Integrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans. by Chandrasekaran Komalapriya, Despoina Kaloriti, Anna T Tillmann, Zhikang Yin, Carmen Herrero-de-Dios, Mette D Jacobsen, Rodrigo C Belmonte, Gary Cameron, Ken Haynes, Celso Grebogi, Alessandro P S de Moura, Neil A R Gow, Marco Thiel, Janet Quinn, Alistair J P Brown, M Carmen Romano

“…The major fungal pathogen of humans, Candida albicans, mounts robust responses to oxidative stress that are critical for its virulence. …”
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Integrating DNA and RNA sequencing for enhanced pathogen detection in respiratory infections by Dejian Gu, Jie Liu, Jiaping Wang, Yuting Yi, Yuxing Chu, Rui Gao, Hao Liu, Jun She, Binghuai Lu

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Tracking ranavirus infections: an integrative review of epidemiological research on pathogen dynamics in anurans by D. D. S. Rodrigues, R. D. C. C. Maia, G. J. B. D. Moura, R. L. M. D. Sousa, J. W. P. Junior

“…We found relevant reports confirming the high prevalence of this pathogen and the risk it poses, including to endangered species. …”
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Proteomics and integrative omic approaches for understanding host–pathogen interactions and infectious diseases by Pierre M Jean Beltran, Joel D Federspiel, Xinlei Sheng, Ileana M Cristea

“…Abstract Organisms are constantly exposed to microbial pathogens in their environments. When a pathogen meets its host, a series of intricate intracellular interactions shape the outcome of the infection. …”
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Electrochemical Impedance Spectroscopy-Based Biosensors for Label-Free Detection of Pathogens by Huaiwei Zhang, Zhuang Sun, Kaiqiang Sun, Quanwang Liu, Wubo Chu, Li Fu, Dan Dai, Zhiqiang Liang, Cheng-Te Lin

“…This review provides a comprehensive overview of the design and application of EIS-based biosensors tailored for pathogen detection, focusing on critical components such as biorecognition elements, electrode materials, nanomaterial integration, and surface immobilization strategies. …”
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Integrating RNA Interference and Nanotechnology: A Transformative Approach in Plant Protection by Mohammad Shafiqul Islam, Md Robel Ahmed, Muhammad Noman, Zhen Zhang, Jing Wang, Ziqi Lu, Yingying Cai, Temoor Ahmed, Bin Li, Yanli Wang, Abul Khayer Mohammad Golam Sarwar, Jiaoyu Wang

“…RNA interference (RNAi) has emerged as a potent mechanism for combating pathogenic fungi and oomycetes over the past decades. …”
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Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles by Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu

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Integrated genome and transcriptome analysis reveals pathogenic mechanisms of Calonectria eucalypti in Eucalyptus leaf blight by QianLi Liu, GuoQing Li, YuHua Liang, Yan Lin, KaiDong Liu, ZhenChi Huang, ShanNi Cao, FeiFei Liu

“…Moreover, most SMGCs were located in transposable element (TE)-rich regions, supporting a “two-speed” genome architecture that may facilitates adaptive evolution and pathogenic innovation. Conclusions This study provides the first integrative genome and infection-stage transcriptome map of C. eucalypti, revealing a coordinated, stage-specific deployment of pathogenicity-related gene clusters. …”
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Integrating next-generation sequencing and artificial intelligence for the identification and validation of pathogenic variants in colorectal cancer by Juliana Rodriguez-Salamanca, Mariana Angulo-Aguado, Sarah Orjuela-Amarillo, Catalina Duque, Diana Carolina Sierra-Díaz, Nora Contreras Bravo, Carlos Figueroa, Carlos M. Restrepo, Andrés López-Cortés, Rodrigo Cabrera, Adrien Morel, Dora Janeth Fonseca-Mendoza

“…We assessed the model’s accuracy in predicting germline variants by comparing its results with the AlphaMissense pathogenicity prediction model. Additionally, a minigene assay was employed for the functional validation of intronic mutations.ResultsOur findings revealed that 12% of the patients carried pathogenic/likely pathogenic (P/LP) variants according to ACMG/AMP criteria. …”
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Integrative bioinformatics analysis to decipher common pathogenic processes in type 2 diabetes mellitus and pancreatic cancer by Faez Falah Alshehri

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Integrating patient metadata and pathogen genomic data: advancing pandemic preparedness with a multi-parametric simulator by Bonjean Maxime, Ambroise Jérôme, Orchard Francisco, Sentis Alexis, Hurel Julie, Hayes Jessica S., Connolly Máire A., Jean-Luc Gala

“…These scenarios are designed by integrating datasets that represent populations exposed to a pandemic pathogen, combining pathogen genomic data generated through high-throughput sequencing (HTS) together with patient epidemiological, clinical, and demographic information. …”
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Why an Integrated Approach to Tick-Borne Pathogens (Bacterial, Viral, and Parasitic) Is Important in the Diagnosis of Clinical Cases by Raúl Contreras-Ferro, Jorge Martín Trueba, Patricia Sánchez-Mora, Raquel Escudero, María Paz Sánchez-Seco, Estrella Montero, Anabel Negredo, Luis Miguel González, Alejandro Dashti, María Teresa Llorente, Judit Gil-Zamorano, Ana Vázquez, Isabel Jado, David González-Barrio

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Integrating Anaerobic Digestion With Struvite Production for Enhanced Nutrient Recovery, Pathogen Reduction, and Circularity in Manure Management by Anita Nagarajan, Bernard Goyette, Vijaya Raghavan, Dominic Poulin‐Laprade, Rajinikanth Rajagopal

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Integrating Metagenomic and Culture-Based Techniques to Detect Foodborne Pathogens and Antimicrobial Resistance Genes in Malaysian Produce by Jerrald Jia Weai Quek, Jun Leong Wong, Joon Liang Tan, Chew Chieng Yeo, Seow Hoon Saw

“…Discrepancies between the methods suggest the need for integrated approaches to improve the pathogen detection accuracy. …”
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Integrative Analysis of Shared Pathogenic Genes and Potential Mechanisms in Gardnerella vaginalis and Persistent HPV16 Infection by Ye Li, Yue Wang, Xianhua Liu, Huifeng Xue, Liying Wang, Maotong Zhang, Pengming Sun

“…Bacterial vaginosis, often accompanied by Gardnerella vaginalis (GV) overgrowth, is associated with persistent high-risk human papillomavirus (HR-HPV) infection, particularly HPV16. This study integrated transcriptomic data from in vitro GV infection experiments and a GEO dataset (GSE75132) of HPV16 persistence to elucidate shared pathogenic mechanisms. …”
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Groundbreaking Technologies and the Biocontrol of Fungal Vascular Plant Pathogens by Carmen Gómez-Lama Cabanás, Jesús Mercado-Blanco

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The putative type 4 secretion system effector BspD is involved in maintaining envelope integrity of the pathogen Brucella by Maren Ketterer, Petra Chiquet, Mara Esposito, Jaroslaw Sedzicki, Maxime Québatte, Christoph Dehio

“…ABSTRACT Brucellosis is a debilitating disease caused by the Gram-negative, facultative intracellular zoonotic pathogen Brucella. En route to its intracellular replicative niche, Brucella encounters various stressful environments that may compromise envelope integrity. …”
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Tickborne <i>Colpodella</i> Species Infections: Time for a New Integrated Approach to Understand Transmission and Pathogenicity by Tobili Y. Sam-Yellowe, Trinity Nims, Sona Qaderi, Mary M. Asraf

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Unraveling ScAPD1-mediated resistance mechanism to Verticillium dahliae through integrated host-pathogen transcriptomics by Qilin Yang, Ruirui Yang, Huan Zhang, Fangliu Yin, Leyi Wang, Daoyuan Zhang, Xiaoshuang Li

“…This study investigates the role of ScAPD1, a Soloist transcription factor from the extremophilic moss Syntrichia caninervis, in conferring resistance to V. dahliae when overexpressed in the model plant Arabidopsis thaliana. We employed an integrated host-pathogen transcriptomics approach (dual RNA-seq), alongside physiological and biochemical experiments. …”
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Integrated evaluation of antifungal activity of pomegranate peel polyphenols against a diverse range of postharvest fruit pathogens by Muhammad Nawaz, Junkun Pan, Hui Liu, Muhammad Jawad Umer, Jiechao Liu, Wenbo Yang, Zhenzhen Lv, Qiang Zhang, Zhonggao Jiao

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