. by Hugh C Welles, Hannah A D King, Leonard Nettey, Nicole Cavett, Jason Gorman, Tongqing Zhou, Yaroslav Tsybovsky, Renguang Du, Kaimei Song, Richard Nguyen, David Ambrozak, Amy Ransier, Chaim A Schramm, Nicole A Doria-Rose, Adrienne E Swanstrom, James A Hoxie, Celia LaBranche, David C Montefiori, Daniel C Douek, Peter D Kwong, John R Mascola, Mario Roederer, Rosemarie D Mason

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Illumination of parainfluenza virus infection and transmission in living animals reveals a tissue-specific dichotomy. by Crystal W Burke, John N Mason, Sherri L Surman, Bart G Jones, Emilie Dalloneau, Julia L Hurwitz, Charles J Russell

“…Since no vaccines or antivirals exist, non-pharmaceutical interventions are the only means of control for these pathogens. …”
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