Malnutrition drives infection susceptibility and dysregulated myelopoiesis that persists after refeeding intervention by Alisa Sukhina, Clemence Queriault, Saptarshi Roy, Elise Hall, Kelly Rome, Muskaan Aggarwal, Elizabeth Nunn, Ashley Weiss, Janet Nguyen, F Chris Bennett, Will Bailis

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Cytokine Networks and the Clinical Outcome of American Teg-Umentary Leishmaniasis: Unveiling Targets for Alternative Therapeutic Interventions by Carolina Cattoni Koh, Kenneth J. Gollob, Walderez O. Dutra

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Contrasting and comparing the efficacy of mobility-targeted interventions on airborne and vector-borne diseases by Bibandhan Poudyal, David Soriano Paños, Gourab Ghoshal

“…These results offer key insights into the design of mobility-targeted interventions and the management of co-circulating pathogens in urban environments.…”
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Expanding Layers of Bacteriocin Applications: From Food Preservation to Human Health Interventions by Furkan Demirgül, Halil İbrahim Kaya, Redife Aslıhan Ucar, Naciye Afranur Mitaf, Ömer Şimşek

“…Bacteriocins, ribosomally synthesized by bacteria, have long been recognized for their role in ensuring food safety and security due to their antibacterial effects against foodborne pathogens and spoilage bacteria. However, recent advancements have unveiled their expanding potential beyond food applications, with increasing evidence of their efficacy against clinically significant pathogenic bacteria, biofilm formation, viral infections, and even cancer. …”
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Early genetic screening and cardiac intervention in patients with cardiomyopathies in a multidisciplinary clinic by Chandu Sadasivan, Luke R. Gagnon, Deepan Hazra, Kaiming Wang, Erik Youngson, Jissy Thomas, Anita Y.M. Chan, D. Ian Paterson, Finlay A. McAlister, Tara Dzwiniel, Wayne Tymchak, Susan Christian, Gavin Y. Oudit

“…Patients were seen in follow‐up at a median of 18 months. A pathogenic/likely pathogenic variant was identified in 28.5% of the total cohort, including 33.3% of the DCM cohort (28% TTN mutations) and 34.1% of the HCM cohort (60% MYBPC3 and 20% MYH7) who underwent genetic testing. …”
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IL-6 Signaling in Immunopathology: From Basic Biology to Selective Therapeutic Intervention by Schumertl T, Lokau J, Garbers C

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Healthy homes: Stakeholder perspectives on housing interventions to reduce environmentally mediated infections. by Matthias Acklin, Jay P Graham, Jade Benjamin-Chung

“…Housing conditions are intrinsically linked to human health, with inadequate housing potentially increasing exposure to environmentally mediated pathogens. Beyond efforts to improve water and sanitation and reduce household air pollution, housing improvements remain relatively under-explored as health interventions. …”
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A Multidisciplinary-Based and Bundle Intervention for Controlling Carbapenem-Resistant Organisms in Neurosurgery by Zhu W, Liang Y, Xu J, Weng C

“…The surveillance analysis and event analysis were used to identify the key links and targeted pathogens of the intervention. PDCA cycle management tool was used to strengthen the bundle management of multidisciplinary collaboration. …”
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Prioritising intervention areas for antimicrobial resistance in Nigeria's human and animal health sectors using a mixed-methods approach by Oche A. Awulu, Akinbowale Jenkins, Babatunde A. Balogun, Emelda E. Chukwu, Folorunso O. Fasina, Abiodun Egwuenu, Oyinlola O. Oduyebo, Tajudeen A. Bamidele, Simeon Cadmus, Mabel K. Aworh, Adewole A. Adekola, Andrew P. Desbois, Kennedy F. Chah, Lucy A. Brunton

“…A One Health approach is essential to prioritise intervention areas to tackle antimicrobial resistance (AMR). …”
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Germline pathogenic variants in DNA repair pathways: a key feature in a significant subset of translocation-associated sarcomas by Carla Saoud, Josephine K. Dermawan, Kanika Arora, William D. Tap, Damon Reed, Emily K. Slotkin, Leonard H. Wexler, Yonina R. Murciano-Goroff, Alicia Latham, Diana L. Mandelker, Cristina R. Antonescu

“…We aimed to investigate the clinical impact of germline pathogenic/likely pathogenic (P/LP) variants in a diverse group of TAS and to conduct a comprehensive comparative analysis of clinicopathologic features, genomic alterations, and survival outcomes. …”
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Presence of toxin-producing bacterial pathogens and associated risk factors in neonatal diarrhea of piglets on commercial sow farms in Vietnam by Duy Tien Do, Tram Thi Ngoc Ngo, Huong Dieu Vu, Nhat Minh Duong, Sittikorn Traiyarach, Danh Cong Lai, Joaquin Miguel Escuder

“…Logistic and ordinal regression models were applied to assess associations between risk factors and pathogen prevalence. Results: All farms tested positive for at least one pathogen. …”
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The Role of Sustained Type I Interferon Secretion in Chronic HIV Pathogenicity: Implications for Viral Persistence, Immune Activation, and Immunometabolism by Eman Teer, Nyasha C. Mukonowenzou, M. Faadiel Essop

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The impact of the SARS-CoV-2 pandemic on the prevalence of respiratory tract pathogens in patients with community-acquired pneumonia in Germany by Theo Dähne, Wolfgang Bauer, Andreas Essig, Bernhard Schaaf, Christoph D. Spinner, Mathias W. Pletz, Gernot Rohde, Jan Rupp, Martin Witzenrath, Marcus Panning

“…We show a shift in the prevalence of respiratory viral pathogens in community-acquired pneumonia patients during the COVID-19 pandemic. …”
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Molecular characterisation of virulence genes in bacterial pathogens from daycare centres in Ile-Ife, Nigeria: implications for infection control by Eunice Damilola Wilkie, Jude Oluwapelumi Alao, Toyosi Teniola Sotala, Anthonia Olufunke Oluduro

“…Conclusion This study highlights the presence of virulent bacterial pathogens in daycare environments, posing a severe infection risk to children. …”
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Being a better version of yourself: genetically engineered probiotic bacteria as host defense enhancers in the control of intestinal pathogens by Ewa Carolak, Joanna Czajkowska, Adrianna Stypułkowska, Wiktoria Waszczuk, Agata Dutkiewicz, Krzysztof Grzymajlo

“…By understanding the complex interplay between probiotics, pathogens, and host immunity, innovative strategies can be developed to harness the full therapeutic potential of probiotic interventions in maintaining gut health.…”
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Budget impact analysis of routinely using whole-genomic sequencing of six multidrug-resistant bacterial pathogens in Queensland, Australia by Philip L Russo, David L Paterson, Thomas M Elliott, Louisa G Gordon, Brian Forde, Brett Mitchell, Patrick N A Harris

“…Objective To predict the cost and health effects of routine use of whole-genome sequencing (WGS) of bacterial pathogens compared with those of standard of care.Design Budget impact analysis was performed over the following 5 years. …”
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Epidemiological trends and pathogen analysis of pediatric acute respiratory infections in Hanzhong Hospital, China: insights from 2023 to 2024 by Yuanfang He, Xiaoliang He, Ning He, Peipei Wang, You Gao, Jiexin Sheng, Jin Tang

“…Understanding the distribution of respiratory pathogens is crucial for effective prevention and treatment. …”
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Burden of bacterial lower respiratory tract infections in hospitalized children and epidemiological characteristics of pathogens in Hanzhong, China (2023–2024) by Chunmei Zheng, Yu Hu, Hang Hu, Wenhua Chen, Sanjun He, Xiaoxia Huang, Chengchao Lai, You Gao, Jin Tang

“…A total of 3413 specimens (62.88%) exhibited mixed growth of normal respiratory flora and were classified as culture-negative for pathogenic bacteria, based on standard microbiological criteria. …”
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Gut microbiota-driven pathogenic Th17 cells mediated autoimmune epididymo-orchitis in a mouse model of colitis by Qunxiong Zeng, Jin-Chuan Liu, Chen Yang, Minmin Lyu, Dongliang Li, William S.B. Yeung, Philip C.N. Chiu, Tao Zhang, Yong-Gang Duan

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Enhancing bloodstream infection diagnostics: a novel filtration and targeted next-generation sequencing approach for precise pathogen identification by Ting-Syuan Lin, Ting-Syuan Lin, Ting-Syuan Lin, ZiHao Zhu, ZiHao Zhu, ZiHao Zhu, XiaoHong Lin, Hsi-Yuan Huang, Hsi-Yuan Huang, Hsi-Yuan Huang, Li-Ping Li, Li-Ping Li, Li-Ping Li, Jing Li, Jing Li, Jing Li, Jie Ni, Jie Ni, Jie Ni, PeiZhi Li, LanChun Chen, WeiXin Tang, HuiXin Liu, XiaoLong Se, MingFei Xie, Canling Long, Chih-Min Chiu, Szu-Han Fang, JiaMing Zhao, Yang-Chi-Dung Lin, Yang-Chi-Dung Lin, Yang-Chi-Dung Lin, XueTao Yu, Hsien-Da Huang, Hsien-Da Huang, Hsien-Da Huang, Hsien-Da Huang

“…These methods often yield low positive rates, have lengthy processing times that delay treatment, and are limited in detecting only a narrow range of pathogens. Such delays and inaccuracies can critically impede timely clinical interventions, potentially compromising patient outcomes. …”
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