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  1. 381

    Mechanistic strategies for secondary prevention of developmental and epileptic encephalopathy in children with tuberous sclerosis complex by Nicola Specchio, Valentina Di Micco, Mirte Scheper, Eleonora Aronica, Paolo Curatolo

    Published 2025-06-01
    “…This review aims to synthesize current evidence on biomarker-informed, mechanism-based strategies for secondary prevention of DEE in TSC, offering a framework for personalized early interventions. Biomarkers, such as interictal epileptiform discharges, pathogenic TSC2 variants, and advanced neuroimaging metrics, predict epilepsy risk and neurodevelopmental trajectories. …”
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    Effector Responses Induced by Pattern Recognition Receptors (PRRs) for Disease Protection by L. Chi, Ya. Chi

    Published 2025-08-01
    “…PRRs function as master regulators of immune responses, serving not only as pathogen detectors but also as sophisticated coordinators of immune activation, tolerance, and resolution. …”
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