Research Progress in Microbe-Gut-Liver Axis and Alcoholic Liver Disease and Nutritional Interventions for It by ZHENG Hongxing, JI Le, QI Shanshan

“…Alcohol can disrupt this bidirectional effect, leading to the disturbance of the gut microbiota and the translocation of pathogens to the liver, and finally causing liver damage. …”
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Targeting alveolar macrophages: a promising intervention for pulmonary infection and acute lung injury by Fei Hou, Nan Shi, Haoran Yuan, Bingyi Li, Junjie Xiao, Kun Xiao, Lixin Xie

“…Abstract Pulmonary infections are common respiratory diseases caused by a variety of pathogens, some of which can lead to epidemics. When they progress to acute lung injury or acute respiratory distress syndrome, the mortality rate is high and effective treatment options are lacking. …”
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Biosecurity measures reducing Salmonella spp. and hepatitis E virus prevalence in pig farms—a systematic review and meta-analysis by Nikolaus Huber, Marina Meester, Elena L. Sassu, Elisabeth S. L. Waller, Gergana Krumova-Valcheva, Giuseppe Aprea, Daniela D’Angelantonio, Veit Zoche-Golob, Silvia Scattolini, Emily Marriott, Richard P. Smith, Elke Burow, Elke Burow, Guido Correia Carreira

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Occurrence and Genotypic Characterization of Selected Multidrug-resistant ESKAPE-E Pathogens Isolated from Integrated Smallholder Fresh Produce Farms by Sheldon Viviers, Loandi Richter-Mouton, Jonathan Featherston, Lise Korsten

“…Antimicrobial resistance (AMR) ranks among the top ten global public health threats, with extended-spectrum β-lactamase (ESBL)-producing Enterobacterales and Pseudomonas aeruginosa emerging as multidrug-resistant (MDR) priority pathogens. This study aimed to evaluate the presence and characteristics (phenotypic and genotypic AMR profiles) of ESBL/AmpC-producing Enterobacterales and P. aeruginosa isolates obtained from the water-soil-plant nexus on smallholder fresh produce farms in South Africa. …”
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Tumor-infiltrating lymphocytes are the key determinants of pathological features associated with pathogenic BRCA variants in high-grade serous ovarian carcinoma by Dang H. Nguyen-Phan, Dang H. Nguyen-Phan, Dang H. Nguyen-Phan, Tin Dang, Anh N. Dang, Loc T. H. Huynh, Phuong T. B. Nguyen, Vu Q. Tran, Hanh T. T. Ngo, Thao T. P. Doan, Tu A. Thai, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen

“…Our framework leverages these insights to prioritize high-risk cases for genetic testing, thereby optimizing resource allocation.ConclusionThe presence of TILs is critical for understanding the association between pathological features and pathogenic BRCA variants in HGSOC. To improve pathogenic BRCA variant prediction, optimize genetic testing, and guide tailored intervention, our framework integrates immune context and morphological markers. …”
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Gut Microbe-Generated Metabolite Trimethylamine-N-Oxide and Ischemic Stroke by Zhen Li, Xinyi He, Qi Fang, Xulong Yin

“…In addition, this paper provides a summary and evaluation of relevant preclinical and clinical studies on interventions regarding the gut-microbiota-dependent TMAO level to provide evidence for the prevention and treatment of ischemic stroke through the gut microbe–TMAO pathway.…”
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An Approach to, and Tool for, Predicting the Time Course of an Infectious Disease Outbreak as a Function of Behavioral Interventions by Abebe HT, Siraj A, Berhane K, Siraj D, Van Breukelen GJ

“…These models incorporate key non-pharmaceutical interventions to limit transmission within communities. …”
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A weather-driven mathematical model of Culex population abundance and the impact of vector control interventions by Suman Bhowmick, Patrick Irwin, Kristina Lopez, Megan Lindsay Fritz, Rebecca Lee Smith

“…This enhancement in modelling of mosquito abundance can be instrumental in guiding interventions aimed at reducing mosquito populations and mitigating mosquito-borne diseases such as the WNV. …”
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Whole-exome sequencing screening for candidate genes and potential pathogenic variants associated with early-onset high myopia in 47 Chinese families by Xue Rui, Huiping Li, Runqing Ma, Shangying Yang, Yuanyuan lian, Wanyu Cheng, Meijiao Ma, Weining Rong, Xunlun Sheng

“…In 28 patients (28/47, 59.6%), 32 potential pathogenic variants in 22 candidate genes were identified, including 24 novel variants. …”
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Population-level respiratory virus–virus interactions, Puerto Rico, 2013-2023 by Zachary J. Madewell, Joshua M. Wong, Maile B. Thayer, Vanessa Rivera-Amill, Diego Sainz de la Peña, Jorge Bertrán Pasarell, Gabriela Paz-Bailey, Laura E. Adams, Yang Yang

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Predicting the impact of non-pharmaceutical interventions against COVID-19 on Mycoplasma pneumoniae in the United States by Sang Woo Park, Brooklyn Noble, Emily Howerton, Bjarke F. Nielsen, Sarah Lentz, Lilliam Ambroggio, Samuel Dominguez, Kevin Messacar, Bryan T. Grenfell

“…The introduction of non-pharmaceutical interventions (NPIs) against COVID-19 disrupted circulation of many respiratory pathogens and eventually caused large, delayed outbreaks, owing to the build up of the susceptible pool during the intervention period. …”
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Acceptability of the ePOWER intervention: Managing previvors' cancer-related uncertainty and supporting decision making by Marleah Dean, Bethany Jowers, Claire Conley, Erica Camacho, Whitney Espinel, Kimberly A. Kaphingst

“…Objective: Previvors—unaffected individuals who have increased risk of cancer due to a pathogenic or likely pathogenic variant in a gene—experience high levels of uncertainty, which is associated with negative outcomes. …”
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Advances in the study of key cells and signaling pathways in renal fibrosis and the interventional role of Chinese medicines by Lijuan Liang, Lijuan Liang, Youjun Mi, Shihan Zhou, Aojian Yang, Chaoyu Wei, Enlai Dai

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Effects of Lactiplantibacillus plantarum HNU082 intervention on fungi and bacteriophages in different intestinal segments of mice by Xinlei Liu, Zhe Han, Wenyao Ma, Weipeng Cui, Dongyu Zhen, Shuaiming Jiang, Jiachao Zhang

“…The relative abundance of pathogenic fungi, such as Candida albicans, decreased in the small intestine. …”
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Targeting gut microbiota for diabetic nephropathy treatment: probiotics, dietary interventions, and fecal microbiota transplantation by Xiaoran Wang, Xinyin Liu, Fanghong Gong, Yan Jiang, Canwei Zhang, Wei Zhou, Wen Zhang

“…This review explores gut microbiota modulation as a promising treatment strategy for DN through probiotic supplementation, dietary interventions, and fecal microbiota transplantation(FMT) protocols. …”
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The maturation of native uropathogenic Escherichia coli biofilms seen through a non-interventional lens by Tianqi Zhang, Sanhita Ray, Keira Melican, Agneta Richter-Dahlfors

“…The UPEC biofilm lifestyle is believed to play an important role in infection recurrency and treatment resistance, but our understanding of how the extracellular matrix (ECM) components curli and cellulose contribute to biofilm formation and pathogenicity is limited. Here, we study the spatial and temporal development of native UPEC biofilm using agar-based detection methods where the non-toxic, optically active fluorescent tracer EbbaBiolight 680 reports the expression and structural location of curli in real-time. …”
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Quasiexperimental intervention study protocol to optimise the use of new antibiotics in Spain: the NEW_SAFE project by Jesús Rodríguez-Baño, Zaira R Palacios-Baena, Clara M Rosso-Fernández, Pilar Retamar, Lucia Valiente de Santis, Natalia Maldonado, Irene Borreguero, Carmen Herrero-Rodríguez, Salvador López-Cárdenas, Franciso J Martínez-Marcos, Andrés Martín-Aspas, Patricia Jiménez-Aguilar, Juan J Castón, Guillermo Ojeda-Burgos, M Pilar Aznarte-Padial, Julia Praena-Segovia, Juan E Corzo-Delgado, M Ángeles Esteban-Moreno

“…Introduction Ceftaroline, tedizolid, dalbavancin, ceftazidime-avibactam and ceftolozane-tazobactam are novel antibiotics used to treat infections caused by multidrug-resistant pathogens (MDR). Their use should be supervised and monitored as part of an antimicrobial stewardship programme (ASP). …”
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Organization of Joint Laboratory Studies during Sanitary and Epidemiological Interventions in the Republic of the Congo by Rospotrebnadzor Specialists by S. A. Portenko, E. V. Naidenova, D. A. Agafonov, D. A. Kuznetsova, A. V. Evteev, A. A. Tushinsky, L. N. Dmitrieva, A. D. Katyshev, V. E. Kuklev, N. Obissa, V. Mabiala, J. Loubano, M. Mpompolo, J.-C. Mobousse Misse, S. A. Shcherbakova, V. V. Kutyrev

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Gut microbiome remodeling in chronic kidney disease: implications of kidney replacement therapies and therapeutic interventions by Qianwei Wang, Yucheng Han, Liang Pang, Zhicheng Zhou, Lijuan Dai

“…., Faecalibacterium, Roseburia), and systemic microbial translocation; whereas PD-driven glucose absorption and iron supplementation foster pathogenic proliferation (e.g., Enterobacteriaceae) and impair short-chain fatty acid (SCFA) metabolism. …”
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A Smart Semi‐Implantable Device Integrating Microchannel‐Enhanced Sampling and Multiplex Biochemical Testing for Deep Wound Monitoring and Pathogen Identification by Qilin Li, Chunyu Wei, Luming Xu, Jiao Zhang, Yuyu Li, Xiaohuan Lu, Rengui Xu, Honglian Guo, Peng Cao, Chenke Ouyang, Jiarong Xu, Wei Chen, Zheng Wang, Lin Wang

“…The device's capability to rapidly and accurately identify pathogenic bacteria is also demonstrated both in vitro and in vivo, potentially facilitating precise intervention in infected wounds. …”
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